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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX19A-IL15RA (FusionGDB2 ID:21916)

Fusion Gene Summary for DDX19A-IL15RA

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX19A-IL15RA
Fusion gene ID: 21916
HgeneTgene
Gene symbol

DDX19A

IL15RA

Gene ID

55308

3601

Gene nameDEAD-box helicase 19Ainterleukin 15 receptor subunit alpha
SynonymsDDX19-DDX19L|DDX19LCD215
Cytomap

16q22.1

10p15.1

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX19ADDX19-like proteinDEAD (Asp-Glu-Ala-As) box polypeptide 19ADEAD (Asp-Glu-Ala-Asp) box polypeptide 19ADEAD box protein 19ARNA helicaseinterleukin-15 receptor subunit alphainterleukin 15 receptor alpha isoform EM2interleukin 15 receptor alpha isoform IC2interleukin 15 receptor alpha isoform IC3interleukin 15 receptor alpha isoform IC4interleukin 15 receptor alpha isoform IC5interle
Modification date2020031320200320
UniProtAcc

Q9NUU7

Q13261

Ensembl transtripts involved in fusion geneENST00000302243, ENST00000417604, 
ENST00000443119, ENST00000562509, 
ENST00000379971, ENST00000379977, 
ENST00000397248, ENST00000397250, 
ENST00000397251, ENST00000397255, 
ENST00000525219, ENST00000528354, 
ENST00000530685, ENST00000534292, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: DDX19A [Title/Abstract] AND IL15RA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX19A(70399034)-IL15RA(6010891), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX19A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL15RA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14V-01ADDX19Achr16

70399034

+IL15RAchr10

6010891

-


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Fusion Gene ORF analysis for DDX19A-IL15RA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302243ENST00000379971DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000379977DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000397248DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000397250DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000397251DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000397255DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000525219DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000528354DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000530685DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000302243ENST00000534292DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000379971DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000379977DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000397248DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000397250DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000397251DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000397255DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000525219DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000528354DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000530685DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000417604ENST00000534292DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000379971DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000379977DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000397248DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000397250DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000397251DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000397255DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000525219DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000528354DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000530685DDX19Achr16

70399034

+IL15RAchr10

6010891

-
5CDS-intronENST00000443119ENST00000534292DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000379971DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000379977DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000397248DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000397250DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000397251DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000397255DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000525219DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000528354DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000530685DDX19Achr16

70399034

+IL15RAchr10

6010891

-
intron-intronENST00000562509ENST00000534292DDX19Achr16

70399034

+IL15RAchr10

6010891

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DDX19A-IL15RA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDX19A-IL15RA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:70399034/:6010891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX19A

Q9NUU7

IL15RA

Q13261

FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}.FUNCTION: High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). {ECO:0000250|UniProtKB:Q60819, ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:8530383}.; FUNCTION: [Isoform 5]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 6]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 7]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 8]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DDX19A-IL15RA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DDX19A-IL15RA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX19A-IL15RA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX19A-IL15RA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource