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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCUN1D4-GPM6B (FusionGDB2 ID:21730)

Fusion Gene Summary for DCUN1D4-GPM6B

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D4-GPM6B
Fusion gene ID: 21730
HgeneTgene
Gene symbol

DCUN1D4

GPM6B

Gene ID

23142

2824

Gene namedefective in cullin neddylation 1 domain containing 4glycoprotein M6B
Synonyms-M6B
Cytomap

4q12

Xp22.2

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4neuronal membrane glycoprotein M6-bprotolipid M6B
Modification date2020031320200313
UniProtAcc

Q92564

Q13491

Ensembl transtripts involved in fusion geneENST00000513800, ENST00000334635, 
ENST00000381441, ENST00000451288, 
ENST00000381437, 		ENST00000454189, 
ENST00000316715, ENST00000355135, 
ENST00000356942, ENST00000398361, 
ENST00000493677, 
Fusion gene scores* DoF score10 X 9 X 7=63011 X 12 X 4=528
# samples 1114
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D4 [Title/Abstract] AND GPM6B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCUN1D4(52729875)-GPM6B(13803927), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DCUN1D4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPM6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7383-01ADCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
ChimerDB4HNSCTCGA-CR-7383DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
ChimerDB4HNSCTCGA-CR-7383DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-


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Fusion Gene ORF analysis for DCUN1D4-GPM6B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000513800ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
3UTR-5UTRENST00000513800ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
3UTR-5UTRENST00000513800ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
3UTR-intronENST00000513800ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
3UTR-intronENST00000513800ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
3UTR-intronENST00000513800ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
3UTR-intronENST00000513800ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000334635ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000334635ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000334635ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000334635ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000334635ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000334635ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000334635ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000381441ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000381441ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000381441ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000381441ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000381441ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000381441ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000381441ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000451288ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000451288ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000451288ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-5UTRENST00000451288ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000451288ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000451288ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5CDS-5UTRENST00000451288ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000334635ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000334635ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000334635ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000334635ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000381441ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000381441ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000381441ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000381441ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000451288ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000451288ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000451288ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5CDS-intronENST00000451288ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-3CDSENST00000381437ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000355135DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-5UTRENST00000381437ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
5UTR-5UTRENST00000381437ENST00000493677DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-intronENST00000381437ENST00000316715DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-intronENST00000381437ENST00000356942DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-intronENST00000381437ENST00000398361DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
5UTR-intronENST00000381437ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13825888

-
In-frameENST00000334635ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
In-frameENST00000381441ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-
In-frameENST00000451288ENST00000454189DCUN1D4chr4

52729875

+GPM6BchrX

13803927

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381441DCUN1D4chr452729875+ENST00000454189GPM6BchrX13803927-41413161141052312
ENST00000334635DCUN1D4chr452729875+ENST00000454189GPM6BchrX13803927-41413161141052312
ENST00000451288DCUN1D4chr452729875+ENST00000454189GPM6BchrX13803927-410027571011334

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381441ENST00000454189DCUN1D4chr452729875+GPM6BchrX13803927-0.0004868590.99951315
ENST00000334635ENST00000454189DCUN1D4chr452729875+GPM6BchrX13803927-0.0004868590.99951315
ENST00000451288ENST00000454189DCUN1D4chr452729875+GPM6BchrX13803927-0.0002018010.99979824

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Fusion Genomic Features for DCUN1D4-GPM6B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCUN1D4-GPM6B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:52729875/chrX:13803927)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D4

Q92564

GPM6B

Q13491

FUNCTION: Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). {ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}.FUNCTION: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269|PubMed:21638316}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000031671518136_15660329.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000031671518224_24460329.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003167151890_11060329.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000035513518136_15660306.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000035513518224_24460306.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003551351890_11060306.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000035694207136_15620266.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000035694207224_24420266.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003569420731_5120266.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003569420790_11020266.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000045418907136_1561247.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST0000045418907224_2441247.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000004541890731_511247.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000004541890790_1101247.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCUN1D4chr4:52729875chrX:13803927ENST00000334635+311101_28745293.0DomainDCUN1
HgeneDCUN1D4chr4:52729875chrX:13803927ENST00000381441+310101_28745258.0DomainDCUN1
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003167151831_5160329.0TransmembraneHelical
TgeneGPM6Bchr4:52729875chrX:13803927ENST000003551351831_5160306.0TransmembraneHelical


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Fusion Gene Sequence for DCUN1D4-GPM6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21730_21730_1_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000334635_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=4141nt_BP=316nt
GAGAGACGCAGCAGGGCGGCCCCTGAGCCGCGGTTTAGCCAATGGAGAAGGCGAGATGGGCGGGCTGGGAGTGCCCGGCGGCGGGTCCTC
AGCTTCGAGCCGAGGTGCAGTGAGCTGGTGGGGGGACCGCGAGGCGAGCGCGGGAGCCTGGGCGGCGAGCCGGGTGTGAGCTGCCTGAAA
ATGCACTCGGATGCCGCCGCTGTCAATTTTCAGCTGAACTCTCATCTCTCAACACTGGCAAATATTCATAAGATCTACCACACCCTTAAT
AAGCTGAACCTAACAGAAGACATTGGCCAAGACGATCACCAAACAGGCTGCTTTGAATGCTGCATCAAGTGTCTGGGAGGAGTCCCCTAC
GCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGCCTTATTCTGCGGCTGTGGGCATGTGGCTCTCGCAGGCACCGTGGCGATT
CTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTTGCTGAGCGAGGTGATACAACTGATGCAGTATGTCATCTATGGAATTGCG
TCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGGCTTTTACACCACAAGTGCAGTGAAAGAACTGCACGGTGAGTTTAAAACA
ACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCTCACCTATGTGCTTGGAGTGGCCTGGCTGGGTGTGTTTGGTTTCTCAGCG
GTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGAAGTCATCAAGTCACCGCAGACCAACGGGACCACGGGTGTGGAGCAGATC
TGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGCTTTCCCCGGAAAAATATGTGGCTCTGCCCTGGAGAACATCTGCAACACA
AACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTGTGCAGGAGCTGGTGCCACCGTCATTGCCCTGCTGATCTACATGATGGCT
ACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGAAGATTGCTGCACTAAATTCTAAATTGCATAAGGAGTTTTAGAGAGCTAT
GCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGCAGAGTCTAGGTTTCTGCAATTTTGTTACAGTAATTTGTAAATAGCTTTA
GTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACTGTACATGAATTACACAATAATGAGATCTGGTGGCTATTTCCACATTTTG
AAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTTTTAAAATAATGTTCTCATACTTAAACATTAGAGAGCAGTATCTTTAAAT
GAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTTTTGATTGCCTGATAACCAGTTTCAATGATGAAAATGAAAACAAGTGCTG
AAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTTTTGTCACACCTGGAAAATACTTTGCAAATATGTTCTAAATTGAAAACAA
TTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAAATAAGCCAGATGAAAATTTGAAGAAAAAGGTCACCCAGTTCTCTGGAAA
AAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAGTTTTTTTTTTGGTACAACACAATCATTCTGTTAGAGCCCACAAAATTGG
TAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGTTTCCTCATAGCTAGTTCTCAAGCTGCATGTAAGATTTTAACGGGAAGAG
AAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAGAAAGTATGAACTATAAGGAACTTGAGATGTAGATTTATTTTGCAGGAAA
TACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGTAAAGAATGATACTGAGGATTTTTACATTTTATGAAATGAAATAATGGCA
TTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTTAACAGAGACTGCATGCTTTGCTTATAGTTCTTAATTTTGGTTTTGACAT
TCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATTTACTCAAAATAAACATTGTTCATGCTTTTAGGCCTTTGGGGGAATTGAT
TTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACACTTATTTCAAATATACAATGTGCTCCCGAACTTTCGCATTAGTCTTTAAA
ATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACCCTCTCGTATTTCATTTTTGCTTTTTCTTAACAATACCTTTGGCCATTTT
TTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCCTTTTAATGCGAAGCCAACTAGTAGAGCATGCTTTCAGGATCTGACAGCT
CTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTTCGCCCCTTTAAAGTCAAGTCTGTCTAATCTAACTAGCGCCTCGCTTTGC
CTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCTTCCAGATCCACTTCCTCATGATACTGTCTTCTAACTGGGCTTACTTAAA
GGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAAAGGAAGAACAGGAACTGCAAGATATCCAGTCTCGGTCAAAAGAACAACT
CAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGACGTATTTACAGCTCTGACAAATCATCAGACAGCTGCTCTGCAGTACAGA
TGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCACTGTCTGTCTCAAGCTGCTGGGATGTATCTCTAGGAAAACCTTCCAGTG
GGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATGTTAGCCATTTTAAAAGGCAACACTTTGACAAAATGATCGTTCATACTTT
GGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTCTACCAAGACACTCAATGGAATATGTCACACTCCTTAATAGGGACCTGTG
ACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGATAAGACCGTAAATTCACATATATGCCATCTGTCCTCAAGTGTTATCTAC
ATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGACAGCTGACATTTATTAAACTTTGGATCAAAGATAATGTGATTCTTATGA
TTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACCCATTAATTTCCTGAGCCAATCAGAAATATATTTTTCAATAATGCTAAAA
TTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGATGCTGGACTCACTGACAAGCTTTCCAGAAGCAATTTTATAACAGATTTC
ATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGAAATGTCAGCTTTGCCTTAATGAGTATTTGCTTTAAATTTCTAAGAATTT
ATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTGTTCCATAAATGTTTTTCTTAATTATTAAGAAGTGTTACCTTATTAAAAT
GACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAAGTTTACAGTTTCATACCAACTATCTAAAACCTAATTGCAAATTGACCAC
AGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAGTAATTTAAATTAGGGTTGGTATTTCATTTTTTTCTTATCTAAATCTTAG
TTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTGCTTGAGTTTAAGCCATTTTCAAAAGAAACTTGCCTTTTACATTATTGTG
TTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGATGGTAAACTTTGTGTTGCTCTTTATGAAATGATCCATATAACTGTTGGG
TGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTAACTATGTATATTCATTGTTAAGAGTTAACTTGTGGTTTGGCTGTTTCCT
GGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAAAGGAAGCATACCTTTATCAAGATGCTATTAAAATTGAACATCAAGTATA

>21730_21730_1_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000334635_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=312AA_BP=67
MVGGPRGERGSLGGEPGVSCLKMHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGCFECCIKCLGGVPYASLVATIL
CFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCIS
GMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH

--------------------------------------------------------------
>21730_21730_2_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000381441_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=4141nt_BP=316nt
GAGAGACGCAGCAGGGCGGCCCCTGAGCCGCGGTTTAGCCAATGGAGAAGGCGAGATGGGCGGGCTGGGAGTGCCCGGCGGCGGGTCCTC
AGCTTCGAGCCGAGGTGCAGTGAGCTGGTGGGGGGACCGCGAGGCGAGCGCGGGAGCCTGGGCGGCGAGCCGGGTGTGAGCTGCCTGAAA
ATGCACTCGGATGCCGCCGCTGTCAATTTTCAGCTGAACTCTCATCTCTCAACACTGGCAAATATTCATAAGATCTACCACACCCTTAAT
AAGCTGAACCTAACAGAAGACATTGGCCAAGACGATCACCAAACAGGCTGCTTTGAATGCTGCATCAAGTGTCTGGGAGGAGTCCCCTAC
GCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGCCTTATTCTGCGGCTGTGGGCATGTGGCTCTCGCAGGCACCGTGGCGATT
CTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTTGCTGAGCGAGGTGATACAACTGATGCAGTATGTCATCTATGGAATTGCG
TCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGGCTTTTACACCACAAGTGCAGTGAAAGAACTGCACGGTGAGTTTAAAACA
ACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCTCACCTATGTGCTTGGAGTGGCCTGGCTGGGTGTGTTTGGTTTCTCAGCG
GTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGAAGTCATCAAGTCACCGCAGACCAACGGGACCACGGGTGTGGAGCAGATC
TGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGCTTTCCCCGGAAAAATATGTGGCTCTGCCCTGGAGAACATCTGCAACACA
AACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTGTGCAGGAGCTGGTGCCACCGTCATTGCCCTGCTGATCTACATGATGGCT
ACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGAAGATTGCTGCACTAAATTCTAAATTGCATAAGGAGTTTTAGAGAGCTAT
GCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGCAGAGTCTAGGTTTCTGCAATTTTGTTACAGTAATTTGTAAATAGCTTTA
GTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACTGTACATGAATTACACAATAATGAGATCTGGTGGCTATTTCCACATTTTG
AAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTTTTAAAATAATGTTCTCATACTTAAACATTAGAGAGCAGTATCTTTAAAT
GAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTTTTGATTGCCTGATAACCAGTTTCAATGATGAAAATGAAAACAAGTGCTG
AAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTTTTGTCACACCTGGAAAATACTTTGCAAATATGTTCTAAATTGAAAACAA
TTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAAATAAGCCAGATGAAAATTTGAAGAAAAAGGTCACCCAGTTCTCTGGAAA
AAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAGTTTTTTTTTTGGTACAACACAATCATTCTGTTAGAGCCCACAAAATTGG
TAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGTTTCCTCATAGCTAGTTCTCAAGCTGCATGTAAGATTTTAACGGGAAGAG
AAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAGAAAGTATGAACTATAAGGAACTTGAGATGTAGATTTATTTTGCAGGAAA
TACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGTAAAGAATGATACTGAGGATTTTTACATTTTATGAAATGAAATAATGGCA
TTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTTAACAGAGACTGCATGCTTTGCTTATAGTTCTTAATTTTGGTTTTGACAT
TCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATTTACTCAAAATAAACATTGTTCATGCTTTTAGGCCTTTGGGGGAATTGAT
TTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACACTTATTTCAAATATACAATGTGCTCCCGAACTTTCGCATTAGTCTTTAAA
ATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACCCTCTCGTATTTCATTTTTGCTTTTTCTTAACAATACCTTTGGCCATTTT
TTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCCTTTTAATGCGAAGCCAACTAGTAGAGCATGCTTTCAGGATCTGACAGCT
CTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTTCGCCCCTTTAAAGTCAAGTCTGTCTAATCTAACTAGCGCCTCGCTTTGC
CTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCTTCCAGATCCACTTCCTCATGATACTGTCTTCTAACTGGGCTTACTTAAA
GGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAAAGGAAGAACAGGAACTGCAAGATATCCAGTCTCGGTCAAAAGAACAACT
CAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGACGTATTTACAGCTCTGACAAATCATCAGACAGCTGCTCTGCAGTACAGA
TGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCACTGTCTGTCTCAAGCTGCTGGGATGTATCTCTAGGAAAACCTTCCAGTG
GGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATGTTAGCCATTTTAAAAGGCAACACTTTGACAAAATGATCGTTCATACTTT
GGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTCTACCAAGACACTCAATGGAATATGTCACACTCCTTAATAGGGACCTGTG
ACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGATAAGACCGTAAATTCACATATATGCCATCTGTCCTCAAGTGTTATCTAC
ATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGACAGCTGACATTTATTAAACTTTGGATCAAAGATAATGTGATTCTTATGA
TTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACCCATTAATTTCCTGAGCCAATCAGAAATATATTTTTCAATAATGCTAAAA
TTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGATGCTGGACTCACTGACAAGCTTTCCAGAAGCAATTTTATAACAGATTTC
ATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGAAATGTCAGCTTTGCCTTAATGAGTATTTGCTTTAAATTTCTAAGAATTT
ATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTGTTCCATAAATGTTTTTCTTAATTATTAAGAAGTGTTACCTTATTAAAAT
GACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAAGTTTACAGTTTCATACCAACTATCTAAAACCTAATTGCAAATTGACCAC
AGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAGTAATTTAAATTAGGGTTGGTATTTCATTTTTTTCTTATCTAAATCTTAG
TTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTGCTTGAGTTTAAGCCATTTTCAAAAGAAACTTGCCTTTTACATTATTGTG
TTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGATGGTAAACTTTGTGTTGCTCTTTATGAAATGATCCATATAACTGTTGGG
TGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTAACTATGTATATTCATTGTTAAGAGTTAACTTGTGGTTTGGCTGTTTCCT
GGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAAAGGAAGCATACCTTTATCAAGATGCTATTAAAATTGAACATCAAGTATA

>21730_21730_2_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000381441_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=312AA_BP=67
MVGGPRGERGSLGGEPGVSCLKMHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGCFECCIKCLGGVPYASLVATIL
CFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCIS
GMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH

--------------------------------------------------------------
>21730_21730_3_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000451288_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=4100nt_BP=275nt
GGGGTGCATGGAGGTGGAGGCAGCGTTGGGCTGTAGCGGGCAGGGCCGGGGATGTGGGGGGGTGGCACCGGCGGGGAGAGGGAGGGAGCG
AGCGAGCGAGCGGGGCACAAGGGTGAGGATTTCCAAAGGGCTGAGTGGTGCGGGCGGCTCCGTGAGAAAGGCGGATTTTCAGCTGAACTC
TCATCTCTCAACACTGGCAAATATTCATAAGATCTACCACACCCTTAATAAGCTGAACCTAACAGAAGACATTGGCCAAGACGATCACCA
AACAGGCTGCTTTGAATGCTGCATCAAGTGTCTGGGAGGAGTCCCCTACGCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGC
CTTATTCTGCGGCTGTGGGCATGTGGCTCTCGCAGGCACCGTGGCGATTCTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTT
GCTGAGCGAGGTGATACAACTGATGCAGTATGTCATCTATGGAATTGCGTCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGG
CTTTTACACCACAAGTGCAGTGAAAGAACTGCACGGTGAGTTTAAAACAACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCT
CACCTATGTGCTTGGAGTGGCCTGGCTGGGTGTGTTTGGTTTCTCAGCGGTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGA
AGTCATCAAGTCACCGCAGACCAACGGGACCACGGGTGTGGAGCAGATCTGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGC
TTTCCCCGGAAAAATATGTGGCTCTGCCCTGGAGAACATCTGCAACACAAACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTG
TGCAGGAGCTGGTGCCACCGTCATTGCCCTGCTGATCTACATGATGGCTACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGA
AGATTGCTGCACTAAATTCTAAATTGCATAAGGAGTTTTAGAGAGCTATGCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGC
AGAGTCTAGGTTTCTGCAATTTTGTTACAGTAATTTGTAAATAGCTTTAGTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACT
GTACATGAATTACACAATAATGAGATCTGGTGGCTATTTCCACATTTTGAAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTT
TTAAAATAATGTTCTCATACTTAAACATTAGAGAGCAGTATCTTTAAATGAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTT
TTGATTGCCTGATAACCAGTTTCAATGATGAAAATGAAAACAAGTGCTGAAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTT
TTGTCACACCTGGAAAATACTTTGCAAATATGTTCTAAATTGAAAACAATTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAA
ATAAGCCAGATGAAAATTTGAAGAAAAAGGTCACCCAGTTCTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAG
TTTTTTTTTTGGTACAACACAATCATTCTGTTAGAGCCCACAAAATTGGTAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGT
TTCCTCATAGCTAGTTCTCAAGCTGCATGTAAGATTTTAACGGGAAGAGAAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAG
AAAGTATGAACTATAAGGAACTTGAGATGTAGATTTATTTTGCAGGAAATACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGT
AAAGAATGATACTGAGGATTTTTACATTTTATGAAATGAAATAATGGCATTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTT
AACAGAGACTGCATGCTTTGCTTATAGTTCTTAATTTTGGTTTTGACATTCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATT
TACTCAAAATAAACATTGTTCATGCTTTTAGGCCTTTGGGGGAATTGATTTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACAC
TTATTTCAAATATACAATGTGCTCCCGAACTTTCGCATTAGTCTTTAAAATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACC
CTCTCGTATTTCATTTTTGCTTTTTCTTAACAATACCTTTGGCCATTTTTTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCC
TTTTAATGCGAAGCCAACTAGTAGAGCATGCTTTCAGGATCTGACAGCTCTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTT
CGCCCCTTTAAAGTCAAGTCTGTCTAATCTAACTAGCGCCTCGCTTTGCCTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCT
TCCAGATCCACTTCCTCATGATACTGTCTTCTAACTGGGCTTACTTAAAGGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAA
AGGAAGAACAGGAACTGCAAGATATCCAGTCTCGGTCAAAAGAACAACTCAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGA
CGTATTTACAGCTCTGACAAATCATCAGACAGCTGCTCTGCAGTACAGATGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCA
CTGTCTGTCTCAAGCTGCTGGGATGTATCTCTAGGAAAACCTTCCAGTGGGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATG
TTAGCCATTTTAAAAGGCAACACTTTGACAAAATGATCGTTCATACTTTGGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTC
TACCAAGACACTCAATGGAATATGTCACACTCCTTAATAGGGACCTGTGACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGA
TAAGACCGTAAATTCACATATATGCCATCTGTCCTCAAGTGTTATCTACATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGA
CAGCTGACATTTATTAAACTTTGGATCAAAGATAATGTGATTCTTATGATTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACC
CATTAATTTCCTGAGCCAATCAGAAATATATTTTTCAATAATGCTAAAATTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGA
TGCTGGACTCACTGACAAGCTTTCCAGAAGCAATTTTATAACAGATTTCATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGA
AATGTCAGCTTTGCCTTAATGAGTATTTGCTTTAAATTTCTAAGAATTTATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTG
TTCCATAAATGTTTTTCTTAATTATTAAGAAGTGTTACCTTATTAAAATGACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAA
GTTTACAGTTTCATACCAACTATCTAAAACCTAATTGCAAATTGACCACAGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAG
TAATTTAAATTAGGGTTGGTATTTCATTTTTTTCTTATCTAAATCTTAGTTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTG
CTTGAGTTTAAGCCATTTTCAAAAGAAACTTGCCTTTTACATTATTGTGTTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGA
TGGTAAACTTTGTGTTGCTCTTTATGAAATGATCCATATAACTGTTGGGTGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTA
ACTATGTATATTCATTGTTAAGAGTTAACTTGTGGTTTGGCTGTTTCCTGGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAA

>21730_21730_3_DCUN1D4-GPM6B_DCUN1D4_chr4_52729875_ENST00000451288_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=334AA_BP=89
MEVEAALGCSGQGRGCGGVAPAGRGRERASERGTRVRISKGLSGAGGSVRKADFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTG
CFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFY
TTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCUN1D4-GPM6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCUN1D4-GPM6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCUN1D4-GPM6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource