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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DENND5A-TMEM9B (FusionGDB2 ID:22276)

Fusion Gene Summary for DENND5A-TMEM9B

Fusion gene summary

Fusion gene information	Fusion gene name: DENND5A-TMEM9B
	Fusion gene ID: 22276
		Hgene	Tgene
	Gene symbol	DENND5A	TMEM9B
	Gene ID	23258	56674
	Gene name	DENN domain containing 5A	TMEM9 domain family member B
	Synonyms	EIEE49\|RAB6IP1	C11orf15
	Cytomap	11p15.4	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1	transmembrane protein 9B
	Modification date	20200313	20200313
	UniProtAcc	Q6IQ26	.
	Ensembl transtripts involved in fusion gene	ENST00000328194, ENST00000530044, ENST00000526523, ENST00000527700,	ENST00000528117, ENST00000534025, ENST00000309134, ENST00000525069,
Fusion gene scores	* DoF score	12 X 10 X 5=600	6 X 6 X 5=180
	# samples	14	8
	** MAII score	log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DENND5A [Title/Abstract] AND TMEM9B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DENND5A(9286507)-TMEM9B(8970022), # samples:1
Anticipated loss of major functional domain due to fusion event.	DENND5A-TMEM9B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DENND5A-TMEM9B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DENND5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMEM9B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A4MR	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-

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Fusion Gene ORF analysis for DENND5A-TMEM9B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000328194	ENST00000528117	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
5CDS-intron	ENST00000530044	ENST00000528117	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
Frame-shift	ENST00000328194	ENST00000534025	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
Frame-shift	ENST00000530044	ENST00000534025	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
In-frame	ENST00000328194	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
In-frame	ENST00000328194	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
In-frame	ENST00000530044	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
In-frame	ENST00000530044	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000526523	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000526523	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000526523	ENST00000534025	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000527700	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000527700	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-3CDS	ENST00000527700	ENST00000534025	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-intron	ENST00000526523	ENST00000528117	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-
intron-intron	ENST00000527700	ENST00000528117	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000328194	DENND5A	chr11	9286507	-	ENST00000309134	TMEM9B	chr11	8970022	-	1612	430	240	563	107
ENST00000328194	DENND5A	chr11	9286507	-	ENST00000525069	TMEM9B	chr11	8970022	-	1405	430	240	563	107
ENST00000530044	DENND5A	chr11	9286507	-	ENST00000309134	TMEM9B	chr11	8970022	-	1309	127	18	260	80
ENST00000530044	DENND5A	chr11	9286507	-	ENST00000525069	TMEM9B	chr11	8970022	-	1102	127	18	260	80

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000328194	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-	0.43311018	0.5668898
ENST00000328194	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-	0.37588778	0.62411225
ENST00000530044	ENST00000309134	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-	0.65098304	0.3490169
ENST00000530044	ENST00000525069	DENND5A	chr11	9286507	-	TMEM9B	chr11	8970022	-	0.46986443	0.5301356

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Fusion Genomic Features for DENND5A-TMEM9B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND5A-TMEM9B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9286507/chr11:8970022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DENND5A Q6IQ26	.
FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:G3V7Q0, ECO:0000269\|PubMed:20937701}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

3_9

1288.0

Compositional bias

Note=Poly-Gly

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

3_9

1242.0

Compositional bias

Note=Poly-Gly

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

593_598

1288.0

Compositional bias

Note=Poly-Asp

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

593_598

1242.0

Compositional bias

Note=Poly-Asp

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

1134_1282

1288.0

Domain

RUN 2

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

278_414

1288.0

Domain

cDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

416_598

1288.0

Domain

dDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

57_259

1288.0

Domain

uDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

787_950

1288.0

Domain

RUN 1

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000328194

954_1062

1288.0

Domain

PLAT

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

1134_1282

1242.0

Domain

RUN 2

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

278_414

1242.0

Domain

cDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

416_598

1242.0

Domain

dDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

57_259

1242.0

Domain

uDENN

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

787_950

1242.0

Domain

RUN 1

Hgene

DENND5A

chr11:9286507

chr11:8970022

ENST00000530044

954_1062

1242.0

Domain

PLAT

Tgene

TMEM9B

chr11:9286507

chr11:8970022

ENST00000534025

105_125

147

199.0

Transmembrane

Helical

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Fusion Gene Sequence for DENND5A-TMEM9B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22276_22276_1_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000328194_TMEM9B_chr11_8970022_ENST00000309134_length(transcript)=1612nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGATCACCAGCCTTTTGCAAA
TGCACACGATGTGCTAGCCCGCTCCCGCAGTCGAGCCAACGTGCTGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCA
AGAGCAGCGAAAGTCTGTCTTTGACCGGCATGTTGTCCTCAGCTAATTGGGAATTGAATTCAAGGTGACTAGAAAGAAACAGGCAGACAA
CTGGAAAGAACTGACTGGGTTTTGCTGGGTTTCATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCA
AAAACTTGCTTGATTTTTTTTTCTTGTTAACGTAATAATAGAGACATTTTTAAAAGCACACAGCTCAAAGTCAGCCAATAAGTCTTTTCC
TATTTGTGACTTTTACTAATAAAAATAAATCTGCCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCACCACAT
AGTTTTAACTTGACTTTCAAGATAATTTTCAGGGTTTTTGTTGTTGTTGTTTTTTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCC
TGGGAAGTGGTTAACAACTTTTTTCAAGTCACTTTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGAGTTTCATTTATA
TTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTGACTTACTCATTTGACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCA
CTTCATGGTAAACGGGATCTAAAATGCCTGGTGGCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGATGTCTGATGCAATGCATCC
TAGAACAAACTGGCCATTTGCTAGTTTACTCTAAAGACTAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGG
ACAAATCCTAAGGACTTGGACACTTGCAATAAAGAAATTTTATTTTAAACCCAAGCCTCCCTGGATTGATAATATATACACATTTGTCAG
CATTTCCGGTCGTGGTGAGAGGCAGCTGTTTGAGCTCCAATGTGTGCAGCTTTGAACTAGGGCTGGGGTTGTGGGTGCCTCTTCTGAAAG

>22276_22276_1_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000328194_TMEM9B_chr11_8970022_ENST00000309134_length(amino acids)=107AA_BP=1
MRADGRAPGLRGLGAAPHCPAGLGPGAMSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSGSPAFCKCTRCASPLPQSSQRAEQGRI

--------------------------------------------------------------
>22276_22276_2_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000328194_TMEM9B_chr11_8970022_ENST00000525069_length(transcript)=1405nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGATCACCAGCCTTTTGCAAA
TGCACACGATGTGCTAGCCCGCTCCCGCAGTCGAGCCAACGTGCTGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCA
AGAGCAGCGAAAGTCTGTCTTTGACCGGCATGTTGTCCTCAGCTAATTGGGAATTGAATTCAAGGTGACTAGAAAGAAACAGGCAGACAA
CTGGAAAGAACTGACTGGGTTTTGCTGGGTTTCATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCA
AAAACTTGCTTGATTTTTTTTTCTTGTTAACGTAATAATAGAGACATTTTTAAAAGCACACAGCTCAAAGTCAGCCAATAAGTCTTTTCC
TATTTGTGACTTTTACTAATAAAAATAAATCTGCCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCACCACAT
AGTTTTAACTTGACTTTCAAGATAATTTTCAGGGTTTTTGTTGTTGTTGTTTTTTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCC
TGGGAAGTGGTTAACAACTTTTTTCAAGTCACTTTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGAGTTTCATTTATA
TTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTGACTTACTCATTTGACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCA
CTTCATGGTAAACGGGATCTAAAATGCCTGGTGGCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGATGTCTGATGCAATGCATCC
TAGAACAAACTGGCCATTTGCTAGTTTACTCTAAAGACTAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGG

>22276_22276_2_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000328194_TMEM9B_chr11_8970022_ENST00000525069_length(amino acids)=107AA_BP=1
MRADGRAPGLRGLGAAPHCPAGLGPGAMSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSGSPAFCKCTRCASPLPQSSQRAEQGRI

--------------------------------------------------------------
>22276_22276_3_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000530044_TMEM9B_chr11_8970022_ENST00000309134_length(transcript)=1309nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGATCACCAGCCTTTTGCAAATGCACACGATGTGCTAGCCCGCTCCCGCAGTCG
AGCCAACGTGCTGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCAAGAGCAGCGAAAGTCTGTCTTTGACCGGCATGT
TGTCCTCAGCTAATTGGGAATTGAATTCAAGGTGACTAGAAAGAAACAGGCAGACAACTGGAAAGAACTGACTGGGTTTTGCTGGGTTTC
ATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCAAAAACTTGCTTGATTTTTTTTTCTTGTTAACGT
AATAATAGAGACATTTTTAAAAGCACACAGCTCAAAGTCAGCCAATAAGTCTTTTCCTATTTGTGACTTTTACTAATAAAAATAAATCTG
CCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCACCACATAGTTTTAACTTGACTTTCAAGATAATTTTCAGG
GTTTTTGTTGTTGTTGTTTTTTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCCTGGGAAGTGGTTAACAACTTTTTTCAAGTCACT
TTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGAGTTTCATTTATATTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTG
ACTTACTCATTTGACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCACTTCATGGTAAACGGGATCTAAAATGCCTGGTG
GCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGATGTCTGATGCAATGCATCCTAGAACAAACTGGCCATTTGCTAGTTTACTCTA
AAGACTAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGGACAAATCCTAAGGACTTGGACACTTGCAATAAA
GAAATTTTATTTTAAACCCAAGCCTCCCTGGATTGATAATATATACACATTTGTCAGCATTTCCGGTCGTGGTGAGAGGCAGCTGTTTGA
GCTCCAATGTGTGCAGCTTTGAACTAGGGCTGGGGTTGTGGGTGCCTCTTCTGAAAGGTCTAACCATTATTGGATAACTGGCTTTTTTCT

>22276_22276_3_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000530044_TMEM9B_chr11_8970022_ENST00000309134_length(amino acids)=80AA_BP=0

--------------------------------------------------------------
>22276_22276_4_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000530044_TMEM9B_chr11_8970022_ENST00000525069_length(transcript)=1102nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGATCACCAGCCTTTTGCAAATGCACACGATGTGCTAGCCCGCTCCCGCAGTCG
AGCCAACGTGCTGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCAAGAGCAGCGAAAGTCTGTCTTTGACCGGCATGT
TGTCCTCAGCTAATTGGGAATTGAATTCAAGGTGACTAGAAAGAAACAGGCAGACAACTGGAAAGAACTGACTGGGTTTTGCTGGGTTTC
ATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCAAAAACTTGCTTGATTTTTTTTTCTTGTTAACGT
AATAATAGAGACATTTTTAAAAGCACACAGCTCAAAGTCAGCCAATAAGTCTTTTCCTATTTGTGACTTTTACTAATAAAAATAAATCTG
CCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCACCACATAGTTTTAACTTGACTTTCAAGATAATTTTCAGG
GTTTTTGTTGTTGTTGTTTTTTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCCTGGGAAGTGGTTAACAACTTTTTTCAAGTCACT
TTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGAGTTTCATTTATATTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTG
ACTTACTCATTTGACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCACTTCATGGTAAACGGGATCTAAAATGCCTGGTG
GCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGATGTCTGATGCAATGCATCCTAGAACAAACTGGCCATTTGCTAGTTTACTCTA
AAGACTAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGGACAAATCCTAAGGACTTGGACACTTGCAATAAA

>22276_22276_4_DENND5A-TMEM9B_DENND5A_chr11_9286507_ENST00000530044_TMEM9B_chr11_8970022_ENST00000525069_length(amino acids)=80AA_BP=0

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DENND5A-TMEM9B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DENND5A-TMEM9B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DENND5A-TMEM9B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source