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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADCY2-HSDL2 (FusionGDB2 ID:2217)

Fusion Gene Summary for ADCY2-HSDL2

Fusion gene summary

Fusion gene information	Fusion gene name: ADCY2-HSDL2
	Fusion gene ID: 2217
		Hgene	Tgene
	Gene symbol	ADCY2	HSDL2
	Gene ID	108	84263
	Gene name	adenylate cyclase 2	hydroxysteroid dehydrogenase like 2
	Synonyms	AC2\|HBAC2	C9orf99\|SDR13C1
	Cytomap	5p15.31	9q32
	Type of gene	protein-coding	protein-coding
	Description	adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase	hydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1
	Modification date	20200313	20200313
	UniProtAcc	Q08462	Q6YN16
	Ensembl transtripts involved in fusion gene	ENST00000338316, ENST00000537121, ENST00000513693,	ENST00000262542, ENST00000488101, ENST00000398803, ENST00000539114, ENST00000398805,
Fusion gene scores	* DoF score	11 X 9 X 6=594	6 X 6 X 6=216
	# samples	10	7
	** MAII score	log2(10/594*10)=-2.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADCY2 [Title/Abstract] AND HSDL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADCY2(7773214)-HSDL2(115179121), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ADCY2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSDL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A1KZ-01A	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+

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Fusion Gene ORF analysis for ADCY2-HSDL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000338316	ENST00000262542	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-3UTR	ENST00000338316	ENST00000488101	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-3UTR	ENST00000537121	ENST00000262542	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-3UTR	ENST00000537121	ENST00000488101	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-intron	ENST00000338316	ENST00000398803	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-intron	ENST00000338316	ENST00000539114	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-intron	ENST00000537121	ENST00000398803	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
5CDS-intron	ENST00000537121	ENST00000539114	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
In-frame	ENST00000338316	ENST00000398805	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
In-frame	ENST00000537121	ENST00000398805	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
intron-3CDS	ENST00000513693	ENST00000398805	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
intron-3UTR	ENST00000513693	ENST00000262542	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
intron-3UTR	ENST00000513693	ENST00000488101	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
intron-intron	ENST00000513693	ENST00000398803	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+
intron-intron	ENST00000513693	ENST00000539114	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000338316

ADCY2

chr5

7773214

ENST00000398805

HSDL2

chr9

115179121

5201

2473

3334

1081

ENST00000537121

ADCY2

chr5

7773214

ENST00000398805

HSDL2

chr9

115179121

4638

1910

2771

901

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338316	ENST00000398805	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+	0.00027331	0.9997267
ENST00000537121	ENST00000398805	ADCY2	chr5	7773214	+	HSDL2	chr9	115179121	+	0.000238572	0.9997614

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Fusion Genomic Features for ADCY2-HSDL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ADCY2	chr5	7773214	+	HSDL2	chr9	115179120	+	9.67E-06	0.99999034
ADCY2	chr5	7773214	+	HSDL2	chr9	115179120	+	9.67E-06	0.99999034

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADCY2-HSDL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7773214/chr9:115179121)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADCY2 Q08462	HSDL2 Q6YN16
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250\|UniProtKB:P26769, ECO:0000269\|PubMed:15385642}.	FUNCTION: Has apparently no steroid dehydrogenase activity. {ECO:0000269\|PubMed:19703561}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

295_300

794

1092.0

Nucleotide binding

ATP

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

337_339

794

1092.0

Nucleotide binding

ATP

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

1_45

794

1092.0

Topological domain

Cytoplasmic

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

208_601

794

1092.0

Topological domain

Cytoplasmic

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

108_128

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

133_153

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

159_179

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

187_207

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

46_66

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

602_622

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

628_652

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

680_701

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

734_755

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

763_780

794

1092.0

Transmembrane

Helical

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

76_96

794

1092.0

Transmembrane

Helical

Tgene

HSDL2

chr5:7773214

chr9:115179121

ENST00000398803

306_415

346.0

Domain

Note=SCP2

Tgene

HSDL2

chr5:7773214

chr9:115179121

ENST00000398805

306_415

131

419.0

Domain

Note=SCP2

Tgene

HSDL2

chr5:7773214

chr9:115179121

ENST00000398803

17_23

346.0

Nucleotide binding

NADP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

1019_1021

794

1092.0

Nucleotide binding

ATP

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

1026_1030

794

1092.0

Nucleotide binding

ATP

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

822_1091

794

1092.0

Topological domain

Cytoplasmic

Hgene

ADCY2

chr5:7773214

chr9:115179121

ENST00000338316

801_821

794

1092.0

Transmembrane

Helical

Tgene

HSDL2

chr5:7773214

chr9:115179121

ENST00000398805

17_23

131

419.0

Nucleotide binding

NADP

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Fusion Gene Sequence for ADCY2-HSDL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2217_2217_1_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000338316_HSDL2_chr9_115179121_ENST00000398805_length(transcript)=5201nt_BP=2473nt
AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA
TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG
ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC
TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG
CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG
GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC
TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC
CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC
TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG
AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC
AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC
GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT
GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA
TGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATG
TCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGG
TCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACC
CATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCC
ACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTAC
ATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAA
GAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGC
TCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCA
AGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCT
CCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCC
TGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATAT
TAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAG
CCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCT
GTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCC
ACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATA
TCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGT
ATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATA
TGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTT
TTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTT
TGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGA
AACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAG
CCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGAT
ATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAA
TGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGAC
TGTGAAGGAAAATATAAAAAAAAAGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCC
TGTTATATTATAAGGATATGCACGTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAA
TCAAACATAAGCTTCATTAAGTGGGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCA
CTGTCTTTCTCCAAGAAAAGTATTTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAA
GCTAGTCTGTTTTAAAATTTTTAGTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAA
AATCTTATATAGTACATTTTACAAAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAAC
TAGCTTTCCAGGTGGACTTAGCCATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAA
TTGTCCTAAAACAAAATAATTTTCTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATG
GGCTGAACTGTGTATCCCCCAATTCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGA
GGTGACTTAAGTTCAAAGGAGGCTGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAA
GACCAGGAGAGGACACAGTGAGAAGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTG
ACTTCTAATCTCCAGAATAGTGAGAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAG
GAGTTCAAGGCCAGCCTGGACAACATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTT
TATTATGGCAGCCCTAGCAAGCTAATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTC
ATTTCAATCAGTTAAAAATACTTGCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCT
AATCCTGACATTTCTTAGATTCATAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGAC
TAGCCCAAGGCCAACATTAACAAGCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCC
AGGAATGGAGTCCATGTAATCAAAGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCC
AGTCAACGTGAGCAAGCGTGATTATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAAC
CAATCTGCTGTGTCTACTATGCTGTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCT

>2217_2217_1_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000338316_HSDL2_chr9_115179121_ENST00000398805_length(amino acids)=1081AA_BP=794
MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF
AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG
QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD
PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI
SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH
ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS
FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK
ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR

--------------------------------------------------------------
>2217_2217_2_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000537121_HSDL2_chr9_115179121_ENST00000398805_length(transcript)=4638nt_BP=1910nt
GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT
CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA
GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG
CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC
CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG
GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA
GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC
ATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATGTCCTGTGTGGCGTGATTGGTCTG
CAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGGTCCCTGGACGTGTTCACATTTCT
TCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACCCATATTTAAAACAGCACCTGGTG
AAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATG
AGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTACATCACAGGGACAGCATGACCACA
GAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAAGAACCAAGTCACAAAAGAAGAGA
TTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGCTCAAGTCTGAAGACATTCAGAGA
ATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCAAGTATTATGTGACTTGTGCCTGT
CTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCTCCTTTGGGGCTGCGTTTCTCTTG
CTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCCTGCTCATGTGGCTTTTGAAGTCC
TCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATATTAATGATGGCCGTGTTCAACATG
TTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAGCCTCAAATAATCAGGTGGCGATT
CTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCTGTTCCGTGTTCCTGCGGGTAAAC
TATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCCACGCCCACGTCCTGGGCGACTAC
AGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATATCCTCAATATCAGTCCACCACTG
AACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGTATGTGCTTGGAATGGCAGAAGAA
TTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATATGCTGGGAGGACCTGGTATCGAA
AGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTTTTACTGGCAACTTTGTCATTGAT
GAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTTTGCAACCAGATTTCTTCTTAGAT
GAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGAAACTGCAGCTGCAACCAAAACCA
CGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAGCCACTCAAGCAATCTATCTGTTT
GAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGATATGGAGAGCCTTCTGATCAGGCA
GATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAATGGCATTCATGTCAGGGAAATTG
AAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGACTGTGAAGGAAAATATAAAAAAAA
AGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCCTGTTATATTATAAGGATATGCAC
GTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAATCAAACATAAGCTTCATTAAGTG
GGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCACTGTCTTTCTCCAAGAAAAGTAT
TTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAAGCTAGTCTGTTTTAAAATTTTTA
GTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAAAATCTTATATAGTACATTTTACA
AAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAACTAGCTTTCCAGGTGGACTTAGCC
ATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAATTGTCCTAAAACAAAATAATTTT
CTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATGGGCTGAACTGTGTATCCCCCAAT
TCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGAGGTGACTTAAGTTCAAAGGAGGC
TGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAAGACCAGGAGAGGACACAGTGAGA
AGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTGACTTCTAATCTCCAGAATAGTGA
GAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGGCCAGCCTGGACAA
CATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTTTATTATGGCAGCCCTAGCAAGCT
AATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTCATTTCAATCAGTTAAAAATACTT
GCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCTAATCCTGACATTTCTTAGATTCA
TAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGACTAGCCCAAGGCCAACATTAACAA
GCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCCAGGAATGGAGTCCATGTAATCAA
AGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCCAGTCAACGTGAGCAAGCGTGATT
ATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAACCAATCTGCTGTGTCTACTATGCT
GTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCTGTTTTATTTTGTAGGCTGGATGC

>2217_2217_2_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000537121_HSDL2_chr9_115179121_ENST00000398805_length(amino acids)=901AA_BP=614
MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG
QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD
PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI
SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH
ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS
FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK
ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR

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Fusion Gene PPI Analysis for ADCY2-HSDL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ADCY2	chr5:7773214	chr9:115179121	ENST00000338316	+	18	25	905_922	794.6666666666666	1092.0	GNAS
Hgene	ADCY2	chr5:7773214	chr9:115179121	ENST00000338316	+	18	25	990_993	794.6666666666666	1092.0	GNAS

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADCY2-HSDL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ADCY2-HSDL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source