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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DEAF1-SH3GL1 (FusionGDB2 ID:22126)

Fusion Gene Summary for DEAF1-SH3GL1

Fusion gene summary

Fusion gene information	Fusion gene name: DEAF1-SH3GL1
	Fusion gene ID: 22126
		Hgene	Tgene
	Gene symbol	DEAF1	SH3GL1
	Gene ID	10522	6455
	Gene name	DEAF1 transcription factor	SH3 domain containing GRB2 like 1, endophilin A2
	Synonyms	MRD24\|NUDR\|SPN\|ZMYND5	CNSA1\|EEN\|SH3D2B\|SH3P8
	Cytomap	11p15.5	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	deformed epidermal autoregulatory factor 1 homolognuclear DEAF-1-related transcriptional regulatorsuppressinzinc finger MYND domain-containing protein 5	endophilin-A2EEN fusion partner of MLLSH3 domain protein 2BSH3 domain-containing GRB2-like protein 1SH3-containing Grb-2-like 1 proteinSH3-domain GRB2-like 1endophilin-2extra 11-19 leukemia fusionextra eleven-nineteen leukemia fusion gene protein
	Modification date	20200313	20200313
	UniProtAcc	O75398	Q99961
	Ensembl transtripts involved in fusion gene	ENST00000382409, ENST00000338675, ENST00000525904,	ENST00000269886, ENST00000417295, ENST00000598564,
Fusion gene scores	* DoF score	6 X 5 X 4=120	10 X 6 X 9=540
	# samples	8	10
	** MAII score	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DEAF1 [Title/Abstract] AND SH3GL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DEAF1(686858)-SH3GL1(4366991), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DEAF1	GO:0000122	negative regulation of transcription by RNA polymerase II	24726472
Hgene	DEAF1	GO:0033599	regulation of mammary gland epithelial cell proliferation	18826651
Hgene	DEAF1	GO:0045892	negative regulation of transcription, DNA-templated	24726472
Hgene	DEAF1	GO:0045893	positive regulation of transcription, DNA-templated	24726472

Fusion gene breakpoints across DEAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SH3GL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-XF-AAMZ-01A	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
ChimerDB4	BLCA	TCGA-XF-AAMZ	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-

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Fusion Gene ORF analysis for DEAF1-SH3GL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000382409	ENST00000269886	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
In-frame	ENST00000382409	ENST00000417295	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
In-frame	ENST00000382409	ENST00000598564	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000338675	ENST00000269886	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000338675	ENST00000417295	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000338675	ENST00000598564	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000525904	ENST00000269886	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000525904	ENST00000417295	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-
intron-3CDS	ENST00000525904	ENST00000598564	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000382409	DEAF1	chr11	686858	-	ENST00000269886	SH3GL1	chr19	4366991	-	3581	1289	485	2350	621
ENST00000382409	DEAF1	chr11	686858	-	ENST00000598564	SH3GL1	chr19	4366991	-	3388	1289	485	2158	557
ENST00000382409	DEAF1	chr11	686858	-	ENST00000417295	SH3GL1	chr19	4366991	-	2491	1289	485	2206	573

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000382409	ENST00000269886	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-	0.012877779	0.98712224
ENST00000382409	ENST00000598564	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-	0.012320465	0.9876795
ENST00000382409	ENST00000417295	DEAF1	chr11	686858	-	SH3GL1	chr19	4366991	-	0.010277053	0.98972297

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Fusion Genomic Features for DEAF1-SH3GL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DEAF1-SH3GL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:686858/chr19:4366991)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DEAF1 O75398	SH3GL1 Q99961
FUNCTION: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269\|PubMed:10521432, ECO:0000269\|PubMed:11427895, ECO:0000269\|PubMed:11705868, ECO:0000269\|PubMed:18826651, ECO:0000269\|PubMed:19668219, ECO:0000269\|PubMed:24726472}.	FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000382409

2_122

268

566.0

Compositional bias

Note=Ala-rich

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000269886

145_250

369.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000417295

145_250

321.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000598564

145_250

305.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000269886

18_249

369.0

Domain

BAR

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000269886

306_365

369.0

Domain

SH3

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000417295

18_249

321.0

Domain

BAR

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000417295

306_365

321.0

Domain

SH3

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000598564

18_249

305.0

Domain

BAR

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000598564

306_365

305.0

Domain

SH3

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000269886

60_87

369.0

Region

Required for dimerization upon membrane association

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000417295

60_87

321.0

Region

Required for dimerization upon membrane association

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000598564

60_87

305.0

Region

Required for dimerization upon membrane association

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000338675

2_122

491.0

Compositional bias

Note=Ala-rich

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000338675

383_439

491.0

Compositional bias

Note=Pro-rich

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000382409

383_439

268

566.0

Compositional bias

Note=Pro-rich

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000338675

193_273

491.0

Domain

SAND

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000382409

193_273

268

566.0

Domain

SAND

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000338675

301_316

491.0

Motif

Nuclear localization signal

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000382409

301_316

268

566.0

Motif

Nuclear localization signal

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000338675

504_540

491.0

Zinc finger

MYND-type

Hgene

DEAF1

chr11:686858

chr19:4366991

ENST00000382409

504_540

268

566.0

Zinc finger

MYND-type

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000269886

1_21

369.0

Region

Membrane-binding amphipathic helix

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000417295

1_21

321.0

Region

Membrane-binding amphipathic helix

Tgene

SH3GL1

chr11:686858

chr19:4366991

ENST00000598564

1_21

305.0

Region

Membrane-binding amphipathic helix

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Fusion Gene Sequence for DEAF1-SH3GL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22126_22126_1_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000269886_length(transcript)=3581nt_BP=1289nt
AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG
GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA
CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA
CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT
CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC
GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG
TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG
AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG
GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG
CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG
ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC
CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT
ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA
AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG
CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA
TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGG
CTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGGTGAAGAACCCCGGCTACCCGCAGTCGGAGGGGCTTCTGGGCGAGT
GCATGATCCGCCACGGGAAGGAGCTGGGCGGCGAGTCCAACTTTGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAG
AGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGC
ACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGG
CGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCT
CGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGG
AAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCC
CCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCC
TGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGA
CCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCC
TGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCC
CTGCTGCCAGGGCGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGG
GGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTGACGGCTCCCTTCCCCACTCCATGGCGCCAGCC
TCCTCCCCCGCTCCCCAACTTCTCGCCCAGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGCAG
CCCCCACCTCCGTCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCGCAGCCTTAACAGGATGGGATCGAGGGTCCCCA
TGGGGTGGCTCAGAGATAGGACCCTGGTTTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGCAC
CCCCGCCTCACACACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCTCCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGA
CAGAGGCCAGCTGGGATCTGCCTGAGGACAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGTAC
CTTTTCAGCTTTTTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCCACACCCACC
CCAGCACACCTCACACGGGACCACAGCCGCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCCAG
GCTCCCCTTGCTGAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCCTCTAGACCAAGGCAGGCAGCCCCGACATCTGC
TTCCTCTATCGCCCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTGAA
GCCTCCGGACCCCAGGCTCTGCTCTGCCCTGCCCTGCACCCCCCTCGTCAGAAGTACATGAGGGGCGCAGAGATGAGCACACAGCTTTGG

>22126_22126_1_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000269886_length(amino acids)=621AA_BP=17
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA
AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP
LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV
SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGE
SNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVA
ETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASS

--------------------------------------------------------------
>22126_22126_2_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000417295_length(transcript)=2491nt_BP=1289nt
AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG
GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA
CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA
CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT
CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC
GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG
TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG
AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG
GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG
CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG
ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC
CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT
ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA
AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG
CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA
TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGGTGACGCAT
TGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAGAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCC
AGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGC
GGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACC
TCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGG
ACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTG
ACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACA
AGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGG
AGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCT
TCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCCTGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGG
CACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGGCGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTG
AGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGGGGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAAC

>22126_22126_2_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000417295_length(amino acids)=573AA_BP=17
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA
AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP
LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV
SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQ
HHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMR
EASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITL

--------------------------------------------------------------
>22126_22126_3_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000598564_length(transcript)=3388nt_BP=1289nt
AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG
GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA
CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA
CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT
CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC
GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG
TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG
AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG
GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG
CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG
ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC
CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT
ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA
AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG
CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA
TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGG
CTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGA
AACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGT
TCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGG
ATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCAC
GCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAG
CCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGA
GCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCG
ATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCCTGCCGCAGTGAC
TCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGG
CGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGGGGGGCTTATCTG
GGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTGACGGCTCCCTTCCCCACTCCATGGCGCCAGCCTCCTCCCCCGCT
CCCCAACTTCTCGCCCAGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGCAGCCCCCACCTCCG
TCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCGCAGCCTTAACAGGATGGGATCGAGGGTCCCCATGGGGTGGCTCA
GAGATAGGACCCTGGTTTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGCACCCCCGCCTCACA
CACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCTCCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGACAGAGGCCAGCT
GGGATCTGCCTGAGGACAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGTACCTTTTCAGCTTT
TTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCCACACCCACCCCAGCACACCTC
ACACGGGACCACAGCCGCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCCAGGCTCCCCTTGCT
GAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCCTCTAGACCAAGGCAGGCAGCCCCGACATCTGCTTCCTCTATCGC
CCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTGAAGCCTCCGGACCC
CAGGCTCTGCTCTGCCCTGCCCTGCACCCCCCTCGTCAGAAGTACATGAGGGGCGCAGAGATGAGCACACAGCTTTGGGCACGGTCCAGG

>22126_22126_3_DEAF1-SH3GL1_DEAF1_chr11_686858_ENST00000382409_SH3GL1_chr19_4366991_ENST00000598564_length(amino acids)=557AA_BP=17
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA
AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP
LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV
SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQNLCEKDLKEIQHHLKKLEGRRLDFDYK
KKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPRE
PFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DEAF1-SH3GL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SH3GL1	chr11:686858	chr19:4366991	ENST00000269886		0	10	218_254	15.0	369.0	ARC
Tgene	SH3GL1	chr11:686858	chr19:4366991	ENST00000417295		0	9	218_254	15.0	321.0	ARC
Tgene	SH3GL1	chr11:686858	chr19:4366991	ENST00000598564		0	10	218_254	15.0	305.0	ARC

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	DEAF1	chr11:686858	chr19:4366991	ENST00000338675	-	1	11	403_478	0	491.0	LMO4
Hgene	DEAF1	chr11:686858	chr19:4366991	ENST00000382409	-	5	12	403_478	268.0	566.0	LMO4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DEAF1-SH3GL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DEAF1-SH3GL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source