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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DEPDC1B-ERCC8 (FusionGDB2 ID:22299)

Fusion Gene Summary for DEPDC1B-ERCC8

check button Fusion gene summary
Fusion gene informationFusion gene name: DEPDC1B-ERCC8
Fusion gene ID: 22299
HgeneTgene
Gene symbol

DEPDC1B

ERCC8

Gene ID

55789

1161

Gene nameDEP domain containing 1BERCC excision repair 8, CSA ubiquitin ligase complex subunit
SynonymsBRCC3|XTP1CKN1|CSA|UVSS2
Cytomap

5q12.1

5q12.1

Type of geneprotein-codingprotein-coding
DescriptionDEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3DNA excision repair protein ERCC-8Cockayne syndrome WD-repeat protein CSAcockayne syndrome WD repeat protein CSAexcision repair cross-complementation group 8excision repair cross-complementing rodent repair deficiency, complementation group 8
Modification date2020031320200322
UniProtAcc

Q8WUY9

Q13216

Ensembl transtripts involved in fusion geneENST00000265036, ENST00000453022, 
ENST00000545085, ENST00000509006, 
ENST00000462279, ENST00000543101, 
ENST00000265038, ENST00000426742, 
Fusion gene scores* DoF score8 X 9 X 7=5048 X 8 X 7=448
# samples 1413
** MAII scorelog2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/448*10)=-1.78498710902915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DEPDC1B [Title/Abstract] AND ERCC8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDEPDC1B(59995873)-ERCC8(60170510), # samples:1
DEPDC1B(59986891)-ERCC8(60221660), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC8

GO:0000012

single strand break repair

29545921

TgeneERCC8

GO:0000209

protein polyubiquitination

12732143

TgeneERCC8

GO:0006283

transcription-coupled nucleotide-excision repair

12732143

TgeneERCC8

GO:0006974

cellular response to DNA damage stimulus

11782547

TgeneERCC8

GO:0006979

response to oxidative stress

11782547

TgeneERCC8

GO:0009411

response to UV

12732143

TgeneERCC8

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

16751180

TgeneERCC8

GO:0051865

protein autoubiquitination

12732143

TgeneERCC8

GO:0097680

double-strand break repair via classical nonhomologous end joining

29545921


check buttonFusion gene breakpoints across DEPDC1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERCC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7716-01ADEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
ChiTaRS5.0N/ABE044774DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+


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Fusion Gene ORF analysis for DEPDC1B-ERCC8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265036ENST00000462279DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000265036ENST00000543101DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000453022ENST00000462279DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000453022ENST00000543101DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5UTR-3CDSENST00000545085ENST00000265038DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5UTR-3CDSENST00000545085ENST00000426742DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5UTR-5UTRENST00000545085ENST00000462279DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
5UTR-5UTRENST00000545085ENST00000543101DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
In-frameENST00000265036ENST00000265038DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
In-frameENST00000265036ENST00000426742DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
In-frameENST00000453022ENST00000265038DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
In-frameENST00000453022ENST00000426742DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
intron-3CDSENST00000509006ENST00000265038DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
intron-3CDSENST00000509006ENST00000426742DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
intron-5UTRENST00000509006ENST00000462279DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
intron-5UTRENST00000509006ENST00000543101DEPDC1Bchr5

59995873

-ERCC8chr5

60170510

-
intron-intronENST00000265036ENST00000265038DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000265036ENST00000426742DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000265036ENST00000462279DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000265036ENST00000543101DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000453022ENST00000265038DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000453022ENST00000426742DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000453022ENST00000462279DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000453022ENST00000543101DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000509006ENST00000265038DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000509006ENST00000426742DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000509006ENST00000462279DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000509006ENST00000543101DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000545085ENST00000265038DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000545085ENST00000426742DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000545085ENST00000462279DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+
intron-intronENST00000545085ENST00000543101DEPDC1Bchr5

59986891

+ERCC8chr5

60221660

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265036DEPDC1Bchr559995873-ENST00000426742ERCC8chr560170510-96911624811743
ENST00000265036DEPDC1Bchr559995873-ENST00000265038ERCC8chr560170510-9681162702880
ENST00000453022DEPDC1Bchr559995873-ENST00000426742ERCC8chr560170510-942892219043
ENST00000453022DEPDC1Bchr559995873-ENST00000265038ERCC8chr560170510-94189243181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265036ENST00000426742DEPDC1Bchr559995873-ERCC8chr560170510-0.61371560.38628444
ENST00000265036ENST00000265038DEPDC1Bchr559995873-ERCC8chr560170510-0.61774080.3822592
ENST00000453022ENST00000426742DEPDC1Bchr559995873-ERCC8chr560170510-0.71887240.28112757
ENST00000453022ENST00000265038DEPDC1Bchr559995873-ERCC8chr560170510-0.725141640.2748584

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Fusion Genomic Features for DEPDC1B-ERCC8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DEPDC1B-ERCC8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:59995873/chr5:60170510)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DEPDC1B

Q8WUY9

ERCC8

Q13216

FUNCTION: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (PubMed:29545921). {ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29545921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000265036-111468_47516530.0Compositional biasNote=Poly-Lys
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000453022-110468_47516468.0Compositional biasNote=Poly-Lys
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000265036-111201_39316530.0DomainRho-GAP
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000265036-11124_10816530.0DomainDEP
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000453022-110201_39316468.0DomainRho-GAP
HgeneDEPDC1Bchr5:59995873chr5:60170510ENST00000453022-11024_10816468.0DomainDEP
TgeneERCC8chr5:59995873chr5:60170510ENST000002650381012133_173374397.0RepeatNote=WD 3
TgeneERCC8chr5:59995873chr5:60170510ENST000002650381012177_216374397.0RepeatNote=WD 4
TgeneERCC8chr5:59995873chr5:60170510ENST000002650381012235_274374397.0RepeatNote=WD 5
TgeneERCC8chr5:59995873chr5:60170510ENST000002650381012281_321374397.0RepeatNote=WD 6
TgeneERCC8chr5:59995873chr5:60170510ENST000002650381012325_363374397.0RepeatNote=WD 7
TgeneERCC8chr5:59995873chr5:60170510ENST00000265038101233_73374397.0RepeatNote=WD 1
TgeneERCC8chr5:59995873chr5:60170510ENST00000265038101288_129374397.0RepeatNote=WD 2


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Fusion Gene Sequence for DEPDC1B-ERCC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22299_22299_1_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000265036_ERCC8_chr5_60170510_ENST00000265038_length(transcript)=968nt_BP=116nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGC
CCGGGCCGTACCGAGCTACCAGGCTGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGGAGCAGCAGTGATGAAGAAG
GATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACTGTATGGTCTATTCCTGACA
GCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAATCCTAAAACAGACTTCTGTA
TAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGTACAAGTAACACAAGTCGTT
GTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAGGCCATCAGTATTGACTTTC
TCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCAAAAATAGTAGTTGAAATGG
TAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCATGCTTTATGTTAAACATTT
TGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGTTTGCTTTATTTTATTTTAA
TGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCTGCCTCATTAATTCAAGCAG

>22299_22299_1_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000265036_ERCC8_chr5_60170510_ENST00000265038_length(amino acids)=80AA_BP=1

--------------------------------------------------------------
>22299_22299_2_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000265036_ERCC8_chr5_60170510_ENST00000426742_length(transcript)=969nt_BP=116nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGC
CCGGGCCGTACCGAGCTACCAGGCTGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGGAGCAGCAGTGATGAAGAAG
GATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACTGTATGGTCTATTCCTGACA
GCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAATCCTAAAACAGACTTCTGTA
TAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGTACAAGTAACACAAGTCGTT
GTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAGGCCATCAGTATTGACTTTC
TCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCAAAAATAGTAGTTGAAATGG
TAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCATGCTTTATGTTAAACATTT
TGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGTTTGCTTTATTTTATTTTAA
TGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCTGCCTCATTAATTCAAGCAG

>22299_22299_2_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000265036_ERCC8_chr5_60170510_ENST00000426742_length(amino acids)=43AA_BP=1

--------------------------------------------------------------
>22299_22299_3_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000453022_ERCC8_chr5_60170510_ENST00000265038_length(transcript)=941nt_BP=89nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGA
CTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGGAGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTT
GTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACTGTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAAT
ATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAATCCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCT
TGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGTACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGAT
TTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAGGCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCT
CGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCAAAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCT
TCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCATGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAA
AATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGTTTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCT
TGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCTGCCTCATTAATTCAAGCAGAAAATATCCTGGCAGGGAATCTGGCTT

>22299_22299_3_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000453022_ERCC8_chr5_60170510_ENST00000265038_length(amino acids)=81AA_BP=1

--------------------------------------------------------------
>22299_22299_4_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000453022_ERCC8_chr5_60170510_ENST00000426742_length(transcript)=942nt_BP=89nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGA
CTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGGAGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTT
GTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACTGTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAAT
ATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAATCCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCT
TGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGTACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGAT
TTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAGGCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCT
CGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCAAAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCT
TCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCATGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAA
AATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGTTTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCT
TGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCTGCCTCATTAATTCAAGCAGAAAATATCCTGGCAGGGAATCTGGCTT

>22299_22299_4_DEPDC1B-ERCC8_DEPDC1B_chr5_59995873_ENST00000453022_ERCC8_chr5_60170510_ENST00000426742_length(amino acids)=43AA_BP=1

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DEPDC1B-ERCC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DEPDC1B-ERCC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DEPDC1B-ERCC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource