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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DCAF8-FCRLA (FusionGDB2 ID:21545)

Fusion Gene Summary for DCAF8-FCRLA

Fusion gene summary

Fusion gene information	Fusion gene name: DCAF8-FCRLA
	Fusion gene ID: 21545
		Hgene	Tgene
	Gene symbol	DCAF8	FCRLA
	Gene ID	50717	84824
	Gene name	DDB1 and CUL4 associated factor 8	Fc receptor like A
	Synonyms	GAN2\|H326\|WDR42A	FCRL\|FCRL1\|FCRLM1\|FCRLX\|FCRLb\|FCRLc1\|FCRLc2\|FCRLd\|FCRLe\|FCRX\|FREB
	Cytomap	1q23.2	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 8WD repeat domain 42AWD repeat-containing protein 42A	Fc receptor-like AFc receptor homolog expressed in B cells (FREB)Fc receptor related protein XFc receptor-like and mucin-like 1fc receptor homolog expressed in B-cellsfc receptor-like and mucin-like protein 1fc receptor-like proteinfc receptor-rela
	Modification date	20200313	20200313
	UniProtAcc	Q5TAQ9	Q7L513
	Ensembl transtripts involved in fusion gene	ENST00000326837, ENST00000368073, ENST00000368074, ENST00000475733, ENST00000610139, ENST00000556710, ENST00000608310,	ENST00000236938, ENST00000294796, ENST00000309691, ENST00000349527, ENST00000350710, ENST00000367949, ENST00000367950, ENST00000367953, ENST00000367957, ENST00000367959, ENST00000540521, ENST00000540926, ENST00000546024, ENST00000470841,
Fusion gene scores	* DoF score	9 X 12 X 6=648	2 X 3 X 2=12
	# samples	12	3
	** MAII score	log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DCAF8 [Title/Abstract] AND FCRLA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DCAF8(160231075)-FCRLA(161682875), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DCAF8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FCRLA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-ZF-AA5P-01A	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
ChimerDB4	BLCA	TCGA-ZF-AA5P	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
ChimerDB4	BLCA	TCGA-ZF-AA5P	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+

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Fusion Gene ORF analysis for DCAF8-FCRLA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000326837	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000326837	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000326837	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368073	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368073	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000368074	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000368074	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000475733	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000475733	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3CDS	ENST00000610139	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3CDS	ENST00000610139	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3UTR	ENST00000326837	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3UTR	ENST00000326837	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3UTR	ENST00000368073	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3UTR	ENST00000368073	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3UTR	ENST00000368074	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3UTR	ENST00000368074	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3UTR	ENST00000475733	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3UTR	ENST00000475733	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
5UTR-3UTR	ENST00000610139	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
5UTR-3UTR	ENST00000610139	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000556710	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000556710	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000236938	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000236938	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000294796	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000294796	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000309691	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000309691	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000349527	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000349527	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000350710	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000350710	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000367949	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000367949	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000367950	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000367950	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000367953	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000367953	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000367957	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000367957	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000367959	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000367959	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000540521	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000540521	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000540926	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000540926	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3CDS	ENST00000608310	ENST00000546024	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3CDS	ENST00000608310	ENST00000546024	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3UTR	ENST00000556710	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3UTR	ENST00000556710	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+
intron-3UTR	ENST00000608310	ENST00000470841	DCAF8	chr1	160231075	-	FCRLA	chr1	161682875	+
intron-3UTR	ENST00000608310	ENST00000470841	DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DCAF8-FCRLA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+	0.000103377	0.99989665
DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+	0.000103377	0.99989665
DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+	0.000103377	0.99989665
DCAF8	chr1	160231074	-	FCRLA	chr1	161682874	+	0.000103377	0.99989665

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCAF8-FCRLA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:160231075/:161682875)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF8 Q5TAQ9	FCRLA Q7L513
FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.	FUNCTION: May be implicated in B-cell differentiation and lymphomagenesis. {ECO:0000269\|PubMed:11754007, ECO:0000269\|PubMed:11891275}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DCAF8-FCRLA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DCAF8-FCRLA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DCAF8-FCRLA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DCAF8-FCRLA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source