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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADAP1-METTL2B (FusionGDB2 ID:2153)

Fusion Gene Summary for ADAP1-METTL2B

Fusion gene summary

Fusion gene information	Fusion gene name: ADAP1-METTL2B
	Fusion gene ID: 2153
		Hgene	Tgene
	Gene symbol	ADAP1	METTL2B
	Gene ID	11033	55798
	Gene name	ArfGAP with dual PH domains 1	methyltransferase like 2B
	Synonyms	CENTA1\|GCS1L\|p42IP4	METL\|METTL2\|METTL2A\|PSENIP1
	Cytomap	7p22.3	7q32.1
	Type of gene	protein-coding	protein-coding
	Description	arf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25	tRNA N(3)-methylcytidine methyltransferase METTL2Bmethyltransferase-like protein 2B
	Modification date	20200313	20200313
	UniProtAcc	O75689	Q6P1Q9
	Ensembl transtripts involved in fusion gene	ENST00000265846, ENST00000449296, ENST00000463358, ENST00000539900,	ENST00000473488, ENST00000262432, ENST00000480046,
Fusion gene scores	* DoF score	13 X 10 X 8=1040	5 X 8 X 4=160
	# samples	18	8
	** MAII score	log2(18/1040*10)=-2.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADAP1 [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADAP1(994032)-METTL2B(128141816), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ADAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across METTL2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-XR-A8TD-01A	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+

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Fusion Gene ORF analysis for ADAP1-METTL2B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265846	ENST00000473488	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
In-frame	ENST00000265846	ENST00000262432	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
In-frame	ENST00000265846	ENST00000480046	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000449296	ENST00000262432	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000449296	ENST00000480046	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000463358	ENST00000262432	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000463358	ENST00000480046	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000539900	ENST00000262432	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-3CDS	ENST00000539900	ENST00000480046	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-intron	ENST00000449296	ENST00000473488	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-intron	ENST00000463358	ENST00000473488	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+
intron-intron	ENST00000539900	ENST00000473488	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000265846

ADAP1

chr7

994032

ENST00000262432

METTL2B

chr7

128141816

1465

302

690

230

ENST00000265846

ADAP1

chr7

994032

ENST00000480046

METTL2B

chr7

128141816

5143

302

690

230

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265846	ENST00000262432	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+	0.2892207	0.7107793
ENST00000265846	ENST00000480046	ADAP1	chr7	994032	-	METTL2B	chr7	128141816	+	0.34901112	0.65098894

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Fusion Genomic Features for ADAP1-METTL2B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ADAP1	chr7	994031	-	METTL2B	chr7	128141815	+	4.59E-12	1
ADAP1	chr7	994031	-	METTL2B	chr7	128141815	+	4.59E-12	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAP1-METTL2B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:994032/chr7:128141816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADAP1 O75689	METTL2B Q6P1Q9
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269\|PubMed:10448098, ECO:0000303\|PubMed:10333475, ECO:0000305}.	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269\|PubMed:28655767}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAP1

chr7:994032

chr7:128141816

ENST00000265846

129_230

375.0

Domain

PH 1

Hgene

ADAP1

chr7:994032

chr7:128141816

ENST00000265846

252_356

375.0

Domain

PH 2

Hgene

ADAP1

chr7:994032

chr7:128141816

ENST00000265846

7_126

375.0

Domain

Arf-GAP

Hgene

ADAP1

chr7:994032

chr7:128141816

ENST00000265846

21_44

375.0

Zinc finger

C4-type

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Fusion Gene Sequence for ADAP1-METTL2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2153_2153_1_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000262432_length(transcript)=1465nt_BP=302nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA

>2153_2153_1_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000262432_length(amino acids)=230AA_BP=1
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF
ALNPNPVHCQLLPSVHLQSAVHQILNFFQSSSGEKRVQFLRGAAVRAARVPRPLQQLQDRPAPLLGHGRDAPAMPMPGPGPGASARLARA

--------------------------------------------------------------
>2153_2153_2_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000480046_length(transcript)=5143nt_BP=302nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA
AAAAATAAAAATAAAAAAAATCTTAGTTCCATGGAATTTTAAGCACTGTTCCCCCTCTAACCTATGTCTAAAGAATTAAAAGAATTTGGC
TGGGTGCGGTAGCTCATGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCT
AACACGGTGAAACCTCGTCTCCACTAAAAATACCAAAAAAAATAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCCTGTAGTCCCAGCTA
CTCGGGAGGCTAAGGCAGGAGAATCGTTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGTCACTGCATTCCAGCCTGGGCA
ACAGAGGAAGACTCTGTCTCAAAAAAATAAAAGAAAAGAATTTTCACTTTTTGCAAAATTATCTTTTTTTACTGCACCCTTAAGTGTTTG
ACACAAAAGGAATTGAGAGAACTTCTTAATTTTAACCACATCATCACTTCACTTCTGAATGTGATCACTGTCAGTGTTAGATGCTTTTTT
TTTTTTTTTTTAGGAGACAGGGCTCTCACTTTGTTGCCCAGGCTGGAGTTCAGTGGTGCAATGATAGCTCATTATCACCTCGAACTTCTG
GCTTGAGCCATCGCTCCACCTCAGCCTCCTGAGTAGCTAGGACTGCAGGTGGGCACCATCATGCCTAGCTAATTGTTAGATCCTTTTTTT
TTATGTTCTGCATTTTTTCAATTATTTTTACATATTTCTGTCTTGATCCATGCAGTTATAGGATATATCCTTAATTTTAGAAAGTAAGGA
CTTTTCGACCAGGCATGGCGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCCAGT
CCAGCCCGGCTAACATAGTGAAACCCCGTCTCCACTAAAAAATAAAAAATCAGCCCGGCATGGTTGTGGGCGCCTGTAATCCCAGCTACT
CAGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATGGTGCCATTGCACTCCAGCCTGGGCGAC
AAGAGCGAAACTGCATCTCAAAAACAAAGATGCCTAGCTTTCACCTTGTTGATGTTTTTCTAAATTTTGGAATAATAAATTTATATAGGA
ATACTGCAAGAATAGTCCATTTTTTTCTGATGTCCCAACATCAGCAAATATATTACCAAATATATCCATCACAAGTAGGAATACATGGAA
ACATTAATGCCAGCCACTAACCATTCATGTTTACCCAGTAGTCCCAATAATAGCTTTGTCACACAAAAACATGATTATGTTGGCTGGGCA
CAGTGGCTCCTGTAATCTTAGCATTTTGGGAGCCCAAGGCAGGAGGATGACTTGAGGCCAGGAGTTCAAGACCAGGCTGGGTAATGTAGC
AAGACCCTGACTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTACAATGGCACGATCTCGGCTCACT
GCAATCTCCACCTCCCAAGTTTAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGAATTACAGGCATGCAGCACCATTCCCAGCTAA
ATTTTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACCCTGACTTTTTAAAAAATGTTAAACATAGGCCGGGTGCAG
TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACTTAA
TGAAACCCCATCTCTGCTAACAATACAGACCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGTGGATCA
CCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATAGCCAGGTGTGATGGCGCAT
GCCTGTAACCCCATCTACTTGGAAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCGCCATT
GCACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAAT
CCCAGCTATCTGGGAGGCTGAGTCTAGAGAATCATTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAG
CCTGGGCAACAGTGAGACTCCGTCTCAAAATAAAAAAACAAAAAAAATGTAAAAAATAAATAATTGTATTGAATTTATTAGTTGTGTCTC
AGTCTCCTTCAGTCTACAGTTTAGGCTTGCTTTTGCACCTTTGCATTTTAAGGTAAGAGGCTATTGTGTAAACTCGAATTGGGTTTGTTG
GTGTTTCTTCATGATTTGGTTCAGGCTCTGCATTTTGGGCAGGAATATTCAGAGGTGATGCTGTGTTCCTCCCATAGGATCGTATCAGGC
GACACATGATTATGAATTTCCCCATTATTGGTGATGTCACTTAGTTGTGTTGTCTGCCAGGTTCTGCCACTGTAAAGTTAATAAGTATTT
TGTAGGGAAGTGCTTTGAGACTAAATATCCTGTTCCTCATCAAACTTCTACCCCCTAGTTTCAGTATCTATTGCTGTTTTTTGTCTGAAT
AACTATGATAGTTGCCAAATAGTGGTTTCTGATCCTTCCATTCCTTCTACACTGATTGGTTGGTATTTTGTACAGAAAAGCTTTCTCATA
TCTGATTTACTTGTCTCAATATGGACCCATGGGTATTTGAGTTTCTTGTGGGGTTATTTGTTGTTGTTTTTGAGACAGGCTCACCCAGGC
TGGAGTGCAGCAGCACGATCACTGCTTACTGCTTACTGCAGCCTCGACCTCCCATGCTCAAGTGATTCTCCCACCCCAGCCTCCCAAGTA
GATGGGACTACAGGCATGTGCCACCAAGCCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTCACCATGTGTCCCAGGCTGGTCTTGAGC
TCCTGAGCTCAAGCAATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATGAGCCACCGTGACTGGCCCCACTTAATGGGTTTTCAGAGGT
GGGAGCAAAGAATGAAGGGAGGAAGAGAGCTCCCATCTTTTCCATTACCGTATTTACTTAAAACTGGAAAAAACTGAATCACTGGGATGG
TATTTCATTTATCTTTTGAAATGAAGAATAGATACATTAATTTAAATGATTCTCTAAAGACTGTCCTTCAGCATCCCTAAAGCATTGCAA
AACTATAGGCACAGTTTTTATTTTATCTTTCTGGCACCTGGTTTGGGCTTTGGCTTAGATTAAAAAGACGAGCCTTCTCCTGCCCCTGCT
CCCTTTTATTCCCTGCCATCTGCTAAGCTCGACTTTTTATCTCTCAGGCCAAATTTGACTCTGTAAGGGACTTTGCATAACGTTTCATCC
TCAGAATCGCTAATGATGGGCAGAGGACTGTTACATGTGTTGGGAGGGATTAAAGTATATGACCTCAGTGCCACTTAAAAAATAAATACT

>2153_2153_2_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000480046_length(amino acids)=230AA_BP=1
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF
ALNPNPVHCQLLPSVHLQSAVHQILNFFQSSSGEKRVQFLRGAAVRAARVPRPLQQLQDRPAPLLGHGRDAPAMPMPGPGPGASARLARA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAP1-METTL2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ADAP1-METTL2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ADAP1-METTL2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source