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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCAF13-DECR1 (FusionGDB2 ID:21482)

Fusion Gene Summary for DCAF13-DECR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF13-DECR1
Fusion gene ID: 21482
HgeneTgene
Gene symbol

DCAF13

DECR1

Gene ID

25879

1666

Gene nameDDB1 and CUL4 associated factor 132,4-dienoyl-CoA reductase 1
SynonymsGM83|HSPC064|Sof1|WDSOF1DECR|NADPH|SDR18C1
Cytomap

8q22.3

8q21.3

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 13WD repeat and SOF domain-containing protein 1WD repeats and SOF1 domain containing2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1
Modification date2020031320200313
UniProtAcc

Q9NV06

Q16698

Ensembl transtripts involved in fusion geneENST00000521999, ENST00000297579, 
ENST00000519682, ENST00000521971, 
ENST00000521716, 
ENST00000220764, 
ENST00000519007, ENST00000522161, 
Fusion gene scores* DoF score8 X 8 X 3=1927 X 8 X 7=392
# samples 810
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF13 [Title/Abstract] AND DECR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCAF13(104439480)-DECR1(91049069), # samples:1
Anticipated loss of major functional domain due to fusion event.DCAF13-DECR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DCAF13-DECR1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDECR1

GO:0006635

fatty acid beta-oxidation

15531764


check buttonFusion gene breakpoints across DCAF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DECR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23Y-01ADCAF13chr8

104439480

+DECR1chr8

91049069

+


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Fusion Gene ORF analysis for DCAF13-DECR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521999ENST00000220764DCAF13chr8

104439480

+DECR1chr8

91049069

+
3UTR-intronENST00000521999ENST00000519007DCAF13chr8

104439480

+DECR1chr8

91049069

+
3UTR-intronENST00000521999ENST00000522161DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000297579ENST00000519007DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000297579ENST00000522161DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000519682ENST00000519007DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000519682ENST00000522161DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000521971ENST00000519007DCAF13chr8

104439480

+DECR1chr8

91049069

+
5CDS-intronENST00000521971ENST00000522161DCAF13chr8

104439480

+DECR1chr8

91049069

+
Frame-shiftENST00000297579ENST00000220764DCAF13chr8

104439480

+DECR1chr8

91049069

+
In-frameENST00000519682ENST00000220764DCAF13chr8

104439480

+DECR1chr8

91049069

+
In-frameENST00000521971ENST00000220764DCAF13chr8

104439480

+DECR1chr8

91049069

+
intron-3CDSENST00000521716ENST00000220764DCAF13chr8

104439480

+DECR1chr8

91049069

+
intron-intronENST00000521716ENST00000519007DCAF13chr8

104439480

+DECR1chr8

91049069

+
intron-intronENST00000521716ENST00000522161DCAF13chr8

104439480

+DECR1chr8

91049069

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000521971DCAF13chr8104439480+ENST00000220764DECR1chr891049069+2447189368469133
ENST00000519682DCAF13chr8104439480+ENST00000220764DECR1chr891049069+123568135544169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000521971ENST00000220764DCAF13chr8104439480+DECR1chr891049069+0.0070636790.9929363
ENST00000519682ENST00000220764DCAF13chr8104439480+DECR1chr891049069+0.0042649890.99573493

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Fusion Genomic Features for DCAF13-DECR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DCAF13chr8104439480+DECR1chr891049068+0.0011175690.9988825
DCAF13chr8104439480+DECR1chr891049068+0.0011175690.9988825

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DCAF13-DECR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:104439480/chr8:91049069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF13

Q9NV06

DECR1

Q16698

FUNCTION: Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16949367}.FUNCTION: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. {ECO:0000269|PubMed:15531764}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511107_146360598.0RepeatNote=WD 2
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511149_191360598.0RepeatNote=WD 3
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511194_234360598.0RepeatNote=WD 4
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511236_276360598.0RepeatNote=WD 5
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511280_319360598.0RepeatNote=WD 6
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+511323_362360598.0RepeatNote=WD 7
HgeneDCAF13chr8:104439480chr8:91049069ENST00000297579+51164_104360598.0RepeatNote=WD 1
TgeneDECR1chr8:104439480chr8:91049069ENST00000220764410240_243188336.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDECR1chr8:104439480chr8:91049069ENST0000022076441066_71188336.0Nucleotide bindingNADP


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Fusion Gene Sequence for DCAF13-DECR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21482_21482_1_DCAF13-DECR1_DCAF13_chr8_104439480_ENST00000519682_DECR1_chr8_91049069_ENST00000220764_length(transcript)=1235nt_BP=681nt
ACACCTCGTGGAGTCCGGCCGGAAGAGCAACCGAGATGAAGGTGAAGATGCTGAGCCGGAATCCGGACAATTATGTCCGCGAAACCAAGT
TGGACTTACAGAGAGTTCCAAGAAACTATGATCCTGCTTTACATCCTTTTGAGGTCCCACGAGAATATATAAGAGCTTTAAATGCTACCA
AACTGGAACGAGTATTTGCAAAACCATTCCTTGCTTCGCTGGATGGTCACCGTGATGGAGTCAATTGCTTGGCAAAGCATCCAGAGAAGC
TGGCTACTGTCCTTTCTGGGGCGTGTGATGGAGAGGTTAGAATTTGGAATCTAACTCAGCGGAATTGTATCCGTACAATACAAGCACATG
AAGGCTTTGTACGAGGAATATGTACTCGCTTTTGTGGGACTTCTTTTTTCACTGTTGGTGATGACAAAACTGTGAAGCAGTGGAAAATGG
ATGGGCCAGGCTATGGAGACGAGGAAGAGCCATTACATACAATATTAGGAAAGGTAATGTTTTTTTTTAAGTATGTTTTACTTATTATGG
CTTAATAATTTCAGTTCTGTTTAGAAAACTTTTGAATGTATGATAGAAACTTCTGAATTTTAATGGTGTTTTGGCATTTTGTCAGTTTTC
CCGATTGTAAATGAGTTCTGATACCTTTGCTCAAATCCCAACATGTTTCCCGAGCAGCATTTCTTTCTATTACTACTATCTATGCTGAGA
CTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTCTCTTGCAGCTGAATGGGGTAAATATG
GAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAA
TGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGA
TTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGT
GGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCTTGGTTACAGAAAAGGGAATAGAAATG

>21482_21482_1_DCAF13-DECR1_DCAF13_chr8_104439480_ENST00000519682_DECR1_chr8_91049069_ENST00000220764_length(amino acids)=169AA_BP=
MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGE

--------------------------------------------------------------
>21482_21482_2_DCAF13-DECR1_DCAF13_chr8_104439480_ENST00000521971_DECR1_chr8_91049069_ENST00000220764_length(transcript)=2447nt_BP=1893nt
GGAGGAGGTGGCGGTGGGCGGAACTCCTAGCGGACACCTCGTGGAGTCCGGCCGGAAGAGCAACCGAGATGAAGGTGAAGATGCTGAGCC
GGAATCCGGACAATTATGTCCGCGAAACCAAGTTGGACTTACAGAGAGTTCCAAGAAACTATGATCCTGCTTTACATCCTTTTGAGGTCC
CACGAGAATATATAAGAGCTTTAAATGCTACCAAACTGGAACGAGTATTTGCAAAACCATTCCTTGCTTCGCTGGATGGTCACCGTGATG
GAGTCAATTGCTTGGCAAAGCATCCAGAGAAGCTGGCTACTGTCCTTTCTGGGGCGTGTGATGGAGAGGTTGGTGATGACAAAACTGTGA
AGCAGTGGAAAATGGATGGGCCAGGCTATGGAGACGAGGAAGAGCCATTACATACAATATTAGGAAAGGTAATGTTTTTTTTTAAGTATG
TTTTACTTATTATGGCTTAATAATTTCAGTTCTGTTTAGAAAACTTTTGAATGTATGATAGAAACTTCTGAATTTTAATGGTGTTTTGGC
ATTTTGTCAGTTTTCCCGATTGTAAATGAGTTCTGATACCTTTGCTCAAATCCCAACATGTTTCCCAGCAGTTTAGTCCCAGATACTAGA
GTTAAGCATTGTTAGAGGAGTGGTGTGTGCATTTGCCCATTGGGGTAAAATCCAAGTAAATATAGTCTTGTTTTAACTTTAGTTTTACTC
ATGCCTTCAACTTCATGTTCCATAGATTATGTCATTGTACATTTAGGAAAATGTTAATTTTTCTACCTGCCTTGGAGGTCAGAAGAAGGA
GCATTGGACATCATTTTGTCTATTTGTAATTGGTAAGGTACCAATGCTTCATAAAAACATTTGTGATTATTGTTGAACTGCATGGTAATT
AGTTATAGTTATATTTTTCTTTGCTCAGAAGTCTGAATTGTGATTCCCAGTTCCTCCAGGCCTAAGGGAAGAGTTGGAGATTGGCCACTA
CATGTCGTCTGTTTAGGTCTGAATTTAGGAATGGAGGCTGTCCTGAAGGCTAAGCTAGCCCTTGGACTCCAGATCTTTCTCTGAACTTTT
TCTTAATGCATAACAATAGATGAACTGATTGTCCAGAAGACTCAGTAGGGATATGTTTTTCCTGTTGAAAGAAAAGGCAATCATAGCATA
TATAAGCCAATTTTAGCAGTTATTGCGAGGCTACCATTTTAGGTAGTATGAGAGAAAAATCCTAATATGCAAGTGTTATGCTCTTAAAGA
CCCAACCTGATAAAAGATAGGAAGTAAGGTTGAGTCAAAATAGTAAGGTATAAAAATAGTTTGTATGATATACTGGAAAATGAGATGCTG
CAGTGCGATGTGAGCTTGGCCTTGAGGAATTACTGAGAAGTCAGAGGACACTCTTCCTGCAACTACCACATGCTCACACACACACTTTCT
AGAGACGCTACAGGTCTAGAATAGGTTGGCAAACTAGTCTGTGAGCCACATGTGGCCCACTGCCTGTTTTTGTAAATAGAGCTCTGCTAG
AAGACAGCCATGTTCTCTTGCGTACATATTGTCTGTAGCTGCTTTCGTGCTATGATGGCAGAGTTAAGTAATTGCCACAGAGACCATATG
GCCCACAAAACCTAAAATACTTACTCTCTGGCCCTTTACAGAAAAAGTTTTCTGATTCCTGGTCTGGAGTGTCTGTCTCTATTATATCTT
TCTCACTCCATCCTCCATCTTCCTTCCTTATGTTTCCCTTGGTTGTAGAAGAGAGAAGTGGCATGGAAAGGCAGCTACCTTTGCAGAGCA
GGACCAAGTGTAAAAGTTGATAACATATGTGAACATTTTTTAAAAGTGCTATCCAAATTCAAGATGGTGACGGTATTACGTACTAAAAAA
AAAGAGCAGCATTTCTTTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGG
AAGCCATGAGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTG
CCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCG
CAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTT
CAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAAGACC
ACTTTGGCCTTCATCTTGGTTACAGAAAAGGGAATAGAAATGAAACAAATTATCTCTCATCTTTTGACTATTTCAAGTCTAATAAATTCT

>21482_21482_2_DCAF13-DECR1_DCAF13_chr8_104439480_ENST00000521971_DECR1_chr8_91049069_ENST00000220764_length(amino acids)=133AA_BP=
MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCAF13-DECR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCAF13-DECR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCAF13-DECR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource