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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX5-PRKCB (FusionGDB2 ID:22091)

Fusion Gene Summary for DDX5-PRKCB

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX5-PRKCB
Fusion gene ID: 22091
HgeneTgene
Gene symbol

DDX5

PRKCB

Gene ID

1655

5579

Gene nameDEAD-box helicase 5protein kinase C beta
SynonymsG17P1|HLR1|HUMP68|p68PKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2
Cytomap

17q23.3

16p12.2-p12.1

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA hprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide
Modification date2020031320200313
UniProtAcc

P17844

.
Ensembl transtripts involved in fusion geneENST00000225792, ENST00000450599, 
ENST00000578804, ENST00000580026, 
ENST00000482000, ENST00000498058, 
ENST00000303531, ENST00000321728, 
Fusion gene scores* DoF score33 X 25 X 10=825020 X 15 X 13=3900
# samples 2725
** MAII scorelog2(27/8250*10)=-4.93336280696971
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3900*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX5 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX5(62502192)-PRKCB(24166004), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX5

GO:0000122

negative regulation of transcription by RNA polymerase II

15298701

HgeneDDX5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21343338

HgeneDDX5

GO:0000956

nuclear-transcribed mRNA catabolic process

23788676

TgenePRKCB

GO:0010827

regulation of glucose transmembrane transport

25982116

TgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790


check buttonFusion gene breakpoints across DDX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD683976DDX5chr17

62502192

-PRKCBchr16

24166004

+


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Fusion Gene ORF analysis for DDX5-PRKCB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000225792ENST00000482000DDX5chr17

62502192

-PRKCBchr16

24166004

+
5CDS-intronENST00000225792ENST00000498058DDX5chr17

62502192

-PRKCBchr16

24166004

+
5CDS-intronENST00000450599ENST00000482000DDX5chr17

62502192

-PRKCBchr16

24166004

+
5CDS-intronENST00000450599ENST00000498058DDX5chr17

62502192

-PRKCBchr16

24166004

+
In-frameENST00000225792ENST00000303531DDX5chr17

62502192

-PRKCBchr16

24166004

+
In-frameENST00000225792ENST00000321728DDX5chr17

62502192

-PRKCBchr16

24166004

+
In-frameENST00000450599ENST00000303531DDX5chr17

62502192

-PRKCBchr16

24166004

+
In-frameENST00000450599ENST00000321728DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-3CDSENST00000578804ENST00000303531DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-3CDSENST00000578804ENST00000321728DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-3CDSENST00000580026ENST00000303531DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-3CDSENST00000580026ENST00000321728DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-intronENST00000578804ENST00000482000DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-intronENST00000578804ENST00000498058DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-intronENST00000580026ENST00000482000DDX5chr17

62502192

-PRKCBchr16

24166004

+
intron-intronENST00000580026ENST00000498058DDX5chr17

62502192

-PRKCBchr16

24166004

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225792DDX5chr1762502192-ENST00000321728PRKCBchr1624166004+18954464491396315
ENST00000225792DDX5chr1762502192-ENST00000303531PRKCBchr1624166004+71984464491402317
ENST00000450599DDX5chr1762502192-ENST00000321728PRKCBchr1624166004+16612122151162315
ENST00000450599DDX5chr1762502192-ENST00000303531PRKCBchr1624166004+69642122151168317

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225792ENST00000321728DDX5chr1762502192-PRKCBchr1624166004+0.0006058810.99939406
ENST00000225792ENST00000303531DDX5chr1762502192-PRKCBchr1624166004+0.0003787080.9996213
ENST00000450599ENST00000321728DDX5chr1762502192-PRKCBchr1624166004+0.0004475130.9995524
ENST00000450599ENST00000303531DDX5chr1762502192-PRKCBchr1624166004+0.0003619770.99963796

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Fusion Genomic Features for DDX5-PRKCB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDX5chr1762502193-PRKCBchr1624166004+0.0001880230.99981195
DDX5chr1762502193-PRKCBchr1624166004+0.0001880230.99981195

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDX5-PRKCB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62502192/chr16:24166004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX5

P17844

.
FUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKCBchr17:62502192chr16:24166004ENST00000303531817601_671355674.0DomainAGC-kinase C-terminal
TgenePRKCBchr17:62502192chr16:24166004ENST00000321728817601_671355672.0DomainAGC-kinase C-terminal
TgenePRKCBchr17:62502192chr16:24166004ENST0000049805802158_275058.0DomainC2
TgenePRKCBchr17:62502192chr16:24166004ENST0000049805802342_600058.0DomainProtein kinase
TgenePRKCBchr17:62502192chr16:24166004ENST0000049805802601_671058.0DomainAGC-kinase C-terminal
TgenePRKCBchr17:62502192chr16:24166004ENST0000049805802348_356058.0Nucleotide bindingATP
TgenePRKCBchr17:62502192chr16:24166004ENST0000049805802101_151058.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr17:62502192chr16:24166004ENST000004980580236_86058.0Zinc fingerPhorbol-ester/DAG-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113125_30014615.0DomainHelicase ATP-binding
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113328_47514615.0DomainHelicase C-terminal
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113248_25114615.0MotifNote=DEAD box
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-11394_12214615.0MotifNote=Q motif
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113114_11614615.0Nucleotide bindingNote=ATP
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113138_14514615.0Nucleotide bindingNote=ATP
HgeneDDX5chr17:62502192chr16:24166004ENST00000225792-113477_61414615.0RegionNote=Transactivation domain
TgenePRKCBchr17:62502192chr16:24166004ENST00000303531817158_275355674.0DomainC2
TgenePRKCBchr17:62502192chr16:24166004ENST00000303531817342_600355674.0DomainProtein kinase
TgenePRKCBchr17:62502192chr16:24166004ENST00000321728817158_275355672.0DomainC2
TgenePRKCBchr17:62502192chr16:24166004ENST00000321728817342_600355672.0DomainProtein kinase
TgenePRKCBchr17:62502192chr16:24166004ENST00000303531817348_356355674.0Nucleotide bindingATP
TgenePRKCBchr17:62502192chr16:24166004ENST00000321728817348_356355672.0Nucleotide bindingATP
TgenePRKCBchr17:62502192chr16:24166004ENST00000303531817101_151355674.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr17:62502192chr16:24166004ENST0000030353181736_86355674.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCBchr17:62502192chr16:24166004ENST00000321728817101_151355672.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr17:62502192chr16:24166004ENST0000032172881736_86355672.0Zinc fingerPhorbol-ester/DAG-type 1


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Fusion Gene Sequence for DDX5-PRKCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22091_22091_1_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000225792_PRKCB_chr16_24166004_ENST00000303531_length(transcript)=7198nt_BP=446nt
AGAAGAAGGTGAGGTCAAGAGAGTGCAGAATGAGGCATTCCAATGGTGGGTGGGCCCTGACCTGAGAGAGTGGCGCGGGGAGGGGTGAAA
GCGCGGCGATCCTGGAACGCCAGCGGGCGTTGCGGCCTATGCGCGAGGGGCGGGGCGATTAGGTCATAGAGCGGCTCCCAGCGTTCCCTG
CGGCGTAGGAGGCGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTT
CGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTT
TTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTCA
TGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTGCA
CTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGT
ACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACG
CTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTCTG
AGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACT
ACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTG
GGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGG
AAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGC
ATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTG
AAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCG
AAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATT
CAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAG
TGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAA
TTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTT
TCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTG
GAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGA
ACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGA
CGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTT
GCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCC
CTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAA
AAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAGAA
GACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAG
TGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCAT
TTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATT
TCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGG
AGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGG
ATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTA
TCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGT
GGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCT
AAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAATG
TCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCC
TCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCT
GACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGA
ATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGA
CATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAA
CCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAA
AGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTT
ATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCT
GTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAG
CTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGA
GTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTA
AAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCAT
TAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGA
AAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCA
CACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAG
ACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAG
AGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACACTA
GTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAACA
AGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACA
ATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCAC
AGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTA
GCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCAAG
AGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGA
GAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAAT
GAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATAC
AAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCG
ATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATA
GGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGG
AGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTT
CTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTT
TGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTT
GGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGA
TCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCA
CCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAATT
CAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACACACACACACACACACACACACACACACCACTTTATGG
CAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAATG
AAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAATGA
CTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAA
CTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGG
CTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAG
CGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGT
ATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAA
CTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGA
AGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGT

>22091_22091_1_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000225792_PRKCB_chr16_24166004_ENST00000303531_length(amino acids)=317AA_BP=0
MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY
AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA
GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNA

--------------------------------------------------------------
>22091_22091_2_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000225792_PRKCB_chr16_24166004_ENST00000321728_length(transcript)=1895nt_BP=446nt
AGAAGAAGGTGAGGTCAAGAGAGTGCAGAATGAGGCATTCCAATGGTGGGTGGGCCCTGACCTGAGAGAGTGGCGCGGGGAGGGGTGAAA
GCGCGGCGATCCTGGAACGCCAGCGGGCGTTGCGGCCTATGCGCGAGGGGCGGGGCGATTAGGTCATAGAGCGGCTCCCAGCGTTCCCTG
CGGCGTAGGAGGCGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTT
CGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTT
TTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTCA
TGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAAGATGATGACGTGGAGTGCA
CTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGT
ACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACG
CTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTCTG
AGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACT
ACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTG
GGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGG
AAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGC
ATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACA
CCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAAT
TTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCA
AGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTT
TCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATT
TTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCA
AGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAAT
TGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAAGAATTGATATGATTAAACTGAATTAATATA

>22091_22091_2_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000225792_PRKCB_chr16_24166004_ENST00000321728_length(amino acids)=315AA_BP=0
MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY
AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA
GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD

--------------------------------------------------------------
>22091_22091_3_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000450599_PRKCB_chr16_24166004_ENST00000303531_length(transcript)=6964nt_BP=212nt
CTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTTCGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCG
TCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTTTTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTAT
TCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTCATGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGA
AGGACGTTGTGATCCAAGATGATGACGTGGAGTGCACTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCC
AGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGTACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAG
TCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACGCTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACC
GTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATG
GGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGT
GGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGG
AACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGG
GTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGC
CCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGACC
AGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAAG
TAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGCA
TCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGGA
TTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTAA
GTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATAA
TTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCTA
TTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGATG
ATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGCT
ACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGAA
ACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTTG
TTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTATT
AACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAAA
TCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTTT
GATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAATA
AAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAAC
TGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGCC
CATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGAC
CAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGCT
TTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCTC
CTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTGA
GAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGCT
TAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAAT
CAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACTT
TATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAAG
TGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGATC
CCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAACA
ATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAGG
AAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTTT
AATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTAT
CCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAAT
GGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCTC
AACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAAG
CAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTCA
GAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTGT
GTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCAT
ACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTTC
TGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTGT
GTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCAA
GAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAGT
GTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCCG
AGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGAT
GGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGCC
CACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCACA
AAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTAA
ACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTGG
CTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTCC
AGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTGC
CTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGGA
AAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGACT
TGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAAT
CGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCTC
TCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTCG
AGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCAG
CAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTTC
TATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACAC
ACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACCA
CATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTCT
GACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTACT
TTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACT
CTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACTC
CATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCAA
CATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATAA
GCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATAC
CAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGAA
TGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAAG

>22091_22091_3_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000450599_PRKCB_chr16_24166004_ENST00000303531_length(amino acids)=317AA_BP=0
MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY
AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA
GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNA

--------------------------------------------------------------
>22091_22091_4_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000450599_PRKCB_chr16_24166004_ENST00000321728_length(transcript)=1661nt_BP=212nt
CTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTTCGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCG
TCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTTTTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTAT
TCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTCATGCTTTCAGAACGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGA
AGGACGTTGTGATCCAAGATGATGACGTGGAGTGCACTATGGTGGAGAAGCGGGTGTTGGCCCTGCCTGGGAAGCCGCCCTTCCTGACCC
AGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGTACTTTGTGATGGAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAG
TCGGCCGGTTCAAGGAGCCCCATGCTGTATTTTACGCTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAGGGCATCATTTACC
GTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATG
GGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGT
GGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGG
AACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGG
GTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGC
CCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTG
ATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATG
CAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGG
CATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTT
AGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGT
CTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTT
CTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTT

>22091_22091_4_DDX5-PRKCB_DDX5_chr17_62502192_ENST00000450599_PRKCB_chr16_24166004_ENST00000321728_length(amino acids)=315AA_BP=0
MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY
AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA
GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDX5-PRKCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX5-PRKCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX5-PRKCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource