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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX39A-EMR3 (FusionGDB2 ID:21968)

Fusion Gene Summary for DDX39A-EMR3

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX39A-EMR3
Fusion gene ID: 21968
HgeneTgene
Gene symbol

DDX39A

EMR3

Gene ID

10212

84658

Gene nameDExD-box helicase 39Aadhesion G protein-coupled receptor E3
SynonymsBAT1|BAT1L|DDX39|DDXL|URH49EMR3
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX39ADEAD (Asp-Glu-Ala-Asp) box polypeptide 39DEAD (Asp-Glu-Ala-Asp) box polypeptide 39ADEAD box protein 39DEAD-box helicase 39ADEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39UAP56-related helicase, 49 kDanuclear RNA heladhesion G protein-coupled receptor E3EGF-like module receptor 3EGF-like module-containing mucin-like hormone receptor-like 3egf-like module containing, mucin-like, hormone receptor-like 3egf-like module-containing mucin-like receptor 3
Modification date2020031320200313
UniProtAcc

O00148

.
Ensembl transtripts involved in fusion geneENST00000242776, ENST00000454233, 
ENST00000592927, 		ENST00000253673, 
ENST00000344373, ENST00000599900, 
ENST00000595472, ENST00000443157, 
Fusion gene scores* DoF score5 X 7 X 4=1403 X 3 X 2=18
# samples 64
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DDX39A [Title/Abstract] AND EMR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX39A(14523824)-EMR3(14762016), # samples:1
DDX39A(14523825)-EMR3(14762016), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX39A-EMR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX39A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EMR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2033-01ADDX39Achr19

14523825

-EMR3chr19

14762016

-
ChimerDB4OVTCGA-24-2033DDX39Achr19

14523824

-EMR3chr19

14762016

-


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Fusion Gene ORF analysis for DDX39A-EMR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000242776ENST00000253673DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000242776ENST00000253673DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-5UTRENST00000242776ENST00000344373DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000242776ENST00000344373DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-5UTRENST00000242776ENST00000599900DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000242776ENST00000599900DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000253673DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000253673DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000344373DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000344373DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000599900DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-5UTRENST00000454233ENST00000599900DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-intronENST00000242776ENST00000595472DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-intronENST00000242776ENST00000595472DDX39Achr19

14523824

-EMR3chr19

14762016

-
5CDS-intronENST00000454233ENST00000595472DDX39Achr19

14523825

-EMR3chr19

14762016

-
5CDS-intronENST00000454233ENST00000595472DDX39Achr19

14523824

-EMR3chr19

14762016

-
Frame-shiftENST00000454233ENST00000443157DDX39Achr19

14523825

-EMR3chr19

14762016

-
Frame-shiftENST00000454233ENST00000443157DDX39Achr19

14523824

-EMR3chr19

14762016

-
In-frameENST00000242776ENST00000443157DDX39Achr19

14523825

-EMR3chr19

14762016

-
In-frameENST00000242776ENST00000443157DDX39Achr19

14523824

-EMR3chr19

14762016

-
intron-3CDSENST00000592927ENST00000443157DDX39Achr19

14523825

-EMR3chr19

14762016

-
intron-3CDSENST00000592927ENST00000443157DDX39Achr19

14523824

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000253673DDX39Achr19

14523825

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000253673DDX39Achr19

14523824

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000344373DDX39Achr19

14523825

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000344373DDX39Achr19

14523824

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000599900DDX39Achr19

14523825

-EMR3chr19

14762016

-
intron-5UTRENST00000592927ENST00000599900DDX39Achr19

14523824

-EMR3chr19

14762016

-
intron-intronENST00000592927ENST00000595472DDX39Achr19

14523825

-EMR3chr19

14762016

-
intron-intronENST00000592927ENST00000595472DDX39Achr19

14523824

-EMR3chr19

14762016

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242776DDX39Achr1914523824-ENST00000443157EMR3chr1914762016-20083101021691529
ENST00000242776DDX39Achr1914523825-ENST00000443157EMR3chr1914762016-20083101021691529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242776ENST00000443157DDX39Achr1914523824-EMR3chr1914762016-0.0094544210.99054563
ENST00000242776ENST00000443157DDX39Achr1914523825-EMR3chr1914762016-0.0094544210.99054563

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Fusion Genomic Features for DDX39A-EMR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDX39A-EMR3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14523824/chr19:14762016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX39A

O00148

.
FUNCTION: [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-21115_1869428.0Compositional biasNote=Poly-Glu
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-21115_1869428.0Compositional biasNote=Poly-Glu
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-21144_7269428.0MotifNote=Q motif
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-21144_7269428.0MotifNote=Q motif
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516301_350192653.0DomainGPS
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415301_350140601.0DomainGPS
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516301_350192653.0DomainGPS
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415301_350140601.0DomainGPS
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516379_389192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516411_416192653.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516438_464192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516486_508192653.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516530_557192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516579_580192653.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516602_652192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415379_389140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415411_416140601.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415438_464140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415486_508140601.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415530_557140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415579_580140601.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415602_652140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516379_389192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516411_416192653.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516438_464192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516486_508192653.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516530_557192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516579_580192653.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516602_652192653.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415379_389140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415411_416140601.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415438_464140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415486_508140601.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415530_557140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415579_580140601.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415602_652140601.0Topological domainCytoplasmic
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516358_378192653.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516390_410192653.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516417_437192653.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516465_485192653.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516509_529192653.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516558_578192653.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14523824chr19:14762016ENST00000253673516581_601192653.0TransmembraneHelical%3B Name%3D7
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415358_378140601.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415390_410140601.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415417_437140601.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415465_485140601.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415509_529140601.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415558_578140601.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14523824chr19:14762016ENST00000344373415581_601140601.0TransmembraneHelical%3B Name%3D7
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516358_378192653.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516390_410192653.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516417_437192653.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516465_485192653.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516509_529192653.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516558_578192653.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14523825chr19:14762016ENST00000253673516581_601192653.0TransmembraneHelical%3B Name%3D7
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415358_378140601.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415390_410140601.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415417_437140601.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415465_485140601.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415509_529140601.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415558_578140601.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14523825chr19:14762016ENST00000344373415581_601140601.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-211260_42169428.0DomainHelicase C-terminal
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-21175_24869428.0DomainHelicase ATP-binding
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-211260_42169428.0DomainHelicase C-terminal
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-21175_24869428.0DomainHelicase ATP-binding
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-211195_19869428.0MotifNote=DECD box
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-211195_19869428.0MotifNote=DECD box
HgeneDDX39Achr19:14523824chr19:14762016ENST00000242776-21188_9569428.0Nucleotide bindingATP
HgeneDDX39Achr19:14523825chr19:14762016ENST00000242776-21188_9569428.0Nucleotide bindingATP
TgeneEMR3chr19:14523824chr19:14762016ENST0000025367351624_66192653.0DomainEGF-like 1
TgeneEMR3chr19:14523824chr19:14762016ENST0000034437341524_66140601.0DomainEGF-like 1
TgeneEMR3chr19:14523825chr19:14762016ENST0000025367351624_66192653.0DomainEGF-like 1
TgeneEMR3chr19:14523825chr19:14762016ENST0000034437341524_66140601.0DomainEGF-like 1
TgeneEMR3chr19:14523824chr19:14762016ENST0000025367351622_357192653.0Topological domainExtracellular
TgeneEMR3chr19:14523824chr19:14762016ENST0000034437341522_357140601.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST0000025367351622_357192653.0Topological domainExtracellular
TgeneEMR3chr19:14523825chr19:14762016ENST0000034437341522_357140601.0Topological domainExtracellular


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Fusion Gene Sequence for DDX39A-EMR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21968_21968_1_DDX39A-EMR3_DDX39A_chr19_14523824_ENST00000242776_EMR3_chr19_14762016_ENST00000443157_length(transcript)=2008nt_BP=310nt
AAGAGGCAGGAAGCGCAGCAACTCGTGTCTGAGCGCCCGGCGGAAAACCGAAGTTGGAAGTGTCTCTTAGCAGCGCGCGGAGAAGAACGG
GGAGCCAGCATCATGGCAGAACAGGATGTGGAAAACGATCTTTTGGATTACGATGAAGAGGAAGAGCCCCAGGCTCCTCAAGAGAGCACA
CCAGCTCCCCCTAAGAAAGACATCAAGGGATCCTACGTTTCCATCCACAGCTCTGGCTTCCGGGACTTTCTGCTGAAGCCGGAGCTCCTG
CGGGCCATCGTGGACTGTGGCTTTGAGCATCCTTCTGAGGCTATTGAAACTCAAGCGATTACAGACAATTGCTCTGAAGAAAGAAAGACA
TTCAACTTGAACGTCCAAATGAACTCAATGGACATCCGTTGCAGTGACATCATCCAGGGAGACACACAAGGTCCCAGTGCCATTGCCTTT
ATCTCATATTCTTCTCTTGGAAACATCATAAATGCAACTTTTTTTGAAGAGATGGATAAGAAAGATCAAGTGTATCTGAACTCTCAGGTT
GTGAGTGCTGCTATTGGACCCAAAAGGAACGTGTCTCTCTCCAAGTCTGTGACGCTGACTTTCCAGCACGTGAAGATGACCCCCAGTACC
AAAAAGGTCTTCTGTGTCTACTGGAAGAGCACAGGGCAGGGCAGCCAGTGGTCCAGGGATGGCTGCTTCCTGATACACGTGAACAAGAGT
CACACCATGTGTAATTGCAGTCACCTGTCCAGCTTCGCTGTCCTGATGGCCCTGACCAGCCAGGAGGAGGATCCCGTGCTGACTGTCATC
ACCTACGTGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCATCCGGAACACCAGCACC
TCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGTGGGGATTGATCGAACTGAACCCAAGGTGCTGTGC
TCCATCATCGCCGGTGCTTTGCACTATCTCTACCTGGCCGCCTTCACCTGGATGCTGCTGGAGGGTGTGCACCTCTTCCTCACTGCACGG
AACCTGACAGTGGTCAACTACTCAAGCATCAATAGACTCATGAAGTGGATCATGTTCCCAGTCGGCTATGGCGTTCCCGCTGTGACTGTG
GCCATTTCTGCAGCCTCCTGGCCTCACCTTTATGGAACTGCTGATCGATGCTGGCTCCACCTGGACCAGGGATTCATGTGGAGTTTCCTT
GGCCCAGTCTGTGCCATTTTCTCTGCGAATTTAGTATTGTTTATCTTGGTCTTTTGGATTTTGAAAAGAAAACTTTCCTCCCTCAATAGT
GAAGTGTCAACCATCCAGAACACAAGGATGCTGGCTTTCAAAGCAACAGCTCAGCTCTTCATCCTGGGCTGCACATGGTGTCTGGGCTTG
CTACAGGTGGGTCCAGCTGCCCAGGTCATGGCCTACCTCTTCACCATCATCAACAGCCTCCAAGGCTTCTTCATCTTCTTGGTCTACTGC
CTCCTCAGCCAGCAGGTCCAGAAACAATATCAAAAGTGGTTTAGAGAGATCGTAAAATCAAAATCTGAGTCTGAGACATACACACTTTCC
AGCAAGATGGGTCCTGACTCAAAACCCAGTGAGGGGGATGTTTTTCCAGGACAAGTGAAGAGAAAATATTAAAACTAGAATATTCAACTC
CATATGGAAAATCATATCCATGGATCTCTTTGGCATTATGAAGAATGAAGCTAAGGAAAAGGGAATTCATTAAACATATCATCCTTGGAG
AGGAAGTAATCAACCTTTACTTCCCAAGCTGTTTGTTCTCCACAATAGGCTCTCAACAAATGTGTGGTAAATTGCATTTCTCTTCACTAT
GGTGTATTCAGTCAATGCTTGTCCCTGGAAACCCAAAGCATGACCACTGCAAATATTTCCTTGACTTTTTGTAAATGAAGAGGTCCTTTT

>21968_21968_1_DDX39A-EMR3_DDX39A_chr19_14523824_ENST00000242776_EMR3_chr19_14762016_ENST00000443157_length(amino acids)=529AA_BP=62
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEAIETQAITDNCSEERKTFNLN
VQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTKKVF
CVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHL
QLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISA
ASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTWCLGLLQVG

--------------------------------------------------------------
>21968_21968_2_DDX39A-EMR3_DDX39A_chr19_14523825_ENST00000242776_EMR3_chr19_14762016_ENST00000443157_length(transcript)=2008nt_BP=310nt
AAGAGGCAGGAAGCGCAGCAACTCGTGTCTGAGCGCCCGGCGGAAAACCGAAGTTGGAAGTGTCTCTTAGCAGCGCGCGGAGAAGAACGG
GGAGCCAGCATCATGGCAGAACAGGATGTGGAAAACGATCTTTTGGATTACGATGAAGAGGAAGAGCCCCAGGCTCCTCAAGAGAGCACA
CCAGCTCCCCCTAAGAAAGACATCAAGGGATCCTACGTTTCCATCCACAGCTCTGGCTTCCGGGACTTTCTGCTGAAGCCGGAGCTCCTG
CGGGCCATCGTGGACTGTGGCTTTGAGCATCCTTCTGAGGCTATTGAAACTCAAGCGATTACAGACAATTGCTCTGAAGAAAGAAAGACA
TTCAACTTGAACGTCCAAATGAACTCAATGGACATCCGTTGCAGTGACATCATCCAGGGAGACACACAAGGTCCCAGTGCCATTGCCTTT
ATCTCATATTCTTCTCTTGGAAACATCATAAATGCAACTTTTTTTGAAGAGATGGATAAGAAAGATCAAGTGTATCTGAACTCTCAGGTT
GTGAGTGCTGCTATTGGACCCAAAAGGAACGTGTCTCTCTCCAAGTCTGTGACGCTGACTTTCCAGCACGTGAAGATGACCCCCAGTACC
AAAAAGGTCTTCTGTGTCTACTGGAAGAGCACAGGGCAGGGCAGCCAGTGGTCCAGGGATGGCTGCTTCCTGATACACGTGAACAAGAGT
CACACCATGTGTAATTGCAGTCACCTGTCCAGCTTCGCTGTCCTGATGGCCCTGACCAGCCAGGAGGAGGATCCCGTGCTGACTGTCATC
ACCTACGTGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCATCCGGAACACCAGCACC
TCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGTGGGGATTGATCGAACTGAACCCAAGGTGCTGTGC
TCCATCATCGCCGGTGCTTTGCACTATCTCTACCTGGCCGCCTTCACCTGGATGCTGCTGGAGGGTGTGCACCTCTTCCTCACTGCACGG
AACCTGACAGTGGTCAACTACTCAAGCATCAATAGACTCATGAAGTGGATCATGTTCCCAGTCGGCTATGGCGTTCCCGCTGTGACTGTG
GCCATTTCTGCAGCCTCCTGGCCTCACCTTTATGGAACTGCTGATCGATGCTGGCTCCACCTGGACCAGGGATTCATGTGGAGTTTCCTT
GGCCCAGTCTGTGCCATTTTCTCTGCGAATTTAGTATTGTTTATCTTGGTCTTTTGGATTTTGAAAAGAAAACTTTCCTCCCTCAATAGT
GAAGTGTCAACCATCCAGAACACAAGGATGCTGGCTTTCAAAGCAACAGCTCAGCTCTTCATCCTGGGCTGCACATGGTGTCTGGGCTTG
CTACAGGTGGGTCCAGCTGCCCAGGTCATGGCCTACCTCTTCACCATCATCAACAGCCTCCAAGGCTTCTTCATCTTCTTGGTCTACTGC
CTCCTCAGCCAGCAGGTCCAGAAACAATATCAAAAGTGGTTTAGAGAGATCGTAAAATCAAAATCTGAGTCTGAGACATACACACTTTCC
AGCAAGATGGGTCCTGACTCAAAACCCAGTGAGGGGGATGTTTTTCCAGGACAAGTGAAGAGAAAATATTAAAACTAGAATATTCAACTC
CATATGGAAAATCATATCCATGGATCTCTTTGGCATTATGAAGAATGAAGCTAAGGAAAAGGGAATTCATTAAACATATCATCCTTGGAG
AGGAAGTAATCAACCTTTACTTCCCAAGCTGTTTGTTCTCCACAATAGGCTCTCAACAAATGTGTGGTAAATTGCATTTCTCTTCACTAT
GGTGTATTCAGTCAATGCTTGTCCCTGGAAACCCAAAGCATGACCACTGCAAATATTTCCTTGACTTTTTGTAAATGAAGAGGTCCTTTT

>21968_21968_2_DDX39A-EMR3_DDX39A_chr19_14523825_ENST00000242776_EMR3_chr19_14762016_ENST00000443157_length(amino acids)=529AA_BP=62
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEAIETQAITDNCSEERKTFNLN
VQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTKKVF
CVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHL
QLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISA
ASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTWCLGLLQVG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDX39A-EMR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX39A-EMR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX39A-EMR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource