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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1B-CD55 (FusionGDB2 ID:22213)

Fusion Gene Summary for DENND1B-CD55

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B-CD55
Fusion gene ID: 22213
HgeneTgene
Gene symbol

DENND1B

CD55

Gene ID

163486

1604

Gene nameDENN domain containing 1BCD55 molecule (Cromer blood group)
SynonymsC1ORF18|C1orf218|FAM31BCHAPLE|CR|CROM|DAF|TC
Cytomap

1q31.3

1q32.2

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member Bcomplement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen
Modification date2020032020200313
UniProtAcc

Q6P3S1

P08174

Ensembl transtripts involved in fusion geneENST00000367396, ENST00000235453, 
ENST00000477581, ENST00000400967, 
ENST00000314754, ENST00000367062, 
ENST00000367065, ENST00000367067, 
ENST00000391920, ENST00000465534, 
ENST00000367063, ENST00000391921, 
ENST00000367064, 
Fusion gene scores* DoF score13 X 7 X 7=63710 X 8 X 4=320
# samples 1610
** MAII scorelog2(16/637*10)=-1.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1B [Title/Abstract] AND CD55 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1B(197741998)-CD55(207532891), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD55

GO:0007204

positive regulation of cytosolic calcium ion concentration

8223854

TgeneCD55

GO:0030449

regulation of complement activation

25284781

TgeneCD55

GO:0031664

regulation of lipopolysaccharide-mediated signaling pathway

12731067

TgeneCD55

GO:0035743

CD4-positive, alpha-beta T cell cytokine production

16818763

TgeneCD55

GO:0045916

negative regulation of complement activation

6211481

TgeneCD55

GO:1903659

regulation of complement-dependent cytotoxicity

25284781

TgeneCD55

GO:2000516

positive regulation of CD4-positive, alpha-beta T cell activation

16818763

TgeneCD55

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

16818763


check buttonFusion gene breakpoints across DENND1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CD55 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01ADENND1Bchr1

197741998

-CD55chr1

207532891

+


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Fusion Gene ORF analysis for DENND1B-CD55

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367396ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-intronENST00000367396ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-intronENST00000367396ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3CDSENST00000235453ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3CDSENST00000477581ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000235453ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000235453ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000477581ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000477581ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
Frame-shiftENST00000367396ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3CDSENST00000400967ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-intronENST00000400967ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-intronENST00000400967ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DENND1B-CD55


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND1Bchr1197741997-CD55chr1207532890+0.0078569450.99214303
DENND1Bchr1197741997-CD55chr1207532890+0.0078569450.99214303

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DENND1B-CD55


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:197741998/:207532891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1B

Q6P3S1

CD55

P08174

FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}.FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DENND1B-CD55


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DENND1B-CD55


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1B-CD55


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1B-CD55


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource