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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DDT-SEC13 (FusionGDB2 ID:21872)

Fusion Gene Summary for DDT-SEC13

Fusion gene summary

Fusion gene information	Fusion gene name: DDT-SEC13
	Fusion gene ID: 21872
		Hgene	Tgene
	Gene symbol	DDT	SEC13
	Gene ID	100037417	6396
	Gene name	D-dopachrome tautomerase like	SEC13 homolog, nuclear pore and COPII coat complex component
	Synonyms	DDT\|KB-226F1.2	D3S1231E\|SEC13L1\|SEC13R\|npp-20
	Cytomap	22q11.23	3p25.3
	Type of gene	protein-coding	protein-coding
	Description	D-dopachrome decarboxylase-like proteinD-dopachrome decarboxylaseD-dopachrome tautomerase-like proteinPhenylpyruvate tautomerase II	protein SEC13 homologGATOR complex protein SEC13SEC13 homolog, nuclear pore and COPII coating complex componentSEC13-like 1 isoformSEC13-like protein 1SEC13-related protein
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000350608, ENST00000398344, ENST00000403754, ENST00000404092, ENST00000430101,	ENST00000383801, ENST00000397117, ENST00000492602, ENST00000337354, ENST00000350697, ENST00000397109,
Fusion gene scores	* DoF score	10 X 3 X 6=180	9 X 8 X 4=288
	# samples	10	8
	** MAII score	log2(10/180*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DDT [Title/Abstract] AND SEC13 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DDT(24315957)-SEC13(10343058), # samples:2
Anticipated loss of major functional domain due to fusion event.	DDT-SEC13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DDT-SEC13 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. DDT-SEC13 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SEC13	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Fusion gene breakpoints across DDT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-PG-A915-01A	DDT	chr22	24315957	-	SEC13	chr3	10343058	-

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Fusion Gene ORF analysis for DDT-SEC13

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000350608	ENST00000383801	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000350608	ENST00000397117	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000350608	ENST00000492602	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000398344	ENST00000383801	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000398344	ENST00000397117	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000398344	ENST00000492602	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000403754	ENST00000383801	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000403754	ENST00000397117	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000403754	ENST00000492602	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000404092	ENST00000383801	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000404092	ENST00000397117	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000404092	ENST00000492602	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000430101	ENST00000383801	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000430101	ENST00000397117	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
5CDS-intron	ENST00000430101	ENST00000492602	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000350608	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000350608	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000350608	ENST00000397109	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000398344	ENST00000397109	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000403754	ENST00000397109	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000404092	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000404092	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000404092	ENST00000397109	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
Frame-shift	ENST00000430101	ENST00000397109	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000398344	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000398344	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000403754	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000403754	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000430101	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-
In-frame	ENST00000430101	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398344	DDT	chr22	24315957	-	ENST00000337354	SEC13	chr3	10343058	-	898	454	429	22	135
ENST00000398344	DDT	chr22	24315957	-	ENST00000350697	SEC13	chr3	10343058	-	898	454	429	22	135
ENST00000403754	DDT	chr22	24315957	-	ENST00000337354	SEC13	chr3	10343058	-	773	329	304	2	101
ENST00000403754	DDT	chr22	24315957	-	ENST00000350697	SEC13	chr3	10343058	-	773	329	304	2	101
ENST00000430101	DDT	chr22	24315957	-	ENST00000337354	SEC13	chr3	10343058	-	773	329	304	2	101
ENST00000430101	DDT	chr22	24315957	-	ENST00000350697	SEC13	chr3	10343058	-	773	329	304	2	101

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398344	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13637851	0.86362153
ENST00000398344	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13637851	0.86362153
ENST00000403754	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13239491	0.8676051
ENST00000403754	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13239491	0.8676051
ENST00000430101	ENST00000337354	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13239491	0.8676051
ENST00000430101	ENST00000350697	DDT	chr22	24315957	-	SEC13	chr3	10343058	-	0.13239491	0.8676051

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Fusion Genomic Features for DDT-SEC13

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDT-SEC13

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24315957/chr3:10343058)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

101_144

288

326.0

Repeat

Note=WD 3

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

11_50

288

326.0

Repeat

Note=WD 1

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

148_204

288

326.0

Repeat

Note=WD 4

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

210_253

288

326.0

Repeat

Note=WD 5

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

260_299

288

326.0

Repeat

Note=WD 6

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000337354

55_96

288

326.0

Repeat

Note=WD 2

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

101_144

285

323.0

Repeat

Note=WD 3

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

11_50

285

323.0

Repeat

Note=WD 1

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

148_204

285

323.0

Repeat

Note=WD 4

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

210_253

285

323.0

Repeat

Note=WD 5

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

260_299

285

323.0

Repeat

Note=WD 6

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000350697

55_96

285

323.0

Repeat

Note=WD 2

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

101_144

271

309.0

Repeat

Note=WD 3

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

11_50

271

309.0

Repeat

Note=WD 1

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

148_204

271

309.0

Repeat

Note=WD 4

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

210_253

271

309.0

Repeat

Note=WD 5

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

260_299

271

309.0

Repeat

Note=WD 6

Tgene

SEC13

chr22:24315957

chr3:10343058

ENST00000397109

55_96

271

309.0

Repeat

Note=WD 2

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Fusion Gene Sequence for DDT-SEC13

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>21872_21872_1_DDT-SEC13_DDT_chr22_24315957_ENST00000398344_SEC13_chr3_10343058_ENST00000337354_length(transcript)=898nt_BP=454nt
GTTTGCAGAAGCGGGAGGTACCCTAGGCAGCCAATCGGGGAGCGCCGAGTCTCTGTCCAGCCAATGAGAAGCCAGGTTGCTGTGGCGCCT
CGCCCCTCCTCCCTGGTCCGCGAGCCTTGGGTACCCCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCC
TGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAAC
CTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCT
CCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGG
ACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGCAGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGT
GACAGAGGGCCAGCAGAACGAGCAGTGACAAGACAGGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAAC
TAACCAGACAACTGGGAAGAGCCCCCAACTCCAACAGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCT
TAACGTGATCGGAGATGCTTTGTAATCTACTGTCCAGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATT

>21872_21872_1_DDT-SEC13_DDT_chr22_24315957_ENST00000398344_SEC13_chr3_10343058_ENST00000337354_length(amino acids)=135AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------
>21872_21872_2_DDT-SEC13_DDT_chr22_24315957_ENST00000398344_SEC13_chr3_10343058_ENST00000350697_length(transcript)=898nt_BP=454nt
GTTTGCAGAAGCGGGAGGTACCCTAGGCAGCCAATCGGGGAGCGCCGAGTCTCTGTCCAGCCAATGAGAAGCCAGGTTGCTGTGGCGCCT
CGCCCCTCCTCCCTGGTCCGCGAGCCTTGGGTACCCCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCC
TGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAAC
CTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCT
CCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGG
ACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGCAGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGT
GACAGAGGGCCAGCAGAACGAGCAGTGACAAGACAGGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAAC
TAACCAGACAACTGGGAAGAGCCCCCAACTCCAACAGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCT
TAACGTGATCGGAGATGCTTTGTAATCTACTGTCCAGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATT

>21872_21872_2_DDT-SEC13_DDT_chr22_24315957_ENST00000398344_SEC13_chr3_10343058_ENST00000350697_length(amino acids)=135AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------
>21872_21872_3_DDT-SEC13_DDT_chr22_24315957_ENST00000403754_SEC13_chr3_10343058_ENST00000337354_length(transcript)=773nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGC
AGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGTGACAGAGGGCCAGCAGAACGAGCAGTGACAAGACA
GGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAACTAACCAGACAACTGGGAAGAGCCCCCAACTCCAAC
AGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCTTAACGTGATCGGAGATGCTTTGTAATCTACTGTCC
AGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATTTTGGGTCATTTTTATGTACCTTTGGGTTCAGGCAT

>21872_21872_3_DDT-SEC13_DDT_chr22_24315957_ENST00000403754_SEC13_chr3_10343058_ENST00000337354_length(amino acids)=101AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------
>21872_21872_4_DDT-SEC13_DDT_chr22_24315957_ENST00000403754_SEC13_chr3_10343058_ENST00000350697_length(transcript)=773nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGC
AGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGTGACAGAGGGCCAGCAGAACGAGCAGTGACAAGACA
GGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAACTAACCAGACAACTGGGAAGAGCCCCCAACTCCAAC
AGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCTTAACGTGATCGGAGATGCTTTGTAATCTACTGTCC
AGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATTTTGGGTCATTTTTATGTACCTTTGGGTTCAGGCAT

>21872_21872_4_DDT-SEC13_DDT_chr22_24315957_ENST00000403754_SEC13_chr3_10343058_ENST00000350697_length(amino acids)=101AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------
>21872_21872_5_DDT-SEC13_DDT_chr22_24315957_ENST00000430101_SEC13_chr3_10343058_ENST00000337354_length(transcript)=773nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGC
AGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGTGACAGAGGGCCAGCAGAACGAGCAGTGACAAGACA
GGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAACTAACCAGACAACTGGGAAGAGCCCCCAACTCCAAC
AGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCTTAACGTGATCGGAGATGCTTTGTAATCTACTGTCC
AGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATTTTGGGTCATTTTTATGTACCTTTGGGTTCAGGCAT

>21872_21872_5_DDT-SEC13_DDT_chr22_24315957_ENST00000430101_SEC13_chr3_10343058_ENST00000337354_length(amino acids)=101AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------
>21872_21872_6_DDT-SEC13_DDT_chr22_24315957_ENST00000430101_SEC13_chr3_10343058_ENST00000350697_length(transcript)=773nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGTGACCCTGTGGAAGGAGTCAGTTGATGGGC
AGTGGGTGTGCATCAGTGATGTCAACAAGGGCCAGGGCTCCGTATCAGCATCAGTGACAGAGGGCCAGCAGAACGAGCAGTGACAAGACA
GGTGGGGCCTGGCTCCCCACCCGCCAGCTCCAGGACTGCCCCTTCCTGGGCCAACTAACCAGACAACTGGGAAGAGCCCCCAACTCCAAC
AGGATTATTTTCCCAGGAGGAGTTACAGATGCAGCCACAGATTGATCATCTGCCTTAACGTGATCGGAGATGCTTTGTAATCTACTGTCC
AGCTGAAAGCACTCATGTTACGAGGAAGAAACTACAAGTGATGTTCAAATCTATTTTGGGTCATTTTTATGTACCTTTGGGTTCAGGCAT

>21872_21872_6_DDT-SEC13_DDT_chr22_24315957_ENST00000430101_SEC13_chr3_10343058_ENST00000350697_length(amino acids)=101AA_BP=
MVRNSKKWALWLRLSSAVPTTPMEEMDSCAQGSVDPLSAMARPGRTVTFTRSAGLPRMEAAAAQSRFSSPAGTRLAGKFVSSSRNGMAGR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDT-SEC13

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DDT-SEC13

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DDT-SEC13

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source