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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DECR1-PRPF18 (FusionGDB2 ID:22133)

Fusion Gene Summary for DECR1-PRPF18

Fusion gene summary

Fusion gene information	Fusion gene name: DECR1-PRPF18
	Fusion gene ID: 22133
		Hgene	Tgene
	Gene symbol	DECR1	PRPF18
	Gene ID	1666	8559
	Gene name	2,4-dienoyl-CoA reductase 1	pre-mRNA processing factor 18
	Synonyms	DECR\|NADPH\|SDR18C1	PRP18\|hPrp18
	Cytomap	8q21.3	10p13
	Type of gene	protein-coding	protein-coding
	Description	2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1	pre-mRNA-splicing factor 18PRP18 homologPRP18 pre-mRNA processing factor 18 homologPRP18 pre-mRNA processing factor 18 homolog(PRPF18)
	Modification date	20200313	20200313
	UniProtAcc	Q16698	.
	Ensembl transtripts involved in fusion gene	ENST00000519007, ENST00000220764, ENST00000522161,	ENST00000378572,
Fusion gene scores	* DoF score	7 X 4 X 6=168	1 X 1 X 1=1
	# samples	7	1
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: DECR1 [Title/Abstract] AND PRPF18 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DECR1(91031400)-PRPF18(13647631), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DECR1	GO:0006635	fatty acid beta-oxidation	15531764

Fusion gene breakpoints across DECR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRPF18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GN-01A	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+

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Fusion Gene ORF analysis for DECR1-PRPF18

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000519007	ENST00000378572	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+
In-frame	ENST00000220764	ENST00000378572	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+
In-frame	ENST00000522161	ENST00000378572	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000220764

DECR1

chr8

91031400

ENST00000378572

PRPF18

chr10

13647631

1813

505

1284

422

ENST00000522161

DECR1

chr8

91031400

ENST00000378572

PRPF18

chr10

13647631

2381

1073

683

1852

389

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000220764	ENST00000378572	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+	0.000191374	0.9998086
ENST00000522161	ENST00000378572	DECR1	chr8	91031400	+	PRPF18	chr10	13647631	+	0.000292155	0.9997079

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Fusion Genomic Features for DECR1-PRPF18

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DECR1	chr8	91031400	+	PRPF18	chr10	13647630	+	0.9991128	0.000887154
DECR1	chr8	91031400	+	PRPF18	chr10	13647630	+	0.9991128	0.000887154

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DECR1-PRPF18

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:91031400/chr10:13647631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DECR1 Q16698	.
FUNCTION: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. {ECO:0000269\|PubMed:15531764}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DECR1

chr8:91031400

chr10:13647631

ENST00000220764

66_71

139

336.0

Nucleotide binding

NADP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DECR1

chr8:91031400

chr10:13647631

ENST00000220764

240_243

139

336.0

Nucleotide binding

NADP

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Fusion Gene Sequence for DECR1-PRPF18

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22133_22133_1_DECR1-PRPF18_DECR1_chr8_91031400_ENST00000220764_PRPF18_chr10_13647631_ENST00000378572_length(transcript)=1813nt_BP=505nt
TCCAGCCCCGAGAACTTTGTTCTTTTTGTCCCGCCCCCTGCGCCCAACCGCCTGCGCCGCCTTCCGGCCCGAGTTCTGGAGACTCAACAT
GAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCTCCTCGGAGGTTTTTCAGTTATGGGACAAAAAT
ATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAAGT
GGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTGATAGCCAGCCG
GAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGATCC
TGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATGTCATCAGAAGATTGAGAGAAAGAGGAGAACCAAT
CAGACTATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCACACCAGAAGTTAACAAGGGATTGAGGAA
TGATTTGAAAGCAGCCTTGGATAAGATTGATCAGCAGTACCTCAATGAAATCGTCGGCGGTCAGGAGCCTGGAGAGGAAGACACACAGAA
TGATCTGAAAGTTCATGAGGAAAACACCACAATTGAAGAGTTAGAGGCGCTTGGAGAGTCCTTAGGGAAAGGCGATGATCATAAAGACAT
GGACATCATCACCAAATTCCTGAAGTTTCTTCTTGGCGTTTGGGCTAAAGAATTGAATGCCAGAGAAGATTATGTGAAACGCAGTGTGCA
GGGTAAACTGAACAGTGCGACCCAGAAACAGACCGAGTCCTACCTAAGACCACTTTTTAGAAAGCTACGGAAAAGGAATCTTCCTGCTGA
TATTAAAGAATCAATAACGGATATTATTAAATTCATGTTGCAGAGAGAATACGTGAAGGCAAATGATGCTTATCTTCAGATGGCCATTGG
AAATGCGCCTTGGCCCATCGGTGTCACTATGGTTGGTATCCATGCCAGAACTGGCAGAGAAAAGATTTTTTCCAAGCATGTTGCACATGT
TTTAAATGACGAAACTCAGCGGAAATATATTCAGGGATTGAAGAGGTTAATGACCATTTGCCAGAAACACTTTCCTACAGACCCATCCAA
ATGTGTGGAGTACAATGCACTGTGAGATCTGTGTATGGTGTGTTAATAACAATAAGAAACTTAGGGAAGCAGGCTGTGGACTTCTGGAAT
TACCAACAGGAATGAGGAAAGAAGAAAACTGGAGTTTCCAGTCTCTGAGTTCTACCTGATGTAACTCTTGATTGGTTTTAAGAACTTTGT
TGGCCTTCATTTCATATCTGACTGCAAGCTGATTTTTCTTTCTTGCTTTCATTTTAATTAGTCCAAAATTAAGTTTTAAAGATTTTTCCT
CACAATTTAAATCCATAGACAACAGAAGGGGGTTTAAAATGACCTTTTTTTCAGTTGACCCGAAAGTTGTGGTTAGATGATTAAAAAGAA
ACATTTGAGGATGGACTTAATTATTTCAGTAAAATATTATAATTTGCCTATTGTCTTTTATGTAATATTTATATAAAATATTTTTATATA
TTTCAAAAACATGGGACCATTGAATGAAACTTTATAGTCCTTAAATGTTGCTGAACTTTTGCTGTCTTGCAATAGAATTTGAATGTAAAT

>22133_22133_1_DECR1-PRPF18_DECR1_chr8_91031400_ENST00000220764_PRPF18_chr10_13647631_ENST00000378572_length(amino acids)=422AA_BP=163
MFFLSRPLRPTACAAFRPEFWRLNMKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITG
GGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNVIRRLRERGEPIRLFGE
TDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITK
FLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWP

--------------------------------------------------------------
>22133_22133_2_DECR1-PRPF18_DECR1_chr8_91031400_ENST00000522161_PRPF18_chr10_13647631_ENST00000378572_length(transcript)=2381nt_BP=1073nt
GTTCTGGAGACTCAACATGAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCTCCTCGGAGGTCTGA
AAAATGAGTAAAGATGGAAGCCAAAGTATCACTTTTATTGTGGTTTGTGAGAGGAAGCTGGGCCTATCAGCTGGATCTCCCGAAGTAGGC
GGACTTACATAACTCTGGAGGAGGGCAGAACATTGTCCTCTGAAGGCAGCTGGCTCCCAAAAGGAAGAAGACCAAGGAGAACTGTTCATA
CCCAACGATCCTGTCAAAATTTACCAGTCATATCAACTGTCTCTGCACAGACAGATTGTACCTCAGTCTGTGTTGCTATAAAGGAATACC
TGAGGCTGGGTAATTTATAAAGAAAAGGGTTTGTTTGACTCATGATTCTGATGCCTGGACAAGTTCAAGACTGGGCATCTGCATCTGGTG
ACGGCCTAAGGCTGCTTGCACTTGTGGCAGAAGGATGAAGATGGTACTACGACATTCATGATGGATCTGCCACCATAACCCAGGCACCTC
CCATTAGACCCCACCTCCAACATTGGGGATCACATTTCAACATGAGTTTTCAAGGGACAAACATCCAAACATCCTTAGCAGGTTGACTAA
GGGGACAGAAAGAAGCCTGGAGTTGTACTACCTGAACTTCTCACAGTAGGGAGATGTCAGGACTGGGGAAGAAGCATCTCCTGCTCATGG
GGGAGTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCTCTTCAAAAAGCGATGC
TACCACCTAATAGTTTTCAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCCAGCC
TAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTC
ATGCAATTCAGTGTGATGTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATGTCATCA
GAAGATTGAGAGAAAGAGGAGAACCAATCAGACTATTTGGAGAGACTGATTATGATGCTTTTCAACGTTTAAGGAAAATAGAGATCCTCA
CACCAGAAGTTAACAAGGGATTGAGGAATGATTTGAAAGCAGCCTTGGATAAGATTGATCAGCAGTACCTCAATGAAATCGTCGGCGGTC
AGGAGCCTGGAGAGGAAGACACACAGAATGATCTGAAAGTTCATGAGGAAAACACCACAATTGAAGAGTTAGAGGCGCTTGGAGAGTCCT
TAGGGAAAGGCGATGATCATAAAGACATGGACATCATCACCAAATTCCTGAAGTTTCTTCTTGGCGTTTGGGCTAAAGAATTGAATGCCA
GAGAAGATTATGTGAAACGCAGTGTGCAGGGTAAACTGAACAGTGCGACCCAGAAACAGACCGAGTCCTACCTAAGACCACTTTTTAGAA
AGCTACGGAAAAGGAATCTTCCTGCTGATATTAAAGAATCAATAACGGATATTATTAAATTCATGTTGCAGAGAGAATACGTGAAGGCAA
ATGATGCTTATCTTCAGATGGCCATTGGAAATGCGCCTTGGCCCATCGGTGTCACTATGGTTGGTATCCATGCCAGAACTGGCAGAGAAA
AGATTTTTTCCAAGCATGTTGCACATGTTTTAAATGACGAAACTCAGCGGAAATATATTCAGGGATTGAAGAGGTTAATGACCATTTGCC
AGAAACACTTTCCTACAGACCCATCCAAATGTGTGGAGTACAATGCACTGTGAGATCTGTGTATGGTGTGTTAATAACAATAAGAAACTT
AGGGAAGCAGGCTGTGGACTTCTGGAATTACCAACAGGAATGAGGAAAGAAGAAAACTGGAGTTTCCAGTCTCTGAGTTCTACCTGATGT
AACTCTTGATTGGTTTTAAGAACTTTGTTGGCCTTCATTTCATATCTGACTGCAAGCTGATTTTTCTTTCTTGCTTTCATTTTAATTAGT
CCAAAATTAAGTTTTAAAGATTTTTCCTCACAATTTAAATCCATAGACAACAGAAGGGGGTTTAAAATGACCTTTTTTTCAGTTGACCCG
AAAGTTGTGGTTAGATGATTAAAAAGAAACATTTGAGGATGGACTTAATTATTTCAGTAAAATATTATAATTTGCCTATTGTCTTTTATG
TAATATTTATATAAAATATTTTTATATATTTCAAAAACATGGGACCATTGAATGAAACTTTATAGTCCTTAAATGTTGCTGAACTTTTGC

>22133_22133_2_DECR1-PRPF18_DECR1_chr8_91031400_ENST00000522161_PRPF18_chr10_13647631_ENST00000378572_length(amino acids)=389AA_BP=130
MSGLGKKHLLLMGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKAT
AEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDK
IDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQ
KQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DECR1-PRPF18

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DECR1-PRPF18

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DECR1-PRPF18

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source