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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDA1-MYO9B (FusionGDB2 ID:21749)

Fusion Gene Summary for DDA1-MYO9B

check button Fusion gene summary
Fusion gene informationFusion gene name: DDA1-MYO9B
Fusion gene ID: 21749
HgeneTgene
Gene symbol

DDA1

MYO9B

Gene ID

79016

4650

Gene nameDET1 and DDB1 associated 1myosin IXB
SynonymsC19orf58|PCIA1CELIAC4|MYR5
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
DescriptionDET1- and DDB1-associated protein 1cross-immune reaction antigen PCIA1placenta cross-immune reaction antigen 1unconventional myosin-IXbmyosin-IXbunconventional myosin-9b
Modification date2020032720200313
UniProtAcc

Q9BW61

Q13459

Ensembl transtripts involved in fusion geneENST00000359866, ENST00000593411, 
ENST00000397274, ENST00000594824, 
ENST00000595618, 
Fusion gene scores* DoF score7 X 6 X 5=21015 X 18 X 8=2160
# samples 818
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDA1 [Title/Abstract] AND MYO9B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDA1(17420466)-MYO9B(17311448), # samples:3
MYO9B(17213367)-DDA1(17424832), # samples:2
Anticipated loss of major functional domain due to fusion event.DDA1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDA1-MYO9B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYO9B

GO:0030048

actin filament-based movement

9490638

TgeneMYO9B

GO:0032011

ARF protein signal transduction

15644318

TgeneMYO9B

GO:0035385

Roundabout signaling pathway

26529257


check buttonFusion gene breakpoints across DDA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO9B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-XR-A8TG-01ADDA1chr19

17426804

-MYO9Bchr19

17270205

+
ChimerDB4LIHCTCGA-XR-A8TG-01ADDA1chr19

17426804

+MYO9Bchr19

17270205

+
ChimerDB4UCECTCGA-AJ-A2QM-01ADDA1chr19

17420466

-MYO9Bchr19

17311448

+
ChimerDB4UCECTCGA-AJ-A2QM-01ADDA1chr19

17420466

+MYO9Bchr19

17311448

+


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Fusion Gene ORF analysis for DDA1-MYO9B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359866ENST00000593411DDA1chr19

17426804

+MYO9Bchr19

17270205

+
5CDS-intronENST00000359866ENST00000593411DDA1chr19

17420466

+MYO9Bchr19

17311448

+
Frame-shiftENST00000359866ENST00000397274DDA1chr19

17420466

+MYO9Bchr19

17311448

+
Frame-shiftENST00000359866ENST00000594824DDA1chr19

17420466

+MYO9Bchr19

17311448

+
Frame-shiftENST00000359866ENST00000595618DDA1chr19

17420466

+MYO9Bchr19

17311448

+
In-frameENST00000359866ENST00000397274DDA1chr19

17426804

+MYO9Bchr19

17270205

+
In-frameENST00000359866ENST00000594824DDA1chr19

17426804

+MYO9Bchr19

17270205

+
In-frameENST00000359866ENST00000595618DDA1chr19

17426804

+MYO9Bchr19

17270205

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359866DDA1chr1917426804+ENST00000595618MYO9Bchr1917270205+64643222850611677
ENST00000359866DDA1chr1917426804+ENST00000594824MYO9Bchr1917270205+64413222854661812
ENST00000359866DDA1chr1917426804+ENST00000397274MYO9Bchr1917270205+64633222850611677

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359866ENST00000595618DDA1chr1917426804+MYO9Bchr1917270205+0.004943110.99505687
ENST00000359866ENST00000594824DDA1chr1917426804+MYO9Bchr1917270205+0.0080620220.99193794
ENST00000359866ENST00000397274DDA1chr1917426804+MYO9Bchr1917270205+0.0049237390.99507624

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Fusion Genomic Features for DDA1-MYO9B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDA1chr1917426804+MYO9Bchr1917270204+7.77E-121
DDA1chr1917420466+MYO9Bchr1917311447+6.80E-111
DDA1chr1917426804+MYO9Bchr1917270204+7.77E-121
DDA1chr1917420466+MYO9Bchr1917311447+6.80E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDA1-MYO9B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17420466/chr19:17311448)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDA1

Q9BW61

MYO9B

Q13459

FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). {ECO:0000269|PubMed:17452440, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31819272}.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391046_10714432189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391880_19014432189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391959_19894432189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401046_10714432458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401880_19014432458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401959_19894432458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391001_10234432189.0DomainIQ 3
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391024_10534432189.0DomainIQ 4
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391703_18884432189.0DomainRho-GAP
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539957_9774432189.0DomainIQ 1
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539979_10004432189.0DomainIQ 2
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401001_10234432458.6666666666665DomainIQ 3
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401024_10534432458.6666666666665DomainIQ 4
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401703_18884432458.6666666666665DomainRho-GAP
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640957_9774432458.6666666666665DomainIQ 1
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640979_10004432458.6666666666665DomainIQ 2
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391045_21574432189.0RegionTail
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539844_8554432189.0RegionActin-binding
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539940_10444432189.0RegionNeck or regulatory domain
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401045_21574432458.6666666666665RegionTail
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640844_8554432458.6666666666665RegionActin-binding
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640940_10444432458.6666666666665RegionNeck or regulatory domain
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391632_16814432189.0Zinc fingerPhorbol-ester/DAG-type
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401632_16814432458.6666666666665Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539146_9534432189.0DomainMyosin motor
TgeneMYO9Bchr19:17426804chr19:17270205ENST0000039727453915_1144432189.0DomainRas-associating
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640146_9534432458.6666666666665DomainMyosin motor
TgeneMYO9Bchr19:17426804chr19:17270205ENST0000059561864015_1144432458.6666666666665DomainRas-associating
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000397274539239_2464432189.0Nucleotide bindingATP
TgeneMYO9Bchr19:17426804chr19:17270205ENST00000595618640239_2464432458.6666666666665Nucleotide bindingATP


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Fusion Gene Sequence for DDA1-MYO9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21749_21749_1_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000397274_length(transcript)=6463nt_BP=322nt
GGCGCCATCAGTGTGGGCTGTGCCGTGGCTGGAAGTTACTGTGAGGCGGCGGCTAAGAAGGCGGCTCTGGTGGCGGCGGTGGAGGCTGAG
GCGGCGGCCGAGGCGGCGACGGAGGAAACAGAAGATGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATT
TCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGAC
AGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGGTGAAGCGAGAAATCTTGGTGGAGGTTCTGACCAAAAG
AAAAACGGTGACCGTCAACGACAAGCTTATCCTTCCCTACAGCCTCAGCGAGGCCATCACTGCCCGCGACTCCATGGCCAAGTCTCTGTA
CAGCGCCCTGTTCGACTGGATTGTGCTGCGGATCAACCACGCACTCCTCAACAAGAAGGACGTGGAAGAGGCAGTCTCGTGCCTGTCCAT
TGGGGTCCTGGACATCTTCGGGTTTGAAGACTTCGAGAGGAACAGCTTTGAGCAGTTCTGCATCAACTACGCCAATGAGCAGCTGCAGTA
TTACTTCAACCAGCACATCTTCAAGCTGGAGCAGGAGGAATATCAGGGCGAGGGGATCACGTGGCACAACATCGGCTACACAGACAATGT
CGGCTGCATCCATCTCATCAGCAAGAAACCCACGGGCCTCTTCTACCTGCTGGACGAGGAGAGCAACTTCCCCCACGCCACGAGCCAGAC
CCTGCTGGCCAAGTTCAAACAGCAACATGAGGACAATAAGTACTTCCTGGGCACCCCGGTCATGGAGCCAGCTTTCATCATCCAGCACTT
CGCAGGGAAGGTGAAATATCAGATCAAGGACTTCCGGGAGAAGAACATGGACTACATGCGGCCAGACATCGTGGCCCTGCTGCGGGGCAG
TGACAGCTCCTACGTGCGGGAGCTCATCGGCATGGACCCCGTGGCCGTGTTCCGCTGGGCCGTGCTCCGGGCTGCTATCCGGGCCATGGC
AGTGCTTCGGGAGGCCGGACGCCTGCGGGCCGAGAGGGCCGAAAAGGCTGCAGGTATGAGCAGCCCTGGTGCCCAAAGTCACCCAGAAGA
GCTGCCAAGAGGAGCCAGCACCCCTTCGGAAAAACTTTACCGCGATTTGCATAACCAAATGATCAAGAGCATCAAAGGATTGCCCTGGCA
GGGCGAGGACCCCCGTAGCCTTCTCCAGTCCCTCAGTCGGCTCCAGAAACCCCGCGCCTTCATCCTGAAAAGTAAAGGTATCAAACAAAA
GCAGATCATTCCAAAGAACCTACTGGACTCCAAGTCCCTGAAACTCATCATCAGCATGACTCTGCACGACCGCACCACCAAGTCCCTACT
GCACCTGCACAAGAAGAAAAAGCCACCAAGCATCAGCGCCCAGTTCCAGACATCCCTTAACAAGCTCTTGGAGGCACTGGGGAAGGCGGA
GCCCTTCTTTATCCGCTGCATCCGTTCCAATGCTGAAAAGAAAGAGCTGTGCTTTGACGACGAGCTGGTCCTGCAGCAGCTGCGCTACAC
CGGCATGCTGGAGACCGTGCGCATCCGGAGGTCAGGGTACAGCGCCAAGTACACGTTCCAGGATTTCACCGAGCAGTTCCAGGTGCTCCT
GCCCAAGGATGCCCAGCCCTGCAGGGAGGTCATCTCCACCCTCCTGGAGAAAATGAAGATAGACAAGAGGAACTACCAGATCGGGAAGAC
CAAGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATCCTGCTGCTGCAGAGCTG
GTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGGCGGTCCTACCGGGTCCG
GAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTCTACCGGCACCAGAAACA
GAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAGAAGCAGAAGGCAGAAGA
GAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGGCAGCAGGTAGCTGAGCA
GGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCCCTAGAGCACTCCTCACC
TGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAAGTCCCCAGCAGCCGGGA
GAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAGGAGGAGAGTGCCCTCAG
AGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGATGAAACCCTTCTAGTCGT
AGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTCTCTGAAGAAACTGAGAA
GACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTCAGCCCACCGGCCCCTGG
CAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGCCCCGGAGGCTCCACGCA
GATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCCGCCGCCAGCCCTAGTGC
CATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAGAGGCGCACCTCCTTCTC
CACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAGCGAAGTGCGAAAAAGCC
AGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTCGACTCTAAATCCACGTT
TAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCAGTGTCCGGGCACGTGGT
GCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAGAAGCGCACCAAGGAACC
AGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCGGTGTTCCGCCAGATCAC
CAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACGCCCATTGAGAGCTTGTT
TATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTGGGCTACAAGGATCTGAT
GGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAACCTCTTCCAGTCACTGCT
AGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAGCGGAAGCAGGAGCGTGC
TGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTCTCCTATATCTGGCTCAT
GGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCACTGCTCCTACACCTACGG
GAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCCTCGGTGCCCATCGTGCT
GGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCCAACCGCACTCGGGAGCT
CCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTGCTGAAGCAGTGGCTGCG
GGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAGCAGGAGCAGCTGGCTGC
CATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTCAAGGTGGCCCTGCTCGA
GGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAACTCGGACCCGCTGACCAG
CATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTGAAGATGGAGGAGATCAG
CCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTCAAACTGGGGTTTTCGTC
TCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTGGAGGAGGAGGCAGCCGG
CGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGGAGGACATCACCTACCGGCTGCCGGA
GCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAGGAGCGGGCCGGGCGGGG
GGCCTCGGAAGGTCAGTATTAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCCCTCCCCACCGTGGCCGC
CCCTCCACGACGAAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCCACGGCCAACATCAAGCT
CCCACCAGGCCTGCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGCCGGGAGCCACCTGCCCG
CCGCCCGGACCAGATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCCCTAGAAGAGGATGGCCA
GCCACCTGGGGCCAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAATGGCTGAGAGCCACAGCT
GACAAAGTCTGCATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGCCCTCAGAGAAGGATCCA
GAATCAAAAGCTCAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGCTGGAGCCAGGCCCCCTC
GCACGCAGCCCCCAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCACTCCCCTTTTTGTACGT
TTAACTGTTTCTTTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTTTATATGTGTATGTACAA
AGTTTTCTATTAACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCACTGCGCGTCTGAGGCTCA
GACCCTGCTGTGGTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCACCTGACCCGTGCCTCTCT
GACACATGTCTCCGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTCTGGGCTATTGGCTGGAG
CCAGGACATGAGTCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGACGCCAAGGGCTGCAGGA
GGCTGCTTTTGGCACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGAGGGCAACGCCTGAAGTC
AGACCTCCCTATAGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCCACTCCCCCAGACACCTG

>21749_21749_1_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000397274_length(amino acids)=1677AA_BP=96
MEVTVRRRLRRRLWWRRWRLRRRPRRRRRKQKMADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRY
LHQQWDKKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFE
DFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQH
EDNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLR
AERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLD
SKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIR
RSGYSAKYTFQDFTEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRH
FLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAA
RAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRG
LEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRP
GQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLS
DRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTK
DKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLD
EFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTK
NDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEP
GHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTF
AQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITT
CVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEI

--------------------------------------------------------------
>21749_21749_2_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000594824_length(transcript)=6441nt_BP=322nt
GGCGCCATCAGTGTGGGCTGTGCCGTGGCTGGAAGTTACTGTGAGGCGGCGGCTAAGAAGGCGGCTCTGGTGGCGGCGGTGGAGGCTGAG
GCGGCGGCCGAGGCGGCGACGGAGGAAACAGAAGATGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATT
TCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGAC
AGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGGTGAAGCGAGAAATCTTGGTGGAGGTTCTGACCAAAAG
AAAAACGGTGACCGTCAACGACAAGCTTATCCTTCCCTACAGCCTCAGCGAGGCCATCACTGCCCGCGACTCCATGGCCAAGTCTCTGTA
CAGCGCCCTGTTCGACTGGATTGTGCTGCGGATCAACCACGCACTCCTCAACAAGAAGGACGTGGAAGAGGCAGTCTCGTGCCTGTCCAT
TGGGGTCCTGGACATCTTCGGGTTTGAAGACTTCGAGAGGAACAGCTTTGAGCAGTTCTGCATCAACTACGCCAATGAGCAGCTGCAGTA
TTACTTCAACCAGCACATCTTCAAGCTGGAGCAGGAGGAATATCAGGGCGAGGGGATCACGTGGCACAACATCGGCTACACAGACAATGT
CGGCTGCATCCATCTCATCAGCAAGAAACCCACGGGCCTCTTCTACCTGCTGGACGAGGAGAGCAACTTCCCCCACGCCACGAGCCAGAC
CCTGCTGGCCAAGTTCAAACAGCAACATGAGGACAATAAGTACTTCCTGGGCACCCCGGTCATGGAGCCAGCTTTCATCATCCAGCACTT
CGCAGGGAAGGTGAAATATCAGATCAAGGACTTCCGGGAGAAGAACATGGACTACATGCGGCCAGACATCGTGGCCCTGCTGCGGGGCAG
TGACAGCTCCTACGTGCGGGAGCTCATCGGCATGGACCCCGTGGCCGTGTTCCGCTGGGCCGTGCTCCGGGCTGCTATCCGGGCCATGGC
AGTGCTTCGGGAGGCCGGACGCCTGCGGGCCGAGAGGGCCGAAAAGGCTGCAGGTATGAGCAGCCCTGGTGCCCAAAGTCACCCAGAAGA
GCTGCCAAGAGGAGCCAGCACCCCTTCGGAAAAACTTTACCGCGATTTGCATAACCAAATGATCAAGAGCATCAAAGGATTGCCCTGGCA
GGGCGAGGACCCCCGTAGCCTTCTCCAGTCCCTCAGTCGGCTCCAGAAACCCCGCGCCTTCATCCTGAAAAGTAAAGGTATCAAACAAAA
GCAGATCATTCCAAAGAACCTACTGGACTCCAAGTCCCTGAAACTCATCATCAGCATGACTCTGCACGACCGCACCACCAAGTCCCTACT
GCACCTGCACAAGAAGAAAAAGCCACCAAGCATCAGCGCCCAGTTCCAGACATCCCTTAACAAGCTCTTGGAGGCACTGGGGAAGGCGGA
GCCCTTCTTTATCCGCTGCATCCGTTCCAATGCTGAAAAGAAAGAGCTGTGCTTTGACGACGAGCTGGTCCTGCAGCAGCTGCGCTACAC
CGGCATGCTGGAGACCGTGCGCATCCGGAGGTCAGGGTACAGCGCCAAGTACACGTTCCAGGATTTCACCGAGCAGTTCCAGGTGCTCCT
GCCCAAGGATGCCCAGCCCTGCAGGGAGGTCATCTCCACCCTCCTGGAGAAAATGAAGATAGACAAGAGGAACTACCAGATCGGGAAGAC
CAAGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATCCTGCTGCTGCAGAGCTG
GTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGGCGGTCCTACCGGGTCCG
GAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTCTACCGGCACCAGAAACA
GAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAGAAGCAGAAGGCAGAAGA
GAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGGCAGCAGGTAGCTGAGCA
GGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCCCTAGAGCACTCCTCACC
TGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAAGTCCCCAGCAGCCGGGA
GAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAGGAGGAGAGTGCCCTCAG
AGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGATGAAACCCTTCTAGTCGT
AGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTCTCTGAAGAAACTGAGAA
GACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTCAGCCCACCGGCCCCTGG
CAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGCCCCGGAGGCTCCACGCA
GATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCCGCCGCCAGCCCTAGTGC
CATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAGAGGCGCACCTCCTTCTC
CACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAGCGAAGTGCGAAAAAGCC
AGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTCGACTCTAAATCCACGTT
TAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCAGTGTCCGGGCACGTGGT
GCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAGAAGCGCACCAAGGAACC
AGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCGGTGTTCCGCCAGATCAC
CAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACGCCCATTGAGAGCTTGTT
TATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTGGGCTACAAGGATCTGAT
GGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAACCTCTTCCAGTCACTGCT
AGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAGCGGAAGCAGGAGCGTGC
TGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTCTCCTATATCTGGCTCAT
GGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCACTGCTCCTACACCTACGG
GAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCCTCGGTGCCCATCGTGCT
GGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCCAACCGCACTCGGGAGCT
CCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTGCTGAAGCAGTGGCTGCG
GGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAGCAGGAGCAGCTGGCTGC
CATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTCAAGGTGGCCCTGCTCGA
GGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAACTCGGACCCGCTGACCAG
CATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTGAAGATGGAGGAGATCAG
CCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTCAAACTGGGGTTTTCGTC
TCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTGGAGGAGGAGGCAGCCGG
CGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGCAAGACATCACCTACCGGCTGCCGGA
GCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAGGAGCGGGCCGGGCGGGG
GGCCTCGGAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCCCTCCCCACCGTGGCCGCCCCTCCACGACG
AAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCCACGGCCAACATCAAGCTCCCACCAGGCCT
GCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGCCGGGAGCCACCTGCCCGCCGCCCGGACCA
GATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCCCTAGAAGAGGATGGCCAGCCACCTGGGGC
CAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAATGGCTGAGAGCCACAGCTGACAAAGTCTGC
ATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGCCCTCAGAGAAGGATCCAGAATCAAAAGCT
CAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGCTGGAGCCAGGCCCCCTCGCACGCAGCCCC
CAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCACTCCCCTTTTTGTACGTTTAACTGTTTCT
TTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTTTATATGTGTATGTACAAAGTTTTCTATTA
ACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCACTGCGCGTCTGAGGCTCAGACCCTGCTGTG
GTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCACCTGACCCGTGCCTCTCTGACACATGTCTC
CGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTCTGGGCTATTGGCTGGAGCCAGGACATGAG
TCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGACGCCAAGGGCTGCAGGAGGCTGCTTTTGG
CACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGAGGGCAACGCCTGAAGTCAGACCTCCCTAT
AGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCCACTCCCCCAGACACCTGGACACGTGGCCA

>21749_21749_2_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000594824_length(amino acids)=1812AA_BP=96
MEVTVRRRLRRRLWWRRWRLRRRPRRRRRKQKMADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRY
LHQQWDKKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFE
DFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQH
EDNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLR
AERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLD
SKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIR
RSGYSAKYTFQDFTEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRH
FLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAA
RAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRG
LEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRP
GQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLS
DRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTK
DKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLD
EFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTK
NDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEP
GHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTF
AQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITT
CVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEI
LIERIQSIKEEKQDITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVR
VKTPRRTPIMPTANIKLPPGLPSHLPRWAPGAREAAAPVRRREPPARRPDQIHSVYITPGADLPVQGALEPLEEDGQPPGAKRRYSDPPT

--------------------------------------------------------------
>21749_21749_3_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000595618_length(transcript)=6464nt_BP=322nt
GGCGCCATCAGTGTGGGCTGTGCCGTGGCTGGAAGTTACTGTGAGGCGGCGGCTAAGAAGGCGGCTCTGGTGGCGGCGGTGGAGGCTGAG
GCGGCGGCCGAGGCGGCGACGGAGGAAACAGAAGATGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATT
TCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGAC
AGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGGTGAAGCGAGAAATCTTGGTGGAGGTTCTGACCAAAAG
AAAAACGGTGACCGTCAACGACAAGCTTATCCTTCCCTACAGCCTCAGCGAGGCCATCACTGCCCGCGACTCCATGGCCAAGTCTCTGTA
CAGCGCCCTGTTCGACTGGATTGTGCTGCGGATCAACCACGCACTCCTCAACAAGAAGGACGTGGAAGAGGCAGTCTCGTGCCTGTCCAT
TGGGGTCCTGGACATCTTCGGGTTTGAAGACTTCGAGAGGAACAGCTTTGAGCAGTTCTGCATCAACTACGCCAATGAGCAGCTGCAGTA
TTACTTCAACCAGCACATCTTCAAGCTGGAGCAGGAGGAATATCAGGGCGAGGGGATCACGTGGCACAACATCGGCTACACAGACAATGT
CGGCTGCATCCATCTCATCAGCAAGAAACCCACGGGCCTCTTCTACCTGCTGGACGAGGAGAGCAACTTCCCCCACGCCACGAGCCAGAC
CCTGCTGGCCAAGTTCAAACAGCAACATGAGGACAATAAGTACTTCCTGGGCACCCCGGTCATGGAGCCAGCTTTCATCATCCAGCACTT
CGCAGGGAAGGTGAAATATCAGATCAAGGACTTCCGGGAGAAGAACATGGACTACATGCGGCCAGACATCGTGGCCCTGCTGCGGGGCAG
TGACAGCTCCTACGTGCGGGAGCTCATCGGCATGGACCCCGTGGCCGTGTTCCGCTGGGCCGTGCTCCGGGCTGCTATCCGGGCCATGGC
AGTGCTTCGGGAGGCCGGACGCCTGCGGGCCGAGAGGGCCGAAAAGGCTGCAGGTATGAGCAGCCCTGGTGCCCAAAGTCACCCAGAAGA
GCTGCCAAGAGGAGCCAGCACCCCTTCGGAAAAACTTTACCGCGATTTGCATAACCAAATGATCAAGAGCATCAAAGGATTGCCCTGGCA
GGGCGAGGACCCCCGTAGCCTTCTCCAGTCCCTCAGTCGGCTCCAGAAACCCCGCGCCTTCATCCTGAAAAGTAAAGGTATCAAACAAAA
GCAGATCATTCCAAAGAACCTACTGGACTCCAAGTCCCTGAAACTCATCATCAGCATGACTCTGCACGACCGCACCACCAAGTCCCTACT
GCACCTGCACAAGAAGAAAAAGCCACCAAGCATCAGCGCCCAGTTCCAGACATCCCTTAACAAGCTCTTGGAGGCACTGGGGAAGGCGGA
GCCCTTCTTTATCCGCTGCATCCGTTCCAATGCTGAAAAGAAAGAGCTGTGCTTTGACGACGAGCTGGTCCTGCAGCAGCTGCGCTACAC
CGGCATGCTGGAGACCGTGCGCATCCGGAGGTCAGGGTACAGCGCCAAGTACACGTTCCAGGATTTCACCGAGCAGTTCCAGGTGCTCCT
GCCCAAGGATGCCCAGCCCTGCAGGGAGGTCATCTCCACCCTCCTGGAGAAAATGAAGATAGACAAGAGGAACTACCAGATCGGGAAGAC
CAAGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATCCTGCTGCTGCAGAGCTG
GTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGGCGGTCCTACCGGGTCCG
GAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTCTACCGGCACCAGAAACA
GAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAGAAGCAGAAGGCAGAAGA
GAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGGCAGCAGGTAGCTGAGCA
GGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCCCTAGAGCACTCCTCACC
TGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAAGTCCCCAGCAGCCGGGA
GAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAGGAGGAGAGTGCCCTCAG
AGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGATGAAACCCTTCTAGTCGT
AGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTCTCTGAAGAAACTGAGAA
GACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTCAGCCCACCGGCCCCTGG
CAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGCCCCGGAGGCTCCACGCA
GATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCCGCCGCCAGCCCTAGTGC
CATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAGAGGCGCACCTCCTTCTC
CACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAGCGAAGTGCGAAAAAGCC
AGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTCGACTCTAAATCCACGTT
TAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCAGTGTCCGGGCACGTGGT
GCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAGAAGCGCACCAAGGAACC
AGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCGGTGTTCCGCCAGATCAC
CAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACGCCCATTGAGAGCTTGTT
TATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTGGGCTACAAGGATCTGAT
GGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAACCTCTTCCAGTCACTGCT
AGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAGCGGAAGCAGGAGCGTGC
TGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTCTCCTATATCTGGCTCAT
GGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCACTGCTCCTACACCTACGG
GAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCCTCGGTGCCCATCGTGCT
GGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCCAACCGCACTCGGGAGCT
CCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTGCTGAAGCAGTGGCTGCG
GGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAGCAGGAGCAGCTGGCTGC
CATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTCAAGGTGGCCCTGCTCGA
GGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAACTCGGACCCGCTGACCAG
CATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTGAAGATGGAGGAGATCAG
CCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTCAAACTGGGGTTTTCGTC
TCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTGGAGGAGGAGGCAGCCGG
CGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGGAGGACATCACCTACCGGCTGCCGGA
GCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAGGAGCGGGCCGGGCGGGG
GGCCTCGGAAGGTCAGTATTAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCCCTCCCCACCGTGGCCGC
CCCTCCACGACGAAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCCACGGCCAACATCAAGCT
CCCACCAGGCCTGCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGCCGGGAGCCACCTGCCCG
CCGCCCGGACCAGATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCCCTAGAAGAGGATGGCCA
GCCACCTGGGGCCAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAATGGCTGAGAGCCACAGCT
GACAAAGTCTGCATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGCCCTCAGAGAAGGATCCA
GAATCAAAAGCTCAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGCTGGAGCCAGGCCCCCTC
GCACGCAGCCCCCAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCACTCCCCTTTTTGTACGT
TTAACTGTTTCTTTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTTTATATGTGTATGTACAA
AGTTTTCTATTAACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCACTGCGCGTCTGAGGCTCA
GACCCTGCTGTGGTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCACCTGACCCGTGCCTCTCT
GACACATGTCTCCGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTCTGGGCTATTGGCTGGAG
CCAGGACATGAGTCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGACGCCAAGGGCTGCAGGA
GGCTGCTTTTGGCACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGAGGGCAACGCCTGAAGTC
AGACCTCCCTATAGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCCACTCCCCCAGACACCTG

>21749_21749_3_DDA1-MYO9B_DDA1_chr19_17426804_ENST00000359866_MYO9B_chr19_17270205_ENST00000595618_length(amino acids)=1677AA_BP=96
MEVTVRRRLRRRLWWRRWRLRRRPRRRRRKQKMADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRY
LHQQWDKKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFE
DFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQH
EDNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLR
AERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLD
SKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIR
RSGYSAKYTFQDFTEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRH
FLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAA
RAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRG
LEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRP
GQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLS
DRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTK
DKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLD
EFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTK
NDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEP
GHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTF
AQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITT
CVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEI

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Fusion Gene PPI Analysis for DDA1-MYO9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMYO9Bchr19:17426804chr19:17270205ENST000003972745391739_1744443.02189.0RHOA
TgeneMYO9Bchr19:17426804chr19:17270205ENST000005956186401739_1744443.02458.6666666666665RHOA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDA1-MYO9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDA1-MYO9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource