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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1A-ENG (FusionGDB2 ID:22194)

Fusion Gene Summary for DENND1A-ENG

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1A-ENG
Fusion gene ID: 22194
HgeneTgene
Gene symbol

DENND1A

ENG

Gene ID

57706

2022

Gene nameDENN domain containing 1Aendoglin
SynonymsFAM31A|KIAA1608END|HHT1|ORW1
Cytomap

9q33.3

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1endoglinCD105 antigen
Modification date2020032020200329
UniProtAcc

Q8TEH3

Q8NFI3

Ensembl transtripts involved in fusion geneENST00000373618, ENST00000373620, 
ENST00000373624, ENST00000394215, 
ENST00000394219, ENST00000473039, 
ENST00000542603, 		ENST00000480266, 
ENST00000344849, ENST00000373203, 
Fusion gene scores* DoF score18 X 18 X 14=45366 X 7 X 4=168
# samples 266
** MAII scorelog2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1A [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1A(126319849)-ENG(130581111), # samples:3
Anticipated loss of major functional domain due to fusion event.DENND1A-ENG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND1A-ENG seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701

TgeneENG

GO:0001934

positive regulation of protein phosphorylation

12015308

TgeneENG

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

12015308

TgeneENG

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

15702480

TgeneENG

GO:0030336

negative regulation of cell migration

19736306

TgeneENG

GO:0030513

positive regulation of BMP signaling pathway

17068149

TgeneENG

GO:0031953

negative regulation of protein autophosphorylation

12015308


check buttonFusion gene breakpoints across DENND1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ENG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A45T-01ADENND1Achr9

126319849

-ENGchr9

130581111

-
ChimerDB4HNSCTCGA-CV-A45TDENND1Achr9

126319849

-ENGchr9

130581111

-


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Fusion Gene ORF analysis for DENND1A-ENG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373618ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
5CDS-intronENST00000373620ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
5CDS-intronENST00000373624ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
5CDS-intronENST00000394215ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
5CDS-intronENST00000394219ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
5UTR-3CDSENST00000473039ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
5UTR-3CDSENST00000473039ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
5UTR-intronENST00000473039ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-
Frame-shiftENST00000373618ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
Frame-shiftENST00000373618ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
Frame-shiftENST00000394215ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
Frame-shiftENST00000394215ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000373620ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000373620ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000373624ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000373624ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000394219ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
In-frameENST00000394219ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
intron-3CDSENST00000542603ENST00000344849DENND1Achr9

126319849

-ENGchr9

130581111

-
intron-3CDSENST00000542603ENST00000373203DENND1Achr9

126319849

-ENGchr9

130581111

-
intron-intronENST00000542603ENST00000480266DENND1Achr9

126319849

-ENGchr9

130581111

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373624DENND1Achr9126319849-ENST00000373203ENGchr9130581111-253111951931860555
ENST00000373624DENND1Achr9126319849-ENST00000344849ENGchr9130581111-266211951931761522
ENST00000394219DENND1Achr9126319849-ENST00000373203ENGchr9130581111-242310871901752520
ENST00000394219DENND1Achr9126319849-ENST00000344849ENGchr9130581111-255410871901653487
ENST00000373620DENND1Achr9126319849-ENST00000373203ENGchr9130581111-255012142121879555
ENST00000373620DENND1Achr9126319849-ENST00000344849ENGchr9130581111-268112142121780522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373624ENST00000373203DENND1Achr9126319849-ENGchr9130581111-0.0151137260.9848862
ENST00000373624ENST00000344849DENND1Achr9126319849-ENGchr9130581111-0.0122308150.9877692
ENST00000394219ENST00000373203DENND1Achr9126319849-ENGchr9130581111-0.024856790.9751432
ENST00000394219ENST00000344849DENND1Achr9126319849-ENGchr9130581111-0.0191255340.9808745
ENST00000373620ENST00000373203DENND1Achr9126319849-ENGchr9130581111-0.0154767930.9845232
ENST00000373620ENST00000344849DENND1Achr9126319849-ENGchr9130581111-0.0124738650.9875261

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Fusion Genomic Features for DENND1A-ENG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND1A-ENG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:126319849/chr9:130581111)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1A

Q8TEH3

ENG

Q8NFI3

FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.FUNCTION: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-121913_145299467.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-1219162_298299467.0DomaincDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-132113_145331560.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-1321162_298331560.0DomaincDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-132213_1453311010.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-1322162_2983311010.0DomaincDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-122013_145301530.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-1220162_298301530.0DomaincDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-112113_1452991021.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-1121162_2982991021.0DomaincDENN
TgeneENGchr9:126319849chr9:130581111ENST00000344849914612_658437626.0Topological domainCytoplasmic
TgeneENGchr9:126319849chr9:130581111ENST00000373203915612_658437659.0Topological domainCytoplasmic
TgeneENGchr9:126319849chr9:130581111ENST00000344849914587_611437626.0TransmembraneHelical
TgeneENGchr9:126319849chr9:130581111ENST00000373203915587_611437659.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-1219649_995299467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-1321649_995331560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-1322649_9953311010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-1220649_995301530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-1121649_9952991021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-114649_9950795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-1219300_378299467.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-1321300_378331560.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-1322300_3783311010.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-1220300_378301530.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-1121300_3782991021.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-11413_1450795.0DomainuDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-114162_2980795.0DomaincDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-114300_3780795.0DomaindDENN
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-1219381_385299467.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373618-1219569_578299467.0MotifClathrin box
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-1321381_385331560.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373620-1321569_578331560.0MotifClathrin box
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-1322381_3853311010.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000373624-1322569_5783311010.0MotifClathrin box
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-1220381_385301530.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394215-1220569_578301530.0MotifClathrin box
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-1121381_3852991021.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000394219-1121569_5782991021.0MotifClathrin box
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-114381_3850795.0MotifFXDXF motif
HgeneDENND1Achr9:126319849chr9:130581111ENST00000542603-114569_5780795.0MotifClathrin box
TgeneENGchr9:126319849chr9:130581111ENST00000344849914336_576437626.0Compositional biasNote=Ser/Thr-rich
TgeneENGchr9:126319849chr9:130581111ENST00000373203915336_576437659.0Compositional biasNote=Ser/Thr-rich
TgeneENGchr9:126319849chr9:130581111ENST00000344849914363_533437626.0DomainZP
TgeneENGchr9:126319849chr9:130581111ENST00000373203915363_533437659.0DomainZP
TgeneENGchr9:126319849chr9:130581111ENST00000344849914399_401437626.0MotifCell attachment site
TgeneENGchr9:126319849chr9:130581111ENST00000373203915399_401437659.0MotifCell attachment site
TgeneENGchr9:126319849chr9:130581111ENST00000344849914200_330437626.0RegionOR1%2C C-terminal part
TgeneENGchr9:126319849chr9:130581111ENST0000034484991426_46437626.0RegionOR1%2C N-terminal part
TgeneENGchr9:126319849chr9:130581111ENST0000034484991447_199437626.0RegionOR2
TgeneENGchr9:126319849chr9:130581111ENST00000373203915200_330437659.0RegionOR1%2C C-terminal part
TgeneENGchr9:126319849chr9:130581111ENST0000037320391526_46437659.0RegionOR1%2C N-terminal part
TgeneENGchr9:126319849chr9:130581111ENST0000037320391547_199437659.0RegionOR2
TgeneENGchr9:126319849chr9:130581111ENST0000034484991426_586437626.0Topological domainExtracellular
TgeneENGchr9:126319849chr9:130581111ENST0000037320391526_586437659.0Topological domainExtracellular


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Fusion Gene Sequence for DENND1A-ENG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22194_22194_1_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373620_ENG_chr9_130581111_ENST00000344849_length(transcript)=2681nt_BP=1214nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGT
ACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAG
TCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAA
ACGACGTGATCTCTTCCCTGAAGAACAGGCTGAAAAAGGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGG
CTGCTTTCTTCGGTAGCTACCGAAACGCTCTGAAAATCGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGG
GCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCG
TCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCA
AGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCA
AAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGA
ACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCG
GGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTGAGTACCCCAGGCCCCCACAGTGAGCATGCCGGGCCCCTCCAT
CCACCCGGGGGAGCCCAGTGAAGCCTCTGAGGGATTGAGGGGCCCTGGCCAGGACCCTGACCTCCGCCCCTGCCCCCGCTCCCGCTCCCA
GGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACC
CAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGA
GCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTC
AGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATG
GCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCT
GGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCA
GAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTG
GGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGG

>22194_22194_1_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373620_ENG_chr9_130581111_ENST00000344849_length(amino acids)=522AA_BP=334
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQA
SNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVAL

--------------------------------------------------------------
>22194_22194_2_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373620_ENG_chr9_130581111_ENST00000373203_length(transcript)=2550nt_BP=1214nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGT
ACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAG
TCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAA
ACGACGTGATCTCTTCCCTGAAGAACAGGCTGAAAAAGGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGG
CTGCTTTCTTCGGTAGCTACCGAAACGCTCTGAAAATCGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGG
GCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCG
TCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCA
AGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCA
AAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGA
ACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCG
GGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGG
CCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCC
CCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCA
GAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGT
CCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAA
GTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAG
GCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCT
AACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTC
CTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTTGTCCTGGGCCTGCCCCTGTGTATTCAC

>22194_22194_2_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373620_ENG_chr9_130581111_ENST00000373203_length(amino acids)=555AA_BP=334
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQA
SNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVAL
RPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHS

--------------------------------------------------------------
>22194_22194_3_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373624_ENG_chr9_130581111_ENST00000344849_length(transcript)=2662nt_BP=1195nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCC
GCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGA
TGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGATCTCTTCCCT
GAAGAACAGGCTGAAAAAGGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGGCTGCTTTCTTCGGTAGCTA
CCGAAACGCTCTGAAAATCGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACA
CTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCA
GTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCT
GCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTG
CACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCT
GTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGC
ACTCTGGTACATCTACTCGCACACGCGTGAGTACCCCAGGCCCCCACAGTGAGCATGCCGGGCCCCTCCATCCACCCGGGGGAGCCCAGT
GAAGCCTCTGAGGGATTGAGGGGCCCTGGCCAGGACCCTGACCTCCGCCCCTGCCCCCGCTCCCGCTCCCAGGTTCCCCCAGCAAGCGGG
AGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCA
CCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACC
CTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGC
AGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACC
ACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTT
GAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCC
CTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAA
GAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTT

>22194_22194_3_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373624_ENG_chr9_130581111_ENST00000344849_length(amino acids)=522AA_BP=334
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQA
SNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVAL

--------------------------------------------------------------
>22194_22194_4_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373624_ENG_chr9_130581111_ENST00000373203_length(transcript)=2531nt_BP=1195nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCC
GCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGA
TGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGATCTCTTCCCT
GAAGAACAGGCTGAAAAAGGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGGCTGCTTTCTTCGGTAGCTA
CCGAAACGCTCTGAAAATCGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACA
CTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCA
GTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCT
GCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTG
CACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCT
GTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGC
ACTCTGGTACATCTACTCGCACACGCGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAG
CACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGA
GAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCG
CGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACC
TTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCT
GGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGC
TGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGA
CAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCT
CTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTTGTCCTGGGCCTGCCCCTGTGTATTCACCACCAATAAATCAGACCAT

>22194_22194_4_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000373624_ENG_chr9_130581111_ENST00000373203_length(amino acids)=555AA_BP=334
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQA
SNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVAL
RPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHS

--------------------------------------------------------------
>22194_22194_5_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000394219_ENG_chr9_130581111_ENST00000344849_length(transcript)=2554nt_BP=1087nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTGACTGC
CTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTG
CTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAA
TGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGATCTCTTCCCTGAAGAACAGGCTGAAAAA
GGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGGCTGCTTTCTTCGGTAGCTACCGAAACGCTCTGAAAAT
CGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAA
CACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCT
GGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGA
GGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCC
CAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAA
AGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTC
GCACACGCGTGAGTACCCCAGGCCCCCACAGTGAGCATGCCGGGCCCCTCCATCCACCCGGGGGAGCCCAGTGAAGCCTCTGAGGGATTG
AGGGGCCCTGGCCAGGACCCTGACCTCCGCCCCTGCCCCCGCTCCCGCTCCCAGGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGG
CTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGC
CCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCA
CTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACA
CCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTA
AAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAG
CCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTG
AACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGA
GCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTTGTCCTGGGCCTGCCCCTG

>22194_22194_5_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000394219_ENG_chr9_130581111_ENST00000344849_length(amino acids)=487AA_BP=299
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVST
TTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLG
PEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLV

--------------------------------------------------------------
>22194_22194_6_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000394219_ENG_chr9_130581111_ENST00000373203_length(transcript)=2423nt_BP=1087nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTGACTGC
CTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTG
CTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAA
TGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGATCTCTTCCCTGAAGAACAGGCTGAAAAA
GGTCTCCACAACCACTGGGGATGGTGTGGCCAGAGCGTTCCTCAAGGCCCAGGCTGCTTTCTTCGGTAGCTACCGAAACGCTCTGAAAAT
CGAGCCGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAA
CACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCT
GGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGA
GGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCC
CAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAA
AGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTC
GCACACGCGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGG
GAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCA
GCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCT
CCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTG
GGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAA
CTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCC
CAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCC
CAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCA

>22194_22194_6_DENND1A-ENG_DENND1A_chr9_126319849_ENST00000394219_ENG_chr9_130581111_ENST00000373203_length(amino acids)=520AA_BP=299
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVST
TTGDGVARAFLKAQAAFFGSYRNALKIEPKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLG
PEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DENND1A-ENG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1A-ENG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1A-ENG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource