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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCUN1D2-TFDP1 (FusionGDB2 ID:21718)

Fusion Gene Summary for DCUN1D2-TFDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D2-TFDP1
Fusion gene ID: 21718
HgeneTgene
Gene symbol

DCUN1D2

TFDP1

Gene ID

55208

7027

Gene namedefective in cullin neddylation 1 domain containing 2transcription factor Dp-1
SynonymsC13orf17DILC|DP1|DRTF1|Dp-1
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 2DCN1, defective in cullin neddylation 1, domain containing 2DCUN1 domain-containing protein 2defective in cullin neddylation protein 1-like protein 2transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells
Modification date2020031320200313
UniProtAcc

Q6PH85

.
Ensembl transtripts involved in fusion geneENST00000375399, ENST00000478244, 
ENST00000332592, ENST00000460318, 
ENST00000465174, ENST00000538138, 
ENST00000544902, ENST00000375370, 
Fusion gene scores* DoF score13 X 6 X 9=70210 X 7 X 10=700
# samples 1814
** MAII scorelog2(18/702*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/700*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D2 [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCUN1D2(114144981)-TFDP1(114265310), # samples:1
DCUN1D2(114144982)-TFDP1(114265311), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537

TgeneTFDP1

GO:0051091

positive regulation of DNA-binding transcription factor activity

17062573

TgeneTFDP1

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

17062573


check buttonFusion gene breakpoints across DCUN1D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TFDP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A7HXDCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
ChimerDB4STADTCGA-D7-8576-01ADCUN1D2chr13

114144982

-TFDP1chr13

114265311

+


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Fusion Gene ORF analysis for DCUN1D2-TFDP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000375399ENST00000465174DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-3UTRENST00000375399ENST00000465174DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5CDS-3UTRENST00000478244ENST00000465174DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-3UTRENST00000478244ENST00000465174DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5CDS-5UTRENST00000375399ENST00000538138DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000375399ENST00000538138DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5CDS-5UTRENST00000375399ENST00000544902DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000375399ENST00000544902DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5CDS-5UTRENST00000478244ENST00000538138DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000478244ENST00000538138DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5CDS-5UTRENST00000478244ENST00000544902DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000478244ENST00000544902DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5UTR-3CDSENST00000332592ENST00000375370DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5UTR-3CDSENST00000332592ENST00000375370DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5UTR-3UTRENST00000332592ENST00000465174DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5UTR-3UTRENST00000332592ENST00000465174DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5UTR-5UTRENST00000332592ENST00000538138DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5UTR-5UTRENST00000332592ENST00000538138DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
5UTR-5UTRENST00000332592ENST00000544902DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
5UTR-5UTRENST00000332592ENST00000544902DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
In-frameENST00000375399ENST00000375370DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
In-frameENST00000375399ENST00000375370DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
In-frameENST00000478244ENST00000375370DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
In-frameENST00000478244ENST00000375370DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
intron-3CDSENST00000460318ENST00000375370DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
intron-3CDSENST00000460318ENST00000375370DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
intron-3UTRENST00000460318ENST00000465174DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
intron-3UTRENST00000460318ENST00000465174DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
intron-5UTRENST00000460318ENST00000538138DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
intron-5UTRENST00000460318ENST00000538138DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+
intron-5UTRENST00000460318ENST00000544902DCUN1D2chr13

114144981

-TFDP1chr13

114265310

+
intron-5UTRENST00000460318ENST00000544902DCUN1D2chr13

114144982

-TFDP1chr13

114265311

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000478244DCUN1D2chr13114144981-ENST00000375370TFDP1chr13114265310+27102862831506407
ENST00000375399DCUN1D2chr13114144981-ENST00000375370TFDP1chr13114265310+246642391262407
ENST00000478244DCUN1D2chr13114144982-ENST00000375370TFDP1chr13114265311+27102862831506407
ENST00000375399DCUN1D2chr13114144982-ENST00000375370TFDP1chr13114265311+246642391262407

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000478244ENST00000375370DCUN1D2chr13114144981-TFDP1chr13114265310+0.0007123950.99928766
ENST00000375399ENST00000375370DCUN1D2chr13114144981-TFDP1chr13114265310+0.0004150890.999585
ENST00000478244ENST00000375370DCUN1D2chr13114144982-TFDP1chr13114265311+0.0007123950.99928766
ENST00000375399ENST00000375370DCUN1D2chr13114144982-TFDP1chr13114265311+0.0004150890.999585

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Fusion Genomic Features for DCUN1D2-TFDP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DCUN1D2chr13114144981-TFDP1chr13114265310+8.87E-070.99999917
DCUN1D2chr13114144981-TFDP1chr13114265310+8.87E-070.99999917
DCUN1D2chr13114144981-TFDP1chr13114265310+8.87E-070.99999917
DCUN1D2chr13114144981-TFDP1chr13114265310+8.87E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DCUN1D2-TFDP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:114144981/chr13:114265310)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D2

Q6PH85

.
FUNCTION: Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112250_2534411.0Compositional biasNote=Poly-Pro
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112394_4104411.0Compositional biasNote=Asp/Glu-rich (acidic%3B NCB domain)
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112250_2534411.0Compositional biasNote=Poly-Pro
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112394_4104411.0Compositional biasNote=Asp/Glu-rich (acidic%3B NCB domain)
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112113_1954411.0DNA bindingOntology_term=ECO:0000255
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112113_1954411.0DNA bindingOntology_term=ECO:0000255
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112161_1954411.0MotifNote=DEF box
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112161_1954411.0MotifNote=DEF box
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112204_2774411.0RegionDimerization
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112211_3274411.0RegionNote=Enhances binding of RB protein to E2F
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112214_2464411.0RegionNote=DCB1
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112259_3154411.0RegionNote=DCB2
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112204_2774411.0RegionDimerization
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112211_3274411.0RegionNote=Enhances binding of RB protein to E2F
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112214_2464411.0RegionNote=DCB1
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112259_3154411.0RegionNote=DCB2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000332592-1560_2480127.0DomainDCUN1
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000332592-158_450127.0DomainNote=UBA-like
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000375399-1560_2481187.0DomainDCUN1
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000375399-158_451187.0DomainNote=UBA-like
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000478244-1760_2481260.0DomainDCUN1
HgeneDCUN1D2chr13:114144981chr13:114265310ENST00000478244-178_451260.0DomainNote=UBA-like
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000332592-1560_2480127.0DomainDCUN1
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000332592-158_450127.0DomainNote=UBA-like
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000375399-1560_2481187.0DomainDCUN1
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000375399-158_451187.0DomainNote=UBA-like
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000478244-1760_2481260.0DomainDCUN1
HgeneDCUN1D2chr13:114144982chr13:114265311ENST00000478244-178_451260.0DomainNote=UBA-like


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Fusion Gene Sequence for DCUN1D2-TFDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21718_21718_1_DCUN1D2-TFDP1_DCUN1D2_chr13_114144981_ENST00000375399_TFDP1_chr13_114265310_ENST00000375370_length(transcript)=2466nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAG
AACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACC
TTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGC
CCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAG
AAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGAC
GAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTAC
GATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAG
GAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAA
ATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCC
TTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACA
TTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAA
ATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCA
GGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAG
TACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGAC
TGACGTCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGG
CCTACTCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCT
GTGGATGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAG
TGCAGAGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCC
TGTTGTGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTG
TTCAGTGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAA
CACCATCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTT
TGCAGCAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTG
GAAGGCTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTAC
ATACTTATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAA
TTAAATATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATT
TAAGGACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTC
TTTTTATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTT

>21718_21718_1_DCUN1D2-TFDP1_DCUN1D2_chr13_114144981_ENST00000375399_TFDP1_chr13_114265310_ENST00000375370_length(amino acids)=407AA_BP=1
MAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQ
PSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIIS
KEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVID
CSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASD

--------------------------------------------------------------
>21718_21718_2_DCUN1D2-TFDP1_DCUN1D2_chr13_114144981_ENST00000478244_TFDP1_chr13_114265310_ENST00000375370_length(transcript)=2710nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAGAACCTTAGTCCCGGGAAAGGCGTGGT
GTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGGACAGTCCAATGTCAACATTGC
CCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACACACCCCCAGCACTCACTTTGC
CTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAATGGCAAGGGCCTACGGCATTT
CTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGACGAGCTGGTTGCGGAGTTCAGTGCTGC
CGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTACGATGCCTTAAACGTGCTAATGGCCAT
GAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAGGAATGTCAGAACTTAGAGGTGGAAAG
ACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAAATTGCCTTCAAGAACCTGGTGCAGAG
AAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCCTTCATCATCGTCAACACCAGCAAGAA
GACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACATTTGAAATCCACGATGACATAGAAGT
GCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGCCAGAAGTCTGGTCCCCAAGGC
TCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTCCACGTCTAACGGCACAAGGTT
CTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAGCGGCTCCAGGGTGGAGACTCC
GGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGACTGACGTCCTCCCCACTTCAGATTCGG
CTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGGCCTACTCCCAAGAAGATATTGGTAAG
CTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCTGTGGATGTGTGTTTTGATACCAGTGT
GCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAGTGCAGAGTTCATTTTTGCCCCTGAAA
AGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCCTGTTGTGGATGGTGAGCCCCTGATGC
CGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTGTTCAGTGGTACGGTGTCCAAGCAAAC
AGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAACACCATCAACCTTATTGACTTTATTG
TCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTTTGCAGCAACAAATTGCGAAGTGCTTT
TGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTGGAAGGCTTGGAATGGTTTATTGCTTA
TGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTACATACTTATAAGTCTATCATTTAAAGA
CATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAATTAAATATAGAGAATGTTTTAACAAT
TTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATTTAAGGACAGGCAGTAGTCTCTTTTAA
AATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTCTTTTTATTGAAACACAAATAAACTTT
TCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTTAGTTTTTATTAATAAAACGCGCATGG

>21718_21718_2_DCUN1D2-TFDP1_DCUN1D2_chr13_114144981_ENST00000478244_TFDP1_chr13_114265310_ENST00000375370_length(amino acids)=407AA_BP=1
MAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQ
PSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIIS
KEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVID
CSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASD

--------------------------------------------------------------
>21718_21718_3_DCUN1D2-TFDP1_DCUN1D2_chr13_114144982_ENST00000375399_TFDP1_chr13_114265311_ENST00000375370_length(transcript)=2466nt_BP=42nt
GAAGGCCGGGGCCGGCCAGAAGCGGGCGGCGCGGGGGAGATGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAG
AACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACC
TTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGC
CCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAG
AAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGAC
GAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTAC
GATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAG
GAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAA
ATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCC
TTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACA
TTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAA
ATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCA
GGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAG
TACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGAC
TGACGTCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGG
CCTACTCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCT
GTGGATGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAG
TGCAGAGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCC
TGTTGTGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTG
TTCAGTGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAA
CACCATCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTT
TGCAGCAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTG
GAAGGCTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTAC
ATACTTATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAA
TTAAATATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATT
TAAGGACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTC
TTTTTATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTT

>21718_21718_3_DCUN1D2-TFDP1_DCUN1D2_chr13_114144982_ENST00000375399_TFDP1_chr13_114265311_ENST00000375370_length(amino acids)=407AA_BP=1
MAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQ
PSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIIS
KEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVID
CSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASD

--------------------------------------------------------------
>21718_21718_4_DCUN1D2-TFDP1_DCUN1D2_chr13_114144982_ENST00000478244_TFDP1_chr13_114265311_ENST00000375370_length(transcript)=2710nt_BP=286nt
AGCACTTCCTGGCCGGCGTGGGGCCTGGCAGCCGCAGGCTGGCGTTGGACCCCGCAGGGGCGAGCCAAGGCCCTCGCAGAGGGCTGGACG
CGCAGGGGCTGTGGGGCGCGAGCTCCCGTGGGCCCCCGGGCGGCGCTGAGCATGCCGGGAGTGGGAGTCCCCGCGGCCGGCTCCCGGCAC
TGCCCCGGAGCCGAGGGCCGCGGCCGTCCGAGGACGAGGGCGGAGCCGCCGCCGCGCCTGCGCAGAAGGCCGGGGCCGGCCAGAAGCGGG
CGGCGCGGGGGAGATGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAGAACCTTAGTCCCGGGAAAGGCGTGGT
GTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGGACAGTCCAATGTCAACATTGC
CCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACACACCCCCAGCACTCACTTTGC
CTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAATGGCAAGGGCCTACGGCATTT
CTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGACGAGCTGGTTGCGGAGTTCAGTGCTGC
CGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTACGATGCCTTAAACGTGCTAATGGCCAT
GAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAGGAATGTCAGAACTTAGAGGTGGAAAG
ACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAAATTGCCTTCAAGAACCTGGTGCAGAG
AAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCCTTCATCATCGTCAACACCAGCAAGAA
GACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACATTTGAAATCCACGATGACATAGAAGT
GCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGCCAGAAGTCTGGTCCCCAAGGC
TCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTCCACGTCTAACGGCACAAGGTT
CTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAGCGGCTCCAGGGTGGAGACTCC
GGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGACTGACGTCCTCCCCACTTCAGATTCGG
CTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGGCCTACTCCCAAGAAGATATTGGTAAG
CTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCTGTGGATGTGTGTTTTGATACCAGTGT
GCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAGTGCAGAGTTCATTTTTGCCCCTGAAA
AGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCCTGTTGTGGATGGTGAGCCCCTGATGC
CGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTGTTCAGTGGTACGGTGTCCAAGCAAAC
AGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAACACCATCAACCTTATTGACTTTATTG
TCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTTTGCAGCAACAAATTGCGAAGTGCTTT
TGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTGGAAGGCTTGGAATGGTTTATTGCTTA
TGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTACATACTTATAAGTCTATCATTTAAAGA
CATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAATTAAATATAGAGAATGTTTTAACAAT
TTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATTTAAGGACAGGCAGTAGTCTCTTTTAA
AATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTCTTTTTATTGAAACACAAATAAACTTT
TCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTTAGTTTTTATTAATAAAACGCGCATGG

>21718_21718_4_DCUN1D2-TFDP1_DCUN1D2_chr13_114144982_ENST00000478244_TFDP1_chr13_114265311_ENST00000375370_length(amino acids)=407AA_BP=1
MAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQ
PSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIIS
KEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVID
CSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCUN1D2-TFDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTFDP1chr13:114144981chr13:114265310ENST00000375370112105_1274.0411.0CEBPA
TgeneTFDP1chr13:114144982chr13:114265311ENST00000375370112105_1274.0411.0CEBPA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCUN1D2-TFDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCUN1D2-TFDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource