Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DENND5B-NUP54 (FusionGDB2 ID:22285)

Fusion Gene Summary for DENND5B-NUP54

Fusion gene summary

Fusion gene information	Fusion gene name: DENND5B-NUP54
	Fusion gene ID: 22285
		Hgene	Tgene
	Gene symbol	DENND5B	NUP54
	Gene ID	160518	53371
	Gene name	DENN domain containing 5B	nucleoporin 54
	Synonyms	-	-
	Cytomap	12p11.21	4q21.1
	Type of gene	protein-coding	protein-coding
	Description	DENN domain-containing protein 5BDENN/MADD domain containing 5Brab6IP1-like protein	nucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000354285, ENST00000389082, ENST00000545147, ENST00000306833, ENST00000536562,	ENST00000515460, ENST00000264883, ENST00000342467, ENST00000458189, ENST00000514987,
Fusion gene scores	* DoF score	6 X 5 X 5=150	5 X 5 X 4=100
	# samples	9	6
	** MAII score	log2(9/150*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DENND5B [Title/Abstract] AND NUP54 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DENND5B(31743640)-NUP54(77039347), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DENND5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP54 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A12D-01A	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-

Top

Fusion Gene ORF analysis for DENND5B-NUP54

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000354285	ENST00000515460	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5CDS-intron	ENST00000389082	ENST00000515460	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5UTR-3CDS	ENST00000545147	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5UTR-3CDS	ENST00000545147	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5UTR-3CDS	ENST00000545147	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5UTR-3CDS	ENST00000545147	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
5UTR-intron	ENST00000545147	ENST00000515460	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000354285	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000354285	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000354285	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000354285	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000389082	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000389082	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000389082	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
In-frame	ENST00000389082	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000306833	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000306833	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000306833	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000306833	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000536562	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000536562	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000536562	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-3CDS	ENST00000536562	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-intron	ENST00000306833	ENST00000515460	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-
intron-intron	ENST00000536562	ENST00000515460	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000389082	DENND5B	chr12	31743640	-	ENST00000264883	NUP54	chr4	77039347	-	1454	392	377	751	124
ENST00000389082	DENND5B	chr12	31743640	-	ENST00000342467	NUP54	chr4	77039347	-	1453	392	377	751	124
ENST00000389082	DENND5B	chr12	31743640	-	ENST00000514987	NUP54	chr4	77039347	-	912	392	377	751	124
ENST00000389082	DENND5B	chr12	31743640	-	ENST00000458189	NUP54	chr4	77039347	-	817	392	377	751	124
ENST00000354285	DENND5B	chr12	31743640	-	ENST00000264883	NUP54	chr4	77039347	-	1369	307	292	666	124
ENST00000354285	DENND5B	chr12	31743640	-	ENST00000342467	NUP54	chr4	77039347	-	1368	307	292	666	124
ENST00000354285	DENND5B	chr12	31743640	-	ENST00000514987	NUP54	chr4	77039347	-	827	307	292	666	124
ENST00000354285	DENND5B	chr12	31743640	-	ENST00000458189	NUP54	chr4	77039347	-	732	307	292	666	124

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000389082	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.19852157	0.8014784
ENST00000389082	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.19503953	0.8049604
ENST00000389082	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.09176332	0.9082366
ENST00000389082	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.09218811	0.9078118
ENST00000354285	ENST00000264883	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.1372535	0.8627465
ENST00000354285	ENST00000342467	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.1352732	0.86472684
ENST00000354285	ENST00000514987	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.078989275	0.92101073
ENST00000354285	ENST00000458189	DENND5B	chr12	31743640	-	NUP54	chr4	77039347	-	0.06098029	0.93901974

Top

Fusion Genomic Features for DENND5B-NUP54

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DENND5B-NUP54

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:31743640/chr4:77039347)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

205_208

172

292.0

Compositional bias

Note=Poly-Gln

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

444_445

388

508.0

Repeat

Note=9

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

444_445

172

292.0

Repeat

Note=9

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

1118_1267

739.0

Domain

RUN 2

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

263_399

739.0

Domain

cDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

39_244

739.0

Domain

uDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

401_581

739.0

Domain

dDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

772_932

739.0

Domain

RUN 1

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

936_1044

739.0

Domain

PLAT

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

1118_1267

1275.0

Domain

RUN 2

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

263_399

1275.0

Domain

cDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

39_244

1275.0

Domain

uDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

401_581

1275.0

Domain

dDENN

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

772_932

1275.0

Domain

RUN 1

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

936_1044

1275.0

Domain

PLAT

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000354285

916_936

739.0

Transmembrane

Helical

Hgene

DENND5B

chr12:31743640

chr4:77039347

ENST00000389082

916_936

1275.0

Transmembrane

Helical

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

205_208

388

508.0

Compositional bias

Note=Poly-Gln

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

30_99

388

508.0

Compositional bias

Note=Thr-rich

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

6_89

388

508.0

Compositional bias

Note=Gly-rich

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

93_97

388

508.0

Compositional bias

Note=Poly-Gln

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

30_99

172

292.0

Compositional bias

Note=Thr-rich

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

6_89

172

292.0

Compositional bias

Note=Gly-rich

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

93_97

172

292.0

Compositional bias

Note=Poly-Gln

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

5_445

388

508.0

Region

Note=9 X 2 AA repeats of F-G

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

5_445

172

292.0

Region

Note=9 X 2 AA repeats of F-G

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

25_26

388

508.0

Repeat

Note=2

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

28_29

388

508.0

Repeat

Note=3

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

53_54

388

508.0

Repeat

Note=4

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

5_6

388

508.0

Repeat

Note=1

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

61_62

388

508.0

Repeat

Note=5

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

63_64

388

508.0

Repeat

Note=6

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

67_68

388

508.0

Repeat

Note=7

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000264883

87_88

388

508.0

Repeat

Note=8

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

25_26

172

292.0

Repeat

Note=2

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

28_29

172

292.0

Repeat

Note=3

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

53_54

172

292.0

Repeat

Note=4

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

5_6

172

292.0

Repeat

Note=1

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

61_62

172

292.0

Repeat

Note=5

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

63_64

172

292.0

Repeat

Note=6

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

67_68

172

292.0

Repeat

Note=7

Tgene

NUP54

chr12:31743640

chr4:77039347

ENST00000342467

87_88

172

292.0

Repeat

Note=8

Top

Fusion Gene Sequence for DENND5B-NUP54

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22285_22285_1_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000264883_length(transcript)=1369nt_BP=307nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT
ACTGTTCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAA
GAAGTGCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTC
CATTGAGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTT
GGAGATTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAA
TGTTTTGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGG
ATATAACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCT

>22285_22285_1_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000264883_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_2_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000342467_length(transcript)=1368nt_BP=307nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT
ACTGTTCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAA
GAAGTGCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTC
CATTGAGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTT
GGAGATTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAA
TGTTTTGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGG
ATATAACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCT

>22285_22285_2_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000342467_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_3_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000458189_length(transcript)=732nt_BP=307nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG

>22285_22285_3_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000458189_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_4_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000514987_length(transcript)=827nt_BP=307nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT

>22285_22285_4_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000354285_NUP54_chr4_77039347_ENST00000514987_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_5_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000264883_length(transcript)=1454nt_BP=392nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT
TCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAAGAAGT
GCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTCCATTG
AGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTTGGAGA
TTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAATGTTT
TGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGGATATA
ACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCTTAATT

>22285_22285_5_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000264883_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_6_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000342467_length(transcript)=1453nt_BP=392nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT
TCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAAGAAGT
GCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTCCATTG
AGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTTGGAGA
TTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAATGTTT
TGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGGATATA
ACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCTTAATT

>22285_22285_6_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000342467_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_7_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000458189_length(transcript)=817nt_BP=392nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT

>22285_22285_7_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000458189_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------
>22285_22285_8_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000514987_length(transcript)=912nt_BP=392nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT

>22285_22285_8_DENND5B-NUP54_DENND5B_chr12_31743640_ENST00000389082_NUP54_chr4_77039347_ENST00000514987_length(amino acids)=124AA_BP=5
MTSWRVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DENND5B-NUP54

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DENND5B-NUP54

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DENND5B-NUP54

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source