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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1A-PBX3 (FusionGDB2 ID:22201)

Fusion Gene Summary for DENND1A-PBX3

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1A-PBX3
Fusion gene ID: 22201
HgeneTgene
Gene symbol

DENND1A

PBX3

Gene ID

57706

5090

Gene nameDENN domain containing 1APBX homeobox 3
SynonymsFAM31A|KIAA1608-
Cytomap

9q33.3

9q33.3

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1pre-B-cell leukemia transcription factor 3homeobox protein PBX3pre-B-cell leukemia homeobox 3
Modification date2020032020200320
UniProtAcc

Q8TEH3

.
Ensembl transtripts involved in fusion geneENST00000373618, ENST00000373620, 
ENST00000373624, ENST00000394215, 
ENST00000394219, ENST00000542603, 
ENST00000473039, 		ENST00000538998, 
ENST00000373483, ENST00000447726, 
ENST00000342287, ENST00000373487, 
ENST00000373489, 
Fusion gene scores* DoF score18 X 18 X 14=453610 X 10 X 7=700
# samples 2612
** MAII scorelog2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1A [Title/Abstract] AND PBX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1A(126345448)-PBX3(128691934), # samples:1
Anticipated loss of major functional domain due to fusion event.DENND1A-PBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND1A-PBX3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701


check buttonFusion gene breakpoints across DENND1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HI-7171-01ADENND1Achr9

126345448

-PBX3chr9

128691934

+


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Fusion Gene ORF analysis for DENND1A-PBX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373618ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-3UTRENST00000373620ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-3UTRENST00000373624ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-3UTRENST00000394215ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-3UTRENST00000394219ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-3UTRENST00000542603ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373618ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373618ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373620ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373620ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373624ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000373624ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000394215ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000394215ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000394219ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000394219ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000542603ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5CDS-5UTRENST00000542603ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-3CDSENST00000473039ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-3CDSENST00000473039ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-3CDSENST00000473039ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-3UTRENST00000473039ENST00000538998DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-5UTRENST00000473039ENST00000373483DENND1Achr9

126345448

-PBX3chr9

128691934

+
5UTR-5UTRENST00000473039ENST00000447726DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000373618ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000373618ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000373618ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000394215ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000394215ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000394215ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000542603ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000542603ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
Frame-shiftENST00000542603ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373620ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373620ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373620ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373624ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373624ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000373624ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000394219ENST00000342287DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000394219ENST00000373487DENND1Achr9

126345448

-PBX3chr9

128691934

+
In-frameENST00000394219ENST00000373489DENND1Achr9

126345448

-PBX3chr9

128691934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373624DENND1Achr9126345448-ENST00000342287PBX3chr9128691934+319910691931608471
ENST00000373624DENND1Achr9126345448-ENST00000373487PBX3chr9128691934+337510691931920575
ENST00000373624DENND1Achr9126345448-ENST00000373489PBX3chr9128691934+303910691931857554
ENST00000394219DENND1Achr9126345448-ENST00000342287PBX3chr9128691934+30919611901500436
ENST00000394219DENND1Achr9126345448-ENST00000373487PBX3chr9128691934+32679611901812540
ENST00000394219DENND1Achr9126345448-ENST00000373489PBX3chr9128691934+29319611901749519
ENST00000373620DENND1Achr9126345448-ENST00000342287PBX3chr9128691934+321810882121627471
ENST00000373620DENND1Achr9126345448-ENST00000373487PBX3chr9128691934+339410882121939575
ENST00000373620DENND1Achr9126345448-ENST00000373489PBX3chr9128691934+305810882121876554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373624ENST00000342287DENND1Achr9126345448-PBX3chr9128691934+0.0003158650.9996841
ENST00000373624ENST00000373487DENND1Achr9126345448-PBX3chr9128691934+0.000497410.99950254
ENST00000373624ENST00000373489DENND1Achr9126345448-PBX3chr9128691934+0.0004255580.9995745
ENST00000394219ENST00000342287DENND1Achr9126345448-PBX3chr9128691934+0.0003439650.9996561
ENST00000394219ENST00000373487DENND1Achr9126345448-PBX3chr9128691934+0.000603810.9993962
ENST00000394219ENST00000373489DENND1Achr9126345448-PBX3chr9128691934+0.000483670.99951637
ENST00000373620ENST00000342287DENND1Achr9126345448-PBX3chr9128691934+0.0003140270.999686
ENST00000373620ENST00000373487DENND1Achr9126345448-PBX3chr9128691934+0.0004969930.999503
ENST00000373620ENST00000373489DENND1Achr9126345448-PBX3chr9128691934+0.0004310870.9995689

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Fusion Genomic Features for DENND1A-PBX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND1Achr9126345447-PBX3chr9128691933+5.26E-111
DENND1Achr9126345447-PBX3chr9128691933+5.26E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DENND1A-PBX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:126345448/chr9:128691934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1A

Q8TEH3

.
FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-111913_145257467.0DomainuDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-122113_145289560.0DomainuDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-122213_1452891010.0DomainuDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-112013_145259530.0DomainuDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-102113_1452571021.0DomainuDENN
TgenePBX3chr9:126345448chr9:128691934ENST0000037348318130_1380254.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:126345448chr9:128691934ENST0000044772629130_13897360.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:126345448chr9:128691934ENST0000034228728235_297172764.6666666666666DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:126345448chr9:128691934ENST0000037348318235_2970254.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:126345448chr9:128691934ENST0000037348929235_297172435.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:126345448chr9:128691934ENST0000044772629235_29797360.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:126345448chr9:128691934ENST000003734831843_2340254.0DomainPBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-1119649_995257467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-1221649_995289560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-1222649_9952891010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-1120649_995259530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-1021649_9952571021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-414649_99573795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-1119162_298257467.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-1119300_378257467.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-1221162_298289560.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-1221300_378289560.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-1222162_2982891010.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-1222300_3782891010.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-1120162_298259530.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-1120300_378259530.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-1021162_2982571021.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-1021300_3782571021.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-41413_14573795.0DomainuDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-414162_29873795.0DomaincDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-414300_37873795.0DomaindDENN
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-1119381_385257467.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373618-1119569_578257467.0MotifClathrin box
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-1221381_385289560.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373620-1221569_578289560.0MotifClathrin box
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-1222381_3852891010.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000373624-1222569_5782891010.0MotifClathrin box
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-1120381_385259530.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394215-1120569_578259530.0MotifClathrin box
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-1021381_3852571021.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000394219-1021569_5782571021.0MotifClathrin box
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-414381_38573795.0MotifFXDXF motif
HgeneDENND1Achr9:126345448chr9:128691934ENST00000542603-414569_57873795.0MotifClathrin box
TgenePBX3chr9:126345448chr9:128691934ENST0000034228728130_138172764.6666666666666Compositional biasNote=Poly-Ala
TgenePBX3chr9:126345448chr9:128691934ENST0000037348929130_138172435.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:126345448chr9:128691934ENST000003422872843_234172764.6666666666666DomainPBC
TgenePBX3chr9:126345448chr9:128691934ENST000003734892943_234172435.0DomainPBC
TgenePBX3chr9:126345448chr9:128691934ENST000004477262943_23497360.0DomainPBC


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Fusion Gene Sequence for DENND1A-PBX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22201_22201_1_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000342287_length(transcript)=3218nt_BP=1088nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGT
ACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAG
TCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAA
ACGACGTGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTG
AAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGAT
CAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCA
ACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAAC
GAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAG
CAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGC
TACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCT
GTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTG
ATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAG
AACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCC
AATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTG
CCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGA
ACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGT
TAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTT
CTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGA
TAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGG
CATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATT
ACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCT
GTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAA
GAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTA
AATACTGAGAAACATTTTGAATGTTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCA
GATTTCAGTATTCAGTACTGTATATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACT
GATTGAGTCATGAAAATAATTTGTGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGA

>22201_22201_1_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=471AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNS

--------------------------------------------------------------
>22201_22201_2_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000373487_length(transcript)=3394nt_BP=1088nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGT
ACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAG
TCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAA
ACGACGTGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTG
AAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGAT
CAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCA
ACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGAGTCTTGTAAAGGATCCAAAAGAAA
GAGGGAGCAAAGGTTCTGACATCCAGCCAACTAGCGTGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCA
AGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCA
ATTCGCCCACCACACCAAATTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAGTCTGAATG
GGGATTCTTACCAAGGGTCCCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACA
GTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGA
CTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAA
GTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACT
TGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATT
AGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAA
TTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTT
CTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAAT
GATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCT
CTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGA
GGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATC
TGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCT
CATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAG
TTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAA
AATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATA
CTGAGAAACATTTTGAATGTTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCAGATT
TCAGTATTCAGTACTGTATATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACTGATT
GAGTCATGAAAATAATTTGTGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGAAAAA

>22201_22201_2_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=575AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKKNIGKFQEEANLYAA
KTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYS

--------------------------------------------------------------
>22201_22201_3_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000373489_length(transcript)=3058nt_BP=1088nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGT
ACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAG
TCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAA
ACGACGTGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTG
AAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGAT
CAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCA
ACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAAC
GAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAG
CAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGGACA
TGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTACCAAGGGTCCCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCCGTC
ATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGC
AGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACAC
TTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTAC
TGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTT
AAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATT
TTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCA
AAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATA
AAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAG
ATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGA
GAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGT
CAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCC
ACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTAC
TACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTA
ATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAAC

>22201_22201_3_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373620_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=554AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNS
PTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTS

--------------------------------------------------------------
>22201_22201_4_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000342287_length(transcript)=3199nt_BP=1069nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCC
GCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGA
TGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGA
ATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCAT
CCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAG
ACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGA
AGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAA
CATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAA
CCAGACCAATTCGCCCACCACACCAAATTCCGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAG
GAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAG
GCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAA
TAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTT
TTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAAC
ATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAG
GGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCAT
TACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAA
GAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAG
TGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATT
GATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGC
TCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATAC
AAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTA
TCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACT
TGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTG
AATGTTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACT
GTATATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAA
TTTGTGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTA

>22201_22201_4_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=471AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNS

--------------------------------------------------------------
>22201_22201_5_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000373487_length(transcript)=3375nt_BP=1069nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCC
GCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGA
TGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGA
ATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCAT
CCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAG
ACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGA
AGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGAGTCTTGTAAAGGATCCAAAAGAAAGAGGGAGCAAAGGTTCTGA
CATCCAGCCAACTAGCGTGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAA
CCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAA
TTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTACCAAGGGTC
CCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAA
TTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCC
AGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGG
AGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAA
GGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTG
TTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTA
AAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACT
GACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAAT
CTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCC
CAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATC
CGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTC
TGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAAC
CAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTT
TTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCA
ACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATG
TTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACTGTAT
ATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAATTTG
TGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTAGTTA

>22201_22201_5_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=575AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKKNIGKFQEEANLYAA
KTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYS

--------------------------------------------------------------
>22201_22201_6_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000373489_length(transcript)=3039nt_BP=1069nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTGACTGCCTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCC
GCATCTGCTGGACTACTGCTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGA
TGATGTCGTGATCCTGAATGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGA
ATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCAT
CCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAG
ACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGA
AGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAA
CATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAA
CCAGACCAATTCGCCCACCACACCAAATTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAG
TCTGAATGGGGATTCTTACCAAGGGTCCCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGG
AGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATC
TTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGC
CTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATT
CGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTT
ATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACA
GTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAA
TTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCC
CTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATC
GTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTG
CTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTC
TGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTT
TATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCA
CGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTT
AAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGT

>22201_22201_6_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000373624_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=554AA_BP=292
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI
LNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNS
PTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTS

--------------------------------------------------------------
>22201_22201_7_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000342287_length(transcript)=3091nt_BP=961nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTGACTGC
CTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTG
CTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAA
TGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGAATTTACTACACATGTGAT
GAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTC
CATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTT
CAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGC
CAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGA
AGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCAC
CACACCAAATTCCGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTC
CACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACT
CGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGC
GTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCAT
TTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTA
GCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATA
CACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCT
TTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGT
TTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGG
TAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTA
CGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATA
TAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAA
CATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAA
TTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACC
GAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATGTTCTTCATCTTATT
ACTAATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACTGTATATTTCACCCTGTGT
AATGGGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAATTTGTGGCGGTGATTCTA
ATGTATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTAGTTATATGTAGTTTCAAA

>22201_22201_7_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=436AA_BP=257
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLL
REQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKC

--------------------------------------------------------------
>22201_22201_8_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000373487_length(transcript)=3267nt_BP=961nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTGACTGC
CTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTG
CTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAA
TGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGAATTTACTACACATGTGAT
GAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTC
CATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTT
CAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGC
CAAGAAATGCAGCATCACAGTGTCACAGAGTCTTGTAAAGGATCCAAAAGAAAGAGGGAGCAAAGGTTCTGACATCCAGCCAACTAGCGT
GGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGAC
GGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTTCTTCTGGTTC
TTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTACCAAGGGTCCCAAGTCGGAGCCAATGT
GCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACA
TAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGA
TACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTT
TTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGT
ATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTA
TTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACT
AAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCT
TTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGT
GTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAAT
AAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGT
GTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGT
GTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATG
TTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAA
CTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGT
GTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATGTTCTTCATCTTATTACTA
ATCCATGCAAAAAAAAAAAAAAAAGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACTGTATATTTCACCCTGTGTAATG
GGGCCCCCTCTCCTTTCTCTCTTTTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAATTTGTGGCGGTGATTCTAATGT
ATTAAAAACGTTTCGTGTTCCTTTCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTAGTTATATGTAGTTTCAAACATG

>22201_22201_8_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=540AA_BP=257
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLL
REQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKC
SITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNL
PNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN

--------------------------------------------------------------
>22201_22201_9_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000373489_length(transcript)=2931nt_BP=961nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTGACTGC
CTGCATCCACGGGTCTGCGGCGATGCTCTACCCCATGTACTGGCAGCACGTGTACATCCCCGTGCTGCCGCCGCATCTGCTGGACTACTG
CTGTGCTCCCATGCCCTACCTCATAGGAATCCATTTAAGTTTAATGGAGAAAGTCAGAAACATGGCCCTGGATGATGTCGTGATCCTGAA
TGTGGACACCAACACCCTGGAAACCCCCTTCGATGACCTCCAGAGCCTCCCAAACGACGTGGCATGTAATGAATTTACTACACATGTGAT
GAACCTTCTCCGAGAACAGAGTAGAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTC
CATTCAGATGCAGCTCAAACAAAGCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTT
CAGTAAACAGGCCACAGAAATCTTGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGC
CAAGAAATGCAGCATCACAGTGTCACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGA
AGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCAC
CACACCAAATTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTA
CCAAGGGTCCCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCT
TGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTAC
AGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAG
AGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCT
GTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGAT
TTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCC
TTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATT
TCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTG
TTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGC
ACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACG
AGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGC
CCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACT
CATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTT
TCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTT
GCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACA

>22201_22201_9_DENND1A-PBX3_DENND1A_chr9_126345448_ENST00000394219_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=519AA_BP=257
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVACNEFTTHVMNLL
REQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKC
SITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGS

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Fusion Gene PPI Analysis for DENND1A-PBX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1A-PBX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1A-PBX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource