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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCLRE1C-FAM171A1 (FusionGDB2 ID:21628)

Fusion Gene Summary for DCLRE1C-FAM171A1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCLRE1C-FAM171A1
Fusion gene ID: 21628
HgeneTgene
Gene symbol

DCLRE1C

FAM171A1

Gene ID

64421

221061

Gene nameDNA cross-link repair 1Cfamily with sequence similarity 171 member A1
SynonymsA-SCID|DCLREC1C|RS-SCID|SCIDA|SNM1CAPCN|C10orf38
Cytomap

10p13

10p13

Type of geneprotein-codingprotein-coding
Descriptionprotein artemisDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)SNM1 homolog CSNM1-like proteinsevere combined immunodeficiency, type a (Athabascan)protein FAM171A1astroprincin
Modification date2020031320200313
UniProtAcc

Q96SD1

Q5VUB5

Ensembl transtripts involved in fusion geneENST00000357717, ENST00000378246, 
ENST00000378249, ENST00000378254, 
ENST00000378255, ENST00000378258, 
ENST00000378278, ENST00000378289, 
ENST00000396817, ENST00000453695, 
ENST00000378242, ENST00000492201, 
ENST00000477161, ENST00000378116, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 7 X 4=196
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCLRE1C [Title/Abstract] AND FAM171A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCLRE1C(14974853)-FAM171A1(15290814), # samples:1
FAM171A1(15412954)-DCLRE1C(14981868), # samples:1
Anticipated loss of major functional domain due to fusion event.DCLRE1C-FAM171A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DCLRE1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM171A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A1Y7-01ADCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-


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Fusion Gene ORF analysis for DCLRE1C-FAM171A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357717ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378246ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378249ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378254ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378255ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378258ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378278ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000378289ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000396817ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
5CDS-intronENST00000453695ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000357717ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000378249ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000378254ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000378258ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000378278ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000378289ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
Frame-shiftENST00000396817ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
In-frameENST00000378246ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
In-frameENST00000378255ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
In-frameENST00000453695ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
intron-3CDSENST00000378242ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
intron-3CDSENST00000492201ENST00000378116DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
intron-intronENST00000378242ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-
intron-intronENST00000492201ENST00000477161DCLRE1Cchr10

14974853

-FAM171A1chr10

15290814

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000453695DCLRE1Cchr1014974853-ENST00000378116FAM171A1chr1015290814-42338658492960703
ENST00000378246DCLRE1Cchr1014974853-ENST00000378116FAM171A1chr1015290814-41778097932904703
ENST00000378255DCLRE1Cchr1014974853-ENST00000378116FAM171A1chr1015290814-4639127112553366703

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000453695ENST00000378116DCLRE1Cchr1014974853-FAM171A1chr1015290814-0.0020056180.9979944
ENST00000378246ENST00000378116DCLRE1Cchr1014974853-FAM171A1chr1015290814-0.0021692760.9978307
ENST00000378255ENST00000378116DCLRE1Cchr1014974853-FAM171A1chr1015290814-0.002318450.9976815

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Fusion Genomic Features for DCLRE1C-FAM171A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCLRE1C-FAM171A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:14974853/chr10:15290814)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCLRE1C

Q96SD1

FAM171A1

Q5VUB5

FUNCTION: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}.FUNCTION: Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM171A1chr10:14974853chr10:15290814ENST0000037811638325_890192891.0Topological domainCytoplasmic
TgeneFAM171A1chr10:14974853chr10:15290814ENST0000037811638304_324192891.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM171A1chr10:14974853chr10:15290814ENST000003781163822_303192891.0Topological domainExtracellular


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Fusion Gene Sequence for DCLRE1C-FAM171A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21628_21628_1_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000378246_FAM171A1_chr10_15290814_ENST00000378116_length(transcript)=4177nt_BP=809nt
GCTTCCCGGAAGTGGCGGCGCGGTCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAG
TTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTC
CCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGCTTGAAGGTTTATCTATACTGTTC
ACCTGTGACTAAGGAGTTGTTGTTAACGAGCCCGAAATACAGATTTTGGAAGAAACGAATTATATCTATTGAAATCGAGACTCCTACCCA
GATATCTTTAGTGGATGAAGCATCAGGAGAGGTTTTTATTTCAGGGCAATAATGGAACTGTCCTGTACACAGGAGACTTCAGATTGGCGC
AAGGAGAAGCTGCTAGAATGGAGCTTCTGCACTCCGGGGGCAGAGTCAAAGACATCCAAAGTGTATATTTGGATACTACGTTCTGTGATC
CAAGATTTTACCAAATTCCAAGTCGGGAGGAGTGTTTAAGTGGAGTCTTAGAGCTGGTCCGAAGCTGGATCACTCGGAGCCCGTACCATG
TTGTGTGGCTGAACTGCAAAGCGGCTTATGGCTATGAATATCTGTTCACCAACCTTAGTGAAGAATTAGGAGTCCAGGTTCATGTGAATA
AGCTAGACATGTTTAGGAACATGCCTGAGATCCTTCATCATCTCACAACAGACCGCAACACTCAGATCCATGCATGCCGGCATCCCAAGG
AAACAGCACCAGGCATGACCTGACCCCAGTCACAGCCGTCAGCGTCCACTTGCTGAGCAGTAATGGAACGCCGGTGCTGGTGGATGGTCC
CATCTATGTCACTGTGCCCCTGGCCACGCAGAGCAGCCTGAGGCACAATGCCTATGTCGCGGCGTGGCGGTTTGACCAGAAGCTGGGAAC
GTGGCTGAAGAGCGGTCTGGGTCTTGTGCACCAGGAAGGCAGCCAGCTGACGTGGACATACATTGCCCCCCAGTTGGGGTACTGGGTGGC
CGCCATGTCCCCTCCCATCCCAGGTCCCGTTGTAACACAGGACATTACCACGTATCACACGGTGTTTCTTTTGGCCATTTTAGGAGGAAT
GGCTTTCATACTTTTGGTTTTGCTGTGTCTCCTTTTATATTATTGCAGGAGGAAGTGCTTGAAACCTCGTCAGCACCACAGAAAACTGCA
GCTCCCTGCAGGACTGGAGAGTTCCAAAAGAGACCAGTCCACGTCCATGTCACACATTAACTTGCTGTTTTCACGCCGAGCGTCAGAATT
CCCTGGCCCGCTGTCCGTCACCAGCCACGGCCGCCCCGAGGCCCCCGGCACGAAGGAACTGATGAGTGGAGTCCATTTGGAAATGATGTC
TCCGGGCGGCGAAGGGGACCTGCACACCCCCATGCTCAAGCTCTCCTACAGCACCTCCCAGGAATTTAGCTCCCGGGAGGAGCTCCTCTC
TTGCAAGGAAGAGGATAAAAGCCAGATCTCCTTTGATAACCTCACTCCAAGTGGGACGCTGGGGAAAGACTACCATAAGTCAGTGGAGGT
TTTTCCCTTAAAGGCAAGAAAATCTATGGAAAGAGAAGGCTACGAGTCCTCGGGCAATGATGACTACAGGGGTAGTTACAACACCGTGCT
CTCACAGCCTTTATTTGAAAAGCAGGACAGAGAAGGTCCAGCCTCCACGGGAAGCAAACTCACCATTCAGGAACATCTGTACCCCGCGCC
TTCATCACCTGAGAAAGAACAGCTGCTGGACCGCAGACCCACTGAATGTATGATGTCGCGATCAGTAGATCACCTCGAGAGACCTACGTC
CTTCCCACGGCCCGGCCAGTTAATCTGCTGCAGTTCTGTCGACCAGGTCAATGACAGCGTTTACAGGAAAGTACTGCCTGCCTTGGTCAT
CCCGGCTCATTATATGAAACTCCCCGGGGACCACTCCTATGTCAGCCAGCCCCTCGTCGTCCCGGCTGATCAGCAGCTTGAGATAGAAAG
ACTACAGGCTGAGCTGTCCAATCCCCATGCCGGGATCTTCCCACACCCGTCCTCACAGATCCAGCCCCAGCCCCTGTCTTCCCAGGCCAT
CTCTCAGCAGCACCTGCAGGATGCGGGCACCCGGGAGTGGAGCCCTCAGAACGCATCCATGTCGGAGTCTCTCTCCATCCCAGCTTCCCT
GAACGACGCGGCTTTGGCTCAGATGAACAGTGAGGTGCAGCTCCTGACTGAAAAGGCCCTGATGGAGCTTGGGGGTGGGAAGCCGCTTCC
GCACCCCCGGGCGTGGTTCGTCTCCTTGGATGGCAGGTCCAACGCTCACGTTAGACATTCATACATTGATCTCCAAAGAGCTGGAAGGAA
CGGAAGTAATGATGCCAGTTTGGACTCTGGCGTAGATATGAATGAACCAAAATCAGCCCGGAAGGGAAGGGGAGATGCTTTGTCTCTGCA
GCAGAACTACCCGCCCGTCCAAGAGCACCAGCAGAAAGAGCCTCGAGCCCCAGACAGCACGGCCTACACGCAGCTCGTGTACCTGGATGA
CGTGGAACAGAGTGGTAGCGAATGTGGGACCACGGTCTGTACCCCCGAGGACAGTGCCCTGCGATGCTTGTTGGAGGGGTCGAGTCGGAG
AAGTGGTGGCCAGCTGCCCAGCCTGCAGGAGGAGACGACCAGACGGACTGCGGATGCCCCCTCGGAGCCAGCAGCCAGCCCCCACCAGAG
AAGATCTGCCCACGAGGAAGAGGAAGACGATGATGATGATGACCAAGGAGAAGACAAGAAAAGCCCCTGGCAGAAACGGGAGGAGAGGCC
CCTGATGGCGTTTAACATTAAATGAGCTATCGCAGACCCACCTGACTGTGGAATATAAAATTGCCAAATATCCTTTCTCATGGAAGCGCG
TACCCGTTCGTGGAGGAAACGGAACGGCAGCCCAGCCGTGGGACGGACGTGGACGTTTACTGCATTCCTGTTTGCCGTGTAAATGTTAGA
AAGGAATTAAAGTTATTACTCGGAATAAAGGATGACTTTGGCGGATGTCGCCCCTGCAAGGAGGTGGCTGAAAGTGGTGTCCAGATGTCC
TTCCGAGGACTCGGCGTATCCGCCACCAGGGACATTAAGAAACCGCACGTGATGTCGCTATGCTCTAACGATCACCTCAGTTCTCCCTCG
GATTCTGGGAACAGATGAAACTTTTTGCATCGCTTGAGTCATTTTTATCACAATAATCCTACTGTGAAGCTGTCGTTGAGAACTTAGGTT
GGCACGTAGCGTCTCAAGGTATGCGTTCTCTCAAAGGAAAGCTATGCATCGCTGCTTCGTTGTCTGATTTTGCTTAGATTTTGCTTTGGT
TAGGTTGCGTTTTGGGGTTTGCCTTTTTTTGTTGTCGCTTAAATGCAATTTGGTTGTAAAGATTTGATTCCTTTGTGTTCATCTGTTCCG
CTTCTCAGCGGTCCATCTCAGCGTCTCCCTTCAGGAACCGCTGAGTGTCCTCTCTTAACATCCAAGCCTTTTAATGAAATCGTACTGAAA
TCTGTATCAGCTAAGAGTCCTCCAATCCTGGTCCCATTAACTCCAAGTGCCTTTTTGACAGTGACAACAGACAGTCCCTCGCTTTTTGTT
GTTGTTGGTTTTCTTAACCCCTTTAATGGAACTGCCTGGATTTTATACAGTTATTAAAGGATGTCTCTTTTGCTTTAAACTGCATGCTGC
CAAGTGCCATTTGGGGTCAGCATCCTCGTTTCAACACAGTGTGCTCTCTAGTTATCATGTGTAACGTGGGTTCTGTTTAGCGAAGATAGA
CTAGAGGACACGTTAGAGATGCCCTTCCCTGCTCCATCCCTGTGGCACCATTATGGTTTTTTGGCTGTTTGTATATACGGTTACGTATTA
ACTCTGGAATCCTATGGGCTCATCTTGCTCACCCAATGTGGGAGTCTGGTTTGAGCAAGCGAGCTGAATGTGACTATTAAAAAAAATTTA
AAAAAAAAAAAGAAAATCTTATGTACTATCCAAAAGTGCCAGAATGACTCTTCTGTGCATTCTTCTTAAAGAGCTGCTTGGTTATCCAAA

>21628_21628_1_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000378246_FAM171A1_chr10_15290814_ENST00000378116_length(amino acids)=703AA_BP=5
MPASQGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQ
LGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMSHINLLFS
RRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDY
HKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDH
LERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQP
LSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDL
QRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLL

--------------------------------------------------------------
>21628_21628_2_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000378255_FAM171A1_chr10_15290814_ENST00000378116_length(transcript)=4639nt_BP=1271nt
GCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACC
GCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGA
AAAGAAGGTTGGAGTGCAGACACACCTGATCACATACAAGCGCGTATTTCCAAGTAACAATGGTGAGGGACCACTGTTGGAGGAGGTCCA
GGGACACCGTGTTTCCACCCCCACCTTGTGCTCTTGGTGGCACTGAAATGGTGTGCATAGCTTGAAGGTTTATCTATACTGTTCACCTGT
GACTAAGGAGTTGTTGTTAACGAGCCCGAAATACAGATTTTGGAAGAAACGAATTAGCAGTCACAACAGCAGGGTTGTTCCTGTTGTCTC
TGGCATTCAGCTTGAAGTTACTACAGGTCAGCCCGGCCAGCAGTCAGGAAGGAAAGCTGGAAGAGAAGTGGAGGGGAACAGAGACAAACT
GGAAGGCAGAATGGCCCACTAGGACAGACCGAAACCCACTTCTGTCTCTCACTTCCTCTGGCCTCAATAGTGCTGGTCTCCCGCTTTGGC
TCTGAAGCACATGCACCTGCCCCAGGACTCGGAGGAGCTGCACACGGGCACCCAGCAGAAGCTGATGTTGCTGCGGCCCTGCCCCAGACT
CTGAGTTAAGCCAGAAGATATCTATTGAAATCGAGACTCCTACCCAGATATCTTTAGTGGATGAAGCATCAGGAGAGAAGGAAGAGATTG
TTGTGACTCTCTTACCAGCTGGTCACTGTCCGGGATCAGTTATGTTTTTATTTCAGGGCAATAATGGAACTGTCCTGTACACAGGAGACT
TCAGATTGGCGCAAGGAGAAGCTGCTAGAATGGAGCTTCTGCACTCCGGGGGCAGAGTCAAAGACATCCAAAGTGTATATTTGGATACTA
CGTTCTGTGATCCAAGATTTTACCAAATTCCAAGTCGGGAGGAGTGTTTAAGTGGAGTCTTAGAGCTGGTCCGAAGCTGGATCACTCGGA
GCCCGTACCATGTTGTGTGGCTGAACTGCAAAGCGGCTTATGGCTATGAATATCTGTTCACCAACCTTAGTGAAGAATTAGGAGTCCAGG
TTCATGTGAATAAGCTAGACATGTTTAGGAACATGCCTGAGATCCTTCATCATCTCACAACAGACCGCAACACTCAGATCCATGCATGCC
GGCATCCCAAGGAAACAGCACCAGGCATGACCTGACCCCAGTCACAGCCGTCAGCGTCCACTTGCTGAGCAGTAATGGAACGCCGGTGCT
GGTGGATGGTCCCATCTATGTCACTGTGCCCCTGGCCACGCAGAGCAGCCTGAGGCACAATGCCTATGTCGCGGCGTGGCGGTTTGACCA
GAAGCTGGGAACGTGGCTGAAGAGCGGTCTGGGTCTTGTGCACCAGGAAGGCAGCCAGCTGACGTGGACATACATTGCCCCCCAGTTGGG
GTACTGGGTGGCCGCCATGTCCCCTCCCATCCCAGGTCCCGTTGTAACACAGGACATTACCACGTATCACACGGTGTTTCTTTTGGCCAT
TTTAGGAGGAATGGCTTTCATACTTTTGGTTTTGCTGTGTCTCCTTTTATATTATTGCAGGAGGAAGTGCTTGAAACCTCGTCAGCACCA
CAGAAAACTGCAGCTCCCTGCAGGACTGGAGAGTTCCAAAAGAGACCAGTCCACGTCCATGTCACACATTAACTTGCTGTTTTCACGCCG
AGCGTCAGAATTCCCTGGCCCGCTGTCCGTCACCAGCCACGGCCGCCCCGAGGCCCCCGGCACGAAGGAACTGATGAGTGGAGTCCATTT
GGAAATGATGTCTCCGGGCGGCGAAGGGGACCTGCACACCCCCATGCTCAAGCTCTCCTACAGCACCTCCCAGGAATTTAGCTCCCGGGA
GGAGCTCCTCTCTTGCAAGGAAGAGGATAAAAGCCAGATCTCCTTTGATAACCTCACTCCAAGTGGGACGCTGGGGAAAGACTACCATAA
GTCAGTGGAGGTTTTTCCCTTAAAGGCAAGAAAATCTATGGAAAGAGAAGGCTACGAGTCCTCGGGCAATGATGACTACAGGGGTAGTTA
CAACACCGTGCTCTCACAGCCTTTATTTGAAAAGCAGGACAGAGAAGGTCCAGCCTCCACGGGAAGCAAACTCACCATTCAGGAACATCT
GTACCCCGCGCCTTCATCACCTGAGAAAGAACAGCTGCTGGACCGCAGACCCACTGAATGTATGATGTCGCGATCAGTAGATCACCTCGA
GAGACCTACGTCCTTCCCACGGCCCGGCCAGTTAATCTGCTGCAGTTCTGTCGACCAGGTCAATGACAGCGTTTACAGGAAAGTACTGCC
TGCCTTGGTCATCCCGGCTCATTATATGAAACTCCCCGGGGACCACTCCTATGTCAGCCAGCCCCTCGTCGTCCCGGCTGATCAGCAGCT
TGAGATAGAAAGACTACAGGCTGAGCTGTCCAATCCCCATGCCGGGATCTTCCCACACCCGTCCTCACAGATCCAGCCCCAGCCCCTGTC
TTCCCAGGCCATCTCTCAGCAGCACCTGCAGGATGCGGGCACCCGGGAGTGGAGCCCTCAGAACGCATCCATGTCGGAGTCTCTCTCCAT
CCCAGCTTCCCTGAACGACGCGGCTTTGGCTCAGATGAACAGTGAGGTGCAGCTCCTGACTGAAAAGGCCCTGATGGAGCTTGGGGGTGG
GAAGCCGCTTCCGCACCCCCGGGCGTGGTTCGTCTCCTTGGATGGCAGGTCCAACGCTCACGTTAGACATTCATACATTGATCTCCAAAG
AGCTGGAAGGAACGGAAGTAATGATGCCAGTTTGGACTCTGGCGTAGATATGAATGAACCAAAATCAGCCCGGAAGGGAAGGGGAGATGC
TTTGTCTCTGCAGCAGAACTACCCGCCCGTCCAAGAGCACCAGCAGAAAGAGCCTCGAGCCCCAGACAGCACGGCCTACACGCAGCTCGT
GTACCTGGATGACGTGGAACAGAGTGGTAGCGAATGTGGGACCACGGTCTGTACCCCCGAGGACAGTGCCCTGCGATGCTTGTTGGAGGG
GTCGAGTCGGAGAAGTGGTGGCCAGCTGCCCAGCCTGCAGGAGGAGACGACCAGACGGACTGCGGATGCCCCCTCGGAGCCAGCAGCCAG
CCCCCACCAGAGAAGATCTGCCCACGAGGAAGAGGAAGACGATGATGATGATGACCAAGGAGAAGACAAGAAAAGCCCCTGGCAGAAACG
GGAGGAGAGGCCCCTGATGGCGTTTAACATTAAATGAGCTATCGCAGACCCACCTGACTGTGGAATATAAAATTGCCAAATATCCTTTCT
CATGGAAGCGCGTACCCGTTCGTGGAGGAAACGGAACGGCAGCCCAGCCGTGGGACGGACGTGGACGTTTACTGCATTCCTGTTTGCCGT
GTAAATGTTAGAAAGGAATTAAAGTTATTACTCGGAATAAAGGATGACTTTGGCGGATGTCGCCCCTGCAAGGAGGTGGCTGAAAGTGGT
GTCCAGATGTCCTTCCGAGGACTCGGCGTATCCGCCACCAGGGACATTAAGAAACCGCACGTGATGTCGCTATGCTCTAACGATCACCTC
AGTTCTCCCTCGGATTCTGGGAACAGATGAAACTTTTTGCATCGCTTGAGTCATTTTTATCACAATAATCCTACTGTGAAGCTGTCGTTG
AGAACTTAGGTTGGCACGTAGCGTCTCAAGGTATGCGTTCTCTCAAAGGAAAGCTATGCATCGCTGCTTCGTTGTCTGATTTTGCTTAGA
TTTTGCTTTGGTTAGGTTGCGTTTTGGGGTTTGCCTTTTTTTGTTGTCGCTTAAATGCAATTTGGTTGTAAAGATTTGATTCCTTTGTGT
TCATCTGTTCCGCTTCTCAGCGGTCCATCTCAGCGTCTCCCTTCAGGAACCGCTGAGTGTCCTCTCTTAACATCCAAGCCTTTTAATGAA
ATCGTACTGAAATCTGTATCAGCTAAGAGTCCTCCAATCCTGGTCCCATTAACTCCAAGTGCCTTTTTGACAGTGACAACAGACAGTCCC
TCGCTTTTTGTTGTTGTTGGTTTTCTTAACCCCTTTAATGGAACTGCCTGGATTTTATACAGTTATTAAAGGATGTCTCTTTTGCTTTAA
ACTGCATGCTGCCAAGTGCCATTTGGGGTCAGCATCCTCGTTTCAACACAGTGTGCTCTCTAGTTATCATGTGTAACGTGGGTTCTGTTT
AGCGAAGATAGACTAGAGGACACGTTAGAGATGCCCTTCCCTGCTCCATCCCTGTGGCACCATTATGGTTTTTTGGCTGTTTGTATATAC
GGTTACGTATTAACTCTGGAATCCTATGGGCTCATCTTGCTCACCCAATGTGGGAGTCTGGTTTGAGCAAGCGAGCTGAATGTGACTATT
AAAAAAAATTTAAAAAAAAAAAAGAAAATCTTATGTACTATCCAAAAGTGCCAGAATGACTCTTCTGTGCATTCTTCTTAAAGAGCTGCT

>21628_21628_2_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000378255_FAM171A1_chr10_15290814_ENST00000378116_length(amino acids)=703AA_BP=5
MPASQGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQ
LGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMSHINLLFS
RRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDY
HKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDH
LERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQP
LSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDL
QRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLL

--------------------------------------------------------------
>21628_21628_3_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000453695_FAM171A1_chr10_15290814_ENST00000378116_length(transcript)=4233nt_BP=865nt
GCTTCCCGGAAGTGGCGGCGCGGTCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAG
TTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTC
CCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGCTTGAAGGTTTATCTATACTGTTC
ACCTGTGACTAAGGAGTTGTTGTTAACGAGCCCGAAATACAGATTTTGGAAGAAACGAATTATATCTATTGAAATCGAGACTCCTACCCA
GATATCTTTAGTGGATGAAGCATCAGGAGAGAAGGAAGAGATTGTTGTGACTCTCTTACCAGCTGGTCACTGTCCGGGATCAGTTATGTT
TTTATTTCAGGGCAATAATGGAACTGTCCTGTACACAGGAGACTTCAGATTGGCGCAAGGAGAAGCTGCTAGAATGGAGCTTCTGCACTC
CGGGGGCAGAGTCAAAGACATCCAAAGTGTATATTTGGATACTACGTTCTGTGATCCAAGATTTTACCAAATTCCAAGTCGGGAGGAGTG
TTTAAGTGGAGTCTTAGAGCTGGTCCGAAGCTGGATCACTCGGAGCCCGTACCATGTTGTGTGGCTGAACTGCAAAGCGGCTTATGGCTA
TGAATATCTGTTCACCAACCTTAGTGAAGAATTAGGAGTCCAGGTTCATGTGAATAAGCTAGACATGTTTAGGAACATGCCTGAGATCCT
TCATCATCTCACAACAGACCGCAACACTCAGATCCATGCATGCCGGCATCCCAAGGAAACAGCACCAGGCATGACCTGACCCCAGTCACA
GCCGTCAGCGTCCACTTGCTGAGCAGTAATGGAACGCCGGTGCTGGTGGATGGTCCCATCTATGTCACTGTGCCCCTGGCCACGCAGAGC
AGCCTGAGGCACAATGCCTATGTCGCGGCGTGGCGGTTTGACCAGAAGCTGGGAACGTGGCTGAAGAGCGGTCTGGGTCTTGTGCACCAG
GAAGGCAGCCAGCTGACGTGGACATACATTGCCCCCCAGTTGGGGTACTGGGTGGCCGCCATGTCCCCTCCCATCCCAGGTCCCGTTGTA
ACACAGGACATTACCACGTATCACACGGTGTTTCTTTTGGCCATTTTAGGAGGAATGGCTTTCATACTTTTGGTTTTGCTGTGTCTCCTT
TTATATTATTGCAGGAGGAAGTGCTTGAAACCTCGTCAGCACCACAGAAAACTGCAGCTCCCTGCAGGACTGGAGAGTTCCAAAAGAGAC
CAGTCCACGTCCATGTCACACATTAACTTGCTGTTTTCACGCCGAGCGTCAGAATTCCCTGGCCCGCTGTCCGTCACCAGCCACGGCCGC
CCCGAGGCCCCCGGCACGAAGGAACTGATGAGTGGAGTCCATTTGGAAATGATGTCTCCGGGCGGCGAAGGGGACCTGCACACCCCCATG
CTCAAGCTCTCCTACAGCACCTCCCAGGAATTTAGCTCCCGGGAGGAGCTCCTCTCTTGCAAGGAAGAGGATAAAAGCCAGATCTCCTTT
GATAACCTCACTCCAAGTGGGACGCTGGGGAAAGACTACCATAAGTCAGTGGAGGTTTTTCCCTTAAAGGCAAGAAAATCTATGGAAAGA
GAAGGCTACGAGTCCTCGGGCAATGATGACTACAGGGGTAGTTACAACACCGTGCTCTCACAGCCTTTATTTGAAAAGCAGGACAGAGAA
GGTCCAGCCTCCACGGGAAGCAAACTCACCATTCAGGAACATCTGTACCCCGCGCCTTCATCACCTGAGAAAGAACAGCTGCTGGACCGC
AGACCCACTGAATGTATGATGTCGCGATCAGTAGATCACCTCGAGAGACCTACGTCCTTCCCACGGCCCGGCCAGTTAATCTGCTGCAGT
TCTGTCGACCAGGTCAATGACAGCGTTTACAGGAAAGTACTGCCTGCCTTGGTCATCCCGGCTCATTATATGAAACTCCCCGGGGACCAC
TCCTATGTCAGCCAGCCCCTCGTCGTCCCGGCTGATCAGCAGCTTGAGATAGAAAGACTACAGGCTGAGCTGTCCAATCCCCATGCCGGG
ATCTTCCCACACCCGTCCTCACAGATCCAGCCCCAGCCCCTGTCTTCCCAGGCCATCTCTCAGCAGCACCTGCAGGATGCGGGCACCCGG
GAGTGGAGCCCTCAGAACGCATCCATGTCGGAGTCTCTCTCCATCCCAGCTTCCCTGAACGACGCGGCTTTGGCTCAGATGAACAGTGAG
GTGCAGCTCCTGACTGAAAAGGCCCTGATGGAGCTTGGGGGTGGGAAGCCGCTTCCGCACCCCCGGGCGTGGTTCGTCTCCTTGGATGGC
AGGTCCAACGCTCACGTTAGACATTCATACATTGATCTCCAAAGAGCTGGAAGGAACGGAAGTAATGATGCCAGTTTGGACTCTGGCGTA
GATATGAATGAACCAAAATCAGCCCGGAAGGGAAGGGGAGATGCTTTGTCTCTGCAGCAGAACTACCCGCCCGTCCAAGAGCACCAGCAG
AAAGAGCCTCGAGCCCCAGACAGCACGGCCTACACGCAGCTCGTGTACCTGGATGACGTGGAACAGAGTGGTAGCGAATGTGGGACCACG
GTCTGTACCCCCGAGGACAGTGCCCTGCGATGCTTGTTGGAGGGGTCGAGTCGGAGAAGTGGTGGCCAGCTGCCCAGCCTGCAGGAGGAG
ACGACCAGACGGACTGCGGATGCCCCCTCGGAGCCAGCAGCCAGCCCCCACCAGAGAAGATCTGCCCACGAGGAAGAGGAAGACGATGAT
GATGATGACCAAGGAGAAGACAAGAAAAGCCCCTGGCAGAAACGGGAGGAGAGGCCCCTGATGGCGTTTAACATTAAATGAGCTATCGCA
GACCCACCTGACTGTGGAATATAAAATTGCCAAATATCCTTTCTCATGGAAGCGCGTACCCGTTCGTGGAGGAAACGGAACGGCAGCCCA
GCCGTGGGACGGACGTGGACGTTTACTGCATTCCTGTTTGCCGTGTAAATGTTAGAAAGGAATTAAAGTTATTACTCGGAATAAAGGATG
ACTTTGGCGGATGTCGCCCCTGCAAGGAGGTGGCTGAAAGTGGTGTCCAGATGTCCTTCCGAGGACTCGGCGTATCCGCCACCAGGGACA
TTAAGAAACCGCACGTGATGTCGCTATGCTCTAACGATCACCTCAGTTCTCCCTCGGATTCTGGGAACAGATGAAACTTTTTGCATCGCT
TGAGTCATTTTTATCACAATAATCCTACTGTGAAGCTGTCGTTGAGAACTTAGGTTGGCACGTAGCGTCTCAAGGTATGCGTTCTCTCAA
AGGAAAGCTATGCATCGCTGCTTCGTTGTCTGATTTTGCTTAGATTTTGCTTTGGTTAGGTTGCGTTTTGGGGTTTGCCTTTTTTTGTTG
TCGCTTAAATGCAATTTGGTTGTAAAGATTTGATTCCTTTGTGTTCATCTGTTCCGCTTCTCAGCGGTCCATCTCAGCGTCTCCCTTCAG
GAACCGCTGAGTGTCCTCTCTTAACATCCAAGCCTTTTAATGAAATCGTACTGAAATCTGTATCAGCTAAGAGTCCTCCAATCCTGGTCC
CATTAACTCCAAGTGCCTTTTTGACAGTGACAACAGACAGTCCCTCGCTTTTTGTTGTTGTTGGTTTTCTTAACCCCTTTAATGGAACTG
CCTGGATTTTATACAGTTATTAAAGGATGTCTCTTTTGCTTTAAACTGCATGCTGCCAAGTGCCATTTGGGGTCAGCATCCTCGTTTCAA
CACAGTGTGCTCTCTAGTTATCATGTGTAACGTGGGTTCTGTTTAGCGAAGATAGACTAGAGGACACGTTAGAGATGCCCTTCCCTGCTC
CATCCCTGTGGCACCATTATGGTTTTTTGGCTGTTTGTATATACGGTTACGTATTAACTCTGGAATCCTATGGGCTCATCTTGCTCACCC
AATGTGGGAGTCTGGTTTGAGCAAGCGAGCTGAATGTGACTATTAAAAAAAATTTAAAAAAAAAAAAGAAAATCTTATGTACTATCCAAA
AGTGCCAGAATGACTCTTCTGTGCATTCTTCTTAAAGAGCTGCTTGGTTATCCAAAAATGAAAATTCAAAATAAACTCTGAAGAAAAGGA

>21628_21628_3_DCLRE1C-FAM171A1_DCLRE1C_chr10_14974853_ENST00000453695_FAM171A1_chr10_15290814_ENST00000378116_length(amino acids)=703AA_BP=5
MPASQGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQ
LGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMSHINLLFS
RRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDY
HKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDH
LERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQP
LSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDL
QRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCLRE1C-FAM171A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCLRE1C-FAM171A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCLRE1C-FAM171A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource