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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX17-FBLN1 (FusionGDB2 ID:21904)

Fusion Gene Summary for DDX17-FBLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX17-FBLN1
Fusion gene ID: 21904
HgeneTgene
Gene symbol

DDX17

FBLN1

Gene ID

10521

2192

Gene nameDEAD-box helicase 17fibulin 1
SynonymsP72|RH70FBLN|FIBL1
Cytomap

22q13.1

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX17DEAD (Asp-Glu-Ala-Asp) box helicase 17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17DEAD box protein p72DEAD box protein p82DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)RNA-dependent helicase p72fibulin-1
Modification date2020032720200313
UniProtAcc.

P23142

Ensembl transtripts involved in fusion geneENST00000381633, ENST00000396821, 
ENST00000432525, ENST00000444597, 
ENST00000262722, ENST00000327858, 
ENST00000340923, ENST00000348697, 
ENST00000402984, ENST00000442170, 
ENST00000476366, 
Fusion gene scores* DoF score17 X 18 X 8=244822 X 22 X 9=4356
# samples 2027
** MAII scorelog2(20/2448*10)=-3.61353165291793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4356*10)=-4.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX17 [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX17(38901955)-FBLN1(45937108), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX17-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDX17-FBLN1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX17

GO:0045944

positive regulation of transcription by RNA polymerase II

17226766

TgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

TgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

TgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

TgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

TgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

TgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

TgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

TgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726


check buttonFusion gene breakpoints across DDX17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3I6DDX17chr22

38901955

-FBLN1chr22

45937108

+


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Fusion Gene ORF analysis for DDX17-FBLN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381633ENST00000262722DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000381633ENST00000327858DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000381633ENST00000340923DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000381633ENST00000348697DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000381633ENST00000402984DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000381633ENST00000442170DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000262722DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000327858DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000340923DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000348697DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000402984DDX17chr22

38901955

-FBLN1chr22

45937108

+
Frame-shiftENST00000396821ENST00000442170DDX17chr22

38901955

-FBLN1chr22

45937108

+
In-frameENST00000381633ENST00000476366DDX17chr22

38901955

-FBLN1chr22

45937108

+
In-frameENST00000396821ENST00000476366DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000262722DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000327858DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000340923DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000348697DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000402984DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000442170DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000432525ENST00000476366DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000262722DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000327858DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000340923DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000348697DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000402984DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000442170DDX17chr22

38901955

-FBLN1chr22

45937108

+
intron-3CDSENST00000444597ENST00000476366DDX17chr22

38901955

-FBLN1chr22

45937108

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396821DDX17chr2238901955-ENST00000476366FBLN1chr2245937108+12593871761078300
ENST00000381633DDX17chr2238901955-ENST00000476366FBLN1chr2245937108+12623901791081300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396821ENST00000476366DDX17chr2238901955-FBLN1chr2245937108+0.0301303230.9698696
ENST00000381633ENST00000476366DDX17chr2238901955-FBLN1chr2245937108+0.0276140380.97238594

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Fusion Genomic Features for DDX17-FBLN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDX17chr2238901955-FBLN1chr2245937108+2.48E-081
DDX17chr2238901955-FBLN1chr2245937108+2.48E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDX17-FBLN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:38901955/chr22:45937108)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBLN1

P23142

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715308_355307684.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715356_398307684.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715399_440307684.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715441_480307684.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715481_524307684.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715525_578307684.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717308_355307704.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717356_398307704.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717399_440307704.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717441_480307704.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717481_524307704.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717525_578307704.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715308_355307567.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715356_398307567.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715399_440307567.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715441_480307567.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715481_524307567.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715525_578307567.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715356_440307684.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717356_440307704.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715356_440307567.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715112_144307684.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715176_215307684.0DomainEGF-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715216_261307684.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000262722715262_307307684.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST0000026272271536_76307684.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST0000026272271577_111307684.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717112_144307704.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717176_215307704.0DomainEGF-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717216_261307704.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000327858717262_307307704.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST0000032785871736_76307704.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST0000032785871777_111307704.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715112_144307567.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715176_215307567.0DomainEGF-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715216_261307567.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST00000340923715262_307307567.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:38901955chr22:45937108ENST0000034092371536_76307567.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:38901955chr22:45937108ENST0000034092371577_111307567.0DomainAnaphylatoxin-like 2


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Fusion Gene Sequence for DDX17-FBLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21904_21904_1_DDX17-FBLN1_DDX17_chr22_38901955_ENST00000381633_FBLN1_chr22_45937108_ENST00000476366_length(transcript)=1262nt_BP=390nt
GTTAAGTTGGAGCCGACTCAGCGGCGGCCGCCATTTTGTGCAGTCGCTGGGAAGGAAGGAGACGCCTAAACCGCGGCACTGCCCGGTTTG
AGCGTAGCCAAACCTGCCCACCGGCTTTGTAGCCCCGATTCTCTGTGTTTTGCTCCCGTCTCCGACGAGAGAGGCGGCGACGGTGGCGTC
TGCGACGGGAGACAGCGCGTCGGAGCGAGAGAGCGCTGCGCCTGCCGCCGCCCCAACAGCGGAGGCGCCGCCGCCATCGGTCGTCACCAG
ACCGGAGCCGCAGGCCCTCCCGAGCCCGGCCATCCGTGCCCCGCTCCCAGATCTCTATCCTTTTGGGACCATGCGCGGAGGAGGCTTTGG
GGACCGGGACCGGGATCGTGACCGTGGAGGATATCAATGAGTGTTTGAGTATCAGTGCCCCGTGCCCTATCGGGCATACATGCATCAACA
CAGAGGGCTCCTACACGTGCCAGAAGAACGTGCCCAACTGTGGCCGTGGCTACCATCTCAACGAGGAGGGAACGCGCTGTGTTGATGTGG
ACGAGTGCGCGCCACCTGCTGAGCCCTGTGGGAAGGGACATCGCTGCGTGAACTCTCCCGGCAGTTTCCGCTGCGAATGCAAGACGGGTT
ACTATTTTGACGGCATCAGCAGGATGTGTGTCGATGTCAACGAGTGCCAGCGCTACCCCGGGCGCCTGTGTGGCCACAAGTGCGAGAACA
CGCTGGGCTCCTACCTCTGCAGCTGTTCCGTGGGCTTCCGGCTCTCTGTGGATGGCAGGTCATGTGAAGACATCAATGAGTGCAGCAGCA
GCCCCTGTAGCCAGGAGTGTGCCAACGTCTACGGCTCCTACCAGTGTTACTGCCGGCGAGGCTACCAGCTCAGCGATGTGGATGGAGTCA
CCTGTGAAGACATTGATGAGTGTGTGACTGGCATCCACAACTGCTCCATCAACGAGACCTGCTTCAACATCCAGGGCGGCTTCCGCTGCC
TGGCCTTCGAGTGCCCTGAGAACTACCGCCGCTCCGCAGCCACGGTGGAAGCCTTGGGCAAGCTCTCTGGGCCTCAGTTTCCTCATCTGT
AACATGCAGATGTCAGAACGTGCTCTGACTGAGATGCATAGGTAGCAATGTCTCCATGTCAGCCCAAAGCCAGGGAGCCGATGTGACCTG
TTGGACGTTGTTGTTAGGTGCCCACCTGAAAGCCAGAATTCGTCCAGCCTGGTGACCGTGTGGGAACGGCATCAAAGATTCCAGATCCTA

>21904_21904_1_DDX17-FBLN1_DDX17_chr22_38901955_ENST00000381633_FBLN1_chr22_45937108_ENST00000476366_length(amino acids)=300AA_BP=70
MRRETARRSERALRLPPPQQRRRRRHRSSPDRSRRPSRARPSVPRSQISILLGPCAEEALGTGTGIVTVEDINECLSISAPCPIGHTCIN
TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN
TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECVTGIHNCSINETCFNIQGGFRC

--------------------------------------------------------------
>21904_21904_2_DDX17-FBLN1_DDX17_chr22_38901955_ENST00000396821_FBLN1_chr22_45937108_ENST00000476366_length(transcript)=1259nt_BP=387nt
AAGTTGGAGCCGACTCAGCGGCGGCCGCCATTTTGTGCAGTCGCTGGGAAGGAAGGAGACGCCTAAACCGCGGCACTGCCCGGTTTGAGC
GTAGCCAAACCTGCCCACCGGCTTTGTAGCCCCGATTCTCTGTGTTTTGCTCCCGTCTCCGACGAGAGAGGCGGCGACGGTGGCGTCTGC
GACGGGAGACAGCGCGTCGGAGCGAGAGAGCGCTGCGCCTGCCGCCGCCCCAACAGCGGAGGCGCCGCCGCCATCGGTCGTCACCAGACC
GGAGCCGCAGGCCCTCCCGAGCCCGGCCATCCGTGCCCCGCTCCCAGATCTCTATCCTTTTGGGACCATGCGCGGAGGAGGCTTTGGGGA
CCGGGACCGGGATCGTGACCGTGGAGGATATCAATGAGTGTTTGAGTATCAGTGCCCCGTGCCCTATCGGGCATACATGCATCAACACAG
AGGGCTCCTACACGTGCCAGAAGAACGTGCCCAACTGTGGCCGTGGCTACCATCTCAACGAGGAGGGAACGCGCTGTGTTGATGTGGACG
AGTGCGCGCCACCTGCTGAGCCCTGTGGGAAGGGACATCGCTGCGTGAACTCTCCCGGCAGTTTCCGCTGCGAATGCAAGACGGGTTACT
ATTTTGACGGCATCAGCAGGATGTGTGTCGATGTCAACGAGTGCCAGCGCTACCCCGGGCGCCTGTGTGGCCACAAGTGCGAGAACACGC
TGGGCTCCTACCTCTGCAGCTGTTCCGTGGGCTTCCGGCTCTCTGTGGATGGCAGGTCATGTGAAGACATCAATGAGTGCAGCAGCAGCC
CCTGTAGCCAGGAGTGTGCCAACGTCTACGGCTCCTACCAGTGTTACTGCCGGCGAGGCTACCAGCTCAGCGATGTGGATGGAGTCACCT
GTGAAGACATTGATGAGTGTGTGACTGGCATCCACAACTGCTCCATCAACGAGACCTGCTTCAACATCCAGGGCGGCTTCCGCTGCCTGG
CCTTCGAGTGCCCTGAGAACTACCGCCGCTCCGCAGCCACGGTGGAAGCCTTGGGCAAGCTCTCTGGGCCTCAGTTTCCTCATCTGTAAC
ATGCAGATGTCAGAACGTGCTCTGACTGAGATGCATAGGTAGCAATGTCTCCATGTCAGCCCAAAGCCAGGGAGCCGATGTGACCTGTTG

>21904_21904_2_DDX17-FBLN1_DDX17_chr22_38901955_ENST00000396821_FBLN1_chr22_45937108_ENST00000476366_length(amino acids)=300AA_BP=70
MRRETARRSERALRLPPPQQRRRRRHRSSPDRSRRPSRARPSVPRSQISILLGPCAEEALGTGTGIVTVEDINECLSISAPCPIGHTCIN
TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN
TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECVTGIHNCSINETCFNIQGGFRC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDX17-FBLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX17-FBLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX17-FBLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource