FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DCAF5-DCAF5 (FusionGDB2 ID:21504)

Fusion Gene Summary for DCAF5-DCAF5

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF5-DCAF5
Fusion gene ID: 21504
HgeneTgene
Gene symbol

DCAF5

DCAF5

Gene ID

8816

8816

Gene nameDDB1 and CUL4 associated factor 5DDB1 and CUL4 associated factor 5
SynonymsBCRG2|BCRP2|D14S1461E|WDR22BCRG2|BCRP2|D14S1461E|WDR22
Cytomap

14q24.1

14q24.1

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2DDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2
Modification date2020031320200313
UniProtAcc

Q96JK2

Q96JK2

Ensembl transtripts involved in fusion geneENST00000341516, ENST00000389997, 
ENST00000553293, ENST00000554215, 
ENST00000556847, ENST00000557386, 
ENST00000341516, ENST00000554215, 
ENST00000389997, ENST00000553293, 
ENST00000556847, ENST00000557386, 
Fusion gene scores* DoF score15 X 13 X 8=156010 X 10 X 6=600
# samples 1611
** MAII scorelog2(16/1560*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF5 [Title/Abstract] AND DCAF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCAF5(69520491)-DCAF5(69520518), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DCAF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DCAF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI081794DCAF5chr14

69520491

+DCAF5chr14

69520518

-
ChiTaRS5.0N/AAI493336DCAF5chr14

69520491

+DCAF5chr14

69520518

-


Top

Fusion Gene ORF analysis for DCAF5-DCAF5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000341516ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000341516ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000389997ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000389997ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000553293ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000553293ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000554215ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000554215ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000556847ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000556847ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000557386ENST00000341516DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-3UTRENST00000557386ENST00000554215DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000341516ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000341516ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000341516ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000341516ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000389997ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000389997ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000389997ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000389997ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000553293ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000553293ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000553293ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000553293ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000554215ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000554215ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000554215ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000554215ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000556847ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000556847ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000556847ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000556847ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000557386ENST00000389997DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000557386ENST00000553293DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000557386ENST00000556847DCAF5chr14

69520491

+DCAF5chr14

69520518

-
intron-intronENST00000557386ENST00000557386DCAF5chr14

69520491

+DCAF5chr14

69520518

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DCAF5-DCAF5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DCAF5-DCAF5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69520491/:69520518)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF5

Q96JK2

DCAF5

Q96JK2

FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DCAF5-DCAF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DCAF5-DCAF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DCAF5-DCAF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DCAF5-DCAF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource