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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:DDX41-MBP (FusionGDB2 ID:21995)

Fusion Gene Summary for DDX41-MBP

Fusion gene summary

Fusion gene information	Fusion gene name: DDX41-MBP
	Fusion gene ID: 21995
		Hgene	Tgene
	Gene symbol	DDX41	MBP
	Gene ID	51428	5553
	Gene name	DEAD-box helicase 41	proteoglycan 2, pro eosinophil major basic protein
	Synonyms	ABS\|MPLPF	BMPG\|MBP\|MBP1\|proMBP
	Cytomap	5q35.3	11q12.1
	Type of gene	protein-coding	protein-coding
	Description	probable ATP-dependent RNA helicase DDX41DEAD (Asp-Glu-Ala-Asp) box polypeptide 41DEAD box protein 41DEAD box protein abstrakt homologDEAD-box protein abstraktputative RNA helicase	bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
	Modification date	20200320	20200313
	UniProtAcc	Q9UJV9	P02686
	Ensembl transtripts involved in fusion gene	ENST00000507955, ENST00000506965,	ENST00000354542, ENST00000359645, ENST00000397860, ENST00000397863, ENST00000397869, ENST00000487778, ENST00000526111, ENST00000527041, ENST00000528160, ENST00000578193, ENST00000579129, ENST00000580402, ENST00000355994, ENST00000382582, ENST00000397865, ENST00000397866, ENST00000397875,
Fusion gene scores	* DoF score	2 X 2 X 1=4	32 X 27 X 4=3456
	# samples	2	32
	** MAII score	log2(2/4*10)=2.32192809488736	log2(32/3456*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DDX41 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DDX41(176943725)-MBP(74696851), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DDX41 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DA267742	DDX41	chr5	176943725	-	MBP	chr18	74696851	-

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Fusion Gene ORF analysis for DDX41-MBP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000507955	ENST00000354542	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000359645	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000397860	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000397863	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000397869	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000487778	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000526111	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000527041	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000528160	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000578193	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000579129	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5CDS-intron	ENST00000507955	ENST00000580402	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-3CDS	ENST00000506965	ENST00000355994	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-3CDS	ENST00000506965	ENST00000382582	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-3CDS	ENST00000506965	ENST00000397865	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-3CDS	ENST00000506965	ENST00000397866	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-3CDS	ENST00000506965	ENST00000397875	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000354542	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000359645	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000397860	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000397863	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000397869	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000487778	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000526111	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000527041	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000528160	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000578193	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000579129	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
5UTR-intron	ENST00000506965	ENST00000580402	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
In-frame	ENST00000507955	ENST00000355994	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
In-frame	ENST00000507955	ENST00000382582	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
In-frame	ENST00000507955	ENST00000397865	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
In-frame	ENST00000507955	ENST00000397866	DDX41	chr5	176943725	-	MBP	chr18	74696851	-
In-frame	ENST00000507955	ENST00000397875	DDX41	chr5	176943725	-	MBP	chr18	74696851	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000507955	DDX41	chr5	176943725	-	ENST00000382582	MBP	chr18	74696851	-	2427	662	348	866	172
ENST00000507955	DDX41	chr5	176943725	-	ENST00000355994	MBP	chr18	74696851	-	2420	662	348	866	172
ENST00000507955	DDX41	chr5	176943725	-	ENST00000397875	MBP	chr18	74696851	-	2402	662	348	866	172
ENST00000507955	DDX41	chr5	176943725	-	ENST00000397866	MBP	chr18	74696851	-	2402	662	348	866	172
ENST00000507955	DDX41	chr5	176943725	-	ENST00000397865	MBP	chr18	74696851	-	2393	662	348	866	172

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000507955	ENST00000382582	DDX41	chr5	176943725	-	MBP	chr18	74696851	-	0.47791666	0.5220833
ENST00000507955	ENST00000355994	DDX41	chr5	176943725	-	MBP	chr18	74696851	-	0.49108613	0.5089139
ENST00000507955	ENST00000397875	DDX41	chr5	176943725	-	MBP	chr18	74696851	-	0.47035113	0.5296489
ENST00000507955	ENST00000397866	DDX41	chr5	176943725	-	MBP	chr18	74696851	-	0.47035113	0.5296489
ENST00000507955	ENST00000397865	DDX41	chr5	176943725	-	MBP	chr18	74696851	-	0.44928318	0.5507168

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Fusion Genomic Features for DDX41-MBP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDX41-MBP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176943725/chr18:74696851)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DDX41 Q9UJV9	MBP P02686
FUNCTION: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. {ECO:0000269\|PubMed:25920683}.	FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269\|PubMed:8544862}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000359645

179_222

132

187.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000359645

246_256

132

187.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000382582

179_222

143

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000382582

246_256

143

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397860

179_222

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397860

246_256

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397863

179_222

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397863

246_256

198.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397865

179_222

106

161.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397865

246_256

106

161.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397866

179_222

117

172.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000397866

246_256

117

172.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

212_396

623.0

Domain

Helicase ATP-binding

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

407_567

623.0

Domain

Helicase C-terminal

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

181_209

623.0

Motif

Q motif

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

344_347

623.0

Motif

DEAD box

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

225_232

623.0

Nucleotide binding

ATP

Hgene

DDX41

chr5:176943725

chr18:74696851

ENST00000507955

580_597

623.0

Zinc finger

Note=CCHC-type

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000355994

179_222

250

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000355994

246_256

250

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000580402

179_222

250

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 1

Tgene

MBP

chr5:176943725

chr18:74696851

ENST00000580402

246_256

250

305.0

Region

Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

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Fusion Gene Sequence for DDX41-MBP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>21995_21995_1_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000355994_length(transcript)=2420nt_BP=662nt
ACACAGGCGCAGTCAGGGAGGCAGGGTGTGTCGAGCGGTTTATCCCGCAACCCCGGCGTCCCCGGCAGGGATGAAAGCGCAGGGCCCACG
CGAACTCGGCCCGCAGCTCCCGGCCCTAGAGGACGCACTGTCCGCCGGCAGGGGCGTGCCCAAGACGCCATGCTCTGGGAGAGGTTGGGC
ACCTGGCAGGCCGCCCCGACTCCGGATCAGCTGTCTCCGCTGCGTACGTCTTCCTCTTCCAATGGGCTTGGATTGAGCCTTCTAGCGCAT
ATTCCAAGTCCTCCAATGTCCCACAATGCCTTGCAGCCGGTTTCGCCCTCGGTCCTGGCAACTGTCGCGTAACCACCCATGAAAGCGTCC
ATGCCTCGCCGTGCGATAGTATCTCCGGAACAAATTTGTCCCTCTGCGCGATCCGGAACTCCGAGGTCGTTCCTACGCGCCGTCGTTCGC
CTCTTCACATCGGATTGGGTCTCACGCAAGGATGAGGCGGGGTTTCGCCGTGGCGCGCATGCGTGCAGCAAAGAATGGAGGAGTCGGAAC
CCGAACGGAAGCGGGCTCGCACCGACGAGGTGCCTGCCGGAGGAAGCCGCTCCGAGGCGGAAGATGAGGACGACGAGGACTACGTGCCCT
ATGTGCCGTTACGGCAGCGCCGGCAGCTACTGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAAT
CGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCAC
CCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCACTTGCC
CCTGTTACCTAATTAGAGCAGATGACCCCTCCCCTAATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAA
TTTCCGGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCCCCCGCAA
TGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGC
CGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCATGGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGAC
TGTTGACATCCAAGCTTCCTTTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGT
CAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTCCAACGTGGGGCAGCACAGAGAG
GGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGC
TGGGCAATGGCCTCACATAGGAAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCC
CTGCATGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAGGAAGACTTGCGCACTC
AGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCCATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGC
AGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAG
GCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTCTGACCATATC
CTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCTGTGATTGATAGG
CCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGAGGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCC
AATTCTAATTCTGAATGTTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAAACTC
CAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCGATCCATACGTGGCCGCACCCACAC

>21995_21995_1_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000355994_length(amino acids)=172AA_BP=105
MKASMPRRAIVSPEQICPSARSGTPRSFLRAVVRLFTSDWVSRKDEAGFRRGAHACSKEWRSRNPNGSGLAPTRCLPEEAAPRRKMRTTR

--------------------------------------------------------------
>21995_21995_2_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000382582_length(transcript)=2427nt_BP=662nt
ACACAGGCGCAGTCAGGGAGGCAGGGTGTGTCGAGCGGTTTATCCCGCAACCCCGGCGTCCCCGGCAGGGATGAAAGCGCAGGGCCCACG
CGAACTCGGCCCGCAGCTCCCGGCCCTAGAGGACGCACTGTCCGCCGGCAGGGGCGTGCCCAAGACGCCATGCTCTGGGAGAGGTTGGGC
ACCTGGCAGGCCGCCCCGACTCCGGATCAGCTGTCTCCGCTGCGTACGTCTTCCTCTTCCAATGGGCTTGGATTGAGCCTTCTAGCGCAT
ATTCCAAGTCCTCCAATGTCCCACAATGCCTTGCAGCCGGTTTCGCCCTCGGTCCTGGCAACTGTCGCGTAACCACCCATGAAAGCGTCC
ATGCCTCGCCGTGCGATAGTATCTCCGGAACAAATTTGTCCCTCTGCGCGATCCGGAACTCCGAGGTCGTTCCTACGCGCCGTCGTTCGC
CTCTTCACATCGGATTGGGTCTCACGCAAGGATGAGGCGGGGTTTCGCCGTGGCGCGCATGCGTGCAGCAAAGAATGGAGGAGTCGGAAC
CCGAACGGAAGCGGGCTCGCACCGACGAGGTGCCTGCCGGAGGAAGCCGCTCCGAGGCGGAAGATGAGGACGACGAGGACTACGTGCCCT
ATGTGCCGTTACGGCAGCGCCGGCAGCTACTGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAAT
CGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCAC
CCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCACTTGCC
CCTGTTACCTAATTAGAGCAGATGACCCCTCCCCTAATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAA
TTTCCGGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCCCCCGCAA
TGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGC
CGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCATGGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGAC
TGTTGACATCCAAGCTTCCTTTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGT
CAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTCCAACGTGGGGCAGCACAGAGAG
GGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGC
TGGGCAATGGCCTCACATAGGAAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCC
CTGCATGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAGGAAGACTTGCGCACTC
AGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCCATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGC
AGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAG
GCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTCTGACCATATC
CTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCTGTGATTGATAGG
CCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGAGGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCC
AATTCTAATTCTGAATGTTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAAACTC
CAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCGATCCATACGTGGCCGCACCCACAC

>21995_21995_2_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000382582_length(amino acids)=172AA_BP=105
MKASMPRRAIVSPEQICPSARSGTPRSFLRAVVRLFTSDWVSRKDEAGFRRGAHACSKEWRSRNPNGSGLAPTRCLPEEAAPRRKMRTTR

--------------------------------------------------------------
>21995_21995_3_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397865_length(transcript)=2393nt_BP=662nt
ACACAGGCGCAGTCAGGGAGGCAGGGTGTGTCGAGCGGTTTATCCCGCAACCCCGGCGTCCCCGGCAGGGATGAAAGCGCAGGGCCCACG
CGAACTCGGCCCGCAGCTCCCGGCCCTAGAGGACGCACTGTCCGCCGGCAGGGGCGTGCCCAAGACGCCATGCTCTGGGAGAGGTTGGGC
ACCTGGCAGGCCGCCCCGACTCCGGATCAGCTGTCTCCGCTGCGTACGTCTTCCTCTTCCAATGGGCTTGGATTGAGCCTTCTAGCGCAT
ATTCCAAGTCCTCCAATGTCCCACAATGCCTTGCAGCCGGTTTCGCCCTCGGTCCTGGCAACTGTCGCGTAACCACCCATGAAAGCGTCC
ATGCCTCGCCGTGCGATAGTATCTCCGGAACAAATTTGTCCCTCTGCGCGATCCGGAACTCCGAGGTCGTTCCTACGCGCCGTCGTTCGC
CTCTTCACATCGGATTGGGTCTCACGCAAGGATGAGGCGGGGTTTCGCCGTGGCGCGCATGCGTGCAGCAAAGAATGGAGGAGTCGGAAC
CCGAACGGAAGCGGGCTCGCACCGACGAGGTGCCTGCCGGAGGAAGCCGCTCCGAGGCGGAAGATGAGGACGACGAGGACTACGTGCCCT
ATGTGCCGTTACGGCAGCGCCGGCAGCTACTGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAAT
CGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCAC
CCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCACTTGCC
CCTGTTACCTAATTAGAGCAGATGACCCCTCCCCTAATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAA
TTTCCGGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCCCCCGCAA
TGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGC
CGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCATGGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGAC
TGTTGACATCCAAGCTTCCTTTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGT
CAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTCCAACGTGGGGCAGCACAGAGAG
GGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGC
TGGGCAATGGCCTCACATAGGAAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCC
CTGCATGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAGGAAGACTTGCGCACTC
AGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCCATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGC
AGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAG
GCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTCTGACCATATC
CTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCTGTGATTGATAGG
CCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGAGGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCC
AATTCTAATTCTGAATGTTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAAACTC
CAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCGATCCATACGTGGCCGCACCCACAC

>21995_21995_3_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397865_length(amino acids)=172AA_BP=105
MKASMPRRAIVSPEQICPSARSGTPRSFLRAVVRLFTSDWVSRKDEAGFRRGAHACSKEWRSRNPNGSGLAPTRCLPEEAAPRRKMRTTR

--------------------------------------------------------------
>21995_21995_4_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397866_length(transcript)=2402nt_BP=662nt
ACACAGGCGCAGTCAGGGAGGCAGGGTGTGTCGAGCGGTTTATCCCGCAACCCCGGCGTCCCCGGCAGGGATGAAAGCGCAGGGCCCACG
CGAACTCGGCCCGCAGCTCCCGGCCCTAGAGGACGCACTGTCCGCCGGCAGGGGCGTGCCCAAGACGCCATGCTCTGGGAGAGGTTGGGC
ACCTGGCAGGCCGCCCCGACTCCGGATCAGCTGTCTCCGCTGCGTACGTCTTCCTCTTCCAATGGGCTTGGATTGAGCCTTCTAGCGCAT
ATTCCAAGTCCTCCAATGTCCCACAATGCCTTGCAGCCGGTTTCGCCCTCGGTCCTGGCAACTGTCGCGTAACCACCCATGAAAGCGTCC
ATGCCTCGCCGTGCGATAGTATCTCCGGAACAAATTTGTCCCTCTGCGCGATCCGGAACTCCGAGGTCGTTCCTACGCGCCGTCGTTCGC
CTCTTCACATCGGATTGGGTCTCACGCAAGGATGAGGCGGGGTTTCGCCGTGGCGCGCATGCGTGCAGCAAAGAATGGAGGAGTCGGAAC
CCGAACGGAAGCGGGCTCGCACCGACGAGGTGCCTGCCGGAGGAAGCCGCTCCGAGGCGGAAGATGAGGACGACGAGGACTACGTGCCCT
ATGTGCCGTTACGGCAGCGCCGGCAGCTACTGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAAT
CGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCAC
CCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCACTTGCC
CCTGTTACCTAATTAGAGCAGATGACCCCTCCCCTAATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAA
TTTCCGGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCCCCCGCAA
TGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGC
CGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCATGGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGAC
TGTTGACATCCAAGCTTCCTTTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGT
CAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTCCAACGTGGGGCAGCACAGAGAG
GGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGC
TGGGCAATGGCCTCACATAGGAAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCC
CTGCATGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAGGAAGACTTGCGCACTC
AGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCCATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGC
AGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAG
GCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTCTGACCATATC
CTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCTGTGATTGATAGG
CCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGAGGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCC
AATTCTAATTCTGAATGTTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAAACTC
CAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCGATCCATACGTGGCCGCACCCACAC

>21995_21995_4_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397866_length(amino acids)=172AA_BP=105
MKASMPRRAIVSPEQICPSARSGTPRSFLRAVVRLFTSDWVSRKDEAGFRRGAHACSKEWRSRNPNGSGLAPTRCLPEEAAPRRKMRTTR

--------------------------------------------------------------
>21995_21995_5_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397875_length(transcript)=2402nt_BP=662nt
ACACAGGCGCAGTCAGGGAGGCAGGGTGTGTCGAGCGGTTTATCCCGCAACCCCGGCGTCCCCGGCAGGGATGAAAGCGCAGGGCCCACG
CGAACTCGGCCCGCAGCTCCCGGCCCTAGAGGACGCACTGTCCGCCGGCAGGGGCGTGCCCAAGACGCCATGCTCTGGGAGAGGTTGGGC
ACCTGGCAGGCCGCCCCGACTCCGGATCAGCTGTCTCCGCTGCGTACGTCTTCCTCTTCCAATGGGCTTGGATTGAGCCTTCTAGCGCAT
ATTCCAAGTCCTCCAATGTCCCACAATGCCTTGCAGCCGGTTTCGCCCTCGGTCCTGGCAACTGTCGCGTAACCACCCATGAAAGCGTCC
ATGCCTCGCCGTGCGATAGTATCTCCGGAACAAATTTGTCCCTCTGCGCGATCCGGAACTCCGAGGTCGTTCCTACGCGCCGTCGTTCGC
CTCTTCACATCGGATTGGGTCTCACGCAAGGATGAGGCGGGGTTTCGCCGTGGCGCGCATGCGTGCAGCAAAGAATGGAGGAGTCGGAAC
CCGAACGGAAGCGGGCTCGCACCGACGAGGTGCCTGCCGGAGGAAGCCGCTCCGAGGCGGAAGATGAGGACGACGAGGACTACGTGCCCT
ATGTGCCGTTACGGCAGCGCCGGCAGCTACTGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGAGCGTCCGACTATAAAT
CGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTTTCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCAC
CCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTAATATAACTGCCTTAAAACTTTAATCCCACTTGCC
CCTGTTACCTAATTAGAGCAGATGACCCCTCCCCTAATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAA
TTTCCGGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCCCCCGCAA
TGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCACCCCTCCACCCTTGGACTTTCTTTTCGC
CGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCATGGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGAC
TGTTGACATCCAAGCTTCCTTTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAGT
CAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTCCAACGTGGGGCAGCACAGAGAG
GGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTGAATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGC
TGGGCAATGGCCTCACATAGGAAACAGGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCC
CTGCATGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAGGAAGACTTGCGCACTC
AGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCCATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGC
AGTGCACAGTGGCCAGCACTAACCCTCCCTGAGAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAG
GCGTGCACCTGCTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTCTGACCATATC
CTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACCTTTTGATTTTAGCGCACCTGTGATTGATAGG
CCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGAGGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCC
AATTCTAATTCTGAATGTTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAAACTC
CAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGCGATCCATACGTGGCCGCACCCACAC

>21995_21995_5_DDX41-MBP_DDX41_chr5_176943725_ENST00000507955_MBP_chr18_74696851_ENST00000397875_length(amino acids)=172AA_BP=105
MKASMPRRAIVSPEQICPSARSGTPRSFLRAVVRLFTSDWVSRKDEAGFRRGAHACSKEWRSRNPNGSGLAPTRCLPEEAAPRRKMRTTR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DDX41-MBP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DDX41-MBP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DDX41-MBP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source