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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABCB7-SH3BGRL (FusionGDB2 ID:216)

Fusion Gene Summary for ABCB7-SH3BGRL

Fusion gene summary

Fusion gene information	Fusion gene name: ABCB7-SH3BGRL
	Fusion gene ID: 216
		Hgene	Tgene
	Gene symbol	ABCB7	SH3BGRL
	Gene ID	22	6451
	Gene name	ATP binding cassette subfamily B member 7	SH3 domain binding glutamate rich protein like
	Synonyms	ABC7\|ASAT\|Atm1p\|EST140535	HEL-S-115\|SH3BGR
	Cytomap	Xq13.3	Xq21.1
	Type of gene	protein-coding	protein-coding
	Description	ATP-binding cassette sub-family B member 7, mitochondrialABC transporter 7 proteinATP-binding cassette transporter 7ATP-binding cassette, sub-family B (MDR/TAP), member 7	SH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115
	Modification date	20200320	20200313
	UniProtAcc	O75027	.
	Ensembl transtripts involved in fusion gene	ENST00000253577, ENST00000339447, ENST00000373394, ENST00000534570,	ENST00000481106, ENST00000373212,
Fusion gene scores	* DoF score	2 X 2 X 2=8	7 X 4 X 5=140
	# samples	2	7
	** MAII score	log2(2/8*10)=1.32192809488736	log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABCB7 [Title/Abstract] AND SH3BGRL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABCB7(74375940)-SH3BGRL(80532483), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ABCB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SH3BGRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8364-01A	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+

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Fusion Gene ORF analysis for ABCB7-SH3BGRL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000253577	ENST00000481106	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
5CDS-3UTR	ENST00000339447	ENST00000481106	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
5CDS-3UTR	ENST00000373394	ENST00000481106	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
In-frame	ENST00000253577	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
In-frame	ENST00000339447	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
In-frame	ENST00000373394	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
intron-3CDS	ENST00000534570	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+
intron-3UTR	ENST00000534570	ENST00000481106	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000253577	ABCB7	chrX	74375940	-	ENST00000373212	SH3BGRL	chrX	80532483	+	1813	193	25	492	155
ENST00000339447	ABCB7	chrX	74375940	-	ENST00000373212	SH3BGRL	chrX	80532483	+	1795	175	7	474	155
ENST00000373394	ABCB7	chrX	74375940	-	ENST00000373212	SH3BGRL	chrX	80532483	+	1796	176	8	475	155

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000253577	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+	0.002295705	0.9977043
ENST00000339447	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+	0.003266439	0.99673355
ENST00000373394	ENST00000373212	ABCB7	chrX	74375940	-	SH3BGRL	chrX	80532483	+	0.003567614	0.9964324

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Fusion Genomic Features for ABCB7-SH3BGRL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ABCB7	chrX	74375939	-	SH3BGRL	chrX	80532482	+	3.79E-06	0.9999962
ABCB7	chrX	74375939	-	SH3BGRL	chrX	80532482	+	3.79E-06	0.9999962

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABCB7-SH3BGRL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:74375940/chrX:80532483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABCB7 O75027	.
FUNCTION: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. {ECO:0000269\|PubMed:10196363}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SH3BGRL

chrX:74375940

chrX:80532483

ENST00000373212

61_67

115.0

Motif

SH3-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

140_436

754.0

Domain

ABC transmembrane type-1

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

472_706

754.0

Domain

ABC transporter

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

140_436

753.0

Domain

ABC transmembrane type-1

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

472_706

753.0

Domain

ABC transporter

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

505_516

754.0

Nucleotide binding

ATP

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

505_516

753.0

Nucleotide binding

ATP

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

141_161

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

186_206

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

260_280

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

291_311

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

383_403

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000253577

410_430

754.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

141_161

753.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

186_206

753.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

260_280

753.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

291_311

753.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

383_403

753.0

Transmembrane

Helical

Hgene

ABCB7

chrX:74375940

chrX:80532483

ENST00000373394

410_430

753.0

Transmembrane

Helical

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Fusion Gene Sequence for ABCB7-SH3BGRL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>216_216_1_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000253577_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1813nt_BP=193nt
CTCGGTTCCTCTTTCCTCGCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCG
GCACTCCGCGATTCTGATCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGC
TCGAGCCTACCAGATTAAGAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGC
CAATGAAGAGAATCGGAAGTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAA
TGAAAGCCAGTATCGCGGGGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACC
TGGTTCAAAGGAAGCAGAAGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTG
CTTTTATAAAATAGCAGAATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACAT
TCAAAATGAATACAAAATTAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGA
TATCGTAGAAATAGTGTTGTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTA
CTATGGCAACTTAAGTGTATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTT
TCATGAACAAGAATATGTACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTA
ATTTCCTATCGTAATTATAACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGC
CTTTCATTGCACATTTCAGTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAA
CTACACAGCTATGATGGAATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGC
TTAAAATGGCATTCTCTAGCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTT
GAGTTTTTGCTAAAACAAATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTT
TTATTTCAGTTTAGCCATGTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGT
ATCAAATAAAAAGGGCAACTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTAC
ATAGTAAGTTTCACACTACCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTT
ACTTTTTGCCAAAATCAACATATAATGAAGAGATGCCTTTGTTTCATGAGATTCAAACTTGATGCTATGCTTTAAAATAAACTCAGTACT

>216_216_1_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000253577_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------
>216_216_2_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000339447_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1795nt_BP=175nt
GCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCGGCACTCCGCGATTCTGAT
CCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGATTAA
GAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGCCAATGAAGAGAATCGGAA
GTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAATGAAAGCCAGTATCGCGG
GGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACCTGGTTCAAAGGAAGCAGA
AGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTGCTTTTATAAAATAGCAGA
ATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACATTCAAAATGAATACAAAAT
TAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGATATCGTAGAAATAGTGTT
GTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTACTATGGCAACTTAAGTGT
ATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTTTCATGAACAAGAATATGT
ACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTAATTTCCTATCGTAATTAT
AACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGCCTTTCATTGCACATTTCA
GTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAACTACACAGCTATGATGGA
ATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGCTTAAAATGGCATTCTCTA
GCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTTGAGTTTTTGCTAAAACAA
ATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTTTTATTTCAGTTTAGCCAT
GTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGTATCAAATAAAAAGGGCAA
CTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTACATAGTAAGTTTCACACTA
CCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTTACTTTTTGCCAAAATCAA

>216_216_2_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000339447_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------
>216_216_3_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000373394_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1796nt_BP=176nt
CGCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCGGCACTCCGCGATTCTGA
TCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGATTA
AGAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGCCAATGAAGAGAATCGGA
AGTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAATGAAAGCCAGTATCGCG
GGGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACCTGGTTCAAAGGAAGCAG
AAGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTGCTTTTATAAAATAGCAG
AATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACATTCAAAATGAATACAAAA
TTAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGATATCGTAGAAATAGTGT
TGTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTACTATGGCAACTTAAGTG
TATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTTTCATGAACAAGAATATG
TACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTAATTTCCTATCGTAATTA
TAACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGCCTTTCATTGCACATTTC
AGTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAACTACACAGCTATGATGG
AATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGCTTAAAATGGCATTCTCT
AGCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTTGAGTTTTTGCTAAAACA
AATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTTTTATTTCAGTTTAGCCA
TGTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGTATCAAATAAAAAGGGCA
ACTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTACATAGTAAGTTTCACACT
ACCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTTACTTTTTGCCAAAATCA

>216_216_3_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000373394_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCB7-SH3BGRL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABCB7-SH3BGRL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABCB7-SH3BGRL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source