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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCAF6-LETM1 (FusionGDB2 ID:21522)

Fusion Gene Summary for DCAF6-LETM1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF6-LETM1
Fusion gene ID: 21522
HgeneTgene
Gene symbol

DCAF6

LETM1

Gene ID

55827

3954

Gene nameDDB1 and CUL4 associated factor 6leucine zipper and EF-hand containing transmembrane protein 1
Synonyms1200006M05Rik|ARCAP|IQWD1|MSTP055|NRIP|PC326SLC55A1
Cytomap

1q24.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction proteinmitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1
Modification date2020031320200328
UniProtAcc

Q58WW2

O95202

Ensembl transtripts involved in fusion geneENST00000312263, ENST00000367840, 
ENST00000367843, ENST00000432587, 
ENST00000470919, 		ENST00000512189, 
ENST00000302787, 
Fusion gene scores* DoF score13 X 10 X 8=10405 X 4 X 4=80
# samples 178
** MAII scorelog2(17/1040*10)=-2.61297687689075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/80*10)=0
Context

PubMed: DCAF6 [Title/Abstract] AND LETM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCAF6(167906246)-LETM1(1850936), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLETM1

GO:0006851

mitochondrial calcium ion transmembrane transport

19797662

TgeneLETM1

GO:0051560

mitochondrial calcium ion homeostasis

19797662

TgeneLETM1

GO:0099093

calcium export from the mitochondrion

19797662


check buttonFusion gene breakpoints across DCAF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LETM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1497-01ADCAF6chr1

167906246

+LETM1chr4

1850936

-


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Fusion Gene ORF analysis for DCAF6-LETM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000312263ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000367840ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000367843ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000432587ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000312263ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000367840ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000367843ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000432587ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
intron-3CDSENST00000470919ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
intron-5UTRENST00000470919ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367843DCAF6chr1167906246+ENST00000302787LETM1chr41850936-54313482512485744
ENST00000432587DCAF6chr1167906246+ENST00000302787LETM1chr41850936-53933102132447744
ENST00000312263DCAF6chr1167906246+ENST00000302787LETM1chr41850936-53843012042438744
ENST00000367840DCAF6chr1167906246+ENST00000302787LETM1chr41850936-5274191942328744

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367843ENST00000302787DCAF6chr1167906246+LETM1chr41850936-0.007019810.9929802
ENST00000432587ENST00000302787DCAF6chr1167906246+LETM1chr41850936-0.0072932680.9927067
ENST00000312263ENST00000302787DCAF6chr1167906246+LETM1chr41850936-0.0072952570.9927047
ENST00000367840ENST00000302787DCAF6chr1167906246+LETM1chr41850936-0.0071358670.99286413

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Fusion Genomic Features for DCAF6-LETM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCAF6-LETM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:167906246/chr4:1850936)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF6

Q58WW2

LETM1

O95202

FUNCTION: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.FUNCTION: Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248). {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662, ECO:0000269|PubMed:24898248}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014676_68827740.0Calcium bindingOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014115_13627740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014462_49027740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014537_62727740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014708_73927740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014252_53727740.0DomainLetm1 RBD
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014663_69827740.0DomainEF-hand
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014116_20827740.0Topological domainMitochondrial intermembrane
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014230_73927740.0Topological domainMitochondrial matrix
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787014209_22927740.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119676_70532861.0DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122676_70532952.0DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120676_70532881.0DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121676_70532921.0DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119139_17932861.0RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119189_22932861.0RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119251_29032861.0RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+11949_8832861.0RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119718_75632861.0RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119759_79832861.0RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+11992_13332861.0RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122139_17932952.0RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122189_22932952.0RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122251_29032952.0RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+12249_8832952.0RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122718_75632952.0RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122759_79832952.0RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+12292_13332952.0RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120139_17932881.0RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120189_22932881.0RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120251_29032881.0RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+12049_8832881.0RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120718_75632881.0RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120759_79832881.0RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+12092_13332881.0RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121139_17932921.0RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121189_22932921.0RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121251_29032921.0RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+12149_8832921.0RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121718_75632921.0RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121759_79832921.0RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+12192_13332921.0RepeatNote=WD 2
TgeneLETM1chr1:167906246chr4:1850936ENST0000030278701418_2127740.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for DCAF6-LETM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21522_21522_1_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000312263_LETM1_chr4_1850936_ENST00000302787_length(transcript)=5384nt_BP=301nt
AGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAGGGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCTGCGCCCTGG
AGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCC
CTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAG
GACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGC
CTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCC
GAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGC
TGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGC
GGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGC
TTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGG
CAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTT
GCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAG
CTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCT
GTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACC
CTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAG
CTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCA
GCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCAT
CAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTG
CAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAG
GCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCC
GAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGAC
ACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAG
CAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAG
AAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGG
CAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTC
ATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAA
AACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTG
GCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTG
AAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTC
TCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAG
TCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGC
TGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATG
AGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGA
AGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCA
TTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCT
TGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGA
TTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGA
GTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCA
ATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGG
GGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCG
GCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGG
AACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACT
TGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTG
AGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACC
CTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCAT
CCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTC
CGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCC
GTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTAT
GTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAG
CTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAA
AATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGA
TACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTT
CTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCT
CTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCC
CGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGG
ATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTT
CATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGC
CACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTT
TTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAG
TGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGC

>21522_21522_1_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000312263_LETM1_chr4_1850936_ENST00000302787_length(amino acids)=744AA_BP=24
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

--------------------------------------------------------------
>21522_21522_2_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000367840_LETM1_chr4_1850936_ENST00000302787_length(transcript)=5274nt_BP=191nt
GCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCCCTCCCACCCGGCTCAGGCAG
AGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAG
TCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTG
CTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTC
GAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGT
TCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCC
CGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGA
CACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGC
TGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAA
CATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCT
CCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCG
GGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCC
GCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTC
CATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCAT
GCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCT
GCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGT
GGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGC
GGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCC
CCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGG
CTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAA
GGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGG
TGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTC
GCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCAT
CAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAA
CATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACT
GGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTGAAGAGCTAGAACCACTGGCC
TGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTCTCAGTGGCTCATCTAATATT
TTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAGTCTGTCTGGAATCCCGGAAC
CCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGCTGGGCTGGGCCAAGGCAGGA
AGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATGAGGACCACGTGGACTCCGCC
CACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGAAGATGCCTCCATTCGCCTGT
GGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCATTGTGGAGACAGAGGTGTCT
GCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCTTGTGTATCGGAGCTCTTTCT
CGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGATTCACTGTGTCAGGGATGAG
CCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGAGTCCAGTGCGCCCACAGCAG
CATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCAATGAGGCATGAGGATCCGGC
ACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGGGGTGGCCTCCCCGCACTCGG
CAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCGGCTGTGTCACACTCATCTTT
TTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGGAACGGCACAGGCGTCCAGGA
AAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACTTGACAAAATAGGAACAGGAG
ATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTGAGAAGTTTGTTTTAGATCCT
TAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACCCTTGAGAACAAGTCTTGCAG
TTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCATCCTCGTCCTCACTGCCTTGG
CTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTCCGCATGGCCTCCAAAAGCCA
GCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCCGTGACATCAGCCGTGCTCTG
ATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTATGTCCTGACCTTTCTTCTTGC
ACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAGCTTCTTAAAACAGTCCTTTC
TTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAAAATGAAACGAATTCCTGATT
TAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGATACAGAGTCTCGCTCTGTCA
CCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTA
ATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTG
CAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCCAGGACTACAAG
CACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACT
TCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTTCATCATGTTGGTCAGGCTGG
TCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCTGAACT
CTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTTTTTTAAATGAAGGACACCCC
GCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAGTGGGTCCCGGTGCTGGCAGG
AGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGCCCGTCCTGGGCCGTGTTAAG

>21522_21522_2_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000367840_LETM1_chr4_1850936_ENST00000302787_length(amino acids)=744AA_BP=24
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

--------------------------------------------------------------
>21522_21522_3_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000367843_LETM1_chr4_1850936_ENST00000302787_length(transcript)=5431nt_BP=348nt
GAGGAGACTGTTGCTGATCTTTGGATGTTCTGGTTAGTCTAAGAAGGAGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAG
GGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCTGCGCCCTGGAGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAA
ACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCCCTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCT
ACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGG
ATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGT
ACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCT
CTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGA
AGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGT
CCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGC
TCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGT
TCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGA
CTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGG
CCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCA
ATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGC
TGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGA
TTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAG
ACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGT
ACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAG
TGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTG
AGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCAC
AGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGA
AGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGC
TGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAAT
CTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGG
CTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGC
ACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGA
TTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGG
AGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTGAAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTG
CCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTCTCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACT
TCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAGTCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGA
TCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGCTGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCT
CAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATGAGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCC
CACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGAAGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAG
TGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCATTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGA
GTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCTTGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTC
TTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGATTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGC
TCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGAGTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAG
TGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCAATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCA
AGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGGGGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGG
CGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCGGCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGC
AAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGGAACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGC
CTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACTTGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTT
GTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTGAGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCT
CACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACCCTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCT
CTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCATCCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAG
CCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTCCGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGG
GGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCCGTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCAT
TCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTATGTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGC
AAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAGCTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACC
CTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAAAATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTC
ACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGATACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGC
GATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCA
CCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACT
GCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAA
TTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCT
CCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTTCATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTG
ATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCA
GGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTTTTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCA
GGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAGTGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTG
TCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGCCCGTCCTGGGCCGTGTTAAGCACCTTTTGTAGAAATCGTATTT

>21522_21522_3_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000367843_LETM1_chr4_1850936_ENST00000302787_length(amino acids)=744AA_BP=24
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

--------------------------------------------------------------
>21522_21522_4_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000432587_LETM1_chr4_1850936_ENST00000302787_length(transcript)=5393nt_BP=310nt
CTAAGAAGGAGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAGGGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCT
GCGCCCTGGAGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGG
TGGTCTCCCCTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTC
GGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTG
AGGAACTGCCTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCT
CTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCT
GTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTG
GAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTAC
TACCATGGCTTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGG
GAGCGCAGGCAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTG
CTGCCTGTTGCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTT
CGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAA
GACTTCTCTGTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGAT
GAGCTGACCCTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTG
CGCTTCCAGCTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAG
CTGCAGGCAGCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTG
CACCTGCATCAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAG
TCCACACTGCAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCC
AAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGAT
TTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACC
TTGAAGGACACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAG
CTGCAGGAGCAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAG
GAGATCAAGAAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAA
ATGATCGGGCAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGG
GAGAACGTCATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCA
CTGGATGAAAACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACC
AGCCAGGTGGCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTC
GCAGAGGTGAAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTG
TGGTGATTCTCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACG
GAGATTCAGTCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCC
AGAGGCAGCTGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGG
AAGAGAATGAGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCT
CAGGGCTGAAGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGA
TGTGGGTCATTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGC
GGTTTCCCTTGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGC
TGCAGTGGATTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGT
GAGGTTTGAGTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCA
GGCTAGTCAATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCC
TCTGGGTGGGGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCT
GCCCAGCCGGCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTG
GAAGACAGGAACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATT
AAAGAAACTTGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTC
AGTTATTTGAGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGT
GTACTTACCCTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCC
GGCTCTCATCCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGC
CCTGGACTCCGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTG
GTGGCTTCCGTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATT
TTTCTCTATGTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTG
TGTAATAAGCTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCG
CCTGGTGAAAATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTT
TTTTTTTGATACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAA
GCGATTCTTCTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAG
AGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCC
TCAGCCTCCCGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTG
TTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAG
ATGGGGTTTCATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACA
GGCATGAGCCACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGT
CCAGACTTTTTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTT
TGTTCGCAGTGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCA

>21522_21522_4_DCAF6-LETM1_DCAF6_chr1_167906246_ENST00000432587_LETM1_chr4_1850936_ENST00000302787_length(amino acids)=744AA_BP=24
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

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Fusion Gene PPI Analysis for DCAF6-LETM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCAF6-LETM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCAF6-LETM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource