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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:DCUN1D2-NVL (FusionGDB2 ID:21714)

Fusion Gene Summary for DCUN1D2-NVL

Fusion gene summary

Fusion gene information	Fusion gene name: DCUN1D2-NVL
	Fusion gene ID: 21714
		Hgene	Tgene
	Gene symbol	DCUN1D2	NVL
	Gene ID	55208	4931
	Gene name	defective in cullin neddylation 1 domain containing 2	nuclear VCP like
	Synonyms	C13orf17	NVL2
	Cytomap	13q34	1q42.11
	Type of gene	protein-coding	protein-coding
	Description	DCN1-like protein 2DCN1, defective in cullin neddylation 1, domain containing 2DCUN1 domain-containing protein 2defective in cullin neddylation protein 1-like protein 2	nuclear valosin-containing protein-likeNVLp
	Modification date	20200313	20200313
	UniProtAcc	Q6PH85	.
	Ensembl transtripts involved in fusion gene	ENST00000375399, ENST00000478244, ENST00000332592, ENST00000460318,	ENST00000361463, ENST00000468673, ENST00000281701, ENST00000340871, ENST00000391875, ENST00000469075, ENST00000482491,
Fusion gene scores	* DoF score	13 X 6 X 9=702	13 X 7 X 6=546
	# samples	18	13
	** MAII score	log2(18/702*10)=-1.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/546*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DCUN1D2 [Title/Abstract] AND NVL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DCUN1D2(114144981)-NVL(224455835), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NVL	GO:0006364	rRNA processing	29107693
Tgene	NVL	GO:0032092	positive regulation of protein binding	29107693
Tgene	NVL	GO:0042273	ribosomal large subunit biogenesis	26166824
Tgene	NVL	GO:1904749	regulation of protein localization to nucleolus	29107693

Fusion gene breakpoints across DCUN1D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NVL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1563	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-

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Fusion Gene ORF analysis for DCUN1D2-NVL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000375399	ENST00000361463	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5CDS-intron	ENST00000375399	ENST00000468673	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5CDS-intron	ENST00000478244	ENST00000361463	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5CDS-intron	ENST00000478244	ENST00000468673	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-3CDS	ENST00000332592	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-3CDS	ENST00000332592	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-3CDS	ENST00000332592	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-3CDS	ENST00000332592	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-3CDS	ENST00000332592	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-intron	ENST00000332592	ENST00000361463	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
5UTR-intron	ENST00000332592	ENST00000468673	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000375399	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000375399	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000375399	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000375399	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000375399	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000478244	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000478244	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000478244	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000478244	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
In-frame	ENST00000478244	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-3CDS	ENST00000460318	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-3CDS	ENST00000460318	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-3CDS	ENST00000460318	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-3CDS	ENST00000460318	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-3CDS	ENST00000460318	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-intron	ENST00000460318	ENST00000361463	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-
intron-intron	ENST00000460318	ENST00000468673	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000478244	DCUN1D2	chr13	114144981	-	ENST00000391875	NVL	chr1	224455835	-	1067	286	283	774	163
ENST00000478244	DCUN1D2	chr13	114144981	-	ENST00000281701	NVL	chr1	224455835	-	1067	286	283	774	163
ENST00000478244	DCUN1D2	chr13	114144981	-	ENST00000469075	NVL	chr1	224455835	-	1032	286	283	774	163
ENST00000478244	DCUN1D2	chr13	114144981	-	ENST00000482491	NVL	chr1	224455835	-	947	286	283	774	163
ENST00000478244	DCUN1D2	chr13	114144981	-	ENST00000340871	NVL	chr1	224455835	-	947	286	283	774	163
ENST00000375399	DCUN1D2	chr13	114144981	-	ENST00000391875	NVL	chr1	224455835	-	823	42	39	530	163
ENST00000375399	DCUN1D2	chr13	114144981	-	ENST00000281701	NVL	chr1	224455835	-	823	42	39	530	163
ENST00000375399	DCUN1D2	chr13	114144981	-	ENST00000469075	NVL	chr1	224455835	-	788	42	39	530	163
ENST00000375399	DCUN1D2	chr13	114144981	-	ENST00000482491	NVL	chr1	224455835	-	703	42	39	530	163
ENST00000375399	DCUN1D2	chr13	114144981	-	ENST00000340871	NVL	chr1	224455835	-	703	42	39	530	163

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000478244	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.006392553	0.9936074
ENST00000478244	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.006392553	0.9936074
ENST00000478244	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.006843308	0.99315673
ENST00000478244	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.007334722	0.99266523
ENST00000478244	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.007334722	0.99266523
ENST00000375399	ENST00000391875	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.003139124	0.99686086
ENST00000375399	ENST00000281701	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.003139124	0.99686086
ENST00000375399	ENST00000469075	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.003592879	0.9964071
ENST00000375399	ENST00000482491	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.004391205	0.99560875
ENST00000375399	ENST00000340871	DCUN1D2	chr13	114144981	-	NVL	chr1	224455835	-	0.004391205	0.99560875

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Fusion Genomic Features for DCUN1D2-NVL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCUN1D2-NVL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:114144981/chr1:224455835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCUN1D2 Q6PH85	.
FUNCTION: Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. {ECO:0000269\|PubMed:19617556, ECO:0000269\|PubMed:23201271, ECO:0000269\|PubMed:26906416}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000340871

622_629

505

668.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000391875

622_629

588

751.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000469075

622_629

603

766.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000332592

60_248

127.0

Domain

DCUN1

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000332592

8_45

127.0

Domain

Note=UBA-like

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000375399

60_248

187.0

Domain

DCUN1

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000375399

8_45

187.0

Domain

Note=UBA-like

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000478244

60_248

260.0

Domain

DCUN1

Hgene

DCUN1D2

chr13:114144981

chr1:224455835

ENST00000478244

8_45

260.0

Domain

Note=UBA-like

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000281701

218_232

694

857.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000281701

49_52

694

857.0

Motif

Nucleolar localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000281701

85_88

694

857.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000340871

218_232

505

668.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000340871

49_52

505

668.0

Motif

Nucleolar localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000340871

85_88

505

668.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000391875

218_232

588

751.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000391875

49_52

588

751.0

Motif

Nucleolar localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000391875

85_88

588

751.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000469075

218_232

603

766.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000469075

49_52

603

766.0

Motif

Nucleolar localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000469075

85_88

603

766.0

Motif

Nuclear localization signal

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000281701

305_312

694

857.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000281701

622_629

694

857.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000340871

305_312

505

668.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000391875

305_312

588

751.0

Nucleotide binding

ATP

Tgene

NVL

chr13:114144981

chr1:224455835

ENST00000469075

305_312

603

766.0

Nucleotide binding

ATP

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Fusion Gene Sequence for DCUN1D2-NVL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>21714_21714_1_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000281701_length(transcript)=823nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGAT
GGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTG
GACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG
GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCT
TCTATCTGTGCCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAA
GCTTTCAAGAAAGTAAGATCATCTATATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAG
CAGCCGGCTTAGAGGAGCTAGCCCATCAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGC
CTCATGTAAACATTTTATTTTCAAATGAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAAT
GCCTTCTTCCTCTTTAAGAAAAAGGACAATTTTTAAACTGCTGAAATAAAATGACTGTTACATTTTTCAAATAAAACTTTTACTTTGAAC

>21714_21714_1_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000281701_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_2_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000340871_length(transcript)=703nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGAT
GGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTG
GACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG
GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCT
TCTATCTGTGCCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAA
GCTTTCAAGAAAGTAAGATCATCTATATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAG
CAGCCGGCTTAGAGGAGCTAGCCCATCAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGC

>21714_21714_2_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000340871_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_3_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000391875_length(transcript)=823nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGAT
GGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTG
GACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG
GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCT
TCTATCTGTGCCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAA
GCTTTCAAGAAAGTAAGATCATCTATATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAG
CAGCCGGCTTAGAGGAGCTAGCCCATCAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGC
CTCATGTAAACATTTTATTTTCAAATGAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAAT
GCCTTCTTCCTCTTTAAGAAAAAGGACAATTTTTAAACTGCTGAAATAAAATGACTGTTACATTTTTCAAATAAAACTTTTACTTTGAAC

>21714_21714_3_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000391875_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_4_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000469075_length(transcript)=788nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGAT
GGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTG
GACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG
GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCT
TCTATCTGTGCCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAA
GCTTTCAAGAAAGTAAGATCATCTATATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAG
CAGCCGGCTTAGAGGAGCTAGCCCATCAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGC
CTCATGTAAACATTTTATTTTCAAATGAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAAT

>21714_21714_4_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000469075_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_5_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000482491_length(transcript)=703nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGAT
GGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTG
GACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG
GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCT
TCTATCTGTGCCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAA
GCTTTCAAGAAAGTAAGATCATCTATATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAG
CAGCCGGCTTAGAGGAGCTAGCCCATCAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGC

>21714_21714_5_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000375399_NVL_chr1_224455835_ENST00000482491_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_6_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000281701_length(transcript)=1067nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTT
TATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACC
GCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTGGATGCAGATGTAAATTTGGAAGCAAT
TGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTGCCCTGAGACAGGAAAT
GGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAAGCTTTCAAGAAAGTAAGATCATCTAT
ATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAGCAGCCGGCTTAGAGGAGCTAGCCCAT
CAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGCCTCATGTAAACATTTTATTTTCAAAT
GAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAATGCCTTCTTCCTCTTTAAGAAAAAGGA

>21714_21714_6_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000281701_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_7_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000340871_length(transcript)=947nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTT
TATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACC
GCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTGGATGCAGATGTAAATTTGGAAGCAAT
TGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTGCCCTGAGACAGGAAAT
GGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAAGCTTTCAAGAAAGTAAGATCATCTAT
ATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAGCAGCCGGCTTAGAGGAGCTAGCCCAT
CAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGCCTCATGTAAACATTTTATTTTCAAAT

>21714_21714_7_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000340871_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_8_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000391875_length(transcript)=1067nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTT
TATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACC
GCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTGGATGCAGATGTAAATTTGGAAGCAAT
TGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTGCCCTGAGACAGGAAAT
GGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAAGCTTTCAAGAAAGTAAGATCATCTAT
ATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAGCAGCCGGCTTAGAGGAGCTAGCCCAT
CAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGCCTCATGTAAACATTTTATTTTCAAAT
GAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAATGCCTTCTTCCTCTTTAAGAAAAAGGA

>21714_21714_8_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000391875_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_9_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000469075_length(transcript)=1032nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTT
TATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACC
GCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTGGATGCAGATGTAAATTTGGAAGCAAT
TGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTGCCCTGAGACAGGAAAT
GGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAAGCTTTCAAGAAAGTAAGATCATCTAT
ATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAGCAGCCGGCTTAGAGGAGCTAGCCCAT
CAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGCCTCATGTAAACATTTTATTTTCAAAT
GAATGAGGCCAAGCTGAAGCTGAAGCTGAAGATTCTTCCCATCTGGCCAGCCTTGTGTGAAAATGCCTTCTTCCTCTTTAAGAAAAAGGA

>21714_21714_9_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000469075_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------
>21714_21714_10_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000482491_length(transcript)=947nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTT
TATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACC
GCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTGGATGCAGATGTAAATTTGGAAGCAAT
TGCTGGTGACCTTCGCTGTGATTGCTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTGCCCTGAGACAGGAAAT
GGCAAGACAGAAGAGTGGAAATGAAAAAGGTGAACTCAAGGTTAGTCATAAGCATTTTGAAGAAGCTTTCAAGAAAGTAAGATCATCTAT
ATCAAAAAAGGATCAAATCATGTATGAACGTTTGCAGGAGTCCCTCAGCCGGTGATGTCTCCAGCAGCCGGCTTAGAGGAGCTAGCCCAT
CAAGCCGGCAGAGAATCCCCCACACGCTCTGAAGGACCCACTTTCAGCTGGACACAGGCGCGGCCTCATGTAAACATTTTATTTTCAAAT

>21714_21714_10_DCUN1D2-NVL_DCUN1D2_chr13_114144981_ENST00000478244_NVL_chr1_224455835_ENST00000482491_length(amino acids)=163AA_BP=1
MTGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DCUN1D2-NVL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000281701		16	23	1_220	694.0	857.0	RPL5
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000340871		14	21	1_220	505.0	668.0	RPL5
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000391875		15	22	1_220	588.0	751.0	RPL5
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000469075		15	22	1_220	603.0	766.0	RPL5
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000281701		16	23	267_474	694.0	857.0	WDR74
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000340871		14	21	267_474	505.0	668.0	WDR74
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000391875		15	22	267_474	588.0	751.0	WDR74
Tgene	NVL	chr13:114144981	chr1:224455835	ENST00000469075		15	22	267_474	603.0	766.0	WDR74

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DCUN1D2-NVL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DCUN1D2-NVL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source