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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAP2-ANAPC11 (FusionGDB2 ID:2160)

Fusion Gene Summary for ADAP2-ANAPC11

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAP2-ANAPC11
Fusion gene ID: 2160
HgeneTgene
Gene symbol

ADAP2

ANAPC11

Gene ID

55803

51529

Gene nameArfGAP with dual PH domains 2anaphase promoting complex subunit 11
SynonymsCENTA2|HSA272195|cent-bAPC11|Apc11p|HSPC214
Cytomap

17q11.2

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 2centaurin betacentaurin-alpha 2 proteinanaphase-promoting complex subunit 11APC11 anaphase promoting complex subunit 11 homologanaphase promoting complex subunit 11 (yeast APC11 homolog)cyclosome subunit 11hepatocellular carcinoma-associated RING finger protein
Modification date2020031320200313
UniProtAcc

Q9NPF8

Q9NYG5

Ensembl transtripts involved in fusion geneENST00000330889, ENST00000580525, 
ENST00000583688, 		ENST00000344877, 
ENST00000571024, ENST00000572851, 
ENST00000574924, ENST00000575195, 
ENST00000357385, ENST00000392376, 
ENST00000571570, ENST00000571874, 
ENST00000572639, ENST00000577425, 
ENST00000577747, ENST00000578544, 
ENST00000578550, ENST00000579133, 
ENST00000579978, ENST00000582222, 
ENST00000583839, ENST00000584314, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 6 X 4=120
# samples 47
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAP2 [Title/Abstract] AND ANAPC11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAP2(29246785)-ANAPC11(79858127), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAP2

GO:0048017

inositol lipid-mediated signaling

14690521

TgeneANAPC11

GO:0016567

protein ubiquitination

11739784

TgeneANAPC11

GO:0070979

protein K11-linked ubiquitination

18485873


check buttonFusion gene breakpoints across ADAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANAPC11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI494072ADAP2chr17

29246785

+ANAPC11chr17

79858127

-


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Fusion Gene ORF analysis for ADAP2-ANAPC11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000330889ENST00000344877ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000330889ENST00000571024ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000330889ENST00000572851ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000330889ENST00000574924ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000330889ENST00000575195ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000580525ENST00000344877ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000580525ENST00000571024ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000580525ENST00000572851ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000580525ENST00000574924ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000580525ENST00000575195ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000583688ENST00000344877ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000583688ENST00000571024ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000583688ENST00000572851ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000583688ENST00000574924ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-3UTRENST00000583688ENST00000575195ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000357385ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000392376ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000571570ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000571874ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000572639ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000577425ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000577747ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000578544ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000578550ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000579133ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000579978ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000582222ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000583839ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000330889ENST00000584314ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000357385ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000392376ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000571570ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000571874ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000572639ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000577425ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000577747ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000578544ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000578550ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000579133ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000579978ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000582222ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000583839ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000580525ENST00000584314ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000357385ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000392376ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000571570ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000571874ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000572639ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000577425ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000577747ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000578544ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000578550ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000579133ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000579978ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000582222ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000583839ADAP2chr17

29246785

+ANAPC11chr17

79858127

-
intron-intronENST00000583688ENST00000584314ADAP2chr17

29246785

+ANAPC11chr17

79858127

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADAP2-ANAPC11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAP2-ANAPC11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29246785/:79858127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAP2

Q9NPF8

ANAPC11

Q9NYG5

FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269|PubMed:14690521, ECO:0000305}.FUNCTION: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADAP2-ANAPC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADAP2-ANAPC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAP2-ANAPC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAP2-ANAPC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource