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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1A-RABGAP1 (FusionGDB2 ID:22204)

Fusion Gene Summary for DENND1A-RABGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1A-RABGAP1
Fusion gene ID: 22204
HgeneTgene
Gene symbol

DENND1A

RABGAP1

Gene ID

57706

23637

Gene nameDENN domain containing 1ARAB GTPase activating protein 1
SynonymsFAM31A|KIAA1608GAPCENA|TBC1D11
Cytomap

9q33.3

9q33.2-q33.3

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1rab GTPase-activating protein 1GAP and centrosome-associated proteinRab6 GTPase activating protein, GAPCenATBC1 domain family, member 11rab6 GTPase activating protein (GAP and centrosome-associated)rab6 GTPase-activating protein GAPCenA
Modification date2020032020200313
UniProtAcc

Q8TEH3

.
Ensembl transtripts involved in fusion geneENST00000373618, ENST00000373620, 
ENST00000373624, ENST00000394215, 
ENST00000394219, ENST00000473039, 
ENST00000542603, 
ENST00000493854, 
ENST00000373643, ENST00000373647, 
Fusion gene scores* DoF score18 X 18 X 14=453612 X 10 X 4=480
# samples 2612
** MAII scorelog2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1A [Title/Abstract] AND RABGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1A(126429305)-RABGAP1(125827627), # samples:1
Anticipated loss of major functional domain due to fusion event.DENND1A-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701

TgeneRABGAP1

GO:0043087

regulation of GTPase activity

17562788


check buttonFusion gene breakpoints across DENND1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RABGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-5577-01ADENND1Achr9

126429305

-RABGAP1chr9

125827627

+


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Fusion Gene ORF analysis for DENND1A-RABGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373618ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000373620ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000373624ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000394215ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000394219ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000373618ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000373620ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000373624ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000394215ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000394219ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5UTR-3CDSENST00000473039ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5UTR-3UTRENST00000473039ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
5UTR-5UTRENST00000473039ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
Frame-shiftENST00000373618ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
Frame-shiftENST00000394215ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
In-frameENST00000373620ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
In-frameENST00000373624ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
In-frameENST00000394219ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
intron-3CDSENST00000542603ENST00000373647DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
intron-3UTRENST00000542603ENST00000493854DENND1Achr9

126429305

-RABGAP1chr9

125827627

+
intron-5UTRENST00000542603ENST00000373643DENND1Achr9

126429305

-RABGAP1chr9

125827627

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000373624DENND1Achr9126429305-ENST00000373647RABGAP1chr9125827627+37787091932124643
ENST00000394219DENND1Achr9126429305-ENST00000373647RABGAP1chr9125827627+36706011902016608
ENST00000373620DENND1Achr9126429305-ENST00000373647RABGAP1chr9125827627+37977282122143643

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373624ENST00000373647DENND1Achr9126429305-RABGAP1chr9125827627+0.0004907990.9995092
ENST00000394219ENST00000373647DENND1Achr9126429305-RABGAP1chr9125827627+0.0005382580.9994617
ENST00000373620ENST00000373647DENND1Achr9126429305-RABGAP1chr9125827627+0.0004955120.99950445

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Fusion Genomic Features for DENND1A-RABGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND1Achr9126429304-RABGAP1chr9125827626+1.14E-060.9999988
DENND1Achr9126429304-RABGAP1chr9125827626+1.14E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DENND1A-RABGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:126429305/chr9:125827627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1A

Q8TEH3

.
FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-82113_145169560.0DomainuDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-82213_1451691010.0DomainuDENN
TgeneRABGAP1chr9:126429305chr9:125827627ENST000003736471226798_10475981070.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-719649_995137467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-821649_995169560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-822649_9951691010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-720649_995139530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-621649_9951371021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-114649_9950795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-71913_145137467.0DomainuDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-719162_298137467.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-719300_378137467.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-821162_298169560.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-821300_378169560.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-822162_2981691010.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-822300_3781691010.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-72013_145139530.0DomainuDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-720162_298139530.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-720300_378139530.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-62113_1451371021.0DomainuDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-621162_2981371021.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-621300_3781371021.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-11413_1450795.0DomainuDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-114162_2980795.0DomaincDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-114300_3780795.0DomaindDENN
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-719381_385137467.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373618-719569_578137467.0MotifClathrin box
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-821381_385169560.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373620-821569_578169560.0MotifClathrin box
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-822381_3851691010.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000373624-822569_5781691010.0MotifClathrin box
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-720381_385139530.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394215-720569_578139530.0MotifClathrin box
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-621381_3851371021.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000394219-621569_5781371021.0MotifClathrin box
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-114381_3850795.0MotifFXDXF motif
HgeneDENND1Achr9:126429305chr9:125827627ENST00000542603-114569_5780795.0MotifClathrin box
TgeneRABGAP1chr9:126429305chr9:125827627ENST000003736471226142_2985981070.0DomainPID
TgeneRABGAP1chr9:126429305chr9:125827627ENST000003736471226566_7525981070.0DomainRab-GAP TBC


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Fusion Gene Sequence for DENND1A-RABGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22204_22204_1_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000373620_RABGAP1_chr9_125827627_ENST00000373647_length(transcript)=3797nt_BP=728nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATGAGTCTCCCCAGGACAGTGCTATCACCCGGGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAG
ATGGACAAGATTCCTTATATAAAATATGCAAGGCTTATTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTG
CTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATTCAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGC
AAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTTGGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATA
TAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCG
ACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAATGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACT
TTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCA
ACATGAAGATTAGTCAGAAGAAGTTGAAAAAATACGAGAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCG
AGCGATTTGAGCGGGAGAATAGGCGTCTACAAGAAGCTAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCA
GCAAGATTGCACTACGGAAGGACCTGGATAACGCTGAGGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGA
TTGATGCAGAAGAAGAGAAAAGACGGCTGGAAGAAGAGTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTG
AGATTAAAAAAAACAGTTCTATCATTGGTGACTATAAGCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATA
AGGTGGAAATTGAGAAAATTCGGCAAAAAGTGGATGACTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAA
GCTCAACCAAGGAGGTTTTAGATGAGGACACGGATGAAGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCAC
AGACCAAACTCCAGCTGGTGGAGGCCGAGTGTAAGATACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCA
AGAAGACGTGGTTTAACCGAACACTGAGCTCCATAAAGACAGCAACCGGGGTTCAAGGGAAAGAGACTTGCTGAGAGCAGCTGCCGCCTC
CCGACACCTTCAGAAAACACGACACCTTTTGTTGCCTTCTTTGGCCAGATGTGTGATTCTGTGACTTGTCCCAGGACCAGAATGTACCTA
AGTCAGATCCATAGACGCATGTTGGTAGGTCACTGGACCAGAGCTTGTGAAGCAGGCAACCTCTGGGGTAAGACTACTGATACTAACAGG
CCTGCTAGCTCAGCCGACGCTCTGGACACTCTAGAAATCACTCCTCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCA
CCCAGCCTAAAGGCTGAGTTTACATGATCAGAGTTAGGGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACA
TATATATATATATATATATATATATATATATATATATATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTT
CTGCTTCAATGCCAGCAGAAGGTCCCCCAGGTAGACATGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCA
CCTGGTTCTGTTAAACTGTATGGTGCAGGTTTTGGGTTTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTTCCTGTT
ACTTTTTAGCATTAGCTGCCAAATGACTTCAAAAGGCTGGGGTGGGTGACTTGACTGTGAGACTGGATTATAACATGGACAAATCTTATT
TTGCTTAATGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATATATATATATAAATATCTTTCCCAATATGCCCCGTTG
ACAGTGTTTAAATTCCAGACTAGGACTGCTGATCTGCACAATTTAATTATGTGGTTATTCGAGCACTTAATTTCACTCAAGGTTCATTGG
GCTCTGCTCTCCTCCCTGCCATTACGGGAGCTGTGGACAGAGCTCCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAA
GTGAGAAAGACTGAGTTGCGTGTCTGTAAATGTCTGCGCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGAT
GGGCTGGGCCTTTGGGCCCTCCTCAGAGTATGCCTGGGTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGA
ATGGATTTTAGCACCTTTAAAAAAAAAAAAAACTTTGACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGT
CCTCTTTTCTGCGTTCAGTGTTGAGGCGGCTGCTTACAAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGCTCTTTT
TCTTATTGGCTGTACTAACGCTTGCTGAGGTTATCTGTAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCACCAACCATCCCCTTTGC
TGCTTTCTGTGTCTTTCTTGTTCAGTTACCAAAATAGCTGTAAGCCTATCTAATGCTAGGTGTGTGGACATTGTGCTAAGGTAGTTTCAG
TGTGTCAACTTTATGAATTGAAATATAAACCAGTAAAATTGTATTACTGTTTCTTTTGTTGGTTTTATTTTAACAGCATATTGATTAAAT

>22204_22204_1_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000373620_RABGAP1_chr9_125827627_ENST00000373647_length(amino acids)=643AA_BP=172
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENESPQDSAI
TRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFY
QLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQ
LPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDN
AEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKV
DDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSS

--------------------------------------------------------------
>22204_22204_2_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000373624_RABGAP1_chr9_125827627_ENST00000373647_length(transcript)=3778nt_BP=709nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATGAGTCTCCCCA
GGACAGTGCTATCACCCGGGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATA
TAAAATATGCAAGGCTTATTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATAT
GCCTGAAGAACAGGCATTCAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCA
TTGCAAATTTTACCAGTTGGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACAT
GTATGCCTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGG
AATAAGTGTTATTTTTAATGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTT
CTTTAGGGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGATTAGTCAGAA
GAAGTTGAAAAAATACGAGAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCGAGCGATTTGAGCGGGAGAA
TAGGCGTCTACAAGAAGCTAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCAGCAAGATTGCACTACGGAA
GGACCTGGATAACGCTGAGGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGATTGATGCAGAAGAAGAGAA
AAGACGGCTGGAAGAAGAGTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTGAGATTAAAAAAAACAGTTC
TATCATTGGTGACTATAAGCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATAAGGTGGAAATTGAGAAAAT
TCGGCAAAAAGTGGATGACTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAAGCTCAACCAAGGAGGTTTT
AGATGAGGACACGGATGAAGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCACAGACCAAACTCCAGCTGGT
GGAGGCCGAGTGTAAGATACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCAAGAAGACGTGGTTTAACCG
AACACTGAGCTCCATAAAGACAGCAACCGGGGTTCAAGGGAAAGAGACTTGCTGAGAGCAGCTGCCGCCTCCCGACACCTTCAGAAAACA
CGACACCTTTTGTTGCCTTCTTTGGCCAGATGTGTGATTCTGTGACTTGTCCCAGGACCAGAATGTACCTAAGTCAGATCCATAGACGCA
TGTTGGTAGGTCACTGGACCAGAGCTTGTGAAGCAGGCAACCTCTGGGGTAAGACTACTGATACTAACAGGCCTGCTAGCTCAGCCGACG
CTCTGGACACTCTAGAAATCACTCCTCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCACCCAGCCTAAAGGCTGAGT
TTACATGATCAGAGTTAGGGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACATATATATATATATATATAT
ATATATATATATATATATATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTTCTGCTTCAATGCCAGCAGA
AGGTCCCCCAGGTAGACATGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCACCTGGTTCTGTTAAACTGT
ATGGTGCAGGTTTTGGGTTTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTTCCTGTTACTTTTTAGCATTAGCTGC
CAAATGACTTCAAAAGGCTGGGGTGGGTGACTTGACTGTGAGACTGGATTATAACATGGACAAATCTTATTTTGCTTAATGTGTTTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATATATATATATAAATATCTTTCCCAATATGCCCCGTTGACAGTGTTTAAATTCCAGA
CTAGGACTGCTGATCTGCACAATTTAATTATGTGGTTATTCGAGCACTTAATTTCACTCAAGGTTCATTGGGCTCTGCTCTCCTCCCTGC
CATTACGGGAGCTGTGGACAGAGCTCCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAAGTGAGAAAGACTGAGTTGC
GTGTCTGTAAATGTCTGCGCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGATGGGCTGGGCCTTTGGGCCC
TCCTCAGAGTATGCCTGGGTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGAATGGATTTTAGCACCTTTA
AAAAAAAAAAAAACTTTGACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGTCCTCTTTTCTGCGTTCAGT
GTTGAGGCGGCTGCTTACAAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGCTCTTTTTCTTATTGGCTGTACTAAC
GCTTGCTGAGGTTATCTGTAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCACCAACCATCCCCTTTGCTGCTTTCTGTGTCTTTCTT
GTTCAGTTACCAAAATAGCTGTAAGCCTATCTAATGCTAGGTGTGTGGACATTGTGCTAAGGTAGTTTCAGTGTGTCAACTTTATGAATT

>22204_22204_2_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000373624_RABGAP1_chr9_125827627_ENST00000373647_length(amino acids)=643AA_BP=172
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENESPQDSAI
TRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFY
QLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQ
LPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDN
AEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKV
DDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSS

--------------------------------------------------------------
>22204_22204_3_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000394219_RABGAP1_chr9_125827627_ENST00000373647_length(transcript)=3670nt_BP=601nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATGAGTCTCCCCAGGACAGTGCTATCACCCG
GGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATATGCAAGGCTTA
TTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATT
CAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTT
GGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTT
TCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAA
TGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCC
TAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGATTAGTCAGAAGAAGTTGAAAAAATACGA
GAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCGAGCGATTTGAGCGGGAGAATAGGCGTCTACAAGAAGC
TAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCAGCAAGATTGCACTACGGAAGGACCTGGATAACGCTGA
GGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGATTGATGCAGAAGAAGAGAAAAGACGGCTGGAAGAAGA
GTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTGAGATTAAAAAAAACAGTTCTATCATTGGTGACTATAA
GCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATAAGGTGGAAATTGAGAAAATTCGGCAAAAAGTGGATGA
CTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAAGCTCAACCAAGGAGGTTTTAGATGAGGACACGGATGA
AGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCACAGACCAAACTCCAGCTGGTGGAGGCCGAGTGTAAGAT
ACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCAAGAAGACGTGGTTTAACCGAACACTGAGCTCCATAAA
GACAGCAACCGGGGTTCAAGGGAAAGAGACTTGCTGAGAGCAGCTGCCGCCTCCCGACACCTTCAGAAAACACGACACCTTTTGTTGCCT
TCTTTGGCCAGATGTGTGATTCTGTGACTTGTCCCAGGACCAGAATGTACCTAAGTCAGATCCATAGACGCATGTTGGTAGGTCACTGGA
CCAGAGCTTGTGAAGCAGGCAACCTCTGGGGTAAGACTACTGATACTAACAGGCCTGCTAGCTCAGCCGACGCTCTGGACACTCTAGAAA
TCACTCCTCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCACCCAGCCTAAAGGCTGAGTTTACATGATCAGAGTTAG
GGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACATATATATATATATATATATATATATATATATATATAT
ATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTTCTGCTTCAATGCCAGCAGAAGGTCCCCCAGGTAGACA
TGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCACCTGGTTCTGTTAAACTGTATGGTGCAGGTTTTGGGT
TTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTTCCTGTTACTTTTTAGCATTAGCTGCCAAATGACTTCAAAAGGC
TGGGGTGGGTGACTTGACTGTGAGACTGGATTATAACATGGACAAATCTTATTTTGCTTAATGTGTTTGTGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTATGTATATATATATATAAATATCTTTCCCAATATGCCCCGTTGACAGTGTTTAAATTCCAGACTAGGACTGCTGATCTGC
ACAATTTAATTATGTGGTTATTCGAGCACTTAATTTCACTCAAGGTTCATTGGGCTCTGCTCTCCTCCCTGCCATTACGGGAGCTGTGGA
CAGAGCTCCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAAGTGAGAAAGACTGAGTTGCGTGTCTGTAAATGTCTGC
GCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGATGGGCTGGGCCTTTGGGCCCTCCTCAGAGTATGCCTGG
GTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGAATGGATTTTAGCACCTTTAAAAAAAAAAAAAACTTTG
ACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGTCCTCTTTTCTGCGTTCAGTGTTGAGGCGGCTGCTTAC
AAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGCTCTTTTTCTTATTGGCTGTACTAACGCTTGCTGAGGTTATCTG
TAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCACCAACCATCCCCTTTGCTGCTTTCTGTGTCTTTCTTGTTCAGTTACCAAAATAG
CTGTAAGCCTATCTAATGCTAGGTGTGTGGACATTGTGCTAAGGTAGTTTCAGTGTGTCAACTTTATGAATTGAAATATAAACCAGTAAA

>22204_22204_3_DENND1A-RABGAP1_DENND1A_chr9_126429305_ENST00000394219_RABGAP1_chr9_125827627_ENST00000373647_length(amino acids)=608AA_BP=137
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVY
DEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTL
FTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEY
HTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQ
LKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DENND1A-RABGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1A-RABGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1A-RABGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource