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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADARB2-LIMA1 (FusionGDB2 ID:2169)

Fusion Gene Summary for ADARB2-LIMA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADARB2-LIMA1
Fusion gene ID: 2169
HgeneTgene
Gene symbol

ADARB2

LIMA1

Gene ID

105

51474

Gene nameadenosine deaminase RNA specific B2 (inactive)LIM domain and actin binding 1
SynonymsADAR3|RED2EPLIN|LDLCQ8|SREBP3
Cytomap

10p15.3

12q13.12

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-specific editase B2RED2 homologRNA-dependent adenosine deaminase 3RNA-editing deaminase 2RNA-editing enzyme 2adenosine deaminase, RNA-specific, B2 (RED1 homolog rat)adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)adenosiLIM domain and actin-binding protein 11110021C24Rikepithelial protein lost in neoplasm betasterol regulatory element binding protein 3
Modification date2020031320200313
UniProtAcc

Q9NS39

Q9UHB6

Ensembl transtripts involved in fusion geneENST00000381305, ENST00000381310, 
ENST00000381312, ENST00000469464, 
ENST00000341247, ENST00000394943, 
ENST00000547825, ENST00000552008, 
ENST00000552491, ENST00000552783, 
ENST00000552823, ENST00000552909, 
Fusion gene scores* DoF score6 X 6 X 2=7211 X 12 X 9=1188
# samples 614
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1188*10)=-3.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADARB2 [Title/Abstract] AND LIMA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADARB2(1645919)-LIMA1(50569571), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIMA1

GO:0030835

negative regulation of actin filament depolymerization

12566430

TgeneLIMA1

GO:0031529

ruffle organization

12566430

TgeneLIMA1

GO:0051017

actin filament bundle assembly

12566430


check buttonFusion gene breakpoints across ADARB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LIMA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACB055210ADARB2chr10

1645919

+LIMA1chr12

50569571

+


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Fusion Gene ORF analysis for ADARB2-LIMA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000381305ENST00000341247ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000394943ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000547825ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000552008ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000552491ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000552783ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000552823ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381305ENST00000552909ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000341247ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000394943ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000547825ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000552008ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000552491ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000552783ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000552823ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381310ENST00000552909ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000341247ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000394943ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000547825ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000552008ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000552491ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000552783ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000552823ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000381312ENST00000552909ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000341247ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000394943ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000547825ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000552008ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000552491ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000552783ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000552823ADARB2chr10

1645919

+LIMA1chr12

50569571

+
intron-intronENST00000469464ENST00000552909ADARB2chr10

1645919

+LIMA1chr12

50569571

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADARB2-LIMA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADARB2-LIMA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1645919/:50569571)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADARB2

Q9NS39

LIMA1

Q9UHB6

FUNCTION: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.FUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADARB2-LIMA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADARB2-LIMA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADARB2-LIMA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADARB2-LIMA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource