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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DBNL-CTTN (FusionGDB2 ID:21455)

Fusion Gene Summary for DBNL-CTTN

check button Fusion gene summary
Fusion gene informationFusion gene name: DBNL-CTTN
Fusion gene ID: 21455
HgeneTgene
Gene symbol

DBNL

CTTN

Gene ID

28988

2017

Gene namedrebrin likecortactin
SynonymsABP1|HIP-55|HIP55|SH3P7EMS1
Cytomap

7p13

11q13.3

Type of geneprotein-codingprotein-coding
Descriptiondrebrin-like proteinHPK1-interacting protein of 55 kDaSH3 domain-containing protein 7actin-binding protein 1cervical SH3P7cervical mucin-associated proteindrebrin-Fsrc homology 3 domain-containing protein HIP-55src substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)epididymis secretory sperm binding proteinoncogene EMS1
Modification date2020031320200327
UniProtAcc

Q9UJU6

Q9P2B4

Ensembl transtripts involved in fusion geneENST00000497184, ENST00000440166, 
ENST00000448521, ENST00000452943, 
ENST00000456905, ENST00000468694, 
ENST00000490734, ENST00000494774, 
ENST00000301843, ENST00000346329, 
ENST00000376561, ENST00000527622, 
ENST00000538675, 
Fusion gene scores* DoF score5 X 5 X 3=7513 X 11 X 6=858
# samples 513
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DBNL [Title/Abstract] AND CTTN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDBNL(44099752)-CTTN(70281131), # samples:1
Anticipated loss of major functional domain due to fusion event.DBNL-CTTN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DBNL-CTTN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DBNL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CTTN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5357NDBNLchr7

44099752

+CTTNchr11

70281131

+


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Fusion Gene ORF analysis for DBNL-CTTN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497184ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
3UTR-3CDSENST00000497184ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
3UTR-intronENST00000497184ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
3UTR-intronENST00000497184ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
3UTR-intronENST00000497184ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000440166ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000440166ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000440166ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000448521ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000448521ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000448521ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000452943ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000452943ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000452943ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000456905ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000456905ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000456905ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000468694ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000468694ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000468694ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000490734ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000490734ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000490734ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000494774ENST00000376561DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000494774ENST00000527622DBNLchr7

44099752

+CTTNchr11

70281131

+
5CDS-intronENST00000494774ENST00000538675DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000440166ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000440166ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000448521ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000448521ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000452943ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000452943ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000456905ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000456905ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000468694ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000468694ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000490734ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000490734ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000494774ENST00000301843DBNLchr7

44099752

+CTTNchr11

70281131

+
Frame-shiftENST00000494774ENST00000346329DBNLchr7

44099752

+CTTNchr11

70281131

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DBNL-CTTN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DBNLchr744099752+CTTNchr1170281131+2.43E-050.9999757
DBNLchr744099752+CTTNchr1170281131+2.43E-050.9999757

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DBNL-CTTN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44099752/:70281131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DBNL

Q9UJU6

CTTN

Q9P2B4

FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.FUNCTION: Regulates lamellipodial actin dynamics in a CTTN-dependent manner. {ECO:0000250|UniProtKB:Q8SX68}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DBNL-CTTN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DBNL-CTTN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DBNL-CTTN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DBNL-CTTN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource