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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ADARB1-MTOR (FusionGDB2 ID:2166) |
Fusion Gene Summary for ADARB1-MTOR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADARB1-MTOR | Fusion gene ID: 2166 | Hgene | Tgene | Gene symbol | ADARB1 | MTOR | Gene ID | 104 | 2475 |
| Gene name | adenosine deaminase RNA specific B1 | mechanistic target of rapamycin kinase | |
| Synonyms | ADAR2|DRABA2|DRADA2|RED1 | FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS | |
| Cytomap | 21q22.3 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | double-stranded RNA-specific editase 1RNA editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)dsRNA adenosine deaminase DRADA2 | serine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o | |
| Modification date | 20200315 | 20200329 | |
| UniProtAcc | P78563 | TLDC1 | |
| Ensembl transtripts involved in fusion gene | ENST00000460734, ENST00000348831, ENST00000389863, ENST00000437626, ENST00000539173, ENST00000360697, | ENST00000361445, ENST00000376838, ENST00000495435, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 12 X 11 X 8=1056 |
| # samples | 4 | 19 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/1056*10)=-2.47453851102751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADARB1 [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADARB1(46494708)-MTOR(11227574), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADARB1 | GO:0006382 | adenosine to inosine editing | 18178553|21289159 |
| Hgene | ADARB1 | GO:0008285 | negative regulation of cell proliferation | 18178553 |
| Hgene | ADARB1 | GO:0030336 | negative regulation of cell migration | 18178553 |
| Hgene | ADARB1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 21289159 |
| Hgene | ADARB1 | GO:0051726 | regulation of cell cycle | 18178553 |
| Tgene | MTOR | GO:0001558 | regulation of cell growth | 18762023 |
| Tgene | MTOR | GO:0001934 | positive regulation of protein phosphorylation | 20233713 |
| Tgene | MTOR | GO:0006468 | protein phosphorylation | 12150926|15467718|18925875 |
| Tgene | MTOR | GO:0009267 | cellular response to starvation | 28223137 |
| Tgene | MTOR | GO:0010507 | negative regulation of autophagy | 30704899 |
| Tgene | MTOR | GO:0016242 | negative regulation of macroautophagy | 25327288 |
| Tgene | MTOR | GO:0016310 | phosphorylation | 11853878|25327288 |
| Tgene | MTOR | GO:0031667 | response to nutrient levels | 29750193 |
| Tgene | MTOR | GO:0034198 | cellular response to amino acid starvation | 22424946 |
| Tgene | MTOR | GO:0038202 | TORC1 signaling | 28223137 |
| Tgene | MTOR | GO:0043200 | response to amino acid | 18497260 |
| Tgene | MTOR | GO:0045727 | positive regulation of translation | 18762023 |
| Tgene | MTOR | GO:0046777 | protein autophosphorylation | 15467718 |
| Tgene | MTOR | GO:0071230 | cellular response to amino acid stimulus | 22424946 |
| Tgene | MTOR | GO:0071233 | cellular response to leucine | 22424946 |
| Tgene | MTOR | GO:1990253 | cellular response to leucine starvation | 22424946 |
| Fusion gene breakpoints across ADARB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MTOR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-B7-5818-01A | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
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Fusion Gene ORF analysis for ADARB1-MTOR |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000460734 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 3UTR-intron | ENST00000460734 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 3UTR-intron | ENST00000460734 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-3CDS | ENST00000348831 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-3CDS | ENST00000389863 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-3CDS | ENST00000437626 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-3CDS | ENST00000539173 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000348831 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000348831 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000389863 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000389863 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000437626 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000437626 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000539173 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| 5UTR-intron | ENST00000539173 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| intron-3CDS | ENST00000360697 | ENST00000361445 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| intron-intron | ENST00000360697 | ENST00000376838 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| intron-intron | ENST00000360697 | ENST00000495435 | ADARB1 | chr21 | 46494708 | + | MTOR | chr1 | 11227574 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ADARB1-MTOR |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ADARB1-MTOR |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46494708/:11227574) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADARB1 | MTOR |
| FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. | 456 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ADARB1-MTOR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ADARB1-MTOR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADARB1-MTOR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADARB1-MTOR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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