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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDT-ACPP (FusionGDB2 ID:21853)

Fusion Gene Summary for DDT-ACPP

check button Fusion gene summary
Fusion gene informationFusion gene name: DDT-ACPP
Fusion gene ID: 21853
HgeneTgene
Gene symbol

DDT

ACPP

Gene ID

100037417

55

Gene nameD-dopachrome tautomerase likeacid phosphatase 3
SynonymsDDT|KB-226F1.25'-NT|ACP-3|ACPP|TM-PAP
Cytomap

22q11.23

3q22.1

Type of geneprotein-codingprotein-coding
DescriptionD-dopachrome decarboxylase-like proteinD-dopachrome decarboxylaseD-dopachrome tautomerase-like proteinPhenylpyruvate tautomerase IIprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000350608, ENST00000398344, 
ENST00000403754, ENST00000404092, 
ENST00000430101, 		ENST00000489084, 
ENST00000336375, ENST00000351273, 
ENST00000475741, 
Fusion gene scores* DoF score10 X 3 X 6=18016 X 8 X 2=256
# samples 1016
** MAII scorelog2(10/180*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/256*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDT [Title/Abstract] AND ACPP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDT(24315957)-ACPP(132075530), # samples:2
Anticipated loss of major functional domain due to fusion event.DDT-ACPP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDT-ACPP seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACPP

GO:0046085

adenosine metabolic process

18940592


check buttonFusion gene breakpoints across DDT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACPP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A7NH-01ADDTchr22

24315957

-ACPPchr3

132075530

+
ChimerDB4PRADTCGA-EJ-A7NHDDTchr22

24315957

-ACPPchr3

132075530

+


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Fusion Gene ORF analysis for DDT-ACPP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000350608ENST00000489084DDTchr22

24315957

-ACPPchr3

132075530

+
5CDS-intronENST00000398344ENST00000489084DDTchr22

24315957

-ACPPchr3

132075530

+
5CDS-intronENST00000403754ENST00000489084DDTchr22

24315957

-ACPPchr3

132075530

+
5CDS-intronENST00000404092ENST00000489084DDTchr22

24315957

-ACPPchr3

132075530

+
5CDS-intronENST00000430101ENST00000489084DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000350608ENST00000336375DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000350608ENST00000351273DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000398344ENST00000336375DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000398344ENST00000475741DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000403754ENST00000336375DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000403754ENST00000475741DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000404092ENST00000336375DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000404092ENST00000351273DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000430101ENST00000336375DDTchr22

24315957

-ACPPchr3

132075530

+
Frame-shiftENST00000430101ENST00000475741DDTchr22

24315957

-ACPPchr3

132075530

+
In-frameENST00000350608ENST00000475741DDTchr22

24315957

-ACPPchr3

132075530

+
In-frameENST00000398344ENST00000351273DDTchr22

24315957

-ACPPchr3

132075530

+
In-frameENST00000403754ENST00000351273DDTchr22

24315957

-ACPPchr3

132075530

+
In-frameENST00000404092ENST00000475741DDTchr22

24315957

-ACPPchr3

132075530

+
In-frameENST00000430101ENST00000351273DDTchr22

24315957

-ACPPchr3

132075530

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398344DDTchr2224315957-ENST00000351273ACPPchr3132075530+1219454116742208
ENST00000350608DDTchr2224315957-ENST00000475741ACPPchr3132075530+734412119604161
ENST00000404092DDTchr2224315957-ENST00000475741ACPPchr3132075530+88155968751227
ENST00000403754DDTchr2224315957-ENST00000351273ACPPchr3132075530+109432936617193
ENST00000430101DDTchr2224315957-ENST00000351273ACPPchr3132075530+109432936617193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398344ENST00000351273DDTchr2224315957-ACPPchr3132075530+0.0269939420.973006
ENST00000350608ENST00000475741DDTchr2224315957-ACPPchr3132075530+0.0212120170.97878796
ENST00000404092ENST00000475741DDTchr2224315957-ACPPchr3132075530+0.0086555030.99134445
ENST00000403754ENST00000351273DDTchr2224315957-ACPPchr3132075530+0.0328224970.9671775
ENST00000430101ENST00000351273DDTchr2224315957-ACPPchr3132075530+0.0328224970.9671775

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Fusion Genomic Features for DDT-ACPP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDTchr2224315956-ACPPchr3132075529+1.26E-060.9999987
DDTchr2224315956-ACPPchr3132075529+1.26E-060.9999987
DDTchr2224315956-ACPPchr3132075529+1.26E-060.9999987
DDTchr2224315956-ACPPchr3132075529+1.26E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDT-ACPP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24315957/chr3:132075530)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DDT-ACPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21853_21853_1_DDT-ACPP_DDT_chr22_24315957_ENST00000350608_ACPP_chr3_132075530_ENST00000475741_length(transcript)=734nt_BP=412nt
GATCCCGGTGCCAGGGACCCTGCCCAGTTCCAGGCGTCGCCCTGACCCAGAAACGACTGGGCGCCGCCGTCCTGGAAAGGCCCCAGCGCA
CGGACATCTGAGGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGG
GGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCA
TGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACA
GCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGC
AGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTC
AAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGGTACTGAAGACAGTACAGATTAGTGTGCACAGAGATCTCTGTAGAAGG
AGTAGCTGCCCTTTCTCAGGGCAGATGATGCTTTGAGAACATACTTTGGCCATTACCCCCAGCTTTGAGGAAAATGGGCTTTGGATGATT

>21853_21853_1_DDT-ACPP_DDT_chr22_24315957_ENST00000350608_ACPP_chr3_132075530_ENST00000475741_length(amino acids)=161AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK

--------------------------------------------------------------
>21853_21853_2_DDT-ACPP_DDT_chr22_24315957_ENST00000398344_ACPP_chr3_132075530_ENST00000351273_length(transcript)=1219nt_BP=454nt
GTTTGCAGAAGCGGGAGGTACCCTAGGCAGCCAATCGGGGAGCGCCGAGTCTCTGTCCAGCCAATGAGAAGCCAGGTTGCTGTGGCGCCT
CGCCCCTCCTCCCTGGTCCGCGAGCCTTGGGTACCCCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCC
TGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAAC
CTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCT
CCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGG
ACCGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTC
CTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGTTCTAA
AGGTCATCTTTGCTGTTGCCTTTTGCCTGATATCTGCTGTCCTAATGGTACTACTGTTTATCCACATTCGCCGTGGACTCTGCTGGCAGA
GAGAATCCTATGGGAACATCTGAACAGACAGCTGGATAAGCCAGGCCAACCTCCTGTGACACAGCATCTCTCAGTGGTGCCGCATCTAAA
GGACAGGCTTTTGCCATGTGGGCATTGCCATCCTCACACCCTGCCTTTTGAATCTGCCCAGAGCAGGGTCTGAACTCACAGTGACCCACA
GGCTGCTGCTGGATGAACACTCAGGCTACCTAGGTCTTCTCATAATGGAGTGGTAGTGCAGGCTGCTTGTTCAGCTAGAAAGAGGCTGTT
ATGCATAGGATGGTTGTATTCTCTGCCACAGTTGTCCGGAGAGAAATAAGAAGCCAAACTCCAATCAGCCTTTTACCTGCAAAGAGTGAA
GGGTGAGAAGGTGGACAAAGACATAGATTAGAAAAATACTGGATATTGGGGGAAGTTAGACTAGAAGTATTATTATACAGGGTGATTCTT

>21853_21853_2_DDT-ACPP_DDT_chr22_24315957_ENST00000398344_ACPP_chr3_132075530_ENST00000351273_length(amino acids)=208AA_BP=112
MGTPSFSSARAVSVPLPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAE
DNRSHSAHFFEFLTKELALGQDREYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQVLKVIFAVAFC

--------------------------------------------------------------
>21853_21853_3_DDT-ACPP_DDT_chr22_24315957_ENST00000403754_ACPP_chr3_132075530_ENST00000351273_length(transcript)=1094nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGGAGTACTTTGTGGAGATGTACTATCGGAAT
GAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTG
ATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGTTCTAAAGGTCATCTTTGCTGTTGCCTTTTGCCTGATATCT
GCTGTCCTAATGGTACTACTGTTTATCCACATTCGCCGTGGACTCTGCTGGCAGAGAGAATCCTATGGGAACATCTGAACAGACAGCTGG
ATAAGCCAGGCCAACCTCCTGTGACACAGCATCTCTCAGTGGTGCCGCATCTAAAGGACAGGCTTTTGCCATGTGGGCATTGCCATCCTC
ACACCCTGCCTTTTGAATCTGCCCAGAGCAGGGTCTGAACTCACAGTGACCCACAGGCTGCTGCTGGATGAACACTCAGGCTACCTAGGT
CTTCTCATAATGGAGTGGTAGTGCAGGCTGCTTGTTCAGCTAGAAAGAGGCTGTTATGCATAGGATGGTTGTATTCTCTGCCACAGTTGT
CCGGAGAGAAATAAGAAGCCAAACTCCAATCAGCCTTTTACCTGCAAAGAGTGAAGGGTGAGAAGGTGGACAAAGACATAGATTAGAAAA
ATACTGGATATTGGGGGAAGTTAGACTAGAAGTATTATTATACAGGGTGATTCTTACGAAAGAAGACCCAATCATAAATTATAAATAAAC

>21853_21853_3_DDT-ACPP_DDT_chr22_24315957_ENST00000403754_ACPP_chr3_132075530_ENST00000351273_length(amino acids)=193AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDREYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQVLKVIFAVAFCLISAVLMVLLFIHIR

--------------------------------------------------------------
>21853_21853_4_DDT-ACPP_DDT_chr22_24315957_ENST00000404092_ACPP_chr3_132075530_ENST00000475741_length(transcript)=881nt_BP=559nt
ATCCCTTCAAGGCCACTCAGTCCACAGCATTCTCTGGTGGCAGACGCTGCAGGAGGAGCCCATCAGTGCTGGCTGCTGAGTCTTTGAAAG
CGGACCCACGGTGGCAGCATGGTGCCCAACACGTGGAGGCTGCAGTGCGGGAGGACCTCTTCCAGGAGGCCCTCCCAGCTGTCCTGAAGG
CCAAGGACCTGCCTCCAGTAGAACCTGCTGTTAAAGAGAATCTGAAGACCTTAATGCAGCTTTTCTTGCTAGCTGTTTCCGTTCCTCTGC
CCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCT
CCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGC
AGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGC
TAGCCCTGGGCCAGGACCGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCT
GCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACA
GCCATCAAGGTACTGAAGACAGTACAGATTAGTGTGCACAGAGATCTCTGTAGAAGGAGTAGCTGCCCTTTCTCAGGGCAGATGATGCTT

>21853_21853_4_DDT-ACPP_DDT_chr22_24315957_ENST00000404092_ACPP_chr3_132075530_ENST00000475741_length(amino acids)=227AA_BP=163
MAAESLKADPRWQHGAQHVEAAVREDLFQEALPAVLKAKDLPPVEPAVKENLKTLMQLFLLAVSVPLPAMPFLELDTNLPANRVPAGLEK
RLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDREYFVEMYYRNETQHEP

--------------------------------------------------------------
>21853_21853_5_DDT-ACPP_DDT_chr22_24315957_ENST00000430101_ACPP_chr3_132075530_ENST00000351273_length(transcript)=1094nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGGAGTACTTTGTGGAGATGTACTATCGGAAT
GAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTG
ATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGTTCTAAAGGTCATCTTTGCTGTTGCCTTTTGCCTGATATCT
GCTGTCCTAATGGTACTACTGTTTATCCACATTCGCCGTGGACTCTGCTGGCAGAGAGAATCCTATGGGAACATCTGAACAGACAGCTGG
ATAAGCCAGGCCAACCTCCTGTGACACAGCATCTCTCAGTGGTGCCGCATCTAAAGGACAGGCTTTTGCCATGTGGGCATTGCCATCCTC
ACACCCTGCCTTTTGAATCTGCCCAGAGCAGGGTCTGAACTCACAGTGACCCACAGGCTGCTGCTGGATGAACACTCAGGCTACCTAGGT
CTTCTCATAATGGAGTGGTAGTGCAGGCTGCTTGTTCAGCTAGAAAGAGGCTGTTATGCATAGGATGGTTGTATTCTCTGCCACAGTTGT
CCGGAGAGAAATAAGAAGCCAAACTCCAATCAGCCTTTTACCTGCAAAGAGTGAAGGGTGAGAAGGTGGACAAAGACATAGATTAGAAAA
ATACTGGATATTGGGGGAAGTTAGACTAGAAGTATTATTATACAGGGTGATTCTTACGAAAGAAGACCCAATCATAAATTATAAATAAAC

>21853_21853_5_DDT-ACPP_DDT_chr22_24315957_ENST00000430101_ACPP_chr3_132075530_ENST00000351273_length(amino acids)=193AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDREYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQVLKVIFAVAFCLISAVLMVLLFIHIR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDT-ACPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDT-ACPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDT-ACPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource