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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX5-SKAP1 (FusionGDB2 ID:22099)

Fusion Gene Summary for DDX5-SKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX5-SKAP1
Fusion gene ID: 22099
HgeneTgene
Gene symbol

DDX5

SKAP1

Gene ID

1655

8631

Gene nameDEAD-box helicase 5src kinase associated phosphoprotein 1
SynonymsG17P1|HLR1|HUMP68|p68HEL-S-81p|SCAP1|SKAP55
Cytomap

17q23.3

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA hsrc kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa
Modification date2020031320200313
UniProtAcc

P17844

.
Ensembl transtripts involved in fusion geneENST00000580026, ENST00000225792, 
ENST00000450599, ENST00000578804, 
ENST00000336915, ENST00000584924, 
Fusion gene scores* DoF score33 X 25 X 10=825024 X 12 X 10=2880
# samples 2729
** MAII scorelog2(27/8250*10)=-4.93336280696971
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/2880*10)=-3.31194400631474
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX5 [Title/Abstract] AND SKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX5(62496667)-SKAP1(46474147), # samples:2
Anticipated loss of major functional domain due to fusion event.DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DDX5-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDX5-SKAP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX5

GO:0000122

negative regulation of transcription by RNA polymerase II

15298701

HgeneDDX5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21343338

HgeneDDX5

GO:0000956

nuclear-transcribed mRNA catabolic process

23788676

TgeneSKAP1

GO:0002821

positive regulation of adaptive immune response

12652296

TgeneSKAP1

GO:0033625

positive regulation of integrin activation

12652296

TgeneSKAP1

GO:0034116

positive regulation of heterotypic cell-cell adhesion

12652296

TgeneSKAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

11909961

TgeneSKAP1

GO:1903039

positive regulation of leukocyte cell-cell adhesion

12652296


check buttonFusion gene breakpoints across DDX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PJ-01ADDX5chr17

62496667

-SKAP1chr17

46474147

-
ChimerDB4STADTCGA-VQ-A8PJDDX5chr17

62496666

-SKAP1chr17

46474147

-


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Fusion Gene ORF analysis for DDX5-SKAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000580026ENST00000336915DDX5chr17

62496667

-SKAP1chr17

46474147

-
5UTR-3CDSENST00000580026ENST00000336915DDX5chr17

62496666

-SKAP1chr17

46474147

-
5UTR-3CDSENST00000580026ENST00000584924DDX5chr17

62496667

-SKAP1chr17

46474147

-
5UTR-3CDSENST00000580026ENST00000584924DDX5chr17

62496666

-SKAP1chr17

46474147

-
Frame-shiftENST00000225792ENST00000336915DDX5chr17

62496667

-SKAP1chr17

46474147

-
Frame-shiftENST00000225792ENST00000336915DDX5chr17

62496666

-SKAP1chr17

46474147

-
Frame-shiftENST00000450599ENST00000336915DDX5chr17

62496667

-SKAP1chr17

46474147

-
Frame-shiftENST00000450599ENST00000336915DDX5chr17

62496666

-SKAP1chr17

46474147

-
Frame-shiftENST00000578804ENST00000336915DDX5chr17

62496667

-SKAP1chr17

46474147

-
Frame-shiftENST00000578804ENST00000336915DDX5chr17

62496666

-SKAP1chr17

46474147

-
In-frameENST00000225792ENST00000584924DDX5chr17

62496667

-SKAP1chr17

46474147

-
In-frameENST00000225792ENST00000584924DDX5chr17

62496666

-SKAP1chr17

46474147

-
In-frameENST00000450599ENST00000584924DDX5chr17

62496667

-SKAP1chr17

46474147

-
In-frameENST00000450599ENST00000584924DDX5chr17

62496666

-SKAP1chr17

46474147

-
In-frameENST00000578804ENST00000584924DDX5chr17

62496667

-SKAP1chr17

46474147

-
In-frameENST00000578804ENST00000584924DDX5chr17

62496666

-SKAP1chr17

46474147

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225792DDX5chr1762496667-ENST00000584924SKAP1chr1746474147-317518432132876887
ENST00000450599DDX5chr1762496667-ENST00000584924SKAP1chr1746474147-27041372392405788
ENST00000578804DDX5chr1762496667-ENST00000584924SKAP1chr1746474147-29401608802641853
ENST00000225792DDX5chr1762496666-ENST00000584924SKAP1chr1746474147-317518432132876887
ENST00000450599DDX5chr1762496666-ENST00000584924SKAP1chr1746474147-27041372392405788
ENST00000578804DDX5chr1762496666-ENST00000584924SKAP1chr1746474147-29401608802641853

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225792ENST00000584924DDX5chr1762496667-SKAP1chr1746474147-0.0028987810.99710125
ENST00000450599ENST00000584924DDX5chr1762496667-SKAP1chr1746474147-0.0023302170.99766976
ENST00000578804ENST00000584924DDX5chr1762496667-SKAP1chr1746474147-0.0026404220.9973596
ENST00000225792ENST00000584924DDX5chr1762496666-SKAP1chr1746474147-0.0028987810.99710125
ENST00000450599ENST00000584924DDX5chr1762496666-SKAP1chr1746474147-0.0023302170.99766976
ENST00000578804ENST00000584924DDX5chr1762496666-SKAP1chr1746474147-0.0026404220.9973596

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Fusion Genomic Features for DDX5-SKAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDX5-SKAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62496667/chr17:46474147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX5

P17844

.
FUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213125_300480615.0DomainHelicase ATP-binding
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213328_475480615.0DomainHelicase C-terminal
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213125_300480615.0DomainHelicase ATP-binding
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213328_475480615.0DomainHelicase C-terminal
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213248_251480615.0MotifNote=DEAD box
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-121394_122480615.0MotifNote=Q motif
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213248_251480615.0MotifNote=DEAD box
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-121394_122480615.0MotifNote=Q motif
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213114_116480615.0Nucleotide bindingNote=ATP
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213138_145480615.0Nucleotide bindingNote=ATP
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213114_116480615.0Nucleotide bindingNote=ATP
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213138_145480615.0Nucleotide bindingNote=ATP
TgeneSKAP1chr17:62496666chr17:46474147ENST00000336915013220_23015448.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:62496666chr17:46474147ENST00000584924012220_23015360.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:62496667chr17:46474147ENST00000336915013220_23015448.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:62496667chr17:46474147ENST00000584924012220_23015360.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:62496666chr17:46474147ENST00000336915013107_21015448.0DomainPH
TgeneSKAP1chr17:62496666chr17:46474147ENST00000336915013294_35515448.0DomainSH3
TgeneSKAP1chr17:62496666chr17:46474147ENST00000584924012107_21015360.0DomainPH
TgeneSKAP1chr17:62496666chr17:46474147ENST00000584924012294_35515360.0DomainSH3
TgeneSKAP1chr17:62496667chr17:46474147ENST00000336915013107_21015448.0DomainPH
TgeneSKAP1chr17:62496667chr17:46474147ENST00000336915013294_35515448.0DomainSH3
TgeneSKAP1chr17:62496667chr17:46474147ENST00000584924012107_21015360.0DomainPH
TgeneSKAP1chr17:62496667chr17:46474147ENST00000584924012294_35515360.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX5chr17:62496666chr17:46474147ENST00000225792-1213477_614480615.0RegionNote=Transactivation domain
HgeneDDX5chr17:62496667chr17:46474147ENST00000225792-1213477_614480615.0RegionNote=Transactivation domain


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Fusion Gene Sequence for DDX5-SKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22099_22099_1_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=3175nt_BP=1843nt
AGAAGAAGGTGAGGTCAAGAGAGTGCAGAATGAGGCATTCCAATGGTGGGTGGGCCCTGACCTGAGAGAGTGGCGCGGGGAGGGGTGAAA
GCGCGGCGATCCTGGAACGCCAGCGGGCGTTGCGGCCTATGCGCGAGGGGCGGGGCGATTAGGTCATAGAGCGGCTCCCAGCGTTCCCTG
CGGCGTAGGAGGCGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTT
CGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTT
TTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTTT
GGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTTGGAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGG
AATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGATTTGGCTAGGCGCACAGCACAAGAGGTGGAAACATAC
AGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAAATTTTTATGAAGCCAATTTCCCTGCAAATGTCATG
GATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGATGGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGA
GTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCCACATCAATCATCAGCCATTCCTAGAGAGAGGCGAT
GGGCCTATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTG
AAGTCTACTTGTATCTACGGTGGTGCTCCTAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACACCTGGA
AGACTGATTGACTTTTTAGAGTGTGGAAAAACCAATCTGAGAAGAACAACCTACCTTGTCCTTGATGAAGCAGATAGAATGCTTGATATG
GGCTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTA
AGACAGCTTGCTGAAGATTTCCTGAAAGACTATATTCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATT
GTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTCTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTT
TTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGT
CAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGAT
GTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAGAACTGCTCGCAGTACC
AAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCA
ATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGC
GCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGA
GACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAG
GATGAGGGAATGGAAGACATCGTAAAAGGAGCTCAAGAACTTGATAACGTAATCAAGCAAGGATACTTGGAGAAGAAAAGCAAAGATCAT
AGTTTCTTTGGATCGGAGTGGCAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCTTCTACTACTATGCTAATGAGAAGAGCAAGCAGCCC
AAAGGGACCTTCCTCATTAAGGGCTACGGTGTACGGATGGCCCCCCACCTGCGAAGAGATTCCAAGAAAGAATCCTGCTTTGAACTGACC
TCCCAGGATAGGCGCAGCTATGAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAGACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGAT
CTGAGCTCCTTAACCATTCCATATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAGAGACATATGATGATATTGATGGTTTTGACTCCCCA
AGTTGTGGTTCCCAGTGCAGACCCACTATCTTGCCTGGGAGTGTGGGGATAAAAGAGCCTACAGAGGAGAAAGAAGAAGAAGATATTTAT
GAAGTCTTGCCAGATGAAGAGCATGATCTAGAAGAGGATGAGAGTGGCACTCGACGAAAAGGAGTAGACTATGCCAGTTACTACCAGGGC
CTATGGGATTGCCATGGTGACCAGCCAGATGAACTGTCCTTCCAACGGGGTGACCTCATCCGTATTCTGAGCAAGGAGTATAACATGTAT
GGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAAC
CCAGGTATCAGAACCATGGCCAATGAACTGCCTAATAGTTGAGTGGAACTTGTGGGCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGC
CAGTGAAGTAGCTTTTCTTCATTTCTCATACTAATGCTAGTGATTCACCACTGATGGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTA
AATTTGGGGACAGTGTCACTTAGGATAAGGTTCAACTAATAGCAACATAAAATCTAAACTAAAAATGACTTAATTAACACAGAAAGCCAG

>22099_22099_1_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=887AA_BP=543
MPESGRHLIHFYRSLVVQLRLVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAG
PLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEP
TAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPK
GPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDY
IHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEF
KHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVED
RGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGA
QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTA
TSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLE

--------------------------------------------------------------
>22099_22099_2_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=2704nt_BP=1372nt
CTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTTCGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCG
TCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTTTTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTAT
TCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTT
GGAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGAT
TTGGCTAGGCGCACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGCGATGGGCCTATTTGTTTGGTGCTG
GCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTACGGT
GGTGCTCCTAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACACCTGGAAGACTGATTGACTTTTTAGAG
TGTGGAAAAACCAATCTGAGAAGAACAACCTACCTTGTCCTTGATGAAGCAGATAGAATGCTTGATATGGGCTTTGAACCCCAAATAAGG
AAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTC
CTGAAAGACTATATTCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTA
GAAAAGGATGAAAAACTTATTCGTCTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGA
TGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTT
CTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTC
ATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAGAACTGCTCGCAGTACCAAAACAGGCACAGCATACACT
TTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAG
TTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCACAGA
GACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAGCTCT
GATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGGAATGGAAGACATC
GTAAAAGGAGCTCAAGAACTTGATAACGTAATCAAGCAAGGATACTTGGAGAAGAAAAGCAAAGATCATAGTTTCTTTGGATCGGAGTGG
CAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCTTCTACTACTATGCTAATGAGAAGAGCAAGCAGCCCAAAGGGACCTTCCTCATTAAG
GGCTACGGTGTACGGATGGCCCCCCACCTGCGAAGAGATTCCAAGAAAGAATCCTGCTTTGAACTGACCTCCCAGGATAGGCGCAGCTAT
GAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAGACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGATCTGAGCTCCTTAACCATTCCA
TATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAGAGACATATGATGATATTGATGGTTTTGACTCCCCAAGTTGTGGTTCCCAGTGCAGA
CCCACTATCTTGCCTGGGAGTGTGGGGATAAAAGAGCCTACAGAGGAGAAAGAAGAAGAAGATATTTATGAAGTCTTGCCAGATGAAGAG
CATGATCTAGAAGAGGATGAGAGTGGCACTCGACGAAAAGGAGTAGACTATGCCAGTTACTACCAGGGCCTATGGGATTGCCATGGTGAC
CAGCCAGATGAACTGTCCTTCCAACGGGGTGACCTCATCCGTATTCTGAGCAAGGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTG
AACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACCCAGGTATCAGAACCATGGCC
AATGAACTGCCTAATAGTTGAGTGGAACTTGTGGGCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGCCAGTGAAGTAGCTTTTCTTCA
TTTCTCATACTAATGCTAGTGATTCACCACTGATGGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTAAATTTGGGGACAGTGTCACTT
AGGATAAGGTTCAACTAATAGCAACATAAAATCTAAACTAAAAATGACTTAATTAACACAGAAAGCCAGGCACAGTGGCTCACACCTGTA

>22099_22099_2_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=788AA_BP=444
MVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWN
LDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLER
GVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALE
LSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI
ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFL
AEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQ
GYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDW
VDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRK

--------------------------------------------------------------
>22099_22099_3_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=2940nt_BP=1608nt
TCCTTTCCCGAAGGCTTGCGCCATTTTGATATTCACGTCACAGTGATTGGAAGAGATTTGACGGTGTAGTGTCTTCAAGCTTGCTTTTTG
TGTGGGGATTGGGGAGCTGTCGGGGCGGCTGCCATTTGGTAGCTGTTGAGGGAGTTGAGAGGGAGCGTATTGTGCGGATGAAAGCGGGAC
GCTTCGAGGCAGACGAAGGAACATCTGTTAGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTTG
GAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGATT
TGGCTAGGCGCACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAA
ATTTTTATGAAGCCAATTTCCCTGCAAATGTCATGGATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGAT
GGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGAGTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCC
ACATCAATCATCAGCCATTCCTAGAGAGAGGCGATGGGCCTATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGC
AAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTACGGTGGTGCTCCTAAGGGACCACAAATACGTGATTTGG
AGAGAGGTGTGGAAATCTGTATTGCAACACCTGGAAGACTGATTGACTTTTTAGAGTGTGGAAAAACCAATCTGAGAAGAACAACCTACC
TTGTCCTTGATGAAGCAGATAGAATGCTTGATATGGGCTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAA
CTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTCCTGAAAGACTATATTCATATAAACATTGGTGCAC
TTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTCTAATGGAAG
AGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATG
GGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTC
TGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATT
ATATTCATCGAATTGGAAGAACTGCTCGCAGTACCAAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCG
ACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGT
TTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAG
CCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCC
TCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGGAATGGAAGACATCGTAAAAGGAGCTCAAGAACTTGATAACGTAATCA
AGCAAGGATACTTGGAGAAGAAAAGCAAAGATCATAGTTTCTTTGGATCGGAGTGGCAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCT
TCTACTACTATGCTAATGAGAAGAGCAAGCAGCCCAAAGGGACCTTCCTCATTAAGGGCTACGGTGTACGGATGGCCCCCCACCTGCGAA
GAGATTCCAAGAAAGAATCCTGCTTTGAACTGACCTCCCAGGATAGGCGCAGCTATGAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAG
ACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGATCTGAGCTCCTTAACCATTCCATATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAG
AGACATATGATGATATTGATGGTTTTGACTCCCCAAGTTGTGGTTCCCAGTGCAGACCCACTATCTTGCCTGGGAGTGTGGGGATAAAAG
AGCCTACAGAGGAGAAAGAAGAAGAAGATATTTATGAAGTCTTGCCAGATGAAGAGCATGATCTAGAAGAGGATGAGAGTGGCACTCGAC
GAAAAGGAGTAGACTATGCCAGTTACTACCAGGGCCTATGGGATTGCCATGGTGACCAGCCAGATGAACTGTCCTTCCAACGGGGTGACC
TCATCCGTATTCTGAGCAAGGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATC
TCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACCCAGGTATCAGAACCATGGCCAATGAACTGCCTAATAGTTGAGTGGAACTTGTGG
GCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGCCAGTGAAGTAGCTTTTCTTCATTTCTCATACTAATGCTAGTGATTCACCACTGAT
GGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTAAATTTGGGGACAGTGTCACTTAGGATAAGGTTCAACTAATAGCAACATAAAATCT

>22099_22099_3_DDX5-SKAP1_DDX5_chr17_62496666_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=853AA_BP=509
MLFVWGLGSCRGGCHLVAVEGVERERIVRMKAGRFEADEGTSVRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQE
HPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP
AIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRR
TTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR
LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNS
SEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQ
QIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVS
RGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEE
EKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQ

--------------------------------------------------------------
>22099_22099_4_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=3175nt_BP=1843nt
AGAAGAAGGTGAGGTCAAGAGAGTGCAGAATGAGGCATTCCAATGGTGGGTGGGCCCTGACCTGAGAGAGTGGCGCGGGGAGGGGTGAAA
GCGCGGCGATCCTGGAACGCCAGCGGGCGTTGCGGCCTATGCGCGAGGGGCGGGGCGATTAGGTCATAGAGCGGCTCCCAGCGTTCCCTG
CGGCGTAGGAGGCGGTCCAGACTATAAAAGCGGCTGCCGGAAAGCGGCCGGCACCTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTT
CGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCGTCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTT
TTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTTT
GGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTTGGAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGG
AATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGATTTGGCTAGGCGCACAGCACAAGAGGTGGAAACATAC
AGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAAATTTTTATGAAGCCAATTTCCCTGCAAATGTCATG
GATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGATGGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGA
GTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCCACATCAATCATCAGCCATTCCTAGAGAGAGGCGAT
GGGCCTATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTG
AAGTCTACTTGTATCTACGGTGGTGCTCCTAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACACCTGGA
AGACTGATTGACTTTTTAGAGTGTGGAAAAACCAATCTGAGAAGAACAACCTACCTTGTCCTTGATGAAGCAGATAGAATGCTTGATATG
GGCTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTA
AGACAGCTTGCTGAAGATTTCCTGAAAGACTATATTCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATT
GTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTCTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTT
TTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGT
CAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGAT
GTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAGAACTGCTCGCAGTACC
AAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCA
ATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGC
GCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGA
GACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAG
GATGAGGGAATGGAAGACATCGTAAAAGGAGCTCAAGAACTTGATAACGTAATCAAGCAAGGATACTTGGAGAAGAAAAGCAAAGATCAT
AGTTTCTTTGGATCGGAGTGGCAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCTTCTACTACTATGCTAATGAGAAGAGCAAGCAGCCC
AAAGGGACCTTCCTCATTAAGGGCTACGGTGTACGGATGGCCCCCCACCTGCGAAGAGATTCCAAGAAAGAATCCTGCTTTGAACTGACC
TCCCAGGATAGGCGCAGCTATGAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAGACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGAT
CTGAGCTCCTTAACCATTCCATATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAGAGACATATGATGATATTGATGGTTTTGACTCCCCA
AGTTGTGGTTCCCAGTGCAGACCCACTATCTTGCCTGGGAGTGTGGGGATAAAAGAGCCTACAGAGGAGAAAGAAGAAGAAGATATTTAT
GAAGTCTTGCCAGATGAAGAGCATGATCTAGAAGAGGATGAGAGTGGCACTCGACGAAAAGGAGTAGACTATGCCAGTTACTACCAGGGC
CTATGGGATTGCCATGGTGACCAGCCAGATGAACTGTCCTTCCAACGGGGTGACCTCATCCGTATTCTGAGCAAGGAGTATAACATGTAT
GGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAAC
CCAGGTATCAGAACCATGGCCAATGAACTGCCTAATAGTTGAGTGGAACTTGTGGGCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGC
CAGTGAAGTAGCTTTTCTTCATTTCTCATACTAATGCTAGTGATTCACCACTGATGGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTA
AATTTGGGGACAGTGTCACTTAGGATAAGGTTCAACTAATAGCAACATAAAATCTAAACTAAAAATGACTTAATTAACACAGAAAGCCAG

>22099_22099_4_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000225792_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=887AA_BP=543
MPESGRHLIHFYRSLVVQLRLVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAG
PLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEP
TAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPK
GPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDY
IHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEF
KHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVED
RGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGA
QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTA
TSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLE

--------------------------------------------------------------
>22099_22099_5_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=2704nt_BP=1372nt
CTCATTCATTTCTACCGGTCTCTAGTAGTGCAGCTTCGGCTGGTGTCATCGGTGTCCTTCCTCCGCTGCCGCCCCCGCAAGGCTTCGCCG
TCATCGAGGCCATTTCCAGCGACTTGTCGCACGCTTTTCTATATACTTCGTTCCCCGCCAACCGCAACCATTGACGCCATGTCGGGTTAT
TCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTT
GGAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGAT
TTGGCTAGGCGCACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGCGATGGGCCTATTTGTTTGGTGCTG
GCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTACGGT
GGTGCTCCTAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTATTGCAACACCTGGAAGACTGATTGACTTTTTAGAG
TGTGGAAAAACCAATCTGAGAAGAACAACCTACCTTGTCCTTGATGAAGCAGATAGAATGCTTGATATGGGCTTTGAACCCCAAATAAGG
AAGATTGTGGATCAAATAAGACCTGATAGGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTC
CTGAAAGACTATATTCATATAAACATTGGTGCACTTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTA
GAAAAGGATGAAAAACTTATTCGTCTAATGGAAGAGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGA
TGTGATGAGCTTACCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTT
CTAAATGAATTCAAACATGGAAAAGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTC
ATCAATTATGACTACCCTAACTCCTCAGAGGATTATATTCATCGAATTGGAAGAACTGCTCGCAGTACCAAAACAGGCACAGCATACACT
TTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAG
TTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCACAGA
GACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAGCTCT
GATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGGAATGGAAGACATC
GTAAAAGGAGCTCAAGAACTTGATAACGTAATCAAGCAAGGATACTTGGAGAAGAAAAGCAAAGATCATAGTTTCTTTGGATCGGAGTGG
CAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCTTCTACTACTATGCTAATGAGAAGAGCAAGCAGCCCAAAGGGACCTTCCTCATTAAG
GGCTACGGTGTACGGATGGCCCCCCACCTGCGAAGAGATTCCAAGAAAGAATCCTGCTTTGAACTGACCTCCCAGGATAGGCGCAGCTAT
GAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAGACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGATCTGAGCTCCTTAACCATTCCA
TATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAGAGACATATGATGATATTGATGGTTTTGACTCCCCAAGTTGTGGTTCCCAGTGCAGA
CCCACTATCTTGCCTGGGAGTGTGGGGATAAAAGAGCCTACAGAGGAGAAAGAAGAAGAAGATATTTATGAAGTCTTGCCAGATGAAGAG
CATGATCTAGAAGAGGATGAGAGTGGCACTCGACGAAAAGGAGTAGACTATGCCAGTTACTACCAGGGCCTATGGGATTGCCATGGTGAC
CAGCCAGATGAACTGTCCTTCCAACGGGGTGACCTCATCCGTATTCTGAGCAAGGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTG
AACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACCCAGGTATCAGAACCATGGCC
AATGAACTGCCTAATAGTTGAGTGGAACTTGTGGGCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGCCAGTGAAGTAGCTTTTCTTCA
TTTCTCATACTAATGCTAGTGATTCACCACTGATGGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTAAATTTGGGGACAGTGTCACTT
AGGATAAGGTTCAACTAATAGCAACATAAAATCTAAACTAAAAATGACTTAATTAACACAGAAAGCCAGGCACAGTGGCTCACACCTGTA

>22099_22099_5_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000450599_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=788AA_BP=444
MVSSVSFLRCRPRKASPSSRPFPATCRTLFYILRSPPTATIDAMSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWN
LDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLER
GVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALE
LSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI
ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFL
AEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQ
GYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDW
VDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRK

--------------------------------------------------------------
>22099_22099_6_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(transcript)=2940nt_BP=1608nt
TCCTTTCCCGAAGGCTTGCGCCATTTTGATATTCACGTCACAGTGATTGGAAGAGATTTGACGGTGTAGTGTCTTCAAGCTTGCTTTTTG
TGTGGGGATTGGGGAGCTGTCGGGGCGGCTGCCATTTGGTAGCTGTTGAGGGAGTTGAGAGGGAGCGTATTGTGCGGATGAAAGCGGGAC
GCTTCGAGGCAGACGAAGGAACATCTGTTAGGTTTGGTGCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTTG
GAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGGAATCTTGATGAGCTGCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGATT
TGGCTAGGCGCACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTAGAGGTCACAACTGCCCGAAGCCAGTTCTAA
ATTTTTATGAAGCCAATTTCCCTGCAAATGTCATGGATGTTATTGCAAGACAGAATTTCACTGAACCCACTGCTATTCAAGCTCAGGGAT
GGCCAGTTGCTCTAAGTGGATTGGATATGGTTGGAGTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATTGTCC
ACATCAATCATCAGCCATTCCTAGAGAGAGGCGATGGGCCTATTTGTTTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGC
AAGTAGCTGCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTACGGTGGTGCTCCTAAGGGACCACAAATACGTGATTTGG
AGAGAGGTGTGGAAATCTGTATTGCAACACCTGGAAGACTGATTGACTTTTTAGAGTGTGGAAAAACCAATCTGAGAAGAACAACCTACC
TTGTCCTTGATGAAGCAGATAGAATGCTTGATATGGGCTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATAGGCAAA
CTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTGCTGAAGATTTCCTGAAAGACTATATTCATATAAACATTGGTGCAC
TTGAACTGAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTAGAAAAGGATGAAAAACTTATTCGTCTAATGGAAG
AGATCATGAGTGAGAAGGAGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGATGTGATGAGCTTACCAGAAAAATGAGGAGAGATG
GGTGGCCTGCCATGGGTATCCATGGTGACAAGAGTCAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAAAGCTCCTATTC
TGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGAAGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATT
ATATTCATCGAATTGGAAGAACTGCTCGCAGTACCAAAACAGGCACAGCATACACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCG
ACCTTATCTCTGTGCTTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAGTTGGTCGAAGACAGAGGTTCAGATGCTGAAGAGT
TTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAG
CCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCC
TCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGGAATGGAAGACATCGTAAAAGGAGCTCAAGAACTTGATAACGTAATCA
AGCAAGGATACTTGGAGAAGAAAAGCAAAGATCATAGTTTCTTTGGATCGGAGTGGCAGAAGCGATGGTGTGTTGTCAGCAGAGGTCTCT
TCTACTACTATGCTAATGAGAAGAGCAAGCAGCCCAAAGGGACCTTCCTCATTAAGGGCTACGGTGTACGGATGGCCCCCCACCTGCGAA
GAGATTCCAAGAAAGAATCCTGCTTTGAACTGACCTCCCAGGATAGGCGCAGCTATGAGTTTACAGCTACTAGTCCAGCAGAAGCCAGAG
ACTGGGTGGATCAAATAAGTTTCTTGTTAAAGGATCTGAGCTCCTTAACCATTCCATATGAAGAGGATGAGGAGGAAGAAGAAAAAGAAG
AGACATATGATGATATTGATGGTTTTGACTCCCCAAGTTGTGGTTCCCAGTGCAGACCCACTATCTTGCCTGGGAGTGTGGGGATAAAAG
AGCCTACAGAGGAGAAAGAAGAAGAAGATATTTATGAAGTCTTGCCAGATGAAGAGCATGATCTAGAAGAGGATGAGAGTGGCACTCGAC
GAAAAGGAGTAGACTATGCCAGTTACTACCAGGGCCTATGGGATTGCCATGGTGACCAGCCAGATGAACTGTCCTTCCAACGGGGTGACC
TCATCCGTATTCTGAGCAAGGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATC
TCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACCCAGGTATCAGAACCATGGCCAATGAACTGCCTAATAGTTGAGTGGAACTTGTGG
GCCACTACTTTGTTTCTCTGAAAGATGAGAGTTGCCAGTGAAGTAGCTTTTCTTCATTTCTCATACTAATGCTAGTGATTCACCACTGAT
GGAAAGAAAATGCCTCTGGAATTGTTTTTTTCTTAAATTTGGGGACAGTGTCACTTAGGATAAGGTTCAACTAATAGCAACATAAAATCT

>22099_22099_6_DDX5-SKAP1_DDX5_chr17_62496667_ENST00000578804_SKAP1_chr17_46474147_ENST00000584924_length(amino acids)=853AA_BP=509
MLFVWGLGSCRGGCHLVAVEGVERERIVRMKAGRFEADEGTSVRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQE
HPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP
AIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRR
TTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR
LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNS
SEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSDAEEFLAEGLRNENLSAVARDHRDHILRGFQ
QIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVS
RGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEE
EKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQ

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Fusion Gene PPI Analysis for DDX5-SKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSKAP1chr17:62496666chr17:46474147ENST00000336915013290_29515.333333333333334448.0FYB1
TgeneSKAP1chr17:62496666chr17:46474147ENST00000584924012290_29515.333333333333334360.0FYB1
TgeneSKAP1chr17:62496667chr17:46474147ENST00000336915013290_29515.333333333333334448.0FYB1
TgeneSKAP1chr17:62496667chr17:46474147ENST00000584924012290_29515.333333333333334360.0FYB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX5-SKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX5-SKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource