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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX52-MRPL48 (FusionGDB2 ID:22042)

Fusion Gene Summary for DDX52-MRPL48

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX52-MRPL48
Fusion gene ID: 22042
HgeneTgene
Gene symbol

DDX52

MRPL48

Gene ID

11056

51642

Gene nameDExD-box helicase 52mitochondrial ribosomal protein L48
SynonymsHUSSY19|ROK1CGI-118|HSPC290|L48MT|MRP-L48
Cytomap

17q12

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52DEAD box protein 52DEAD-box helicase 5239S ribosomal protein L48, mitochondrialmitochondrial large ribosomal subunit protein mL48
Modification date2020031320200313
UniProtAcc

Q9Y2R4

Q96GC5

Ensembl transtripts involved in fusion geneENST00000349699, ENST00000394367, 
ENST00000314282, ENST00000398483, 
ENST00000411840, ENST00000542303, 
ENST00000310614, ENST00000535529, 
Fusion gene scores* DoF score12 X 16 X 5=96013 X 10 X 8=1040
# samples 1416
** MAII scorelog2(14/960*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX52 [Title/Abstract] AND MRPL48 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX52(35990060)-MRPL48(73555852), # samples:1
DDX52(35990060)-MRPL48(73536753), # samples:1
DDX52(35992143)-MRPL48(73536753), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX52-MRPL48 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDX52-MRPL48 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX52 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPL48 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SM-01ADDX52chr17

35990060

-MRPL48chr11

73536753

+
ChimerDB4BRCATCGA-A1-A0SM-01ADDX52chr17

35990060

-MRPL48chr11

73555852

+
ChimerDB4BRCATCGA-A1-A0SM-01ADDX52chr17

35992143

-MRPL48chr11

73536753

+


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Fusion Gene ORF analysis for DDX52-MRPL48

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000349699ENST00000314282DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000349699ENST00000398483DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000349699ENST00000398483DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000349699ENST00000398483DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000349699ENST00000411840DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000349699ENST00000411840DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000349699ENST00000411840DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000349699ENST00000542303DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000349699ENST00000542303DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000314282DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000394367ENST00000398483DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000398483DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000394367ENST00000398483DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000411840DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000411840DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-5UTRENST00000394367ENST00000411840DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000542303DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000394367ENST00000542303DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-intronENST00000349699ENST00000314282DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-intronENST00000349699ENST00000314282DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-intronENST00000349699ENST00000542303DDX52chr17

35990060

-MRPL48chr11

73555852

+
5CDS-intronENST00000394367ENST00000314282DDX52chr17

35990060

-MRPL48chr11

73536753

+
5CDS-intronENST00000394367ENST00000314282DDX52chr17

35992143

-MRPL48chr11

73536753

+
5CDS-intronENST00000394367ENST00000542303DDX52chr17

35990060

-MRPL48chr11

73555852

+
Frame-shiftENST00000349699ENST00000310614DDX52chr17

35990060

-MRPL48chr11

73536753

+
Frame-shiftENST00000349699ENST00000310614DDX52chr17

35992143

-MRPL48chr11

73536753

+
Frame-shiftENST00000349699ENST00000535529DDX52chr17

35990060

-MRPL48chr11

73536753

+
Frame-shiftENST00000349699ENST00000535529DDX52chr17

35992143

-MRPL48chr11

73536753

+
Frame-shiftENST00000394367ENST00000310614DDX52chr17

35990060

-MRPL48chr11

73536753

+
Frame-shiftENST00000394367ENST00000310614DDX52chr17

35992143

-MRPL48chr11

73536753

+
Frame-shiftENST00000394367ENST00000535529DDX52chr17

35990060

-MRPL48chr11

73536753

+
Frame-shiftENST00000394367ENST00000535529DDX52chr17

35992143

-MRPL48chr11

73536753

+
In-frameENST00000349699ENST00000310614DDX52chr17

35990060

-MRPL48chr11

73555852

+
In-frameENST00000349699ENST00000535529DDX52chr17

35990060

-MRPL48chr11

73555852

+
In-frameENST00000394367ENST00000310614DDX52chr17

35990060

-MRPL48chr11

73555852

+
In-frameENST00000394367ENST00000535529DDX52chr17

35990060

-MRPL48chr11

73555852

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000349699DDX52chr1735990060-ENST00000310614MRPL48chr1173555852+1470791441228394
ENST00000349699DDX52chr1735990060-ENST00000535529MRPL48chr1173555852+1992791441228394
ENST00000394367DDX52chr1735990060-ENST00000310614MRPL48chr1173555852+15799003871337316
ENST00000394367DDX52chr1735990060-ENST00000535529MRPL48chr1173555852+21019003871337316

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000349699ENST00000310614DDX52chr1735990060-MRPL48chr1173555852+0.0014361840.9985638
ENST00000349699ENST00000535529DDX52chr1735990060-MRPL48chr1173555852+0.0015958790.9984041
ENST00000394367ENST00000310614DDX52chr1735990060-MRPL48chr1173555852+0.0011531880.99884677
ENST00000394367ENST00000535529DDX52chr1735990060-MRPL48chr1173555852+0.0015439330.9984561

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Fusion Genomic Features for DDX52-MRPL48


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDX52chr1735990059-MRPL48chr1173536752+8.56E-080.9999999
DDX52chr1735990059-MRPL48chr1173555851+4.38E-121
DDX52chr1735992142-MRPL48chr1173536752+2.74E-081
DDX52chr1735990059-MRPL48chr1173536752+8.56E-080.9999999
DDX52chr1735990059-MRPL48chr1173555851+4.38E-121
DDX52chr1735992142-MRPL48chr1173536752+2.74E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDX52-MRPL48


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35990060/chr11:73555852)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX52

Q9Y2R4

MRPL48

Q96GC5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515165_193249600.0MotifNote=Q motif
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515209_216249600.0Nucleotide bindingNote=ATP
TgeneMRPL48chr17:35990060chr11:73555852ENST000003106143869_7467213.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515543_592249600.0Compositional biasNote=Lys-rich
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515196_374249600.0DomainHelicase ATP-binding
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515385_546249600.0DomainHelicase C-terminal
HgeneDDX52chr17:35990060chr11:73555852ENST00000349699-515318_321249600.0MotifNote=DEAD box


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Fusion Gene Sequence for DDX52-MRPL48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22042_22042_1_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000349699_MRPL48_chr11_73555852_ENST00000310614_length(transcript)=1470nt_BP=791nt
AGTCTGCGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAAT
TCGACACGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGAC
TGGACTTTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAG
AGAGCCTAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAAATTGCTTCCCAAGAAGAAGGTGCTACTA
TACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCCGGAAAGTTGGAGAATCTCA
GAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCAATTGCTACATTTCAGCAAC
TTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACGCCAATCCAAATGCAAGCCA
TCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTTAGCATTCCTATTTTAATGC
AGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAGCCCAAGAAGAAGAAGGGAA
AAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATGGGGTTTTAAATATTCATCTGACTGCATATGATATGACCCTGGCAG
AGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCATTAAAGTCGAGGAAAGTTATGCAATGCCAACCAAAACCATAGAAG
TGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAGTGCTTACCACCCATGAGCGAGTGGTTCAGATCAGCGGTTTGAGTG
CTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTCCTGAAGGAGTCAGACTGTCAGTGAAGGAGCACACTGAAGAAGACT
TCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGGCCAAGTTGAAGTAGCTACTGTAGACCCTTTCATGCCAGCAGTGGT
CATATTGAGTGCCAAAGAGAAGAGCTTACTGGGTAGTTAGAGTTCATCAGGAGACCCAACCCTTAGATTTCATAAGTACCCATTCCCATA
GCCAGTAATGTCCTCACTCCTCTGTGGCTTGGCTGTACTTGCCATTTCTTACCACTTACCTATGAGGTAATGCTTGTTATCTTCCATCTA

>22042_22042_1_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000349699_MRPL48_chr11_73555852_ENST00000310614_length(amino acids)=394AA_BP=248
MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKR
KTMTSEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNI
LDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQPKKKKGKVEVRAINLGTDYEY
GVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSL

--------------------------------------------------------------
>22042_22042_2_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000349699_MRPL48_chr11_73555852_ENST00000535529_length(transcript)=1992nt_BP=791nt
AGTCTGCGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAAT
TCGACACGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGAC
TGGACTTTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAG
AGAGCCTAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAAATTGCTTCCCAAGAAGAAGGTGCTACTA
TACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCCGGAAAGTTGGAGAATCTCA
GAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCAATTGCTACATTTCAGCAAC
TTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACGCCAATCCAAATGCAAGCCA
TCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTTAGCATTCCTATTTTAATGC
AGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAGCCCAAGAAGAAGAAGGGAA
AAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATGGGGTTTTAAATATTCATCTGACTGCATATGATATGACCCTGGCAG
AGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCATTAAAGTCGAGGAAAGTTATGCAATGCCAACCAAAACCATAGAAG
TGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAGTGCTTACCACCCATGAGCGAGTGGTTCAGATCAGCGGTTTGAGTG
CTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTCCTGAAGGAGTCAGACTGTCAGTGAAGGAGCACACTGAAGAAGACT
TCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGGCCAAGTTGAAGTAGCTACTGTAGACCCTTTCATGCCAGCAGTGGT
CATATTGAGTGCCAAAGAGAAGAGCTTACTGGGTAGTTAGAGTTCATCAGGAGACCCAACCCTTAGATTTCATAAGTACCCATTCCCATA
GCCAGTAATGTCCTCACTCCTCTGTGGCTTGGCTGTACTTGCCATTTCTTACCACTTACCTATGAGGTAATGCTTGTTATCTTCCATCTA
ATAAAAATCTGCTGCAGATGTGTATATGTATGTGTGTGTGAGAGAGAGAAATTGGCCCATCCTGTGGAGTATCTTTAAGAGATTCTATAT
TCTGGCCAGGCACCGTGGTGCATCCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCAGGAGGACTGCTCGAGGCCAGGAGCTTGAGACCA
GCCTGGCAACATTCTGTCTTTACCAAAAACATTCTTTTTTTTTTTTCCGAAACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGG
CACGATCTAGACTCACTGCAAGCTCTGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCGCCCG
CCACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTTACCATGTTAGCCAAGATGGTCTCGATCTCCTGACCTCGTGAT
CCGCCAGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCAAACTTTTTATTTTAATTAGCTGGACGTGGT

>22042_22042_2_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000349699_MRPL48_chr11_73555852_ENST00000535529_length(amino acids)=394AA_BP=248
MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKR
KTMTSEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNI
LDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQPKKKKGKVEVRAINLGTDYEY
GVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSL

--------------------------------------------------------------
>22042_22042_3_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000394367_MRPL48_chr11_73555852_ENST00000310614_length(transcript)=1579nt_BP=900nt
CGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAATTCGACA
CGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGACTGGACT
TTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAGAGAGCC
TAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAGACAGGGTTTCACCATGTTAGCCAGTATGGTCTCG
ATCTCCTGACCTCGTGATTCACCCACCTTGGGCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACGCCCAGCCAGAAATTGCTTCC
CAAGAAGAAGGTGCTACTATACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCC
GGAAAGTTGGAGAATCTCAGAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCA
ATTGCTACATTTCAGCAACTTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACG
CCAATCCAAATGCAAGCCATCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTT
AGCATTCCTATTTTAATGCAGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAG
CCCAAGAAGAAGAAGGGAAAAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATGGGGTTTTAAATATTCATCTGACTGCA
TATGATATGACCCTGGCAGAGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCATTAAAGTCGAGGAAAGTTATGCAATG
CCAACCAAAACCATAGAAGTGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAGTGCTTACCACCCATGAGCGAGTGGTT
CAGATCAGCGGTTTGAGTGCTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTCCTGAAGGAGTCAGACTGTCAGTGAAG
GAGCACACTGAAGAAGACTTCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGGCCAAGTTGAAGTAGCTACTGTAGACC
CTTTCATGCCAGCAGTGGTCATATTGAGTGCCAAAGAGAAGAGCTTACTGGGTAGTTAGAGTTCATCAGGAGACCCAACCCTTAGATTTC
ATAAGTACCCATTCCCATAGCCAGTAATGTCCTCACTCCTCTGTGGCTTGGCTGTACTTGCCATTTCTTACCACTTACCTATGAGGTAAT

>22042_22042_3_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000394367_MRPL48_chr11_73555852_ENST00000310614_length(amino acids)=316AA_BP=2
MGSQSAGITDVSHHAQPEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQ
EYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQPKKKKGKVE
VRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATF

--------------------------------------------------------------
>22042_22042_4_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000394367_MRPL48_chr11_73555852_ENST00000535529_length(transcript)=2101nt_BP=900nt
CGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAATTCGACA
CGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGACTGGACT
TTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAGAGAGCC
TAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAGACAGGGTTTCACCATGTTAGCCAGTATGGTCTCG
ATCTCCTGACCTCGTGATTCACCCACCTTGGGCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACGCCCAGCCAGAAATTGCTTCC
CAAGAAGAAGGTGCTACTATACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCC
GGAAAGTTGGAGAATCTCAGAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCA
ATTGCTACATTTCAGCAACTTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACG
CCAATCCAAATGCAAGCCATCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTT
AGCATTCCTATTTTAATGCAGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAG
CCCAAGAAGAAGAAGGGAAAAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATGGGGTTTTAAATATTCATCTGACTGCA
TATGATATGACCCTGGCAGAGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCATTAAAGTCGAGGAAAGTTATGCAATG
CCAACCAAAACCATAGAAGTGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAGTGCTTACCACCCATGAGCGAGTGGTT
CAGATCAGCGGTTTGAGTGCTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTCCTGAAGGAGTCAGACTGTCAGTGAAG
GAGCACACTGAAGAAGACTTCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGGCCAAGTTGAAGTAGCTACTGTAGACC
CTTTCATGCCAGCAGTGGTCATATTGAGTGCCAAAGAGAAGAGCTTACTGGGTAGTTAGAGTTCATCAGGAGACCCAACCCTTAGATTTC
ATAAGTACCCATTCCCATAGCCAGTAATGTCCTCACTCCTCTGTGGCTTGGCTGTACTTGCCATTTCTTACCACTTACCTATGAGGTAAT
GCTTGTTATCTTCCATCTAATAAAAATCTGCTGCAGATGTGTATATGTATGTGTGTGTGAGAGAGAGAAATTGGCCCATCCTGTGGAGTA
TCTTTAAGAGATTCTATATTCTGGCCAGGCACCGTGGTGCATCCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCAGGAGGACTGCTCGA
GGCCAGGAGCTTGAGACCAGCCTGGCAACATTCTGTCTTTACCAAAAACATTCTTTTTTTTTTTTCCGAAACGGAGTCTCGCTCTGTTGC
CCAGGCTGGAGTGCAGTGGCACGATCTAGACTCACTGCAAGCTCTGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAG
CTGGGACTGCAGGCGCCCGCCACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTTACCATGTTAGCCAAGATGGTCTC
GATCTCCTGACCTCGTGATCCGCCAGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCAAACTTTTTATT

>22042_22042_4_DDX52-MRPL48_DDX52_chr17_35990060_ENST00000394367_MRPL48_chr11_73555852_ENST00000535529_length(amino acids)=316AA_BP=2
MGSQSAGITDVSHHAQPEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQ
EYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQPKKKKGKVE
VRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATF

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Fusion Gene PPI Analysis for DDX52-MRPL48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX52-MRPL48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX52-MRPL48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource