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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADARB1-ADARB1 (FusionGDB2 ID:2164)

Fusion Gene Summary for ADARB1-ADARB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADARB1-ADARB1
Fusion gene ID: 2164
HgeneTgene
Gene symbol

ADARB1

ADARB1

Gene ID

104

104

Gene nameadenosine deaminase RNA specific B1adenosine deaminase RNA specific B1
SynonymsADAR2|DRABA2|DRADA2|RED1ADAR2|DRABA2|DRADA2|RED1
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-specific editase 1RNA editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)dsRNA adenosine deaminase DRADA2double-stranded RNA-specific editase 1RNA editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)dsRNA adenosine deaminase DRADA2
Modification date2020031520200315
UniProtAcc

P78563

P78563

Ensembl transtripts involved in fusion geneENST00000437626, ENST00000348831, 
ENST00000360697, ENST00000389863, 
ENST00000539173, ENST00000460734, 
ENST00000348831, ENST00000360697, 
ENST00000389863, ENST00000437626, 
ENST00000539173, ENST00000460734, 
Fusion gene scores* DoF score3 X 4 X 2=248 X 10 X 5=400
# samples 411
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADARB1 [Title/Abstract] AND ADARB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADARB1(46640923)-ADARB1(46645503), # samples:1
ADARB1(46622953)-ADARB1(46619993), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADARB1

GO:0006382

adenosine to inosine editing

18178553|21289159

HgeneADARB1

GO:0008285

negative regulation of cell proliferation

18178553

HgeneADARB1

GO:0030336

negative regulation of cell migration

18178553

HgeneADARB1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

21289159

HgeneADARB1

GO:0051726

regulation of cell cycle

18178553

TgeneADARB1

GO:0006382

adenosine to inosine editing

18178553|21289159

TgeneADARB1

GO:0008285

negative regulation of cell proliferation

18178553

TgeneADARB1

GO:0030336

negative regulation of cell migration

18178553

TgeneADARB1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

21289159

TgeneADARB1

GO:0051726

regulation of cell cycle

18178553


check buttonFusion gene breakpoints across ADARB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADARB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA525040ADARB1chr21

46640923

+ADARB1chr21

46645503

-
ChiTaRS5.0N/ABI053543ADARB1chr21

46622953

+ADARB1chr21

46619993

+


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Fusion Gene ORF analysis for ADARB1-ADARB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000437626ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
3UTR-3UTRENST00000437626ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
3UTR-3UTRENST00000437626ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
3UTR-3UTRENST00000437626ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
3UTR-3UTRENST00000437626ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
3UTR-intronENST00000437626ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000348831ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000348831ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000348831ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000348831ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000348831ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000360697ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000360697ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000360697ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000360697ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000360697ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000389863ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000389863ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000389863ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000389863ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000389863ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000539173ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000539173ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000539173ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000539173ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-3UTRENST00000539173ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-intronENST00000348831ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-intronENST00000360697ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-intronENST00000389863ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
5CDS-intronENST00000539173ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-3UTRENST00000460734ENST00000348831ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-3UTRENST00000460734ENST00000360697ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-3UTRENST00000460734ENST00000389863ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-3UTRENST00000460734ENST00000437626ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-3UTRENST00000460734ENST00000539173ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-intronENST00000348831ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000348831ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000348831ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000348831ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000348831ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000348831ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000360697ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000389863ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000437626ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000460734ADARB1chr21

46640923

+ADARB1chr21

46645503

-
intron-intronENST00000460734ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000460734ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000348831ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000360697ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000389863ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000437626ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000460734ADARB1chr21

46622953

+ADARB1chr21

46619993

+
intron-intronENST00000539173ENST00000539173ADARB1chr21

46622953

+ADARB1chr21

46619993

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADARB1-ADARB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADARB1-ADARB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46640923/:46645503)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADARB1

P78563

ADARB1

P78563

FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADARB1-ADARB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADARB1-ADARB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADARB1-ADARB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADARB1-ADARB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource