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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCX-PASD1 (FusionGDB2 ID:21738)

Fusion Gene Summary for DCX-PASD1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCX-PASD1
Fusion gene ID: 21738
HgeneTgene
Gene symbol

DCX

PASD1

Gene ID

1641

139135

Gene namedoublecortinPAS domain containing repressor 1
SynonymsDBCN|DC|LISX|SCLH|XLISCT63|CT64|OXTES1
Cytomap

Xq23

Xq28

Type of geneprotein-codingprotein-coding
Descriptionneuronal migration protein doublecortindoublecortexdoublinlis-Xlissencephalin-Xcircadian clock protein PASD1PAS domain containing 1cancer/testis antigen 63
Modification date2020031320200315
UniProtAcc

O43602

.
Ensembl transtripts involved in fusion geneENST00000338081, ENST00000356220, 
ENST00000356915, ENST00000371993, 
ENST00000488120, ENST00000496551, 
ENST00000370357, 
Fusion gene scores* DoF score1 X 2 X 1=24 X 4 X 4=64
# samples 15
** MAII scorelog2(1/2*10)=2.32192809488736log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCX [Title/Abstract] AND PASD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCX(110574132)-PASD1(150828185), # samples:2
DCX(110574147)-PASD1(150828185), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCX

GO:0001764

neuron migration

14741102

TgenePASD1

GO:0042754

negative regulation of circadian rhythm

25936801

TgenePASD1

GO:0045892

negative regulation of transcription, DNA-templated

25936801


check buttonFusion gene breakpoints across DCX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PASD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-5681-01ADCXchrX

110574132

-PASD1chrX

150828185

+
ChimerDB4KIRCTCGA-CJ-5681-01ADCXchrX

110574147

-PASD1chrX

150828185

+


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Fusion Gene ORF analysis for DCX-PASD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000338081ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+
Frame-shiftENST00000356220ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
In-frameENST00000356915ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
In-frameENST00000371993ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+
In-frameENST00000488120ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+
intron-3CDSENST00000338081ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
intron-3CDSENST00000356220ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+
intron-3CDSENST00000356915ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+
intron-3CDSENST00000371993ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
intron-3CDSENST00000488120ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
intron-3CDSENST00000496551ENST00000370357DCXchrX

110574132

-PASD1chrX

150828185

+
intron-3CDSENST00000496551ENST00000370357DCXchrX

110574147

-PASD1chrX

150828185

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356915DCXchrX110574132-ENST00000370357PASD1chrX150828185+321010099072613568
ENST00000371993DCXchrX110574147-ENST00000370357PASD1chrX150828185+326310629752666563
ENST00000488120DCXchrX110574147-ENST00000370357PASD1chrX150828185+3392119111042795563

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356915ENST00000370357DCXchrX110574132-PASD1chrX150828185+0.0023957940.9976042
ENST00000371993ENST00000370357DCXchrX110574147-PASD1chrX150828185+0.002144720.99785525
ENST00000488120ENST00000370357DCXchrX110574147-PASD1chrX150828185+0.0022655220.9977344

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Fusion Genomic Features for DCX-PASD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DCXchrX110574131-PASD1chrX150828184+5.41E-070.9999994
DCXchrX110574146-PASD1chrX150828184+1.80E-070.99999976
DCXchrX110574131-PASD1chrX150828184+5.41E-070.9999994
DCXchrX110574146-PASD1chrX150828184+1.80E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DCX-PASD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:110574132/chrX:150828185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCX

O43602

.
FUNCTION: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCXchrX:110574147chrX:150828185ENST00000338081-57287_365391442.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000356220-68180_263315366.0DomainDoublecortin 2
HgeneDCXchrX:110574132chrX:150828185ENST00000356220-6853_139315366.0DomainDoublecortin 1
HgeneDCXchrX:110574132chrX:150828185ENST00000356915-57180_263315366.0DomainDoublecortin 2
HgeneDCXchrX:110574132chrX:150828185ENST00000356915-5753_139315366.0DomainDoublecortin 1
HgeneDCXchrX:110574147chrX:150828185ENST00000338081-57180_263391442.0DomainDoublecortin 2
HgeneDCXchrX:110574147chrX:150828185ENST00000338081-5753_139391442.0DomainDoublecortin 1
HgeneDCXchrX:110574147chrX:150828185ENST00000371993-57180_263310361.0DomainDoublecortin 2
HgeneDCXchrX:110574147chrX:150828185ENST00000371993-5753_139310361.0DomainDoublecortin 1
HgeneDCXchrX:110574147chrX:150828185ENST00000488120-57180_263310361.0DomainDoublecortin 2
HgeneDCXchrX:110574147chrX:150828185ENST00000488120-5753_139310361.0DomainDoublecortin 1
TgenePASD1chrX:110574132chrX:150828185ENST00000370357816365_412239774.0Coiled coilOntology_term=ECO:0000255
TgenePASD1chrX:110574132chrX:150828185ENST00000370357816475_553239774.0Coiled coilOntology_term=ECO:0000255
TgenePASD1chrX:110574147chrX:150828185ENST00000370357816365_412239774.0Coiled coilOntology_term=ECO:0000255
TgenePASD1chrX:110574147chrX:150828185ENST00000370357816475_553239774.0Coiled coilOntology_term=ECO:0000255
TgenePASD1chrX:110574132chrX:150828185ENST00000370357816508_548239774.0Compositional biasNote=Lys-rich
TgenePASD1chrX:110574132chrX:150828185ENST00000370357816665_668239774.0Compositional biasNote=Poly-Ser
TgenePASD1chrX:110574147chrX:150828185ENST00000370357816508_548239774.0Compositional biasNote=Lys-rich
TgenePASD1chrX:110574147chrX:150828185ENST00000370357816665_668239774.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCXchrX:110574132chrX:150828185ENST00000338081-17287_3650442.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000356220-68287_365315366.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000356915-57287_365315366.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000371993-17287_3650361.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000488120-17287_3650361.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574147chrX:150828185ENST00000356220-18287_3650366.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574147chrX:150828185ENST00000356915-17287_3650366.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574147chrX:150828185ENST00000371993-57287_365310361.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574147chrX:150828185ENST00000488120-57287_365310361.0Compositional biasNote=Pro/Ser-rich
HgeneDCXchrX:110574132chrX:150828185ENST00000338081-17180_2630442.0DomainDoublecortin 2
HgeneDCXchrX:110574132chrX:150828185ENST00000338081-1753_1390442.0DomainDoublecortin 1
HgeneDCXchrX:110574132chrX:150828185ENST00000371993-17180_2630361.0DomainDoublecortin 2
HgeneDCXchrX:110574132chrX:150828185ENST00000371993-1753_1390361.0DomainDoublecortin 1
HgeneDCXchrX:110574132chrX:150828185ENST00000488120-17180_2630361.0DomainDoublecortin 2
HgeneDCXchrX:110574132chrX:150828185ENST00000488120-1753_1390361.0DomainDoublecortin 1
HgeneDCXchrX:110574147chrX:150828185ENST00000356220-18180_2630366.0DomainDoublecortin 2
HgeneDCXchrX:110574147chrX:150828185ENST00000356220-1853_1390366.0DomainDoublecortin 1
HgeneDCXchrX:110574147chrX:150828185ENST00000356915-17180_2630366.0DomainDoublecortin 2
HgeneDCXchrX:110574147chrX:150828185ENST00000356915-1753_1390366.0DomainDoublecortin 1
TgenePASD1chrX:110574132chrX:150828185ENST00000370357816229_236239774.0Compositional biasNote=Poly-Ala
TgenePASD1chrX:110574147chrX:150828185ENST00000370357816229_236239774.0Compositional biasNote=Poly-Ala
TgenePASD1chrX:110574132chrX:150828185ENST0000037035781630_102239774.0DomainPAS
TgenePASD1chrX:110574147chrX:150828185ENST0000037035781630_102239774.0DomainPAS


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Fusion Gene Sequence for DCX-PASD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21738_21738_1_DCX-PASD1_DCX_chrX_110574132_ENST00000356915_PASD1_chrX_150828185_ENST00000370357_length(transcript)=3210nt_BP=1009nt
TTTCTTTCTCTCAGCATCTCCACCCAACCAGCAGAAAACCGGTCTCTGAGGTTCCACCAAAATATGGAACTTGATTTTGGACACTTTGAC
GAAAGAGATAAGACATCCAGGAACATGCGAGGCTCCCGGATGAATGGGTTGCCTAGCCCCACTCACAGCGCCCACTGTAGCTTCTACCGA
ACCAGAACCTTGCAGGCACTGAGTAATGAGAAGAAAGCCAAGAAGGTACGTTTCTACCGCAATGGGGACCGCTACTTCAAGGGGATTGTG
TACGCTGTGTCCTCTGACCGTTTTCGCAGCTTTGACGCCTTGCTGGCTGACCTGACGCGATCTCTGTCTGACAACATCAACCTGCCTCAG
GGAGTGCGTTACATTTACACCATTGATGGATCCAGGAAGATCGGAAGCATGGATGAACTGGAGGAAGGGGAAAGCTATGTCTGTTCCTCA
GACAACTTCTTTAAAAAGGTGGAGTACACCAAGAATGTCAATCCCAACTGGTCTGTCAACGTAAAAACATCTGCCAATATGAAAGCCCCC
CAGTCCTTGGCTAGCAGCAACAGTGCACAGGCCAGGGAGAACAAGGACTTTGTGCGCCCCAAGCTGGTTACCATCATCCGCAGTGGGGTG
AAGCCTCGGAAGGCTGTGCGTGTGCTTCTGAACAAGAAGACAGCCCACTCTTTTGAGCAAGTCCTCACTGATATCACAGAAGCCATCAAA
CTGGAGACCGGGGTTGTCAAAAAACTCTACACTCTGGATGGAAAACAGGTAACTTGTCTCCATGATTTCTTTGGTGATGATGATGTGTTT
ATTGCCTGTGGTCCTGAAAAATTTCGCTATGCTCAGGATGATTTTTCTCTGGATGAAAATGAATGCCGAGTCATGAAGGGAAACCCATCA
GCCACAGCTGGCCCAAAGGCATCCCCAACACCTCAGAAGACTTCAGCCAAGAGCCCTGGTCCTATGCGCCGAAGCAAGTCTCCAGCTGAC
TCAGGTAACGACCAAGACGGACCAAATTGATATTGCAGAGGTTGAGCAGTATGGACCACAAGAAAACGTTCACATGTTTGTAGATTCTGA
TTCAACTTATTGCTCCAGTACAGTTTTCCTGGATACTATGCCTGAATCTCCAGCCTTATCCTTGCAAGACTTTCGAGGTGAGCCTGAGGT
GAATCCATTGTACAGGGCAGACCCAGTGGACCTGGAGTTCTCGGTGGATCAGGTGGACTCAGTGGACCAGGAGGGCCCAATGGACCAGCA
GGACCCAGAGAACCCAGTTGCCCCGTTGGACCAGGCAGGCCTGATGGATCCAGTGGATCCAGAGGACTCAGTGGACCTGGGGGCTGCTGG
CGCAAGTGCTCAGCCATTACAGCCATCATCACCAGTTGCATATGACATCATTAGCCAGGAACTGGAACTGATGAAGAAGTTGAAGGAGCA
GCTAGAAGAGAGGACTTGGTTGCTGCATGATGCCATCCAAAACCAGCAGAATGCATTGGAATTGATGATGGATCACCTTCAGAAGCAGCC
AAACACATTACGCCACGTTGTCATTCCTGATCTCCAATCTTCGGAGGCAGTGCCCAAGAAACAACAGAAACAACACGCTGGGCAAGTGAA
GCGGCCTCTCCCACATCCCAAGGACGTCAAGTGTTTCTGTGGTTTATCTTTATCCAACTCTCTCAAAAACACTGGGGAGCTTCAGGAGCC
TTGTGTTGCCTTCAACCAGCAGCAACTGGTGCAGCAAGAACAACACCTGAAGGAGCAGCAGCGGCAGCTGCGGGAGCAGCTGCAACAGCT
GAGAGAGCAAAGGAAGGTGCAGAAGCAGAAGAAGATGCAGGAGAAGAAGAAGCTGCAGGAGCAGAAAATGCAGGAGAAGAAGAAGCTGCA
GGAGCAGAGGCGGCAAAAGAAGAAGAAGCTACAGGAGCGGAAGAAGTGGCAGGGGCAGATGCTACAGAAAGAGCCAGAGGAGGAGCAGCA
GAAGCAGCAGCTGCAAGAGCAGCCACTGAAGCATAATGTCATCGTGGGGAATGAGAGGGTGCAGATATGCCTGCAAAACCCACGTGACGT
ATCTGTGCCCCTCTGCAATCACCCTGTTAGATTTTTACAGGCCCAACCCATTGTTCCTGTCCAGAGAGCAGCTGAACAACAGCCCTCTGG
CTTCTATCAAGATGAAAACTGTGGGCAACAGGAAGATGAGAGTCAAAGTTTTTATCCTGAGGCGTATCAAGGGCCCCCCGTGAACCAGCT
GCCATTGATAGATACCTCAAACTCTGAGGCAATTTCTTCTTCCAGCATTCCTCAGTTTCCCATAACTTCAGACTCAACCATAAGCACCCT
GGAGACCCCACAGGATTACATCCGGCTTTGGCAAGAGTTGTCTGATTCACTCGGTCCTGTTGTCCAAGTGAACACTTGGTCTTGCGATGA
GCAGGGCACCCTGCACGGCCAACCCACCTACCATCAGGTGCAAGTTTCTGAGGTAGGAGTCGAGGGACCTCCTGATCCACAGGCTTTCCA
AGGCCCTGCTGCATACCAGCCAGACCAGATGAGATCTGCGGAGCAGACCAGATTGATGCCTGCAGAGCAACGTGACTCAAATAAGCCGTG
CTAACAGTACTTTCATGACCAGTGATGAGGGGAAATGGGGGGAGGGGGCAGGCCAATGAGGTCTGCATGGCCAGGGGACCTTCAAGGTGC
GTAAAGTCCCTTGGGGTAGGGTTTAGTGGGTAGAGACTTATTTGTTTCCTGATAGGTTATGTTTGTAATTGTTTGTTAAGCACAGCCTGT
TTCTTGGAAGTTATGCTGTAGAGGCAGCCTGTGATCCGTAGTATGCTAGGGTGTGACAGCAGCCAGCCACAGCTGGATCTGATGTCTTGT
CTGCCCCGCCCAGCTTTGCATATCCATGTTCTACCACAGGAAGGTGGCCTGCCAAGAGTCTGCTCAAAGTTTTCAACATAAAGAATAAAG
AAAAAAAAATGCCAAAGTGCTTTTCAATCTAGTAAATCTAGAGGGTTGTTTTGTCTTAGCCACAAGAATTCCGAGGTCTTGACCCTGATG
ATCAACCTGCCTCCCCTCCATAGTCTTGTTGGAGAAGCCCAGAGAGAATGGGACTCCAACTAAGGGAACCTGAAATCAACTCAATGGAGG

>21738_21738_1_DCX-PASD1_DCX_chrX_110574132_ENST00000356915_PASD1_chrX_150828185_ENST00000370357_length(amino acids)=568AA_BP=34
MAQRHPQHLRRLQPRALVLCAEASLQLTQVTTKTDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNP
LYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLE
ERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCV
AFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQ
QLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPL
IDTSNSEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGP

--------------------------------------------------------------
>21738_21738_2_DCX-PASD1_DCX_chrX_110574147_ENST00000371993_PASD1_chrX_150828185_ENST00000370357_length(transcript)=3263nt_BP=1062nt
CACAAGGCAAAGCCTGCTCTCTCTGTCTCTCTGTCTCCTCTTCTCCTTTTTTGCCTTATTCTATCCGATTTTTTCCCTAAGCTTCTACCT
GGGATTTTCCTTTGGAAAAGTCTCTGAGGTTCCACCAAAATATGGAACTTGATTTTGGACACTTTGACGAAAGAGATAAGACATCCAGGA
ACATGCGAGGCTCCCGGATGAATGGGTTGCCTAGCCCCACTCACAGCGCCCACTGTAGCTTCTACCGAACCAGAACCTTGCAGGCACTGA
GTAATGAGAAGAAAGCCAAGAAGGTACGTTTCTACCGCAATGGGGACCGCTACTTCAAGGGGATTGTGTACGCTGTGTCCTCTGACCGTT
TTCGCAGCTTTGACGCCTTGCTGGCTGACCTGACGCGATCTCTGTCTGACAACATCAACCTGCCTCAGGGAGTGCGTTACATTTACACCA
TTGATGGATCCAGGAAGATCGGAAGCATGGATGAACTGGAGGAAGGGGAAAGCTATGTCTGTTCCTCAGACAACTTCTTTAAAAAGGTGG
AGTACACCAAGAATGTCAATCCCAACTGGTCTGTCAACGTAAAAACATCTGCCAATATGAAAGCCCCCCAGTCCTTGGCTAGCAGCAACA
GTGCACAGGCCAGGGAGAACAAGGACTTTGTGCGCCCCAAGCTGGTTACCATCATCCGCAGTGGGGTGAAGCCTCGGAAGGCTGTGCGTG
TGCTTCTGAACAAGAAGACAGCCCACTCTTTTGAGCAAGTCCTCACTGATATCACAGAAGCCATCAAACTGGAGACCGGGGTTGTCAAAA
AACTCTACACTCTGGATGGAAAACAGGTAACTTGTCTCCATGATTTCTTTGGTGATGATGATGTGTTTATTGCCTGTGGTCCTGAAAAAT
TTCGCTATGCTCAGGATGATTTTTCTCTGGATGAAAATGAATGCCGAGTCATGAAGGGAAACCCATCAGCCACAGCTGGCCCAAAGGCAT
CCCCAACACCTCAGAAGACTTCAGCCAAGAGCCCTGGTCCTATGCGCCGAAGCAAGTCTCCAGCTGACTCAGGACCAAATTGATATTGCA
GAGGTTGAGCAGTATGGACCACAAGAAAACGTTCACATGTTTGTAGATTCTGATTCAACTTATTGCTCCAGTACAGTTTTCCTGGATACT
ATGCCTGAATCTCCAGCCTTATCCTTGCAAGACTTTCGAGGTGAGCCTGAGGTGAATCCATTGTACAGGGCAGACCCAGTGGACCTGGAG
TTCTCGGTGGATCAGGTGGACTCAGTGGACCAGGAGGGCCCAATGGACCAGCAGGACCCAGAGAACCCAGTTGCCCCGTTGGACCAGGCA
GGCCTGATGGATCCAGTGGATCCAGAGGACTCAGTGGACCTGGGGGCTGCTGGCGCAAGTGCTCAGCCATTACAGCCATCATCACCAGTT
GCATATGACATCATTAGCCAGGAACTGGAACTGATGAAGAAGTTGAAGGAGCAGCTAGAAGAGAGGACTTGGTTGCTGCATGATGCCATC
CAAAACCAGCAGAATGCATTGGAATTGATGATGGATCACCTTCAGAAGCAGCCAAACACATTACGCCACGTTGTCATTCCTGATCTCCAA
TCTTCGGAGGCAGTGCCCAAGAAACAACAGAAACAACACGCTGGGCAAGTGAAGCGGCCTCTCCCACATCCCAAGGACGTCAAGTGTTTC
TGTGGTTTATCTTTATCCAACTCTCTCAAAAACACTGGGGAGCTTCAGGAGCCTTGTGTTGCCTTCAACCAGCAGCAACTGGTGCAGCAA
GAACAACACCTGAAGGAGCAGCAGCGGCAGCTGCGGGAGCAGCTGCAACAGCTGAGAGAGCAAAGGAAGGTGCAGAAGCAGAAGAAGATG
CAGGAGAAGAAGAAGCTGCAGGAGCAGAAAATGCAGGAGAAGAAGAAGCTGCAGGAGCAGAGGCGGCAAAAGAAGAAGAAGCTACAGGAG
CGGAAGAAGTGGCAGGGGCAGATGCTACAGAAAGAGCCAGAGGAGGAGCAGCAGAAGCAGCAGCTGCAAGAGCAGCCACTGAAGCATAAT
GTCATCGTGGGGAATGAGAGGGTGCAGATATGCCTGCAAAACCCACGTGACGTATCTGTGCCCCTCTGCAATCACCCTGTTAGATTTTTA
CAGGCCCAACCCATTGTTCCTGTCCAGAGAGCAGCTGAACAACAGCCCTCTGGCTTCTATCAAGATGAAAACTGTGGGCAACAGGAAGAT
GAGAGTCAAAGTTTTTATCCTGAGGCGTATCAAGGGCCCCCCGTGAACCAGCTGCCATTGATAGATACCTCAAACTCTGAGGCAATTTCT
TCTTCCAGCATTCCTCAGTTTCCCATAACTTCAGACTCAACCATAAGCACCCTGGAGACCCCACAGGATTACATCCGGCTTTGGCAAGAG
TTGTCTGATTCACTCGGTCCTGTTGTCCAAGTGAACACTTGGTCTTGCGATGAGCAGGGCACCCTGCACGGCCAACCCACCTACCATCAG
GTGCAAGTTTCTGAGGTAGGAGTCGAGGGACCTCCTGATCCACAGGCTTTCCAAGGCCCTGCTGCATACCAGCCAGACCAGATGAGATCT
GCGGAGCAGACCAGATTGATGCCTGCAGAGCAACGTGACTCAAATAAGCCGTGCTAACAGTACTTTCATGACCAGTGATGAGGGGAAATG
GGGGGAGGGGGCAGGCCAATGAGGTCTGCATGGCCAGGGGACCTTCAAGGTGCGTAAAGTCCCTTGGGGTAGGGTTTAGTGGGTAGAGAC
TTATTTGTTTCCTGATAGGTTATGTTTGTAATTGTTTGTTAAGCACAGCCTGTTTCTTGGAAGTTATGCTGTAGAGGCAGCCTGTGATCC
GTAGTATGCTAGGGTGTGACAGCAGCCAGCCACAGCTGGATCTGATGTCTTGTCTGCCCCGCCCAGCTTTGCATATCCATGTTCTACCAC
AGGAAGGTGGCCTGCCAAGAGTCTGCTCAAAGTTTTCAACATAAAGAATAAAGAAAAAAAAATGCCAAAGTGCTTTTCAATCTAGTAAAT
CTAGAGGGTTGTTTTGTCTTAGCCACAAGAATTCCGAGGTCTTGACCCTGATGATCAACCTGCCTCCCCTCCATAGTCTTGTTGGAGAAG
CCCAGAGAGAATGGGACTCCAACTAAGGGAACCTGAAATCAACTCAATGGAGGCACTTCAGAGCTAAAATAATTATGGCTTCCTTGCTTA

>21738_21738_2_DCX-PASD1_DCX_chrX_110574147_ENST00000371993_PASD1_chrX_150828185_ENST00000370357_length(amino acids)=563AA_BP=28
MAQRHPQHLRRLQPRALVLCAEASLQLTQDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRAD
PVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWL
LHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQ
QLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQ
PLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSN
SEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQP

--------------------------------------------------------------
>21738_21738_3_DCX-PASD1_DCX_chrX_110574147_ENST00000488120_PASD1_chrX_150828185_ENST00000370357_length(transcript)=3392nt_BP=1191nt
GAAACCTTTCTAGCTGTTAATGCAGCCTGTGAATTTTTTTAAAAGCATGTAATTAATCATAGGAGGTTGGGGGGATTCACTAAGCCTGAG
TTACATGGGAGAAGCTGGACAAGGCACTAGGACCTAGAAGGCATCTATCCACCCTGGCAGGAATTTCTTGCTTGGAGCTCAGACAACAAA
GGCATAGAGAGATTGGTTTTCTTTCTCTCAGCATCTCCACCCAACCAGCAGAAAACCGGTCTCTGAGGTTCCACCAAAATATGGAACTTG
ATTTTGGACACTTTGACGAAAGAGATAAGACATCCAGGAACATGCGAGGCTCCCGGATGAATGGGTTGCCTAGCCCCACTCACAGCGCCC
ACTGTAGCTTCTACCGAACCAGAACCTTGCAGGCACTGAGTAATGAGAAGAAAGCCAAGAAGGTACGTTTCTACCGCAATGGGGACCGCT
ACTTCAAGGGGATTGTGTACGCTGTGTCCTCTGACCGTTTTCGCAGCTTTGACGCCTTGCTGGCTGACCTGACGCGATCTCTGTCTGACA
ACATCAACCTGCCTCAGGGAGTGCGTTACATTTACACCATTGATGGATCCAGGAAGATCGGAAGCATGGATGAACTGGAGGAAGGGGAAA
GCTATGTCTGTTCCTCAGACAACTTCTTTAAAAAGGTGGAGTACACCAAGAATGTCAATCCCAACTGGTCTGTCAACGTAAAAACATCTG
CCAATATGAAAGCCCCCCAGTCCTTGGCTAGCAGCAACAGTGCACAGGCCAGGGAGAACAAGGACTTTGTGCGCCCCAAGCTGGTTACCA
TCATCCGCAGTGGGGTGAAGCCTCGGAAGGCTGTGCGTGTGCTTCTGAACAAGAAGACAGCCCACTCTTTTGAGCAAGTCCTCACTGATA
TCACAGAAGCCATCAAACTGGAGACCGGGGTTGTCAAAAAACTCTACACTCTGGATGGAAAACAGGTAACTTGTCTCCATGATTTCTTTG
GTGATGATGATGTGTTTATTGCCTGTGGTCCTGAAAAATTTCGCTATGCTCAGGATGATTTTTCTCTGGATGAAAATGAATGCCGAGTCA
TGAAGGGAAACCCATCAGCCACAGCTGGCCCAAAGGCATCCCCAACACCTCAGAAGACTTCAGCCAAGAGCCCTGGTCCTATGCGCCGAA
GCAAGTCTCCAGCTGACTCAGGACCAAATTGATATTGCAGAGGTTGAGCAGTATGGACCACAAGAAAACGTTCACATGTTTGTAGATTCT
GATTCAACTTATTGCTCCAGTACAGTTTTCCTGGATACTATGCCTGAATCTCCAGCCTTATCCTTGCAAGACTTTCGAGGTGAGCCTGAG
GTGAATCCATTGTACAGGGCAGACCCAGTGGACCTGGAGTTCTCGGTGGATCAGGTGGACTCAGTGGACCAGGAGGGCCCAATGGACCAG
CAGGACCCAGAGAACCCAGTTGCCCCGTTGGACCAGGCAGGCCTGATGGATCCAGTGGATCCAGAGGACTCAGTGGACCTGGGGGCTGCT
GGCGCAAGTGCTCAGCCATTACAGCCATCATCACCAGTTGCATATGACATCATTAGCCAGGAACTGGAACTGATGAAGAAGTTGAAGGAG
CAGCTAGAAGAGAGGACTTGGTTGCTGCATGATGCCATCCAAAACCAGCAGAATGCATTGGAATTGATGATGGATCACCTTCAGAAGCAG
CCAAACACATTACGCCACGTTGTCATTCCTGATCTCCAATCTTCGGAGGCAGTGCCCAAGAAACAACAGAAACAACACGCTGGGCAAGTG
AAGCGGCCTCTCCCACATCCCAAGGACGTCAAGTGTTTCTGTGGTTTATCTTTATCCAACTCTCTCAAAAACACTGGGGAGCTTCAGGAG
CCTTGTGTTGCCTTCAACCAGCAGCAACTGGTGCAGCAAGAACAACACCTGAAGGAGCAGCAGCGGCAGCTGCGGGAGCAGCTGCAACAG
CTGAGAGAGCAAAGGAAGGTGCAGAAGCAGAAGAAGATGCAGGAGAAGAAGAAGCTGCAGGAGCAGAAAATGCAGGAGAAGAAGAAGCTG
CAGGAGCAGAGGCGGCAAAAGAAGAAGAAGCTACAGGAGCGGAAGAAGTGGCAGGGGCAGATGCTACAGAAAGAGCCAGAGGAGGAGCAG
CAGAAGCAGCAGCTGCAAGAGCAGCCACTGAAGCATAATGTCATCGTGGGGAATGAGAGGGTGCAGATATGCCTGCAAAACCCACGTGAC
GTATCTGTGCCCCTCTGCAATCACCCTGTTAGATTTTTACAGGCCCAACCCATTGTTCCTGTCCAGAGAGCAGCTGAACAACAGCCCTCT
GGCTTCTATCAAGATGAAAACTGTGGGCAACAGGAAGATGAGAGTCAAAGTTTTTATCCTGAGGCGTATCAAGGGCCCCCCGTGAACCAG
CTGCCATTGATAGATACCTCAAACTCTGAGGCAATTTCTTCTTCCAGCATTCCTCAGTTTCCCATAACTTCAGACTCAACCATAAGCACC
CTGGAGACCCCACAGGATTACATCCGGCTTTGGCAAGAGTTGTCTGATTCACTCGGTCCTGTTGTCCAAGTGAACACTTGGTCTTGCGAT
GAGCAGGGCACCCTGCACGGCCAACCCACCTACCATCAGGTGCAAGTTTCTGAGGTAGGAGTCGAGGGACCTCCTGATCCACAGGCTTTC
CAAGGCCCTGCTGCATACCAGCCAGACCAGATGAGATCTGCGGAGCAGACCAGATTGATGCCTGCAGAGCAACGTGACTCAAATAAGCCG
TGCTAACAGTACTTTCATGACCAGTGATGAGGGGAAATGGGGGGAGGGGGCAGGCCAATGAGGTCTGCATGGCCAGGGGACCTTCAAGGT
GCGTAAAGTCCCTTGGGGTAGGGTTTAGTGGGTAGAGACTTATTTGTTTCCTGATAGGTTATGTTTGTAATTGTTTGTTAAGCACAGCCT
GTTTCTTGGAAGTTATGCTGTAGAGGCAGCCTGTGATCCGTAGTATGCTAGGGTGTGACAGCAGCCAGCCACAGCTGGATCTGATGTCTT
GTCTGCCCCGCCCAGCTTTGCATATCCATGTTCTACCACAGGAAGGTGGCCTGCCAAGAGTCTGCTCAAAGTTTTCAACATAAAGAATAA
AGAAAAAAAAATGCCAAAGTGCTTTTCAATCTAGTAAATCTAGAGGGTTGTTTTGTCTTAGCCACAAGAATTCCGAGGTCTTGACCCTGA
TGATCAACCTGCCTCCCCTCCATAGTCTTGTTGGAGAAGCCCAGAGAGAATGGGACTCCAACTAAGGGAACCTGAAATCAACTCAATGGA

>21738_21738_3_DCX-PASD1_DCX_chrX_110574147_ENST00000488120_PASD1_chrX_150828185_ENST00000370357_length(amino acids)=563AA_BP=28
MAQRHPQHLRRLQPRALVLCAEASLQLTQDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRAD
PVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWL
LHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQ
QLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQ
PLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSN
SEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCX-PASD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCX-PASD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCX-PASD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource