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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCAF5-DPY19L2 (FusionGDB2 ID:21505)

Fusion Gene Summary for DCAF5-DPY19L2

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF5-DPY19L2
Fusion gene ID: 21505
HgeneTgene
Gene symbol

DCAF5

DPY19L2

Gene ID

8816

283417

Gene nameDDB1 and CUL4 associated factor 5dpy-19 like 2
SynonymsBCRG2|BCRP2|D14S1461E|WDR22SPATA34|SPGF9
Cytomap

14q24.1

12q14.2

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2probable C-mannosyltransferase DPY19L2protein dpy-19 homolog 2spermatogenesis associated 34
Modification date2020031320200313
UniProtAcc

Q96JK2

Q6ZN68

Ensembl transtripts involved in fusion geneENST00000341516, ENST00000389997, 
ENST00000557386, ENST00000553293, 
ENST00000554215, ENST00000556847, 
ENST00000413230, ENST00000324472, 
Fusion gene scores* DoF score15 X 13 X 8=15605 X 8 X 4=160
# samples 166
** MAII scorelog2(16/1560*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/160*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF5 [Title/Abstract] AND DPY19L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCAF5(69619482)-DPY19L2(64055261), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DCAF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPY19L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AS-01ADCAF5chr14

69619482

-DPY19L2chr12

64055261

-


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Fusion Gene ORF analysis for DCAF5-DPY19L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341516ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
5CDS-intronENST00000389997ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
5CDS-intronENST00000557386ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
In-frameENST00000341516ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
In-frameENST00000389997ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
In-frameENST00000557386ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-3CDSENST00000553293ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-3CDSENST00000554215ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-3CDSENST00000556847ENST00000324472DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-intronENST00000553293ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-intronENST00000554215ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-
intron-intronENST00000556847ENST00000413230DCAF5chr14

69619482

-DPY19L2chr12

64055261

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341516DCAF5chr1469619482-ENST00000324472DPY19L2chr1264055261-37883622182188656
ENST00000557386DCAF5chr1469619482-ENST00000324472DPY19L2chr1264055261-3665239952065656
ENST00000389997DCAF5chr1469619482-ENST00000324472DPY19L2chr1264055261-3645219752045656

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341516ENST00000324472DCAF5chr1469619482-DPY19L2chr1264055261-0.0003837210.99961627
ENST00000557386ENST00000324472DCAF5chr1469619482-DPY19L2chr1264055261-0.0003663910.99963355
ENST00000389997ENST00000324472DCAF5chr1469619482-DPY19L2chr1264055261-0.0003685550.9996314

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Fusion Genomic Features for DCAF5-DPY19L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCAF5-DPY19L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:69619482/chr12:64055261)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF5

Q96JK2

DPY19L2

Q6ZN68

FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222154_174150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222195_215150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222243_265150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222269_286150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222297_317150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222344_364150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222372_392150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222423_443150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222489_509150759.0TransmembraneHelical
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222534_554150759.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-19140_18071943.0RepeatNote=WD 3
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-19185_22571943.0RepeatNote=WD 4
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-19277_31771943.0RepeatNote=WD 5
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-19331_37071943.0RepeatNote=WD 6
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-1951_9171943.0RepeatNote=WD 1
HgeneDCAF5chr14:69619482chr12:64055261ENST00000341516-1999_13971943.0RepeatNote=WD 2
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-19140_1800861.0RepeatNote=WD 3
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-19185_2250861.0RepeatNote=WD 4
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-19277_3170861.0RepeatNote=WD 5
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-19331_3700861.0RepeatNote=WD 6
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-1951_910861.0RepeatNote=WD 1
HgeneDCAF5chr14:69619482chr12:64055261ENST00000554215-1999_1390861.0RepeatNote=WD 2
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-19140_1800861.0RepeatNote=WD 3
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-19185_2250861.0RepeatNote=WD 4
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-19277_3170861.0RepeatNote=WD 5
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-19331_3700861.0RepeatNote=WD 6
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-1951_910861.0RepeatNote=WD 1
HgeneDCAF5chr14:69619482chr12:64055261ENST00000556847-1999_1390861.0RepeatNote=WD 2
TgeneDPY19L2chr14:69619482chr12:64055261ENST00000324472222108_128150759.0TransmembraneHelical


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Fusion Gene Sequence for DCAF5-DPY19L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21505_21505_1_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000341516_DPY19L2_chr12_64055261_ENST00000324472_length(transcript)=3788nt_BP=362nt
TGTCTGCACACCTCGCTCTGCCTGCCATGGCTGGTTAAAGAACCATCCGGATCGCAGCGCGGGGGGAGGGCCGGGTGGGGGGAGCAGCGG
CCGCGCGTGAGGCCGAGGGAGGGGCGGCGGCGCGAGCGGCGGCGGCGGCGGTTCCAGCATGAAGAGGAGAGCTGGCCTGGGGGGCAGCAT
GAGGTCAGTGGTGGGCTTCTTGTCCCAGCGGGGCTTGCATGGGGACCCCCTGCTCACTCAGGACTTTCAGAGGAGACGCCTGCGGGGCTG
CAGAAACCTCTACAAGAAGGACCTCCTCGGCCACTTCGGCTGTGTCAATGCCATTGAATTCTCCAACAATGGAGGCCAGTGGCTGGTCTC
AGGGACTTTATTATTCATACTTCAAGACCATTATTGAAGCACCTTCGTTTTTGGAAGGACTGTGGATGATTATGAATGACAGGCTTACTG
AATATCCTCTTATAATTAATGCAATAAAACGCTTCCATCTTTATCCAGAGGTAATCATAGCCTCCTGGTATTGCACATTCATGGGAATAA
TGAATTTATTTGGACTAGAAACTAAGACCTGCTGGAATGTCACCAGAATAGAACCTCTTAATGAAGTTCAAAGCTGTGAAGGATTGGGAG
ATCCTGCTTGCTTTTATGTTGGTGTAATCTTTATTTTAAATGGACTAATGATGGGATTGTTCTTCATGTATGGAGCATACCTGAGTGGGA
CTCAACTGGGAGGTCTTATTACAGTACTGTGCTTCTTTTTCAACCATGGAGAGGCCACCCGTGTGATGTGGACACCACCTCTCCGTGAAA
GTTTTTCCTATCCTTTCCTTGTACTTCAGATGTGTATTTTAACTTTGATTCTCAGGACCTCAAGCAATGATAGAAGGCCCTTCATTGCAC
TCTGTCTTTCCAATGTTGCTTTTATGCTTCCCTGGCAATTTGCTCAGTTTATACTTTTTACACAGATAGCATCATTATTTCCCATGTATG
TTGTGGGATACATTGAACCAAGCAAATTTCAGAAGATCATTTATATGAACATGATTTCAGTTACCCTTAGTTTCATTTTGATGTTTGGAA
ATTCAATGTACTTATCTTCTTATTATTCTTCATCTTTGTTAATGACGTGGGCAATAATTCTAAAGAGAAATGAAATTCAAAAACTGGGAG
TATCTAAACTCAACTTTTGGCTAATTCAAGGTAGTGCCTGGTGGTGTGGAACAATCATTTTGAAATTTCTGACATCTAAAATCTTAGGCG
TTTCAGACCACATTCGCCTGAGTGATCTTATAGCAGCCAGAATCTTAAGGTATACAGATTTTGATACTTTAATATATACCTGTGCTCCCG
AATTTGACTTCATGGAAAAAGCGACTCCGCTGAGATACACAAAGACATTATTGCTTCCAGTTGTTATGGTGATTACATGTTTTATCTTTA
AAAAGACTGTTCGTGATATTTCATATGTTTTAGCTACAAACATTTATCTAAGAAAACAGCTCCTTGAACACAGTGAGCTGGCTTTTCACA
CATTGCAGTTGTTAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAGATGTTTTTGACACCGCACATGTGTGTTATGGCTTCCT
TGATATGCTCTCGACAGCTCTTTGGCTGGCTTTTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATTTTAACAGTGATGTCAATAC
AAGGTTATGCAAACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAATTTGCCTCAGGAAGAACTTTTACAGTGGATCAAATACA
GTACCACATCAGATGCTGTCTTTGCAGGTGCCATGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCATCCCATTGTGAATCATCCAC
ATTACGAAGATGCAGACTTGAGGGCTCGGACAAAAATAGTTTATTCTACATATAGTCGAAAATCTGCCAAAGAAGTAAGAGATAAATTGT
TGGAGTTACATGTGAATTATTATGTTTTAGAAGAGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGCAGTATGCTTGAAATCTGGGATG
TGGAAGACCCTTCCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTACTTCACCACAGTATTTCAGAATA
GTGTGTACAGAGTATTAAAGGTTAACTGAGAAGGATACTACCCATTTTACTATGGCACAATGCCGTGTGTCAAAAACAATCACCCTTTGG
CTTATTCACATTAATAAAAATCACAAGCTTTAATAACAGACACTTAAAAATAAGATAAAAATGGATTGGAAATTTTTCTGATTACTAAAA
GGTAAATTACTTTTCTGTTCATTGAATGTCAGCCTTATTAAGCTTGTCATATAAGTTATTAAATCATTCATGTCATACTGCATAAACAAA
TGTTCATTTCAGAATTTTAAAGAGAAATGTATATAAAAGAACAATGAATTTTAATAAATCAGGGGTATGTAAGTCCTTTTTCATCCAACT
AGGTGAATTGCTTCAGATTTTCTCTAGTACCAGAGGGTACCTCCTCAAACTCTTTGAACCACTTAAGGCAGAAGAATGCAAGCTCTGAAA
TGACATCCTTAAAATGCTGATACTGGTCACAGCCTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGTCTTTTAAGGTGTTTTTATTTTA
CCAGCCCTTAAGAAAGATCTCTAATACCTTTTAATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTTTTAAAAACACTTTGTTTTGTAA
TGTTTTGAATCTCTTGAGATGTGTTTACCCCACTAGATACATATTTGCCACTGGTTAGTTCTCCATCTAAGCTCAAGAGGTTATTCATCT
CTCTTTAGATTCCAGTGGCTTTTCTTTTAACATCCAGGTAAAACAGAAACTGCTATGGTATACAACCAAGTTTTGGGGTTAAACATAATC
AGAAAAGAAAATCCAGTTAAATTTATGAAGTGAGATTTTCAGATCCTAGATCTTGAATAAAGGAAAGGTCTTTTCATCTTGATGGCCCCA
AAGCTTGTTGGTCATGGTCTTTATTTCTGGCCACTATCTTCTTAAATAATATATTTTTAAGCCCTCATTTATTTTTGGTTTTGGGTGAGG
AAAGTCATGTTTTCTAAGTCCTCTCCCCTAATAAAACCTACCCAACAATAGTGCTTTGAAAAGTGGTAGTTATCTTGAAGATACTCTTGC
CAAATGCAAAGATAAACATTCTTTTTGTCTGCTTTATAAATATGAAATATGCCAGATCTATAGTATTTTAATGTGCATCTACTTTAAATG
AGTCATCTTGGGGTTTTTATAATTCCCTTATGTTCTTGCCCCTCTACACTTGAAATAACAAAATGCCTTAATTTTATGGATTAGTTCTCT
TATAGTAGACAGGCAGCTATATGCAGCAAAACCAATAAAGTTATTTTTCAACTTTCATAGTTGTAAAATATCTTATAACAGAATACAAAA
CAGCTAAGAAAACATGCCACATTTTATTTTAGCATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGGATAAAAAAGGAGAGCGTCAAAG
AAAAGAGACATAACACCTAACATTCATAAAAATTAACAAAGTATATTTTGGATGATGTTTTTACAGGAAATATTTTAAATAAGTTGGTAG
AACTTTTAAAATGGTACTGTATTAGCTAATAAAATATTCAGTACAAATATATGTTTGGATTTATGCATTAAAAAACTAATAAAATTATTT

>21505_21505_1_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000341516_DPY19L2_chr12_64055261_ENST00000324472_length(amino acids)=656AA_BP=48
MGTPCSLRTFRGDACGAAETSTRRTSSATSAVSMPLNSPTMEASGWSQGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFH
LYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFF
FNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKI
IYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAA
RILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAIL
IMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMP
TMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLC

--------------------------------------------------------------
>21505_21505_2_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000389997_DPY19L2_chr12_64055261_ENST00000324472_length(transcript)=3645nt_BP=219nt
CCAGCATGAAGAGGAGAGCTGGCCTGGGGGGCAGCATGAGGTCAGTGGTGGGCTTCTTGTCCCAGCGGGGCTTGCATGGGGACCCCCTGC
TCACTCAGGACTTTCAGAGGAGACGCCTGCGGGGCTGCAGAAACCTCTACAAGAAGGACCTCCTCGGCCACTTCGGCTGTGTCAATGCCA
TTGAATTCTCCAACAATGGAGGCCAGTGGCTGGTCTCAGGGACTTTATTATTCATACTTCAAGACCATTATTGAAGCACCTTCGTTTTTG
GAAGGACTGTGGATGATTATGAATGACAGGCTTACTGAATATCCTCTTATAATTAATGCAATAAAACGCTTCCATCTTTATCCAGAGGTA
ATCATAGCCTCCTGGTATTGCACATTCATGGGAATAATGAATTTATTTGGACTAGAAACTAAGACCTGCTGGAATGTCACCAGAATAGAA
CCTCTTAATGAAGTTCAAAGCTGTGAAGGATTGGGAGATCCTGCTTGCTTTTATGTTGGTGTAATCTTTATTTTAAATGGACTAATGATG
GGATTGTTCTTCATGTATGGAGCATACCTGAGTGGGACTCAACTGGGAGGTCTTATTACAGTACTGTGCTTCTTTTTCAACCATGGAGAG
GCCACCCGTGTGATGTGGACACCACCTCTCCGTGAAAGTTTTTCCTATCCTTTCCTTGTACTTCAGATGTGTATTTTAACTTTGATTCTC
AGGACCTCAAGCAATGATAGAAGGCCCTTCATTGCACTCTGTCTTTCCAATGTTGCTTTTATGCTTCCCTGGCAATTTGCTCAGTTTATA
CTTTTTACACAGATAGCATCATTATTTCCCATGTATGTTGTGGGATACATTGAACCAAGCAAATTTCAGAAGATCATTTATATGAACATG
ATTTCAGTTACCCTTAGTTTCATTTTGATGTTTGGAAATTCAATGTACTTATCTTCTTATTATTCTTCATCTTTGTTAATGACGTGGGCA
ATAATTCTAAAGAGAAATGAAATTCAAAAACTGGGAGTATCTAAACTCAACTTTTGGCTAATTCAAGGTAGTGCCTGGTGGTGTGGAACA
ATCATTTTGAAATTTCTGACATCTAAAATCTTAGGCGTTTCAGACCACATTCGCCTGAGTGATCTTATAGCAGCCAGAATCTTAAGGTAT
ACAGATTTTGATACTTTAATATATACCTGTGCTCCCGAATTTGACTTCATGGAAAAAGCGACTCCGCTGAGATACACAAAGACATTATTG
CTTCCAGTTGTTATGGTGATTACATGTTTTATCTTTAAAAAGACTGTTCGTGATATTTCATATGTTTTAGCTACAAACATTTATCTAAGA
AAACAGCTCCTTGAACACAGTGAGCTGGCTTTTCACACATTGCAGTTGTTAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAG
ATGTTTTTGACACCGCACATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAGCTCTTTGGCTGGCTTTTTCGCAGAGTTCGTTTTGAG
AAGGTTATCTTTGGCATTTTAACAGTGATGTCAATACAAGGTTATGCAAACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAAT
TTGCCTCAGGAAGAACTTTTACAGTGGATCAAATACAGTACCACATCAGATGCTGTCTTTGCAGGTGCCATGCCTACAATGGCAAGCATC
AAGCTGTCTACACTTCATCCCATTGTGAATCATCCACATTACGAAGATGCAGACTTGAGGGCTCGGACAAAAATAGTTTATTCTACATAT
AGTCGAAAATCTGCCAAAGAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGAAGAGGCATGGTGTGTTGTGAGA
ACTAAGCCTGGTTGCAGTATGCTTGAAATCTGGGATGTGGAAGACCCTTCCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAA
GACGCCAGGCCTTACTTCACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGAGAAGGATACTACCCATTTTACTAT
GGCACAATGCCGTGTGTCAAAAACAATCACCCTTTGGCTTATTCACATTAATAAAAATCACAAGCTTTAATAACAGACACTTAAAAATAA
GATAAAAATGGATTGGAAATTTTTCTGATTACTAAAAGGTAAATTACTTTTCTGTTCATTGAATGTCAGCCTTATTAAGCTTGTCATATA
AGTTATTAAATCATTCATGTCATACTGCATAAACAAATGTTCATTTCAGAATTTTAAAGAGAAATGTATATAAAAGAACAATGAATTTTA
ATAAATCAGGGGTATGTAAGTCCTTTTTCATCCAACTAGGTGAATTGCTTCAGATTTTCTCTAGTACCAGAGGGTACCTCCTCAAACTCT
TTGAACCACTTAAGGCAGAAGAATGCAAGCTCTGAAATGACATCCTTAAAATGCTGATACTGGTCACAGCCTCTTTACCTCTGTGAGGAA
ATTGTAACAGTGTGTCTTTTAAGGTGTTTTTATTTTACCAGCCCTTAAGAAAGATCTCTAATACCTTTTAATACTTTTTTTTAATAATTT
CAAGTTGAAGTGTTTTTAAAAACACTTTGTTTTGTAATGTTTTGAATCTCTTGAGATGTGTTTACCCCACTAGATACATATTTGCCACTG
GTTAGTTCTCCATCTAAGCTCAAGAGGTTATTCATCTCTCTTTAGATTCCAGTGGCTTTTCTTTTAACATCCAGGTAAAACAGAAACTGC
TATGGTATACAACCAAGTTTTGGGGTTAAACATAATCAGAAAAGAAAATCCAGTTAAATTTATGAAGTGAGATTTTCAGATCCTAGATCT
TGAATAAAGGAAAGGTCTTTTCATCTTGATGGCCCCAAAGCTTGTTGGTCATGGTCTTTATTTCTGGCCACTATCTTCTTAAATAATATA
TTTTTAAGCCCTCATTTATTTTTGGTTTTGGGTGAGGAAAGTCATGTTTTCTAAGTCCTCTCCCCTAATAAAACCTACCCAACAATAGTG
CTTTGAAAAGTGGTAGTTATCTTGAAGATACTCTTGCCAAATGCAAAGATAAACATTCTTTTTGTCTGCTTTATAAATATGAAATATGCC
AGATCTATAGTATTTTAATGTGCATCTACTTTAAATGAGTCATCTTGGGGTTTTTATAATTCCCTTATGTTCTTGCCCCTCTACACTTGA
AATAACAAAATGCCTTAATTTTATGGATTAGTTCTCTTATAGTAGACAGGCAGCTATATGCAGCAAAACCAATAAAGTTATTTTTCAACT
TTCATAGTTGTAAAATATCTTATAACAGAATACAAAACAGCTAAGAAAACATGCCACATTTTATTTTAGCATTTTCAAATAATTTGTTTT
TGGTGTAAGCACAGGATAAAAAAGGAGAGCGTCAAAGAAAAGAGACATAACACCTAACATTCATAAAAATTAACAAAGTATATTTTGGAT
GATGTTTTTACAGGAAATATTTTAAATAAGTTGGTAGAACTTTTAAAATGGTACTGTATTAGCTAATAAAATATTCAGTACAAATATATG

>21505_21505_2_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000389997_DPY19L2_chr12_64055261_ENST00000324472_length(amino acids)=656AA_BP=48
MGTPCSLRTFRGDACGAAETSTRRTSSATSAVSMPLNSPTMEASGWSQGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFH
LYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFF
FNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKI
IYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAA
RILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAIL
IMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMP
TMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLC

--------------------------------------------------------------
>21505_21505_3_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000557386_DPY19L2_chr12_64055261_ENST00000324472_length(transcript)=3665nt_BP=239nt
GAGCGGCGGCGGCGGCGGTTCCAGCATGAAGAGGAGAGCTGGCCTGGGGGGCAGCATGAGGTCAGTGGTGGGCTTCTTGTCCCAGCGGGG
CTTGCATGGGGACCCCCTGCTCACTCAGGACTTTCAGAGGAGACGCCTGCGGGGCTGCAGAAACCTCTACAAGAAGGACCTCCTCGGCCA
CTTCGGCTGTGTCAATGCCATTGAATTCTCCAACAATGGAGGCCAGTGGCTGGTCTCAGGGACTTTATTATTCATACTTCAAGACCATTA
TTGAAGCACCTTCGTTTTTGGAAGGACTGTGGATGATTATGAATGACAGGCTTACTGAATATCCTCTTATAATTAATGCAATAAAACGCT
TCCATCTTTATCCAGAGGTAATCATAGCCTCCTGGTATTGCACATTCATGGGAATAATGAATTTATTTGGACTAGAAACTAAGACCTGCT
GGAATGTCACCAGAATAGAACCTCTTAATGAAGTTCAAAGCTGTGAAGGATTGGGAGATCCTGCTTGCTTTTATGTTGGTGTAATCTTTA
TTTTAAATGGACTAATGATGGGATTGTTCTTCATGTATGGAGCATACCTGAGTGGGACTCAACTGGGAGGTCTTATTACAGTACTGTGCT
TCTTTTTCAACCATGGAGAGGCCACCCGTGTGATGTGGACACCACCTCTCCGTGAAAGTTTTTCCTATCCTTTCCTTGTACTTCAGATGT
GTATTTTAACTTTGATTCTCAGGACCTCAAGCAATGATAGAAGGCCCTTCATTGCACTCTGTCTTTCCAATGTTGCTTTTATGCTTCCCT
GGCAATTTGCTCAGTTTATACTTTTTACACAGATAGCATCATTATTTCCCATGTATGTTGTGGGATACATTGAACCAAGCAAATTTCAGA
AGATCATTTATATGAACATGATTTCAGTTACCCTTAGTTTCATTTTGATGTTTGGAAATTCAATGTACTTATCTTCTTATTATTCTTCAT
CTTTGTTAATGACGTGGGCAATAATTCTAAAGAGAAATGAAATTCAAAAACTGGGAGTATCTAAACTCAACTTTTGGCTAATTCAAGGTA
GTGCCTGGTGGTGTGGAACAATCATTTTGAAATTTCTGACATCTAAAATCTTAGGCGTTTCAGACCACATTCGCCTGAGTGATCTTATAG
CAGCCAGAATCTTAAGGTATACAGATTTTGATACTTTAATATATACCTGTGCTCCCGAATTTGACTTCATGGAAAAAGCGACTCCGCTGA
GATACACAAAGACATTATTGCTTCCAGTTGTTATGGTGATTACATGTTTTATCTTTAAAAAGACTGTTCGTGATATTTCATATGTTTTAG
CTACAAACATTTATCTAAGAAAACAGCTCCTTGAACACAGTGAGCTGGCTTTTCACACATTGCAGTTGTTAGTGTTTACTGCCCTTGCCA
TTTTAATTATGAGGCTAAAGATGTTTTTGACACCGCACATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAGCTCTTTGGCTGGCTTT
TTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATTTTAACAGTGATGTCAATACAAGGTTATGCAAACCTCCGTAATCAATGGAGCA
TAATAGGAGAATTTAATAATTTGCCTCAGGAAGAACTTTTACAGTGGATCAAATACAGTACCACATCAGATGCTGTCTTTGCAGGTGCCA
TGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCATCCCATTGTGAATCATCCACATTACGAAGATGCAGACTTGAGGGCTCGGACAA
AAATAGTTTATTCTACATATAGTCGAAAATCTGCCAAAGAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGAAG
AGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGCAGTATGCTTGAAATCTGGGATGTGGAAGACCCTTCCAATGCAGCTAACCCTCCCT
TATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTACTTCACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGAGAAG
GATACTACCCATTTTACTATGGCACAATGCCGTGTGTCAAAAACAATCACCCTTTGGCTTATTCACATTAATAAAAATCACAAGCTTTAA
TAACAGACACTTAAAAATAAGATAAAAATGGATTGGAAATTTTTCTGATTACTAAAAGGTAAATTACTTTTCTGTTCATTGAATGTCAGC
CTTATTAAGCTTGTCATATAAGTTATTAAATCATTCATGTCATACTGCATAAACAAATGTTCATTTCAGAATTTTAAAGAGAAATGTATA
TAAAAGAACAATGAATTTTAATAAATCAGGGGTATGTAAGTCCTTTTTCATCCAACTAGGTGAATTGCTTCAGATTTTCTCTAGTACCAG
AGGGTACCTCCTCAAACTCTTTGAACCACTTAAGGCAGAAGAATGCAAGCTCTGAAATGACATCCTTAAAATGCTGATACTGGTCACAGC
CTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGTCTTTTAAGGTGTTTTTATTTTACCAGCCCTTAAGAAAGATCTCTAATACCTTTTA
ATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTTTTAAAAACACTTTGTTTTGTAATGTTTTGAATCTCTTGAGATGTGTTTACCCCAC
TAGATACATATTTGCCACTGGTTAGTTCTCCATCTAAGCTCAAGAGGTTATTCATCTCTCTTTAGATTCCAGTGGCTTTTCTTTTAACAT
CCAGGTAAAACAGAAACTGCTATGGTATACAACCAAGTTTTGGGGTTAAACATAATCAGAAAAGAAAATCCAGTTAAATTTATGAAGTGA
GATTTTCAGATCCTAGATCTTGAATAAAGGAAAGGTCTTTTCATCTTGATGGCCCCAAAGCTTGTTGGTCATGGTCTTTATTTCTGGCCA
CTATCTTCTTAAATAATATATTTTTAAGCCCTCATTTATTTTTGGTTTTGGGTGAGGAAAGTCATGTTTTCTAAGTCCTCTCCCCTAATA
AAACCTACCCAACAATAGTGCTTTGAAAAGTGGTAGTTATCTTGAAGATACTCTTGCCAAATGCAAAGATAAACATTCTTTTTGTCTGCT
TTATAAATATGAAATATGCCAGATCTATAGTATTTTAATGTGCATCTACTTTAAATGAGTCATCTTGGGGTTTTTATAATTCCCTTATGT
TCTTGCCCCTCTACACTTGAAATAACAAAATGCCTTAATTTTATGGATTAGTTCTCTTATAGTAGACAGGCAGCTATATGCAGCAAAACC
AATAAAGTTATTTTTCAACTTTCATAGTTGTAAAATATCTTATAACAGAATACAAAACAGCTAAGAAAACATGCCACATTTTATTTTAGC
ATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGGATAAAAAAGGAGAGCGTCAAAGAAAAGAGACATAACACCTAACATTCATAAAAAT
TAACAAAGTATATTTTGGATGATGTTTTTACAGGAAATATTTTAAATAAGTTGGTAGAACTTTTAAAATGGTACTGTATTAGCTAATAAA

>21505_21505_3_DCAF5-DPY19L2_DCAF5_chr14_69619482_ENST00000557386_DPY19L2_chr12_64055261_ENST00000324472_length(amino acids)=656AA_BP=48
MGTPCSLRTFRGDACGAAETSTRRTSSATSAVSMPLNSPTMEASGWSQGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFH
LYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFF
FNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKI
IYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAA
RILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAIL
IMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMP
TMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCAF5-DPY19L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCAF5-DPY19L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCAF5-DPY19L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource