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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY3-CENPO (FusionGDB2 ID:2227)

Fusion Gene Summary for ADCY3-CENPO

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY3-CENPO
Fusion gene ID: 2227
HgeneTgene
Gene symbol

ADCY3

CENPO

Gene ID

114

79172

Gene nameadenylate cyclase 8centromere protein O
SynonymsAC8|ADCY3|HBAC1CENP-O|ICEN-36|MCM21R
Cytomap

8q24.22

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li centromere protein Ocentromeric protein Ointerphase centromere complex protein 36
Modification date2020031320200313
UniProtAcc

O60266

Q9BU64

Ensembl transtripts involved in fusion geneENST00000260600, ENST00000405392, 
ENST00000450524, 		ENST00000395845, 
ENST00000260662, ENST00000380834, 
ENST00000473706, 
Fusion gene scores* DoF score7 X 6 X 5=2104 X 4 X 4=64
# samples 74
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY3 [Title/Abstract] AND CENPO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY3(25141181)-CENPO(25037244), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADCY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CENPO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-DQ-7593ADCY3chr2

25141181

-CENPOchr2

25037244

+


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Fusion Gene ORF analysis for ADCY3-CENPO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260600ENST00000395845ADCY3chr2

25141181

-CENPOchr2

25037244

+
In-frameENST00000260600ENST00000260662ADCY3chr2

25141181

-CENPOchr2

25037244

+
In-frameENST00000260600ENST00000380834ADCY3chr2

25141181

-CENPOchr2

25037244

+
In-frameENST00000260600ENST00000473706ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000405392ENST00000260662ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000405392ENST00000380834ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000405392ENST00000473706ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000450524ENST00000260662ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000450524ENST00000380834ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-3CDSENST00000450524ENST00000473706ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-intronENST00000405392ENST00000395845ADCY3chr2

25141181

-CENPOchr2

25037244

+
intron-intronENST00000450524ENST00000395845ADCY3chr2

25141181

-CENPOchr2

25037244

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260600ADCY3chr225141181-ENST00000473706CENPOchr225037244+527215278522213453
ENST00000260600ADCY3chr225141181-ENST00000380834CENPOchr225037244+527215278522213453
ENST00000260600ADCY3chr225141181-ENST00000260662CENPOchr225037244+281115278522213453

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260600ENST00000473706ADCY3chr225141181-CENPOchr225037244+0.0079945350.9920055
ENST00000260600ENST00000380834ADCY3chr225141181-CENPOchr225037244+0.0079945350.9920055
ENST00000260600ENST00000260662ADCY3chr225141181-CENPOchr225037244+0.0066955810.99330443

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Fusion Genomic Features for ADCY3-CENPO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADCY3chr225141181-CENPOchr225037244+1.72E-091
ADCY3chr225141181-CENPOchr225037244+1.72E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADCY3-CENPO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25141181/chr2:25037244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY3

O60266

CENPO

Q9BU64

FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-1211_792251145.0Topological domainCytoplasmic
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121105_1252251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121139_1592251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121173_1932251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-12180_1002251145.0TransmembraneHelical
TgeneCENPOchr2:25141181chr2:25037244ENST000002606622883_10972469.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneCENPOchr2:25141181chr2:25037244ENST000003808342883_109721189.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCENPOchr2:25141181chr2:25037244ENST000004737061783_109661183.6666666666667Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-1211062_10642251145.0Nucleotide bindingATP
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-1211069_10732251145.0Nucleotide bindingATP
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121324_3292251145.0Nucleotide bindingATP
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121366_3682251145.0Nucleotide bindingATP
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121402_6322251145.0Topological domainCytoplasmic
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121854_11442251145.0Topological domainCytoplasmic
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121226_2462251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121381_4012251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121633_6532251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121664_6842251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121708_7282251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121754_7742251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121775_7952251145.0TransmembraneHelical
HgeneADCY3chr2:25141181chr2:25037244ENST00000260600-121833_8532251145.0TransmembraneHelical
TgeneCENPOchr2:25141181chr2:25037244ENST000002606622818_4272469.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneCENPOchr2:25141181chr2:25037244ENST000003808342818_42721189.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCENPOchr2:25141181chr2:25037244ENST000004737061718_42661183.6666666666667Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ADCY3-CENPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2227_2227_1_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000260662_length(transcript)=2811nt_BP=1527nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGGTG
AAAGCATGTATTGCCAATGTAGAACCCAACCAAACAGTGGAGATCAATGAGCAAGAAGCATTGGAAGAGAAATTGGAAAATGTGAAAGCC
ATTCTGCAGGCATATCATTTTACAGGCCTCAGTGGTAAACTGACCAGCCGAGGAGTTTGTGTCTGCATCAGTACTGCTTTTGAGGGGAAC
CTATTGGATTCCTATTTTGTGGACCTTGTCATACAGAAACCACTCCGGATACATCACCATTCAGTCCCAGTCTTCATTCCCCTGGAAGAG
ATAGCTGCAAAATATTTACAGACCAACATCCAGCACTTCCTGTTCAGTCTCTGCGAGTACCTGAATGCTTACTCTGGGAGGAAGTACCAG
GCAGACCGGCTTCAGAGTGACTTTGCAGCCCTCCTGACTGGGCCCTTGCAGAGAAACCCACTGTGTAACTTGCTGTCATTTACTTACAAA
CTGGATCCAGGGGGTCAGTCCTTCCCGTTCTGTGCTAGATTGCTGTATAAGGACCTCACAGCAACTCTTCCCACTGACGTCACCGTGACA
TGTCAAGGAGTGGAAGTATTATCCACTTCATGGGAGGAGCAACGAGCATCTCATGAAACTCTGTTCTGTACGAAGCCCTTGCATCAAGTG
TTTGCCTCATTTACAAGAAAAGGAGAAAAGTTGGATATGAGTCTGGTCTCCTAATAGATTGTTTTCACTGCACTGGGAGCACATCAGAGA
AATAAATCCCCCCTCCCCTGCCAGGTGAAAGGAAATATTGCACTTTCTGTTCTCATGACTAAGGGGACAGGAGTTCCAGAAGAACCTTTC
AAGATGATCAGGAACACCAGGACGAGGGCCGTCTCACCTCACTCGGACCACATGGAGACCTCCCTTCAAAATGGGAGCCATGTCCTGCCC
CACCAAGCCCTGTCTGAAGTGGAGCTTCCCCGCCTGTGCTCCCTCCACAGTCCCGGAAAGCCCAGCGGCAAAGGCAGCTTTGTCCCAGCT
CTGCCACCCTCCTGCTCACAGTGGTCAGGGCCCCTCAGGGGCAAGGACGGCAGGGATTGGAACGAGGGCTCTGGAAGGACTGTTCAGCCC
TATGCCTAAGACCCCTATGCTGGGGACACTACAGGCACACACAGGAATAGCAGGGCCACCCTCAGAGCTCACACATCCACGAACAAATGA
AGGCTGAGGAGGTTTCTAAACCTAAAGTCCATGAGTGTGCACTTCAATCCAGGAAGGTCGGGACTTCCTTCAGTTTCAAAAAATAAATTC

>2227_2227_1_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000260662_length(amino acids)=453AA_BP=225
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKL
TSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTG
PLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMS

--------------------------------------------------------------
>2227_2227_2_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000380834_length(transcript)=5272nt_BP=1527nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGGTG
AAAGCATGTATTGCCAATGTAGAACCCAACCAAACAGTGGAGATCAATGAGCAAGAAGCATTGGAAGAGAAATTGGAAAATGTGAAAGCC
ATTCTGCAGGCATATCATTTTACAGGCCTCAGTGGTAAACTGACCAGCCGAGGAGTTTGTGTCTGCATCAGTACTGCTTTTGAGGGGAAC
CTATTGGATTCCTATTTTGTGGACCTTGTCATACAGAAACCACTCCGGATACATCACCATTCAGTCCCAGTCTTCATTCCCCTGGAAGAG
ATAGCTGCAAAATATTTACAGACCAACATCCAGCACTTCCTGTTCAGTCTCTGCGAGTACCTGAATGCTTACTCTGGGAGGAAGTACCAG
GCAGACCGGCTTCAGAGTGACTTTGCAGCCCTCCTGACTGGGCCCTTGCAGAGAAACCCACTGTGTAACTTGCTGTCATTTACTTACAAA
CTGGATCCAGGGGGTCAGTCCTTCCCGTTCTGTGCTAGATTGCTGTATAAGGACCTCACAGCAACTCTTCCCACTGACGTCACCGTGACA
TGTCAAGGAGTGGAAGTATTATCCACTTCATGGGAGGAGCAACGAGCATCTCATGAAACTCTGTTCTGTACGAAGCCCTTGCATCAAGTG
TTTGCCTCATTTACAAGAAAAGGAGAAAAGTTGGATATGAGTCTGGTCTCCTAATAGATTGTTTTCACTGCACTGGGAGCACATCAGAGA
AATAAATCCCCCCTCCCCTGCCAGGTGAAAGGAAATATTGCACTTTCTGTTCTCATGACTAAGGGGACAGGAGTTCCAGAAGAACCTTTC
AAGATGATCAGGAACACCAGGACGAGGGCCGTCTCACCTCACTCGGACCACATGGAGACCTCCCTTCAAAATGGGAGCCATGTCCTGCCC
CACCAAGCCCTGTCTGAAGTGGAGCTTCCCCGCCTGTGCTCCCTCCACAGTCCCGGAAAGCCCAGCGGCAAAGGCAGCTTTGTCCCAGCT
CTGCCACCCTCCTGCTCACAGTGGTCAGGGCCCCTCAGGGGCAAGGACGGCAGGGATTGGAACGAGGGCTCTGGAAGGACTGTTCAGCCC
TATGCCTAAGACCCCTATGCTGGGGACACTACAGGCACACACAGGAATAGCAGGGCCACCCTCAGAGCTCACACATCCACGAACAAATGA
AGGCTGAGGAGGTTTCTAAACCTAAAGTCCATGAGTGTGCACTTCAATCCAGGAAGGTCGGGACTTCCTTCAGTTTCAAAAAATAAATTC
TCCCTTCCGGTTTGGACTGTTGCAGGCTCGAGGCCATTCAGGAGTTGTCCACCACCTGGTGGGGCAGTGTGACAGAGGGGCCATTGGGGA
AGGTGGCTAGCTTATCCCGCCCCTTCAAGAAGAAGGTCAGCAGCTCCCCCTTCCCCTTCACAAAGATGGGGCCTCGCCTCACAAAGCGGA
AGCCGTACTCTCGGAGGATGACTTGGGTTTCTTCTACCACCTGGAGAGGGAGGGGGAGCAAGAACGTGGCGTTACGGGGGGAGCCTAGAC
TGAGGGCGGGTGGGGGCTTTGGGTGGTTGGAGCCGAGCACTGATCCATGGGTCCCAAGCAGTACGGGACACTCCCCAAACCTCCCAGGGC
CAAGCCCTTCCACCCGTGGCGAGCAGCGGGTGGGAAGGAGAACCCTGGAGTGACTGGCTGGGGGCCTCCTCTCATCCAGAGACTTCTCTC
CTAGGATGGCCATGGTCACCTGGGTGGCAGCACTGTTACCTGGAAACTGCCACTGCCTGCTCTTCTGTCCCTTTGCCCCTTTCGTGGAGC
TTTTCTGCCAGACGCCACTGAGACAGATCACAAGGTATTAGAAGGTTCATACCCAAAGGTAGGCCATATGCATCTAGAACTTCAGCCCAG
ATTTTGTGGATGGGTGGAAGTGTTTCTTCCTGTGCTGAGGCTAGCTATTGCAGAGATTCTTTTCCACTTGCCCCACGTCTCTGCCTCTGG
ACTTACTGTTCAGGGCCAGGGTGGGAGGCAGGGGCACGTGGGAAAGCACTGTTCCGGTTTTGTTCTCATGCCGAGTCTGAGCACGTGCCA
GCTGTGCCACTGGACATACCTGAATGTTGCCCATGACCCCCGTGGACTCCATCCTGCTGGCTACATTGACTGTATTGCCCCAGATGTCGT
AGTGTGGTTTCCGGGCTCCGATGACCCCAGCCAGAACCCCGCCTTTGTTCATGCCTAGGGTAGAGGCATAAAGTTCAGCACAGCCACAGG
CCACACCTTGTTATGGGCCTCAGAAGCCATCTCCTCTCCAGACCTGTACCACAAAGCTCCTAATGTAACACATCATTGTCCTCATTCAAC
TTGGCTGTATGCTATTGGAGGGTGGAAATCACATCTCCTGTTTATCCGTGTGCTTGTTAGGTGTCAGCCGCCACCCCCCCCCCATATGCA
GATTTACTCGGCATGGTAGTGGCCAGCTTCTAACACAGCTGGTATTTCAAGTCTCCTGGGACCTCACTCAGGAATGATACCCCCTCAGTA
GAAGCAGCAGGTGATCTTAACTCCTTTCAAAGAGCAGGCCTGTCTGGGAAGCCATGTCCTCAGCAGGCACAGCAACCCCTCTGGAAATGG
ATCACAAACTCACTTCTCAGCCAGGCAGGCCAAGCTTCTATTGTAACAGTAGGCACAGTATAGTCGGATCATCACATCAGCTGGGTTTTT
GGTTTAGTCATCTAGAGTCGTCTGGACTAAAGGTCTTTCAGGTCTCCTTGCCCTGTGAGTGCGTGAACCTCCCCACCCGAATTGCCTCAG
TTGTCCTGAGCCTCATGTCTCTCCTGGTGGTGGGCCAGGCCCCTGCATGGGAAGGGAGCCTGCTGCGGGGCAGGCCAGCTGGGGGTGCTC
ACCTATGCGCAGCATGAAGTTATTGAAGGACTGGTTGTTGATGTTGGTGAGCGTATCCTTCATGGCCAGCGCGAAGTCGGCCAGGTCAGC
CAGGTGCTGCCAGCGCTCTCTCTCGGACTTGTCTTCCTGTGCCAGGGGACCGTGGAGAAAGTGTCAGGGGCCGCTCACTGCAGCAGCCTG
CTCTGCTGCCTTCCCTGGCAGTGTTCTGGGGGTGGATTCCCTACACCTAGATGTTCAAGGCCTTACTTTTCCTCCCACAAAGGAGTCGCA
GCCACGCTAGCTCTGACTTGCCACTGTGACAAAGTTCACGTAGCAGGTCTAGGCAAAGACTGGGCAATTGAGCAGAGGAGACGGACCTGT
GAGTCTGACCACGAGGCGGACCCCTTCACCTTGGCTGGGCCTGGTCCTGGTCCTTAGGTTTTGTCAGGTTGTCCTTGTTTGGATCCCTCA
ACTAGGTGATAAGCACTGGAGGGGGATGACCCGCCTTGGACGTGTTTCTTTAACCTCATCCATATAATAGGGCCGTGGGATGGTTGTAGA
GGTAAAGCAGGATGATGGTGTTTTAAGACCAGAGCTTGGGACCAGGGCTCCTACACCTAATTTTCTCTCCTGGTAGCTGAACAAAGGTCT
AAATTAGCTTAACAAAAGAACAGGCTGCCGTCAGCCAGAGTTCTGAAGGCCATGCTTTCAGTTTCCCTTGTTGACAATTGCTCTCCAGTT
CCTATGAAAGCACAGAGCCTTAGGGGGCCTGGCCACAGAACACAACCATCTTAGGCCTGAGCTGTGAACAGCAGGGGGTTGTGTGTCTGT

>2227_2227_2_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000380834_length(amino acids)=453AA_BP=225
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKL
TSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTG
PLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMS

--------------------------------------------------------------
>2227_2227_3_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000473706_length(transcript)=5272nt_BP=1527nt
CGGGCCTGACGGCGGGAGATCGCGCTCCGGCCGGGCCCCGAGGCGCTGCCGGGGCGGCGCGGCTCTGCGGGGAGCAGCCCTCGGGCGCGC
CGAGCTCTCCCGCCCCAGCCCGCGCGGGGACCGTCCCGGAGCACGCGGTGGCCGAGTTCCCGCACAGGTAAACGCAGGGGCAGGGCCAGG
CTTCCGGGGGGGAAGACAGCGCCCCGAGCGTGGGAAGGGGGCCGGATCGGAGCCCGAGCCTCCAAGGGTTTGGTGGAAAAAGGAAGTAAA
CAGAAGGAAGGCTCAGGAATCCCCCACGATGGTCCTGATTTCTTTCCGGCACATTTTATTTACAGCTTCTAAGGACTGGGCCTGGAGGGA
ATTTAGGTGAGGAAGTCGGGGACTGAGAAAGAAGAGATGACAGAGAGAAACCGGTTACCAGGGATGGAAAGGCGGCTAGGCCCTTCCACA
AGCCAGGGACAGGAAATTGAGTGTCTGGCGTGGACAGGACTAAGTGTGCCTGCGGTGGGCGGTGGTGTGAGCCGGGGGTGGCAGGGAAGG
CCCTGGGTTGGGAGGCTCTTGCAGCAGAGATCCTTTTATGAGGGTTAGGGCGGGTCATGGGGAAACCGCAAGGTAGGAGGGAAGAGGTGC
TTCTACTCAGCAATGCCCTTTTCAGTTCTAGCTGATCAGTGCTACCTGTGCTCTGGAAACCCGCTCTGCGTTCCTGCTGGAGGTGGCCTC
CCCTCCGCCCCAGACAAGAAGAGGCCCTCAGCCCTCCCCCGGTCTCAGAGAGCCCTGAGAGGAGGCCCAGTCCAGAGCTCTTCCTCCGTT
CCCAGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTAC
TCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGAACTCGGGCTCCTGC
CTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAG
ACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCT
TCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGC
AGAGTGCTGCCCTACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGT
GACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTC
TCCTGTGTGGTGCACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGGTG
AAAGCATGTATTGCCAATGTAGAACCCAACCAAACAGTGGAGATCAATGAGCAAGAAGCATTGGAAGAGAAATTGGAAAATGTGAAAGCC
ATTCTGCAGGCATATCATTTTACAGGCCTCAGTGGTAAACTGACCAGCCGAGGAGTTTGTGTCTGCATCAGTACTGCTTTTGAGGGGAAC
CTATTGGATTCCTATTTTGTGGACCTTGTCATACAGAAACCACTCCGGATACATCACCATTCAGTCCCAGTCTTCATTCCCCTGGAAGAG
ATAGCTGCAAAATATTTACAGACCAACATCCAGCACTTCCTGTTCAGTCTCTGCGAGTACCTGAATGCTTACTCTGGGAGGAAGTACCAG
GCAGACCGGCTTCAGAGTGACTTTGCAGCCCTCCTGACTGGGCCCTTGCAGAGAAACCCACTGTGTAACTTGCTGTCATTTACTTACAAA
CTGGATCCAGGGGGTCAGTCCTTCCCGTTCTGTGCTAGATTGCTGTATAAGGACCTCACAGCAACTCTTCCCACTGACGTCACCGTGACA
TGTCAAGGAGTGGAAGTATTATCCACTTCATGGGAGGAGCAACGAGCATCTCATGAAACTCTGTTCTGTACGAAGCCCTTGCATCAAGTG
TTTGCCTCATTTACAAGAAAAGGAGAAAAGTTGGATATGAGTCTGGTCTCCTAATAGATTGTTTTCACTGCACTGGGAGCACATCAGAGA
AATAAATCCCCCCTCCCCTGCCAGGTGAAAGGAAATATTGCACTTTCTGTTCTCATGACTAAGGGGACAGGAGTTCCAGAAGAACCTTTC
AAGATGATCAGGAACACCAGGACGAGGGCCGTCTCACCTCACTCGGACCACATGGAGACCTCCCTTCAAAATGGGAGCCATGTCCTGCCC
CACCAAGCCCTGTCTGAAGTGGAGCTTCCCCGCCTGTGCTCCCTCCACAGTCCCGGAAAGCCCAGCGGCAAAGGCAGCTTTGTCCCAGCT
CTGCCACCCTCCTGCTCACAGTGGTCAGGGCCCCTCAGGGGCAAGGACGGCAGGGATTGGAACGAGGGCTCTGGAAGGACTGTTCAGCCC
TATGCCTAAGACCCCTATGCTGGGGACACTACAGGCACACACAGGAATAGCAGGGCCACCCTCAGAGCTCACACATCCACGAACAAATGA
AGGCTGAGGAGGTTTCTAAACCTAAAGTCCATGAGTGTGCACTTCAATCCAGGAAGGTCGGGACTTCCTTCAGTTTCAAAAAATAAATTC
TCCCTTCCGGTTTGGACTGTTGCAGGCTCGAGGCCATTCAGGAGTTGTCCACCACCTGGTGGGGCAGTGTGACAGAGGGGCCATTGGGGA
AGGTGGCTAGCTTATCCCGCCCCTTCAAGAAGAAGGTCAGCAGCTCCCCCTTCCCCTTCACAAAGATGGGGCCTCGCCTCACAAAGCGGA
AGCCGTACTCTCGGAGGATGACTTGGGTTTCTTCTACCACCTGGAGAGGGAGGGGGAGCAAGAACGTGGCGTTACGGGGGGAGCCTAGAC
TGAGGGCGGGTGGGGGCTTTGGGTGGTTGGAGCCGAGCACTGATCCATGGGTCCCAAGCAGTACGGGACACTCCCCAAACCTCCCAGGGC
CAAGCCCTTCCACCCGTGGCGAGCAGCGGGTGGGAAGGAGAACCCTGGAGTGACTGGCTGGGGGCCTCCTCTCATCCAGAGACTTCTCTC
CTAGGATGGCCATGGTCACCTGGGTGGCAGCACTGTTACCTGGAAACTGCCACTGCCTGCTCTTCTGTCCCTTTGCCCCTTTCGTGGAGC
TTTTCTGCCAGACGCCACTGAGACAGATCACAAGGTATTAGAAGGTTCATACCCAAAGGTAGGCCATATGCATCTAGAACTTCAGCCCAG
ATTTTGTGGATGGGTGGAAGTGTTTCTTCCTGTGCTGAGGCTAGCTATTGCAGAGATTCTTTTCCACTTGCCCCACGTCTCTGCCTCTGG
ACTTACTGTTCAGGGCCAGGGTGGGAGGCAGGGGCACGTGGGAAAGCACTGTTCCGGTTTTGTTCTCATGCCGAGTCTGAGCACGTGCCA
GCTGTGCCACTGGACATACCTGAATGTTGCCCATGACCCCCGTGGACTCCATCCTGCTGGCTACATTGACTGTATTGCCCCAGATGTCGT
AGTGTGGTTTCCGGGCTCCGATGACCCCAGCCAGAACCCCGCCTTTGTTCATGCCTAGGGTAGAGGCATAAAGTTCAGCACAGCCACAGG
CCACACCTTGTTATGGGCCTCAGAAGCCATCTCCTCTCCAGACCTGTACCACAAAGCTCCTAATGTAACACATCATTGTCCTCATTCAAC
TTGGCTGTATGCTATTGGAGGGTGGAAATCACATCTCCTGTTTATCCGTGTGCTTGTTAGGTGTCAGCCGCCACCCCCCCCCCATATGCA
GATTTACTCGGCATGGTAGTGGCCAGCTTCTAACACAGCTGGTATTTCAAGTCTCCTGGGACCTCACTCAGGAATGATACCCCCTCAGTA
GAAGCAGCAGGTGATCTTAACTCCTTTCAAAGAGCAGGCCTGTCTGGGAAGCCATGTCCTCAGCAGGCACAGCAACCCCTCTGGAAATGG
ATCACAAACTCACTTCTCAGCCAGGCAGGCCAAGCTTCTATTGTAACAGTAGGCACAGTATAGTCGGATCATCACATCAGCTGGGTTTTT
GGTTTAGTCATCTAGAGTCGTCTGGACTAAAGGTCTTTCAGGTCTCCTTGCCCTGTGAGTGCGTGAACCTCCCCACCCGAATTGCCTCAG
TTGTCCTGAGCCTCATGTCTCTCCTGGTGGTGGGCCAGGCCCCTGCATGGGAAGGGAGCCTGCTGCGGGGCAGGCCAGCTGGGGGTGCTC
ACCTATGCGCAGCATGAAGTTATTGAAGGACTGGTTGTTGATGTTGGTGAGCGTATCCTTCATGGCCAGCGCGAAGTCGGCCAGGTCAGC
CAGGTGCTGCCAGCGCTCTCTCTCGGACTTGTCTTCCTGTGCCAGGGGACCGTGGAGAAAGTGTCAGGGGCCGCTCACTGCAGCAGCCTG
CTCTGCTGCCTTCCCTGGCAGTGTTCTGGGGGTGGATTCCCTACACCTAGATGTTCAAGGCCTTACTTTTCCTCCCACAAAGGAGTCGCA
GCCACGCTAGCTCTGACTTGCCACTGTGACAAAGTTCACGTAGCAGGTCTAGGCAAAGACTGGGCAATTGAGCAGAGGAGACGGACCTGT
GAGTCTGACCACGAGGCGGACCCCTTCACCTTGGCTGGGCCTGGTCCTGGTCCTTAGGTTTTGTCAGGTTGTCCTTGTTTGGATCCCTCA
ACTAGGTGATAAGCACTGGAGGGGGATGACCCGCCTTGGACGTGTTTCTTTAACCTCATCCATATAATAGGGCCGTGGGATGGTTGTAGA
GGTAAAGCAGGATGATGGTGTTTTAAGACCAGAGCTTGGGACCAGGGCTCCTACACCTAATTTTCTCTCCTGGTAGCTGAACAAAGGTCT
AAATTAGCTTAACAAAAGAACAGGCTGCCGTCAGCCAGAGTTCTGAAGGCCATGCTTTCAGTTTCCCTTGTTGACAATTGCTCTCCAGTT
CCTATGAAAGCACAGAGCCTTAGGGGGCCTGGCCACAGAACACAACCATCTTAGGCCTGAGCTGTGAACAGCAGGGGGTTGTGTGTCTGT

>2227_2227_3_ADCY3-CENPO_ADCY3_chr2_25141181_ENST00000260600_CENPO_chr2_25037244_ENST00000473706_length(amino acids)=453AA_BP=225
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC
YVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKL
TSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTG
PLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADCY3-CENPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY3-CENPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY3-CENPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource