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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND3-PTK2 (FusionGDB2 ID:22236)

Fusion Gene Summary for DENND3-PTK2

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND3-PTK2
Fusion gene ID: 22236
HgeneTgene
Gene symbol

DENND3

PTK2

Gene ID

22898

5747

Gene nameDENN domain containing 3protein tyrosine kinase 2
Synonyms-FADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 3DENN/MADD domain containing 3focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
Modification date2020031320200327
UniProtAcc

A2RUS2

.
Ensembl transtripts involved in fusion geneENST00000262585, ENST00000424248, 
ENST00000519811, ENST00000518347, 
ENST00000518806, ENST00000523308, 
ENST00000522950, ENST00000517712, 
ENST00000519635, ENST00000519881, 
ENST00000520151, ENST00000520892, 
ENST00000340930, ENST00000395218, 
ENST00000430260, ENST00000517887, 
ENST00000519419, ENST00000519465, 
ENST00000521059, ENST00000522684, 
ENST00000535192, ENST00000538769, 
Fusion gene scores* DoF score4 X 4 X 3=4819 X 20 X 13=4940
# samples 429
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/4940*10)=-4.09038623645711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND3 [Title/Abstract] AND PTK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND3(142154358)-PTK2(141669777), # samples:3
PTK2(142011224)-DENND3(142146608), # samples:2
Anticipated loss of major functional domain due to fusion event.DENND3-PTK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DENND3-PTK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

TgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

TgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

TgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

TgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

TgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

TgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

TgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

TgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

TgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across DENND3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-26-5133-01ADENND3chr8

142154358

+PTK2chr8

141669777

-
ChimerDB4GBMTCGA-26-5133DENND3chr8

142154358

+PTK2chr8

141669777

-


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Fusion Gene ORF analysis for DENND3-PTK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262585ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-3UTRENST00000424248ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-3UTRENST00000519811ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000262585ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000262585ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000262585ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000262585ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000262585ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000424248ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000424248ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000424248ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000424248ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000424248ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000519811ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000519811ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000519811ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000519811ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
5CDS-intronENST00000519811ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000262585ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000424248ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
Frame-shiftENST00000519811ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000262585ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000262585ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000424248ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000424248ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000519811ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
In-frameENST00000519811ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518347ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000518806ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000340930DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000395218DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000430260DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000517887DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000519419DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000519465DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000521059DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000522684DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000535192DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3CDSENST00000523308ENST00000538769DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3UTRENST00000518347ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3UTRENST00000518806ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-3UTRENST00000523308ENST00000522950DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518347ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518347ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518347ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518347ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518347ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518806ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518806ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518806ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518806ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000518806ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000523308ENST00000517712DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000523308ENST00000519635DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000523308ENST00000519881DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000523308ENST00000520151DENND3chr8

142154358

+PTK2chr8

141669777

-
intron-intronENST00000523308ENST00000520892DENND3chr8

142154358

+PTK2chr8

141669777

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000424248DENND3chr8142154358+ENST00000535192PTK2chr8141669777-2061773140985281
ENST00000424248DENND3chr8142154358+ENST00000538769PTK2chr8141669777-2047773140985281
ENST00000262585DENND3chr8142154358+ENST00000535192PTK2chr8141669777-2061773140985281
ENST00000262585DENND3chr8142154358+ENST00000538769PTK2chr8141669777-2047773140985281
ENST00000519811DENND3chr8142154358+ENST00000535192PTK2chr8141669777-2093805701017315
ENST00000519811DENND3chr8142154358+ENST00000538769PTK2chr8141669777-2079805701017315

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000424248ENST00000535192DENND3chr8142154358+PTK2chr8141669777-0.0122598160.9877402
ENST00000424248ENST00000538769DENND3chr8142154358+PTK2chr8141669777-0.0125948910.9874051
ENST00000262585ENST00000535192DENND3chr8142154358+PTK2chr8141669777-0.0122598160.9877402
ENST00000262585ENST00000538769DENND3chr8142154358+PTK2chr8141669777-0.0125948910.9874051
ENST00000519811ENST00000535192DENND3chr8142154358+PTK2chr8141669777-0.0004276190.99957234
ENST00000519811ENST00000538769DENND3chr8142154358+PTK2chr8141669777-0.0004623080.9995377

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Fusion Genomic Features for DENND3-PTK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND3-PTK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:142154358/chr8:141669777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND3

A2RUS2

.
FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+5231_1631651199.0DomainuDENN
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+5221_1631651147.0DomainuDENN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523186_3181651199.0DomaincDENN
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523320_4241651199.0DomaindDENN
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522186_3181651147.0DomaincDENN
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522320_4241651147.0DomaindDENN
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523438_8881651199.0RegionLinker
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522438_8881651147.0RegionLinker
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+5231022_10591651199.0RepeatWD 4
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+5231065_11051651199.0RepeatWD 5
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+5231110_11521651199.0RepeatWD 6
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+5231158_11971651199.0RepeatWD 7
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523893_9311651199.0RepeatWD 1
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523937_9731651199.0RepeatWD 2
HgeneDENND3chr8:142154358chr8:141669777ENST00000262585+523977_10181651199.0RepeatWD 3
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+5221022_10591651147.0RepeatWD 4
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+5221065_11051651147.0RepeatWD 5
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+5221110_11521651147.0RepeatWD 6
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+5221158_11971651147.0RepeatWD 7
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522893_9311651147.0RepeatWD 1
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522937_9731651147.0RepeatWD 2
HgeneDENND3chr8:142154358chr8:141669777ENST00000424248+522977_10181651147.0RepeatWD 3
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133712_7339951066.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133863_9139951066.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032712_7339821053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032863_9139821053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032712_7339821053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032863_9139821053.0Compositional biasNote=Pro-rich
TgenePTK2chr8:142154358chr8:141669777ENST00000340930313335_3559951066.0DomainFERM
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133422_6809951066.0DomainProtein kinase
TgenePTK2chr8:142154358chr8:141669777ENST00000521059303235_3559821053.0DomainFERM
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032422_6809821053.0DomainProtein kinase
TgenePTK2chr8:142154358chr8:141669777ENST00000522684303235_3559821053.0DomainFERM
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032422_6809821053.0DomainProtein kinase
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133428_4349951066.0Nucleotide bindingATP
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133500_5029951066.0Nucleotide bindingATP
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032428_4349821053.0Nucleotide bindingATP
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032500_5029821053.0Nucleotide bindingATP
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032428_4349821053.0Nucleotide bindingATP
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032500_5029821053.0Nucleotide bindingATP


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Fusion Gene Sequence for DENND3-PTK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22236_22236_1_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000535192_length(transcript)=2061nt_BP=773nt
GGCGGCGCGGCTGGTCCCCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATG
GCGGAGGCCGCGTCGCCGCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGT
CTCGAGCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCAAATGGCCGGTGCCAACTGCGGCACTCTCGGTA
AAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAAGGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGC
CTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTTCCCAGGGGGTGTGTGCGTGGCCACTGAACCTA
AGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGGCGTGGTGGCCCAGTACTACCGGCCCCTGCATG
ATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCCCTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCT
ATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAAAGATTTTGAAGTGGACAGTCATATAAAAGATT
TCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGG
GTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTC
ACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCT
CCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCC
AGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTT
TTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTT
TTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACC
TTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATT
ATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAA
GACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAAC
TAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGA
AATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAA
GATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAG
GAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATA

>22236_22236_1_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------
>22236_22236_2_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000538769_length(transcript)=2047nt_BP=773nt
GGCGGCGCGGCTGGTCCCCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATG
GCGGAGGCCGCGTCGCCGCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGT
CTCGAGCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCAAATGGCCGGTGCCAACTGCGGCACTCTCGGTA
AAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAAGGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGC
CTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTTCCCAGGGGGTGTGTGCGTGGCCACTGAACCTA
AGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGGCGTGGTGGCCCAGTACTACCGGCCCCTGCATG
ATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCCCTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCT
ATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAAAGATTTTGAAGTGGACAGTCATATAAAAGATT
TCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGG
GTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTC
ACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCT
CCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCC
AGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTT
TTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTT
TTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACC
TTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATT
ATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAA
GACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAAC
TAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGA
AATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAA
GATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAG
GAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATA

>22236_22236_2_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------
>22236_22236_3_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000535192_length(transcript)=2061nt_BP=773nt
GGCGGCGCGGCTGGTCCCCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATG
GCGGAGGCCGCGTCGCCGCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGT
CTCGAGCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCAAATGGCCGGTGCCAACTGCGGCACTCTCGGTA
AAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAAGGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGC
CTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTTCCCAGGGGGTGTGTGCGTGGCCACTGAACCTA
AGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGGCGTGGTGGCCCAGTACTACCGGCCCCTGCATG
ATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCCCTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCT
ATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAAAGATTTTGAAGTGGACAGTCATATAAAAGATT
TCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGG
GTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTC
ACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCT
CCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCC
AGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTT
TTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTT
TTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACC
TTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATT
ATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAA
GACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAAC
TAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGA
AATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAA
GATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAG
GAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATA

>22236_22236_3_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------
>22236_22236_4_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000538769_length(transcript)=2047nt_BP=773nt
GGCGGCGCGGCTGGTCCCCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATG
GCGGAGGCCGCGTCGCCGCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGT
CTCGAGCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCAAATGGCCGGTGCCAACTGCGGCACTCTCGGTA
AAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAAGGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGC
CTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTTCCCAGGGGGTGTGTGCGTGGCCACTGAACCTA
AGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGGCGTGGTGGCCCAGTACTACCGGCCCCTGCATG
ATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCCCTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCT
ATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAAAGATTTTGAAGTGGACAGTCATATAAAAGATT
TCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGG
GTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTC
ACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCT
CCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCC
AGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTT
TTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTT
TTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACC
TTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATT
ATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAA
GACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAAC
TAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGA
AATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAA
GATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAG
GAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATA

>22236_22236_4_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------
>22236_22236_5_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000535192_length(transcript)=2093nt_BP=805nt
CCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATGGCGGAGGCCGCGTCGCC
GCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGTCTCGAGCAGGTTGCTTA
TAAAAAGGGAGTCAAACATCTTTCTGCTCTTCTTGATCCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCA
AATGGCCGGTGCCAACTGCGGCACTCTCGGTAAAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAA
GGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGCCTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTT
CCCAGGGGGTGTGTGCGTGGCCACTGAACCTAAGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGG
CGTGGTGGCCCAGTACTACCGGCCCCTGCATGATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCC
CTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCTATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAA
AGATTTTGAAGTGGACAGTCATATAAAAGATTTCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGA
GATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCA
AGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAA
AATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGC
AGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATAT
AAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCG
TTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGG
CCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGG
CTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCA
CTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTT
CGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTT
TTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCC
CTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTAT
CTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAA
TATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACCTATTAAAAAGGT

>22236_22236_5_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=315AA_BP=231
MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREK
PRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE
CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQY

--------------------------------------------------------------
>22236_22236_6_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000538769_length(transcript)=2079nt_BP=805nt
CCAGGGGTCTGCGGGCGACTGCGCGGCTGAGGCGCCCGAGTGCGGTACTGGCGGCGGGCGGCGGGCAGCCATGGCGGAGGCCGCGTCGCC
GCACTTGTCGCTGCCCTCGGGGCTGCTGGAGCTCTGCGCGCTGCTGGGCGCCCCCCGGGACAGTCTCCGAAGTCTCGAGCAGGTTGCTTA
TAAAAAGGGAGTCAAACATCTTTCTGCTCTTCTTGATCCAGAGGTCCTGTCCATTTTCGTGCCTCCTTTTATCAGTAAAGAGGACAGTCA
AATGGCCGGTGCCAACTGCGGCACTCTCGGTAAAACCCGGATGCGCTCCTTGAGAAAGAAGAGAGAGAAGCCCAGACCAGAGCAGTGGAA
GGGCCTCCCGGGGCCCCCCAGAGCGCCAGAGCCTGAGGATGTCGCCGTCCCGGGCGGCGTGGACCTCCTCACCCTGCCGCAGCTGTGCTT
CCCAGGGGGTGTGTGCGTGGCCACTGAACCTAAGGAGGATTGCGTCCACTTCCTGGTGCTGACCGATGTCTGCGGGAATAGGACCTATGG
CGTGGTGGCCCAGTACTACCGGCCCCTGCATGATGAGTACTGTTTCTACAATGGCAAAACGCACCGGGAGTGTCCTGGCTGCTTCGTGCC
CTTCGCGGTGTGCGTGGTCTCCAGGTTTCCCTATTACAACTCCCTCAAGGACTGCCTTTCCTGTTTATTGGCTCTTCTGAAGCCCTGTAA
AGATTTTGAAGTGGACAGTCATATAAAAGATTTCGCTGCGAAGCTGTCTTTAATACCCAGCCCGCCACCTGGACCGCTCCATTTGATTGA
GATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCA
AGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAA
AATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGC
AGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATAT
AAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCG
TTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGG
CCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGG
CTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCA
CTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTT
CGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTT
TTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCC
CTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTAT
CTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAA
TATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACCTATTAAAAAGGT

>22236_22236_6_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=315AA_BP=231
MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREK
PRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE
CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQY

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Fusion Gene PPI Analysis for DENND3-PTK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePTK2chr8:142154358chr8:141669777ENST000003409303133912_1052995.01066.0ARHGEF28
TgenePTK2chr8:142154358chr8:141669777ENST000005210593032912_1052982.01053.0ARHGEF28
TgenePTK2chr8:142154358chr8:141669777ENST000005226843032912_1052982.01053.0ARHGEF28


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND3-PTK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND3-PTK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource