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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DEAF1-HRAS (FusionGDB2 ID:22123) |
Fusion Gene Summary for DEAF1-HRAS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DEAF1-HRAS | Fusion gene ID: 22123 | Hgene | Tgene | Gene symbol | DEAF1 | HRAS | Gene ID | 10522 | 3265 |
| Gene name | DEAF1 transcription factor | HRas proto-oncogene, GTPase | |
| Synonyms | MRD24|NUDR|SPN|ZMYND5 | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras | |
| Cytomap | 11p15.5 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | deformed epidermal autoregulatory factor 1 homolognuclear DEAF-1-related transcriptional regulatorsuppressinzinc finger MYND domain-containing protein 5 | GTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinp19 H-RasIDX proteintransformation gene: | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | O75398 | P01112 | |
| Ensembl transtripts involved in fusion gene | ENST00000338675, ENST00000382409, ENST00000525904, | ENST00000311189, ENST00000397594, ENST00000397596, ENST00000417302, ENST00000451590, ENST00000468682, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 5 X 6 X 4=120 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DEAF1 [Title/Abstract] AND HRAS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DEAF1(680963)-HRAS(532755), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DEAF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24726472 |
| Hgene | DEAF1 | GO:0033599 | regulation of mammary gland epithelial cell proliferation | 18826651 |
| Hgene | DEAF1 | GO:0045892 | negative regulation of transcription, DNA-templated | 24726472 |
| Hgene | DEAF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 24726472 |
| Tgene | HRAS | GO:0001934 | positive regulation of protein phosphorylation | 22065586 |
| Tgene | HRAS | GO:0007050 | cell cycle arrest | 9054499 |
| Tgene | HRAS | GO:0007093 | mitotic cell cycle checkpoint | 9054499 |
| Tgene | HRAS | GO:0007265 | Ras protein signal transduction | 23027131 |
| Tgene | HRAS | GO:0008284 | positive regulation of cell proliferation | 9765203 |
| Tgene | HRAS | GO:0008285 | negative regulation of cell proliferation | 9054499 |
| Tgene | HRAS | GO:0010629 | negative regulation of gene expression | 23027131 |
| Tgene | HRAS | GO:0010863 | positive regulation of phospholipase C activity | 11022048 |
| Tgene | HRAS | GO:0030335 | positive regulation of cell migration | 23027131 |
| Tgene | HRAS | GO:0034260 | negative regulation of GTPase activity | 23027131 |
| Tgene | HRAS | GO:0043406 | positive regulation of MAP kinase activity | 23027131 |
| Tgene | HRAS | GO:0043410 | positive regulation of MAPK cascade | 9765203 |
| Tgene | HRAS | GO:0043547 | positive regulation of GTPase activity | 23027131 |
| Tgene | HRAS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22065586|23027131 |
| Tgene | HRAS | GO:0046330 | positive regulation of JNK cascade | 22065586 |
| Tgene | HRAS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Tgene | HRAS | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Tgene | HRAS | GO:0090303 | positive regulation of wound healing | 23027131 |
| Tgene | HRAS | GO:0090398 | cellular senescence | 9054499 |
| Tgene | HRAS | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | 12202034 |
| Tgene | HRAS | GO:1900029 | positive regulation of ruffle assembly | 23027131 |
| Tgene | HRAS | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027131 |
| Tgene | HRAS | GO:2000630 | positive regulation of miRNA metabolic process | 23027131 |
| Fusion gene breakpoints across DEAF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HRAS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-AD-6888-01A | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| ChimerDB4 | COAD | TCGA-AD-6888-01A | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
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Fusion Gene ORF analysis for DEAF1-HRAS |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000338675 | ENST00000311189 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000338675 | ENST00000397594 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000338675 | ENST00000397596 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000338675 | ENST00000417302 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000338675 | ENST00000451590 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000311189 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000311189 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000397594 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000397594 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000397596 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000397596 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000417302 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000417302 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000451590 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-3UTR | ENST00000382409 | ENST00000451590 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-intron | ENST00000338675 | ENST00000468682 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5CDS-intron | ENST00000382409 | ENST00000468682 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5CDS-intron | ENST00000382409 | ENST00000468682 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| 5UTR-3UTR | ENST00000525904 | ENST00000311189 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5UTR-3UTR | ENST00000525904 | ENST00000397594 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5UTR-3UTR | ENST00000525904 | ENST00000397596 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5UTR-3UTR | ENST00000525904 | ENST00000417302 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5UTR-3UTR | ENST00000525904 | ENST00000451590 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| 5UTR-intron | ENST00000525904 | ENST00000468682 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000338675 | ENST00000311189 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000338675 | ENST00000397594 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000338675 | ENST00000397596 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000338675 | ENST00000417302 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000338675 | ENST00000451590 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000525904 | ENST00000311189 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000525904 | ENST00000397594 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000525904 | ENST00000397596 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000525904 | ENST00000417302 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| intron-3UTR | ENST00000525904 | ENST00000451590 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| intron-intron | ENST00000338675 | ENST00000468682 | DEAF1 | chr11 | 680963 | - | HRAS | chr11 | 532755 | - |
| intron-intron | ENST00000525904 | ENST00000468682 | DEAF1 | chr11 | 684898 | - | HRAS | chr11 | 532755 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DEAF1-HRAS |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DEAF1-HRAS |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:680963/:532755) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEAF1 | HRAS |
| FUNCTION: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:0000269|PubMed:11705868, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}. | FUNCTION: Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DEAF1-HRAS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for DEAF1-HRAS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DEAF1-HRAS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DEAF1-HRAS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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