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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCTN3-LINGO2 (FusionGDB2 ID:21692)

Fusion Gene Summary for DCTN3-LINGO2

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTN3-LINGO2
Fusion gene ID: 21692
HgeneTgene
Gene symbol

DCTN3

LINGO2

Gene ID

11258

158038

Gene namedynactin subunit 3leucine rich repeat and Ig domain containing 2
SynonymsDCTN-22|DCTN22LERN3|LRRN6C
Cytomap

9p13.3

9p21.2-p21.1

Type of geneprotein-codingprotein-coding
Descriptiondynactin subunit 3dynactin 3 (p22)dynactin complex subunit 22 kDa subunitdynactin light chainleucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2leucine rich repeat neuronal 6Cleucine-rich repeat neuronal protein 3leucine-rich repeat neuronal protein 6C
Modification date2020031320200313
UniProtAcc

O75935

Q7L985

Ensembl transtripts involved in fusion geneENST00000259632, ENST00000341694, 
ENST00000378913, ENST00000378916, 
ENST00000447983, ENST00000477738, 
ENST00000479399, 		ENST00000308675, 
ENST00000493941, ENST00000379992, 
Fusion gene scores* DoF score4 X 4 X 3=4811 X 8 X 8=704
# samples 413
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/704*10)=-2.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCTN3 [Title/Abstract] AND LINGO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCTN3(34618673)-LINGO2(28670278), # samples:2
LINGO2(28295206)-DCTN3(34618757), # samples:1
Anticipated loss of major functional domain due to fusion event.DCTN3-LINGO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCTN3

GO:0061640

cytoskeleton-dependent cytokinesis

9722614


check buttonFusion gene breakpoints across DCTN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LINGO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5MM-01ADCTN3chr9

34618673

-LINGO2chr9

28670278

-
ChimerDB4LUSCTCGA-63-A5MMDCTN3chr9

34618673

-LINGO2chr9

28670278

-


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Fusion Gene ORF analysis for DCTN3-LINGO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000259632ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000259632ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000341694ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000341694ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000378913ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000378913ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000378916ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000378916ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000447983ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000447983ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000477738ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
5CDS-intronENST00000477738ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-
Frame-shiftENST00000259632ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
Frame-shiftENST00000378913ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
Frame-shiftENST00000378916ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
Frame-shiftENST00000477738ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
In-frameENST00000341694ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
In-frameENST00000447983ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
intron-3CDSENST00000479399ENST00000379992DCTN3chr9

34618673

-LINGO2chr9

28670278

-
intron-intronENST00000479399ENST00000308675DCTN3chr9

34618673

-LINGO2chr9

28670278

-
intron-intronENST00000479399ENST00000493941DCTN3chr9

34618673

-LINGO2chr9

28670278

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341694DCTN3chr934618673-ENST00000379992LINGO2chr928670278-32351916412461606
ENST00000447983DCTN3chr934618673-ENST00000379992LINGO2chr928670278-32792356852505606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341694ENST00000379992DCTN3chr934618673-LINGO2chr928670278-0.001465590.99853444
ENST00000447983ENST00000379992DCTN3chr934618673-LINGO2chr928670278-0.0014639250.9985361

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Fusion Genomic Features for DCTN3-LINGO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCTN3-LINGO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:34618673/chr9:28670278)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTN3

O75935

LINGO2

Q7L985

FUNCTION: Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269|PubMed:9722614}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLINGO2chr9:34618673chr9:28670278ENST000003086750428_570607.0DomainNote=LRRNT
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504355_4090607.0DomainNote=LRRCT
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504410_4990607.0DomainNote=Ig-like C2-type
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-1628_570607.0DomainNote=LRRNT
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16355_4090607.0DomainNote=LRRCT
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16410_4990607.0DomainNote=Ig-like C2-type
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504106_1270607.0RepeatNote=LRR 3
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504130_1510607.0RepeatNote=LRR 4
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504154_1750607.0RepeatNote=LRR 5
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504178_1990607.0RepeatNote=LRR 6
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504202_2230607.0RepeatNote=LRR 7
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504226_2470607.0RepeatNote=LRR 8
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504250_2710607.0RepeatNote=LRR 9
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504274_2950607.0RepeatNote=LRR 10
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504298_3190607.0RepeatNote=LRR 11
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504322_3430607.0RepeatNote=LRR 12
TgeneLINGO2chr9:34618673chr9:28670278ENST000003086750458_790607.0RepeatNote=LRR 1
TgeneLINGO2chr9:34618673chr9:28670278ENST000003086750482_1030607.0RepeatNote=LRR 2
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16106_1270607.0RepeatNote=LRR 3
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16130_1510607.0RepeatNote=LRR 4
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16154_1750607.0RepeatNote=LRR 5
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16178_1990607.0RepeatNote=LRR 6
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16202_2230607.0RepeatNote=LRR 7
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16226_2470607.0RepeatNote=LRR 8
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16250_2710607.0RepeatNote=LRR 9
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16274_2950607.0RepeatNote=LRR 10
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16298_3190607.0RepeatNote=LRR 11
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16322_3430607.0RepeatNote=LRR 12
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-1658_790607.0RepeatNote=LRR 1
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-1682_1030607.0RepeatNote=LRR 2
TgeneLINGO2chr9:34618673chr9:28670278ENST000003086750428_5450607.0Topological domainExtracellular
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504567_6060607.0Topological domainCytoplasmic
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-1628_5450607.0Topological domainExtracellular
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16567_6060607.0Topological domainCytoplasmic
TgeneLINGO2chr9:34618673chr9:28670278ENST0000030867504546_5660607.0TransmembraneHelical
TgeneLINGO2chr9:34618673chr9:28670278ENST00000379992-16546_5660607.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCTN3chr9:34618673chr9:28670278ENST00000259632-27135_15760187.0Coiled coilOntology_term=ECO:0000255
HgeneDCTN3chr9:34618673chr9:28670278ENST00000341694-27135_15760272.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneDCTN3chr9:34618673chr9:28670278ENST00000378916-26135_15760159.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for DCTN3-LINGO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21692_21692_1_DCTN3-LINGO2_DCTN3_chr9_34618673_ENST00000341694_LINGO2_chr9_28670278_ENST00000379992_length(transcript)=3235nt_BP=191nt
GGTAGTAGCGATGGCGGGTCTGACTGACTTGCAGCGGCTACAGGCCCGAGTGGAAGAGCTGGAGCGCTGGGTGTACGGGCCGGGCGGGGC
GCGCGGCTCACGGAAGGTGGCTGACGGCCTGGTCAAGGTGCAGGTGGCTTTGGGGAACATTTCCAGCAAGAGGGAGAGGGTGAAGATTCT
CTACAAAAAGATGTAGGAATTGATGAGTGCCATCAGAAAGCTGTATCATGAGCTGCCTGCACTTCTAAAGTGTCCAGTGGATTTTTAATC
ACATGAGCCTGGAAATAGGGTTATGAGAAGAAGCTCAGAGCAGAGCACCGAAAGTGGCCACTACCAGCATGAAGAGCCCAACAATTCAAA
CTGGTGAAGTGAGAAAAACAGAATGCAGCTTTCAAGGTTCGTTTCAAGCAGTTGGCTTGTGGGACTCTGAGAGATGCTGCTGCCCATGAC
ATGCGGGAATTATCATGATCAACTACCCAGCTTGGATTTCACCCAGTGGCCAAGAGCTTTGTGTGGGAGACGGCAAGGGTTGGATTTTTC
AAAAGAGTAAACCAGGATAAATCATGAGGAACCTATAACCCTTTTGGCCACATGCAAAAAAGCAAGACCCGTGACCAAGGTGTAGACTAA
GAAGTGGAGTCATGCTTCACACGGCCATATCATGCTGGCAGCCATTCCTGGGTCTGGCTGTGGTGTTAATCTTCATGGGATCCACCATTG
GCTGCCCCGCTCGCTGTGAGTGCTCTGCCCAGAACAAATCTGTTAGCTGTCACAGAAGGCGATTGATCGCCATCCCAGAGGGCATTCCCA
TCGAAACCAAAATCTTGGACCTCAGTAAAAACAGGCTAAAAAGCGTCAACCCTGAAGAATTCATATCATATCCTCTGCTGGAAGAGATAG
ACTTGAGTGACAACATCATTGCCAATGTGGAACCAGGAGCATTCAACAATCTCTTTAACCTGCGTTCCCTCCGCCTAAAAGGCAATCGTC
TAAAGCTGGTCCCTTTGGGAGTATTCACGGGGCTGTCCAATCTCACTAAGCTTGACATTAGTGAGAATAAGATTGTCATTTTACTAGACT
ACATGTTCCAAGATCTACATAACCTGAAGTCTCTAGAAGTGGGGGACAATGATTTGGTTTATATATCACACAGGGCATTCAGTGGGCTTC
TTAGCTTGGAGCAGCTCACCCTGGAGAAATGCAACTTAACAGCAGTACCAACAGAAGCCCTCTCCCACCTCCGCAGCCTCATCAGCCTGC
ATCTGAAGCATCTCAATATCAACAATATGCCTGTGTATGCCTTTAAAAGATTGTTCCACCTGAAACACCTAGAGATTGACTATTGGCCTT
TACTGGATATGATGCCTGCCAATAGCCTCTACGGTCTCAACCTCACATCCCTTTCAGTCACCAACACCAATCTGTCTACTGTACCCTTCC
TTGCCTTTAAACACCTGGTATACCTGACTCACCTTAACCTCTCCTACAATCCCATCAGCACTATTGAAGCAGGCATGTTCTCTGACCTGA
TCCGCCTTCAGGAGCTTCATATAGTGGGGGCCCAGCTTCGCACCATTGAGCCTCACTCCTTCCAAGGGCTCCGCTTCCTACGCGTGCTCA
ATGTGTCTCAGAACCTGCTGGAAACTTTGGAAGAGAATGTCTTCTCCTCCCCTAGGGCTCTGGAGGTCTTGAGCATTAACAACAACCCTC
TGGCCTGTGACTGCCGCCTTCTCTGGATCTTGCAGCGACAGCCCACCCTGCAGTTTGGTGGCCAGCAACCTATGTGTGCTGGCCCAGACA
CCATCCGTGAGAGGTCTTTCAAGGATTTCCATAGCACTGCCCTTTCTTTTTACTTTACCTGCAAAAAACCCAAAATCCGTGAAAAGAAGT
TGCAGCATCTGCTAGTAGATGAAGGGCAGACAGTCCAGCTAGAATGCAGTGCAGATGGAGACCCGCAGCCTGTGATTTCCTGGGTGACAC
CCCGAAGGCGTTTCATCACCACCAAGTCCAATGGAAGAGCCACCGTGTTGGGTGATGGCACCTTGGAAATCCGCTTTGCCCAGGATCAAG
ACAGCGGGATGTATGTTTGCATCGCTAGCAATGCTGCTGGGAATGATACCTTCACAGCCTCCTTAACTGTGAAAGGATTCGCTTCAGATC
GTTTTCTTTATGCGAACAGGACCCCTATGTACATGACCGACTCCAATGACACCATTTCCAATGGCACCAATGCCAATACTTTTTCCCTGG
ACCTTAAAACAATACTGGTGTCTACAGCTATGGGCTGCTTCACATTCCTGGGAGTGGTTTTATTTTGTTTTCTTCTCCTTTTTGTGTGGA
GCCGAGGGAAAGGCAAGCACAAAAACAGCATTGACCTTGAGTATGTGCCCAGAAAAAACAATGGTGCTGTTGTGGAAGGGGAGGTAGCTG
GACCCAGGAGGTTCAACATGAAAATGATTTGAAGGCCCACCCCTCACATTACTGTCTCTTTGTCAATGTGGGTAATCAGTAAGACAGTAT
GGCACAGTAAATTACTAGATTAAGAGGCAGCCATGTGCAGCTGCCCCTGTATCAAAAGCAGGGTCTATGGAAGCAGGAGGACTTCCAATG
GAGACTCTCCATCGAAAGGCAGGCAGGCAGGCATGTGTCAGAGCCCTTCACACAGTGGGATACTAAGTGTTTGCGTTGCAAATATTGGCG
TTCTGGGGATCTCAGTAATGAACCTGAATATTTGGCTCACACTCACGGACAATTATTCAGCATTTTCTACCACTGCAAAAAACAAAAGAA
AAAATAAAAAAGAACAACCTACAGTGTAGGATTTACATATTAAAAAGACACATTTGTCTAAAACATACTCTACAGAAAAATTTGTATCTA
TGATTATCATTTGTTAAAGCCTTGCATCATACCATATTGTTGGTTCAGTACCACAAAGAGATCAATATATTCTTTTCTTCCTTTTTTGAA
ACATATATGCTGTACATGTTTTAAAGCAATATGAATGAGAGGTTGTGCTTTTAGTTACTCACCACTATAGATCCAAGTGTGATTTCACCT
TCCGTTACCTACAGATGACCCTGAGACTAGATCCCTGGAGTTATGGGCGGAGATATTTTGAGAGATGTGTTTGTCTGATGTAGGATGCCA

>21692_21692_1_DCTN3-LINGO2_DCTN3_chr9_34618673_ENST00000341694_LINGO2_chr9_28670278_ENST00000379992_length(amino acids)=606AA_BP=
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSD
NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK
HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT

--------------------------------------------------------------
>21692_21692_2_DCTN3-LINGO2_DCTN3_chr9_34618673_ENST00000447983_LINGO2_chr9_28670278_ENST00000379992_length(transcript)=3279nt_BP=235nt
GACTGACGTCCCGCCCTCTGGCTGTTTCCTGGCCGAGGTGGGTCGGTAGTAGCGATGGCGGGTCTGACTGACTTGCAGCGGCTACAGGCC
CGAGTGGAAGAGCTGGAGCGCTGGGTGTACGGGCCGGGCGGGGCGCGCGGCTCACGGAAGGTGGCTGACGGCCTGGTCAAGGTGCAGGTG
GCTTTGGGGAACATTTCCAGCAAGAGGGAGAGGGTGAAGATTCTCTACAAAAAGATGTAGGAATTGATGAGTGCCATCAGAAAGCTGTAT
CATGAGCTGCCTGCACTTCTAAAGTGTCCAGTGGATTTTTAATCACATGAGCCTGGAAATAGGGTTATGAGAAGAAGCTCAGAGCAGAGC
ACCGAAAGTGGCCACTACCAGCATGAAGAGCCCAACAATTCAAACTGGTGAAGTGAGAAAAACAGAATGCAGCTTTCAAGGTTCGTTTCA
AGCAGTTGGCTTGTGGGACTCTGAGAGATGCTGCTGCCCATGACATGCGGGAATTATCATGATCAACTACCCAGCTTGGATTTCACCCAG
TGGCCAAGAGCTTTGTGTGGGAGACGGCAAGGGTTGGATTTTTCAAAAGAGTAAACCAGGATAAATCATGAGGAACCTATAACCCTTTTG
GCCACATGCAAAAAAGCAAGACCCGTGACCAAGGTGTAGACTAAGAAGTGGAGTCATGCTTCACACGGCCATATCATGCTGGCAGCCATT
CCTGGGTCTGGCTGTGGTGTTAATCTTCATGGGATCCACCATTGGCTGCCCCGCTCGCTGTGAGTGCTCTGCCCAGAACAAATCTGTTAG
CTGTCACAGAAGGCGATTGATCGCCATCCCAGAGGGCATTCCCATCGAAACCAAAATCTTGGACCTCAGTAAAAACAGGCTAAAAAGCGT
CAACCCTGAAGAATTCATATCATATCCTCTGCTGGAAGAGATAGACTTGAGTGACAACATCATTGCCAATGTGGAACCAGGAGCATTCAA
CAATCTCTTTAACCTGCGTTCCCTCCGCCTAAAAGGCAATCGTCTAAAGCTGGTCCCTTTGGGAGTATTCACGGGGCTGTCCAATCTCAC
TAAGCTTGACATTAGTGAGAATAAGATTGTCATTTTACTAGACTACATGTTCCAAGATCTACATAACCTGAAGTCTCTAGAAGTGGGGGA
CAATGATTTGGTTTATATATCACACAGGGCATTCAGTGGGCTTCTTAGCTTGGAGCAGCTCACCCTGGAGAAATGCAACTTAACAGCAGT
ACCAACAGAAGCCCTCTCCCACCTCCGCAGCCTCATCAGCCTGCATCTGAAGCATCTCAATATCAACAATATGCCTGTGTATGCCTTTAA
AAGATTGTTCCACCTGAAACACCTAGAGATTGACTATTGGCCTTTACTGGATATGATGCCTGCCAATAGCCTCTACGGTCTCAACCTCAC
ATCCCTTTCAGTCACCAACACCAATCTGTCTACTGTACCCTTCCTTGCCTTTAAACACCTGGTATACCTGACTCACCTTAACCTCTCCTA
CAATCCCATCAGCACTATTGAAGCAGGCATGTTCTCTGACCTGATCCGCCTTCAGGAGCTTCATATAGTGGGGGCCCAGCTTCGCACCAT
TGAGCCTCACTCCTTCCAAGGGCTCCGCTTCCTACGCGTGCTCAATGTGTCTCAGAACCTGCTGGAAACTTTGGAAGAGAATGTCTTCTC
CTCCCCTAGGGCTCTGGAGGTCTTGAGCATTAACAACAACCCTCTGGCCTGTGACTGCCGCCTTCTCTGGATCTTGCAGCGACAGCCCAC
CCTGCAGTTTGGTGGCCAGCAACCTATGTGTGCTGGCCCAGACACCATCCGTGAGAGGTCTTTCAAGGATTTCCATAGCACTGCCCTTTC
TTTTTACTTTACCTGCAAAAAACCCAAAATCCGTGAAAAGAAGTTGCAGCATCTGCTAGTAGATGAAGGGCAGACAGTCCAGCTAGAATG
CAGTGCAGATGGAGACCCGCAGCCTGTGATTTCCTGGGTGACACCCCGAAGGCGTTTCATCACCACCAAGTCCAATGGAAGAGCCACCGT
GTTGGGTGATGGCACCTTGGAAATCCGCTTTGCCCAGGATCAAGACAGCGGGATGTATGTTTGCATCGCTAGCAATGCTGCTGGGAATGA
TACCTTCACAGCCTCCTTAACTGTGAAAGGATTCGCTTCAGATCGTTTTCTTTATGCGAACAGGACCCCTATGTACATGACCGACTCCAA
TGACACCATTTCCAATGGCACCAATGCCAATACTTTTTCCCTGGACCTTAAAACAATACTGGTGTCTACAGCTATGGGCTGCTTCACATT
CCTGGGAGTGGTTTTATTTTGTTTTCTTCTCCTTTTTGTGTGGAGCCGAGGGAAAGGCAAGCACAAAAACAGCATTGACCTTGAGTATGT
GCCCAGAAAAAACAATGGTGCTGTTGTGGAAGGGGAGGTAGCTGGACCCAGGAGGTTCAACATGAAAATGATTTGAAGGCCCACCCCTCA
CATTACTGTCTCTTTGTCAATGTGGGTAATCAGTAAGACAGTATGGCACAGTAAATTACTAGATTAAGAGGCAGCCATGTGCAGCTGCCC
CTGTATCAAAAGCAGGGTCTATGGAAGCAGGAGGACTTCCAATGGAGACTCTCCATCGAAAGGCAGGCAGGCAGGCATGTGTCAGAGCCC
TTCACACAGTGGGATACTAAGTGTTTGCGTTGCAAATATTGGCGTTCTGGGGATCTCAGTAATGAACCTGAATATTTGGCTCACACTCAC
GGACAATTATTCAGCATTTTCTACCACTGCAAAAAACAAAAGAAAAAATAAAAAAGAACAACCTACAGTGTAGGATTTACATATTAAAAA
GACACATTTGTCTAAAACATACTCTACAGAAAAATTTGTATCTATGATTATCATTTGTTAAAGCCTTGCATCATACCATATTGTTGGTTC
AGTACCACAAAGAGATCAATATATTCTTTTCTTCCTTTTTTGAAACATATATGCTGTACATGTTTTAAAGCAATATGAATGAGAGGTTGT
GCTTTTAGTTACTCACCACTATAGATCCAAGTGTGATTTCACCTTCCGTTACCTACAGATGACCCTGAGACTAGATCCCTGGAGTTATGG
GCGGAGATATTTTGAGAGATGTGTTTGTCTGATGTAGGATGCCAAGAAACAGGACCCAAGGCAAAACTGCTCAACTCTGTTAACTTCTGT

>21692_21692_2_DCTN3-LINGO2_DCTN3_chr9_34618673_ENST00000447983_LINGO2_chr9_28670278_ENST00000379992_length(amino acids)=606AA_BP=
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSD
NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK
HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT

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Fusion Gene PPI Analysis for DCTN3-LINGO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCTN3-LINGO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCTN3-LINGO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource