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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND4A-MEGF11 (FusionGDB2 ID:22244)

Fusion Gene Summary for DENND4A-MEGF11

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND4A-MEGF11
Fusion gene ID: 22244
HgeneTgene
Gene symbol

DENND4A

MEGF11

Gene ID

10260

84465

Gene nameDENN domain containing 4Amultiple EGF like domains 11
SynonymsIRLB|MYCPBP-
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
DescriptionC-myc promoter-binding proteinDENN domain-containing protein 4ADENN/MADD domain containing 4Ac-myc promoter binding proteinmultiple epidermal growth factor-like domains protein 11multiple EGF-like domains protein 11
Modification date2020031320200313
UniProtAcc

Q7Z401

A6BM72

Ensembl transtripts involved in fusion geneENST00000431932, ENST00000443035, 
ENST00000567323, 		ENST00000288745, 
ENST00000360698, ENST00000395625, 
ENST00000422354, ENST00000478721, 
ENST00000395614, ENST00000409699, 
Fusion gene scores* DoF score11 X 12 X 8=105612 X 12 X 5=720
# samples 1413
** MAII scorelog2(14/1056*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND4A [Title/Abstract] AND MEGF11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND4A(66084347)-MEGF11(66420749), # samples:1
DENND4A(66007816)-MEGF11(66191272), # samples:1
Anticipated loss of major functional domain due to fusion event.DENND4A-MEGF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DENND4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEGF11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29D-06ADENND4Achr15

66007816

-MEGF11chr15

66191272

-
ChimerDB4STADTCGA-HU-A4GFDENND4Achr15

66084347

-MEGF11chr15

66420749

-


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Fusion Gene ORF analysis for DENND4A-MEGF11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000431932ENST00000288745DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000431932ENST00000360698DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000431932ENST00000395625DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000431932ENST00000422354DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000443035ENST00000288745DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000443035ENST00000360698DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000443035ENST00000395625DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-3UTRENST00000443035ENST00000422354DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-5UTRENST00000431932ENST00000478721DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-5UTRENST00000443035ENST00000478721DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-intronENST00000431932ENST00000395614DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5CDS-intronENST00000443035ENST00000395614DENND4Achr15

66007816

-MEGF11chr15

66191272

-
5UTR-5UTRENST00000431932ENST00000360698DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000431932ENST00000395614DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000431932ENST00000395625DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000431932ENST00000409699DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000431932ENST00000422354DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000443035ENST00000360698DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000443035ENST00000395614DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000443035ENST00000395625DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000443035ENST00000409699DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-5UTRENST00000443035ENST00000422354DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-intronENST00000431932ENST00000288745DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-intronENST00000431932ENST00000478721DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-intronENST00000443035ENST00000288745DENND4Achr15

66084347

-MEGF11chr15

66420749

-
5UTR-intronENST00000443035ENST00000478721DENND4Achr15

66084347

-MEGF11chr15

66420749

-
Frame-shiftENST00000443035ENST00000409699DENND4Achr15

66007816

-MEGF11chr15

66191272

-
In-frameENST00000431932ENST00000409699DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-3CDSENST00000567323ENST00000409699DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-3UTRENST00000567323ENST00000288745DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-3UTRENST00000567323ENST00000360698DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-3UTRENST00000567323ENST00000395625DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-3UTRENST00000567323ENST00000422354DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-5UTRENST00000567323ENST00000360698DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-5UTRENST00000567323ENST00000395614DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-5UTRENST00000567323ENST00000395625DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-5UTRENST00000567323ENST00000409699DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-5UTRENST00000567323ENST00000422354DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-5UTRENST00000567323ENST00000478721DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-intronENST00000567323ENST00000288745DENND4Achr15

66084347

-MEGF11chr15

66420749

-
intron-intronENST00000567323ENST00000395614DENND4Achr15

66007816

-MEGF11chr15

66191272

-
intron-intronENST00000567323ENST00000478721DENND4Achr15

66084347

-MEGF11chr15

66420749

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000431932DENND4Achr1566007816-ENST00000409699MEGF11chr1566191272-538521622092170653

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000431932ENST00000409699DENND4Achr1566007816-MEGF11chr1566191272-0.0001992140.99980086

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Fusion Genomic Features for DENND4A-MEGF11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND4A-MEGF11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:66084347/chr15:66420749)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND4A

Q7Z401

MEGF11

A6BM72

FUNCTION: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.FUNCTION: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432192_3646511864.0DomainuDENN
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432385_5216511864.0DomaincDENN
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-143242_2006511864.0DomainMABP
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432523_6416511864.0DomaindDENN
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433192_3646511907.0DomainuDENN
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433385_5216511907.0DomaincDENN
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-143342_2006511907.0DomainMABP
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433523_6416511907.0DomaindDENN
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023143_1730138.0DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023181_2160138.0DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023224_2590138.0DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST0000039561402324_1010138.0DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023267_3020138.0DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023310_3450138.0DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023399_4340138.0DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023442_4770138.0DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023490_5200138.0DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023571_6060138.0DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023659_6940138.0DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023707_7370138.0DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023750_7800138.0DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023788_8230138.0DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST0000039561402395_1300138.0DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821870_1044847970.0Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST0000039561402320_8480138.0Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023870_10440138.0Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922870_1044847970.0Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821849_869847970.0TransmembraneHelical
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395614023849_8690138.0TransmembraneHelical
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922849_869847970.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-14321183_11896511864.0Compositional biasNote=Poly-Glu
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-14331183_11896511907.0Compositional biasNote=Poly-Glu
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432917_9336511864.0MotifBipartite nuclear localization signal
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433917_9336511907.0MotifBipartite nuclear localization signal
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432772_8086511864.0RepeatNote=PPR 1
HgeneDENND4Achr15:66007816chr15:66191272ENST00000431932-1432809_8436511864.0RepeatNote=PPR 2
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433772_8086511907.0RepeatNote=PPR 1
HgeneDENND4Achr15:66007816chr15:66191272ENST00000443035-1433809_8436511907.0RepeatNote=PPR 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821143_173847970.0DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821181_216847970.0DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821224_259847970.0DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST00000288745182124_101847970.0DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821267_302847970.0DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821310_345847970.0DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821399_434847970.0DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821442_477847970.0DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821490_520847970.0DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821571_606847970.0DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821659_694847970.0DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821707_737847970.0DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821750_780847970.0DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST000002887451821788_823847970.0DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST00000288745182195_130847970.0DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023143_1739991840.6666666666667DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023181_2169991840.6666666666667DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023224_2599991840.6666666666667DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST00000360698202324_1019991840.6666666666667DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023267_3029991840.6666666666667DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023310_3459991840.6666666666667DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023399_4349991840.6666666666667DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023442_4779991840.6666666666667DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023490_5209991840.6666666666667DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023571_6069991840.6666666666667DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023659_6949991840.6666666666667DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023707_7379991840.6666666666667DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023750_7809991840.6666666666667DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023788_8239991840.6666666666667DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST00000360698202395_1309991840.6666666666667DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922143_173847970.0DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922181_216847970.0DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922224_259847970.0DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395625192224_101847970.0DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922267_302847970.0DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922310_345847970.0DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922399_434847970.0DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922442_477847970.0DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922490_520847970.0DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922571_606847970.0DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922659_694847970.0DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922707_737847970.0DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922750_780847970.0DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST000003956251922788_823847970.0DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395625192295_130847970.0DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023143_1739221045.0DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023181_2169221045.0DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023224_2599221045.0DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST00000409699202324_1019221045.0DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023267_3029221045.0DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023310_3459221045.0DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023399_4349221045.0DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023442_4779221045.0DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023490_5209221045.0DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023571_6069221045.0DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023659_6949221045.0DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023707_7379221045.0DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023750_7809221045.0DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023788_8239221045.0DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST00000409699202395_1309221045.0DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023143_1739221045.0DomainEGF-like 2
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023181_2169221045.0DomainEGF-like 3
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023224_2599221045.0DomainEGF-like 4
TgeneMEGF11chr15:66007816chr15:66191272ENST00000422354202324_1019221045.0DomainEMI
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023267_3029221045.0DomainEGF-like 5
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023310_3459221045.0DomainEGF-like 6
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023399_4349221045.0DomainEGF-like 7
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023442_4779221045.0DomainEGF-like 8
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023490_5209221045.0DomainEGF-like 9
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023571_6069221045.0DomainEGF-like 10
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023659_6949221045.0DomainEGF-like 11
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023707_7379221045.0DomainEGF-like 12
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023750_7809221045.0DomainEGF-like 13
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023788_8239221045.0DomainEGF-like 14
TgeneMEGF11chr15:66007816chr15:66191272ENST00000422354202395_1309221045.0DomainEGF-like 1
TgeneMEGF11chr15:66007816chr15:66191272ENST00000288745182120_848847970.0Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST00000360698202320_8489991840.6666666666667Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023870_10449991840.6666666666667Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST00000395625192220_848847970.0Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST00000409699202320_8489221045.0Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023870_10449221045.0Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST00000422354202320_8489221045.0Topological domainExtracellular
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023870_10449221045.0Topological domainCytoplasmic
TgeneMEGF11chr15:66007816chr15:66191272ENST000003606982023849_8699991840.6666666666667TransmembraneHelical
TgeneMEGF11chr15:66007816chr15:66191272ENST000004096992023849_8699221045.0TransmembraneHelical
TgeneMEGF11chr15:66007816chr15:66191272ENST000004223542023849_8699221045.0TransmembraneHelical


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Fusion Gene Sequence for DENND4A-MEGF11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22244_22244_1_DENND4A-MEGF11_DENND4A_chr15_66007816_ENST00000431932_MEGF11_chr15_66191272_ENST00000409699_length(transcript)=5385nt_BP=2162nt
AAGCGGGCTCAGAGCGCCGCGGCATTCAGCCCCTCGTGTTCCGCTACCGCGCGTGCGGGATTCCGGCGCCGCTCTCCGAGCTCGATCCGC
TGCTCGCACGGGAGCCAGCTGGGTGTTATTTCTCAAACTCTGAGGCTGCGGAGTTCACACATTGAAATCTGTCATCTTTTTCAGAGAGAA
ACTTTCGATGTAACCTTCTGTAATGGAAGATGATTGAAGACAAGGGGCCTCGTGTTGCTGACTACTTTGTTGTAGCAGGATTAACTGATG
TTTCAAAGCCTCTAGAAGAAGAAATTCACTTCAATGATGCTTGTCATAAAGTAGCTAAACCAAAAGAACCTATTACAGATGTTTCAGTTA
TTATCAAATCTCTTGGGGAGGAAGTCCCACAGGATTATATCTGTATTGATGTTACCCCAACTGGATTGTCAGCTGATCTTAATAATGGAA
GTCTTGTGGGGCCACAGATTTACCTTTGCTATAGAAGAGGAAGAGATAAGCCTCCACTTACAGATCTGGGGGTTTTATATGACTGGAAAG
AAAGATTGAAACAGGGTTGTGAAATTATTCAGAGTACTCCCTATGGGCGCCCCGCAAATATTAGTGGGAGTACCTCATCACAAAGAATTT
ATATCACTTACCGAAGAGCCTCTGAAAACATGACTCAGAATACGTTGGCTGTCACTGACATATGTATTATTATACCCAGTAAAGGAGAAA
GCCCACCACACACGTTCTGCAAAGTCGACAAGAATCTCAATAACAGTATGTGGGGATCAGCAGTATACTTGTGTTATAAAAAATCGGTGG
CAAAGACGAACACTGTATCTTACAAAGCTGGCCTAATTTGTAGATATCCTCAAGAAGATTATGAGTCATTCTCACTACCGGAATCTGTTC
CTCTATTTTGTTTACCAATGGGTGCAACCATTGAATGTTGGCCATCAAATAGCAAATACCCTCTGCCTGTATTTTCTACTTTTGTTTTAA
CTGGAGCCTCAGCTGAAAAGGTTTATGGTGCTGCTATTCAGTTTTATGAACCATACTCTGAGGAGAATCTCACAGAAAAGCAGAGACTTC
TTTTGGGTTTAACATCAGCAGATGGGAAGTCTGATAGTTCCAAAACAATTCATACTAACAAATGCATCTGTCTTCTTTCTCACTGGCCTT
TTTTTGATGCATTCAGGAAGTTTCTGACTTTTCTGTATCGTTATTCCATCTCTGGGCCTCATGTCCTTCCAATTGAGAAGCATATTTCTC
ATTTTATGCATAAAGTTCCTTTTCCATCTCCTCAGAGACCACGGATTTTAGTTCAGTTATCACCACATGATAATCTGATTCTCAGTCAGC
CTGTGTCTTCACCTCTTCCACTAAGTGGTGGCAAGTTTTCAACACTACTGCAGAATTTAGGCCCTGAAAATGCTGTGACACTACTGGTGT
TTGCAGTAACAGAACATAAAATTCTTATCCATTCCCTACGGCCATCCGTGCTTACTAGTGTGACAGAAGCATTAGTGTCTATGATTTTCC
CTTTCCACTGGCCATGCCCGTATGTTCCTCTCTGCCCACTGGCTTTAGCAGATGTCTTGAGTGCACCATGTCCATTCATAGTAGGGATTG
ATTCAAGATACTTTGATCTCTATGATCCTCCACCAGATGTCAGTTGTGTTGATGTAGATACCAACACTATTTCTCAAATTGGTGACAAGA
AAAATGTAGCCTGGAAGATACTTCCAAAGAAGCCATGTAAAAATCTGATGAACACACTGAATAATTTGCATCAGCAATTGGCAAAATTGC
AGCAGAGACCGAGAGATGATGGACTCATGGATTTAGCAATAAATGACTATGATTTTAATTCTGGAAAGAGGTTGCACATGATAGATTTGG
AAATCCAAGAGGCATTTTTGTTTTTCATGGCCTCTATTTTAAAAGGTTACAGATCATACTTAAGGCCAATAACACAAGCCCCATCTGAGA
CAGCCACAGATGCAGCCTCTCTCTTTGCCCTACAAGCTTTCTTAAGAAGCCGGGACCGGTCACATCAAAAATTCTATAACATGATGACCA
AAACACAAATGTTTATTCGCTTCATTGAAGAATGTTCTTTTGTTAGTGACAAAGATGCAAGCCTGGCATTTTTTGATGATTGTGTAGATA
AAATTACATGAAAGAATCCGTGTGCAGTTCTAGTACTTGTTCCTTGAATAGCAGTGAAAACCCTTACGCCACAATTAAGGACCCACCCAT
CCTCACCTGCAAGCTTCCAGAAAGCAGCTATGTAGAAATGAAGTCGCCTGTGCACATGGGGTCTCCGTACACAGATGTGCCATCCTTGTC
GACATCTAATAAAAATATATATGAAGTTGAGCCCACAGTCAGTGTGGTCCAAGAAGGTTGCGGTCATAACTCCAGCTATATCCAGAATGC
ATACGACCTACCTAGGAACAGCCATATTCCTGGTCATTATGACCTCCTCCCAGTAAGACAGAGCCCTGCCAATGGGCCGTCCCAGGACAA
GCAATCTTAAGAGGGATAAGCTTCTCTCTTGCAGTGTGCTCTACTGAATATTCTGACTCTGAAAGAAGACAGTCCCTTGACTTGAAGTAA
TGGTACAGACTGGCTCCAGCTGCATGTTAGTTATTACGTTCACCTGGAACTAAAGAAGAGCGTCCAGGTGGGACTGGGATAATTGTTCAA
GGAATTGTGTTCTCAAAGGCAAATCCTATCACCCACTCAGCCCCAAATGCCCTGGATTATATGATTTTTAAAACATTTTAAGATACAGCT
ACTCATCAACATCAGCTAAATATAGCTGATATATATATATATATTTATCTGAAACGTGATATTTTAAAAACATGTAGGTTTAACAAACCT
TCCTAGGACAAAAAGGAGACTGGGGAGGGAAGAGGATTACTTTAAAGCACCTGAAACGTATATGTACTTTTGGTTGCTGTTACCATCAAC
ATCTGTTTTATTACCGAAGACAATTAGTACACAGACATGAACTGTTCTTAAACAGAACAGTCTTAAAATGTCTGTACATATCTGTCTGGT
CCATCAAATTACAACAGCCAAGATTACAGAATCTATATAGTCTAATGCTGACAACTTCTATTTTAAAAAACAAGACTTTACTTTCTTCTG
CCCCCTAAGTGATAGGTTTAAACACACAGAGACACACACACACGTTTCCAAAGTGCAGCAGTGTCTCTTTCAGTCTACAATAAGATTCCT
AGGGCAGCTTTATCAAATTTTGCCAATTCAAAGTTCAAGGACATTACAAGTTAGTCCTGGCTTTGTCATATCTACTTAGTCCATCCGACA
CCTGAATCATTCCATGTAAAACAGAGCTCTAAGATGATCCTTTAAGCAAGCAGTCATAGACTGGTCGGGATTAAGTAAAAGACGGCTAGT
TGGCCTCCTCATTTTATTTGGTCAGCATCCCTTGACTCAAGAGTACTTGCTTTCAAGTTCTTCATAAATCTTGAGATTGACGTAGTATGA
AACCTAAAAGTATACAGGAAATTGGACAAATGTGGATACAGCAAGTTTACACTGCTTAAAGTACATTATGCTTTTTAATGGAACTAAATG
ATCAAAAAAAGAATGGACTGTAACCAGTTGCTGTAACGTGATGTAAAAACGTTACTGTAAACAGCATGAGGATATGAAGTCCTTCCACCT
TCTATCTTAAAACTACTACTTACTGAGCTAGCCCAATATGCATTACAATGAGCTAATGCTCCAGATCCCAGTATTCAGATGTGTCTATAC
CTTCCACTATGAACACAGATAAACTGAGGCTCAGATAAGTCCAAATGAAATGAAATCAACTCCCAAGCCCTAAAGAGAACCTTCTCACAA
GAATTAAAAACAAAAAGGGCAAACCTAGGAAGCTAACGGCTACTCCTGTACCACTCTATTCACTGGTACAGTCCAGCCAGTAAAAAACAC
TTCCAAAAAGATACACAGAAGAGGAACTAAATGACTGCGAAGCTGGAATACTGCTACAGGAAGTATGAGAGTTCTGAAACCCTTGATAGA
AACTGGAAGCCTGCCATGGAACACAATACTTTGGGCAATAATCAGAAAAAGCAAAAAAATAAATAAATGAGTACATCTCCCCTTCCCACA
TCACTCAAGGCATAAGCAGATTTTACTGTTAGAGGAAAATATGTAATACTTACATGAATGTTGCATGTGTGCATGGGAGCAACTGAGTAG
CAATAGTAAATTTACTTTCCAAAAAAGCCTTATTAAAATATAAATATTAGAAAATTACTTTGGAGACCCAAGTAAATATTTCTCATACAT
ATGTAGAAAGAAATATAGGTAAGCAGCTTACCTCAGTATTTCAGGGCAGCAAGTGTTTGTGAAGCAAGGATGAGCAGCATGAAGATGTCA
GATCAGCAAGGAGAAACTTCAACTCAATCCCAGGTTTTCTCTTCTTCCCTTATCCTGCATGTACAATAACTGCTGCCTGGCAAACTGCAA
ACAAGCAGCATCACTCAAGTTTGAAGTTTCGCCGCTTTTGTCAACTATCCTCTGGGCAAAGGTATTCAGCAAGAGGTGGAATGGCTAGAC
ACTGAATCAAGAGATTTCAGTGTTACTCTGGTCAAGTTAGTCGCCCTCTCTGGGCTCCCTTTTTTCCTATGCATAAAAAGGGGAGAAGCA
GAGAGTGGGAAGACAGCTCTACTAACCCTTCAGCTCTAGCAGTCCATGACTTTTTAAGGAAATGTAATACAAGTCAAACCAGGCAATACA
GAGGAGAAGGGAAAGGCAGAGGGTGTGATTATGGTGACAATAGCTGCCTTCCCCTATCGAACAGTTATCAGTAAAAGACATTTCAATCTT
ACAAAGCAACTGTTAGAAACTTCTGTCTAACACCATCACAAATAGGTTCATGGTCAGCCTAAACATGTATACTGTGCATTTTATGGGTGA
CTTTGAAAGATCTGTTCAATTATTTTTCAGAAACTAAATTTTCAAAAAATTAATATGTGTACAATTAAAATGAATGAAAGAAAAACCATT
ATTGTACAGAGGTATTAATGAGACTATGAAACGGCAATACTTTTTTAAATCACAGATTTGTAATATATGTTCACTGTGCAGAGGGATTGT
ACCTTGTACAAAATAAAACAAATTTCTCAAACTAATTTAACAAGAATGCCTACTGTTGTGTTGCAAATGGAAAACGTGCTTATAATCTAC
ACCTTAAGTTTAAGGGTAGAACTAACCTACATCCTGCTTGGGCACTTTGAACACCTGGAAGAATGAAAATTATTCTAGTAGATGTTTGAA

>22244_22244_1_DENND4A-MEGF11_DENND4A_chr15_66007816_ENST00000431932_MEGF11_chr15_66191272_ENST00000409699_length(amino acids)=653AA_BP=
MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVPQDYICIDVTPTGLSADLNNGSLVGPQIYLC
YRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYG
AAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVP
LCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIE

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Fusion Gene PPI Analysis for DENND4A-MEGF11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND4A-MEGF11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND4A-MEGF11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource