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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DET1-PPIP5K2 (FusionGDB2 ID:22366)

Fusion Gene Summary for DET1-PPIP5K2

check button Fusion gene summary
Fusion gene informationFusion gene name: DET1-PPIP5K2
Fusion gene ID: 22366
HgeneTgene
Gene symbol

DET1

PPIP5K2

Gene ID

55070

23262

Gene nameDET1 partner of COP1 E3 ubiquitin ligasediphosphoinositol pentakisphosphate kinase 2
Synonyms-CFAP160|DFNB100|HISPPD1|IP7K2|VIP2
Cytomap

15q26.1

5q21.1

Type of geneprotein-codingprotein-coding
DescriptionDET1 homologDET1, COP1 ubiquitin ligase partnerde-etiolated homolog 1inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2VIP1 homolog 2deafness, autosomal recessive 100histidine acid phosphatase domain-containing protein 1inositol heptaphosphate kinase 2insP6 and PP-IP5 kinase 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000268148, ENST00000444300, 
ENST00000564406, ENST00000558413, 
ENST00000559656, 		ENST00000414217, 
ENST00000513500, ENST00000321521, 
ENST00000358359, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 3=90
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DET1 [Title/Abstract] AND PPIP5K2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDET1(89060012)-PPIP5K2(102490373), # samples:1
Anticipated loss of major functional domain due to fusion event.DET1-PPIP5K2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DET1-PPIP5K2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDET1

GO:0065003

protein-containing complex assembly

14739464


check buttonFusion gene breakpoints across DET1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPIP5K2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A93EDET1chr15

89060012

-PPIP5K2chr5

102490373

+


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Fusion Gene ORF analysis for DET1-PPIP5K2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000268148ENST00000414217DET1chr15

89060012

-PPIP5K2chr5

102490373

+
5CDS-3UTRENST00000268148ENST00000513500DET1chr15

89060012

-PPIP5K2chr5

102490373

+
5CDS-3UTRENST00000444300ENST00000414217DET1chr15

89060012

-PPIP5K2chr5

102490373

+
5CDS-3UTRENST00000444300ENST00000513500DET1chr15

89060012

-PPIP5K2chr5

102490373

+
5CDS-3UTRENST00000564406ENST00000414217DET1chr15

89060012

-PPIP5K2chr5

102490373

+
5CDS-3UTRENST00000564406ENST00000513500DET1chr15

89060012

-PPIP5K2chr5

102490373

+
Frame-shiftENST00000268148ENST00000321521DET1chr15

89060012

-PPIP5K2chr5

102490373

+
Frame-shiftENST00000268148ENST00000358359DET1chr15

89060012

-PPIP5K2chr5

102490373

+
In-frameENST00000444300ENST00000321521DET1chr15

89060012

-PPIP5K2chr5

102490373

+
In-frameENST00000444300ENST00000358359DET1chr15

89060012

-PPIP5K2chr5

102490373

+
In-frameENST00000564406ENST00000321521DET1chr15

89060012

-PPIP5K2chr5

102490373

+
In-frameENST00000564406ENST00000358359DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3CDSENST00000558413ENST00000321521DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3CDSENST00000558413ENST00000358359DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3CDSENST00000559656ENST00000321521DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3CDSENST00000559656ENST00000358359DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3UTRENST00000558413ENST00000414217DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3UTRENST00000558413ENST00000513500DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3UTRENST00000559656ENST00000414217DET1chr15

89060012

-PPIP5K2chr5

102490373

+
intron-3UTRENST00000559656ENST00000513500DET1chr15

89060012

-PPIP5K2chr5

102490373

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000444300DET1chr1589060012-ENST00000321521PPIP5K2chr5102490373+151131496039471315
ENST00000444300DET1chr1589060012-ENST00000358359PPIP5K2chr5102490373+55831496040101336
ENST00000564406DET1chr1589060012-ENST00000321521PPIP5K2chr5102490373+15274165714941081319
ENST00000564406DET1chr1589060012-ENST00000358359PPIP5K2chr5102490373+5744165714941711340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000444300ENST00000321521DET1chr1589060012-PPIP5K2chr5102490373+5.04E-050.9999497
ENST00000444300ENST00000358359DET1chr1589060012-PPIP5K2chr5102490373+0.0001077170.99989223
ENST00000564406ENST00000321521DET1chr1589060012-PPIP5K2chr5102490373+6.19E-050.999938
ENST00000564406ENST00000358359DET1chr1589060012-PPIP5K2chr5102490373+0.0001382920.9998617

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Fusion Genomic Features for DET1-PPIP5K2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DET1chr1589060012-PPIP5K2chr5102490373+0.0011902730.9988097
DET1chr1589060012-PPIP5K2chr5102490373+0.0011902730.9988097

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DET1-PPIP5K2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:89060012/chr5:102490373)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030237_2404051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030246_2484051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030321_3234051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031237_2404051244.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031246_2484051244.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031321_3234051244.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929237_2404051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929246_2484051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929321_3234051223.0Nucleotide bindingATP
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030213_2144051223.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030326_3294051223.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003215211030371_4424051223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000321521103053_544051223.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031213_2144051244.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031326_3294051244.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST000003583591031371_4424051244.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000358359103153_544051244.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929213_2144051223.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929326_3294051223.0RegionSubstrate binding
TgenePPIP5K2chr15:89060012chr5:102490373ENST00000414217929371_4424051223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr15:89060012chr5:102490373ENST0000041421792953_544051223.0RegionSubstrate binding


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Fusion Gene Sequence for DET1-PPIP5K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22366_22366_1_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000444300_PPIP5K2_chr5_102490373_ENST00000321521_length(transcript)=15113nt_BP=1496nt
ATGGTGGGACAGATACTAAAAAGAGATGTGATAATGGATCATCATGTTTCTACCATCAAGCCTCGAAGAATCCAAAACCAAAATGTCATT
CACCGCTTGGAACGCCGGCGGATCAGTTCAGGCAAGGCAGGTACCCACTGGCACCAAGTCCGAGTGTTCCATCAGAATGTCTTCCCCAAC
TTCACAGTTGTCAACGTTGAAAAGCCTCCTTGTTTCTTGCGTAAATTCTCACCTGATGGACGCTACTTTATTGCTTTTTCTTCAGACCAG
ACATCTCTTGAAATCTATGAGTACCAGGGCTGCCAGGCAGCAGAGGACCTACTGCAGGGATACGAAGGAGAAATCCTGTCCAATGGCAAT
GACCAGCGGTCAGTGAATATCCGGGGCCGGCTCTTTGAACGCTTTTTTGTCCTGCTGCACATTACCAATGTTGCGGCCAATGGTGAGCAC
CTGAACCGGGAGTGTAGTCTCTTCACTGATGACTGCCGCTGTGTCATCGTGGGCTCAGCTGCCTACCTCCCAGATGAGCCTCACCCTCCA
TTTTTTGAGGTATATCGGAACAGTGAATCAGTGACCCCCAACCCACGGTCCCCTCTAGAAGACTATTCCCTCCATATCATTGACCTTCAC
ACCGGCCGCTTATGTGATACACGCACGTTCAAGTGTGACAAGGTGGTCTTGTCACACAACCAAGGGCTGTACTTGTACAAAAACATCCTG
GCCATCTTGTCTGTGCAACAACAGACCATCCATGTCTTCCAGGTGACTCCTGAAGGCACTTTCATTGATGTGCGGACCATTGGCCGCTTT
TGCTATGAGGATGACCTGCTCACTGTGTCAGCTGTTTTCCCTGAGGTACAGCGGGACAGTCAGACAGGCATGGCCAATCCCTTTAGGGAT
CCTTTCATCAATTCCCTCAAACACCGGTTGCTGGTATATTTGTGGCGCCGGGCAGAACAGGATGGTAGTGCAATGGCCAAGAGGCGCTTC
TTCCAGTATTTTGACCAACTGCGGCAGCTGCGAATGTGGAAAATGCAGCTTCTGGATGAAAACCACCTGTTTATCAAGTACACTAGTGAG
GATGTAGTAACACTGCGAGTCACAGATCCATCACAGGCATCTTTCTTTGTGGTGTACAATATGGTGACGACAGAGGTGATTGCTGTGTTT
GAGAATACATCAGATGAGCTTTTGGAGCTCTTTGAGAACTTCTGTGACCTTTTTCGTAATGCTACCCTGCACAGTGAAGTTCAGTTTCCC
TGCTCAGCTTCTAGCAACAATTTTGCAAGGCAGATCCAGCGCCGGTTCAAAGACACTATTATAAATGCCAAGTATGGAGGGCACACAGAG
GCAGTACGCCGGCTGCTGGGTCAGCTCCCCATCAGTGCTCAGTCTTACAGCGGTAGCCCCTATCTGGATTTGTCTCTCTTCAGTTATGAT
GACAAGTGGGTATCTGTCATGGAGCGGCCCAAGACTTGTGGAGATCACCCAATCAGATTTTTTGATCTTTTTGAAAAGTGTGATGGATAT
AAATCAGGGAAATTAAAACTCAAAAAACCAAAACAGTTACAGGAAGTGCTAGATATTGCACGACAGCTTCTTATGGAGCTAGGGCAAAAT
AATGATTCTGAAATTGAAGAAAACAAGCCAAAACTTGAACAACTTAAGACTGTATTAGAGATGTATGGTCATTTTTCTGGAATAAATCGT
AAGGTTCAGTTGACCTATCTCCCTCATGGTTGTCCTAAAACATCTAGTGAAGAGGAGGACAGCCGAAGAGAAGAACCATCTTTACTTTTG
GTTCTAAAATGGGGAGGTGAATTAACTCCTGCAGGCAGGGTCCAGGCTGAAGAACTTGGAAGAGCCTTCAGGTGTATGTATCCTGGAGGT
CAAGGAGATTATGCAGGATTTCCTGGTTGTGGTTTACTTAGATTACATAGCACCTACAGACATGACCTCAAAATATATGCCTCTGATGAA
GGACGAGTCCAGATGACTGCAGCTGCTTTTGCAAAGGGGCTTTTAGCTTTGGAAGGAGAGCTTACACCCATTCTTGTTCAAATGGTGAAA
AGTGCAAATATGAACGGTCTTTTGGATAGTGATAGTGACTCTCTGAGCAGTTGTCAGCAACGTGTGAAGGCAAGGCTTCATGAAATACTT
CAGAAAGACAGAGATTTTACTGCTGAAGATTATGAAAAGCTTACTCCATCTGGAAGCATTTCTCTTATCAAATCAATGCATTTAATTAAA
AACCCTGTGAAGACCTGTGATAAAGTTTATTCCTTAATTCAGAGTTTGACTTCTCAAATCAGACATCGAATGGAAGATCCTAAATCATCA
GATATTCAGCTTTACCATAGTGAAACATTGGAGCTTATGCTACGTAGATGGTCCAAGTTAGAGAAAGACTTTAAAACAAAGAATGGAAGA
TATGATATTAGTAAAATCCCTGACATATATGACTGTATAAAATATGATGTCCAGCATAATGGTTCCTTGAAATTAGAAAACACAATGGAA
TTATATAGGCTTTCGAAGGCATTAGCAGATATTGTTATCCCTCAGGAATATGGTATAACTAAAGCTGAAAAACTGGAGATTGCCAAAGGC
TACTGTACTCCTCTGGTTAGAAAAATTCGCTCAGACCTTCAGAGGACACAAGATGATGACACTGTAAATAAACTTCATCCTGTGTATTCT
AGAGGTGTTCTGTCTCCTGAACGTCATGTTCGTACTAGATTATATTTTACCAGTGAAAGTCATGTACATTCTTTGCTGTCTATTCTTCGC
TATGGTGCCTTATGCAATGAATCAAAGGATGAACAGTGGAAACGAGCTATGGATTATTTAAACGTTGTCAATGAGCTCAACTACATGACT
CAGATTGTTATCATGCTTTATGAGGATCCTAATAAGGATCTTTCCTCAGAAGAACGCTTTCATGTTGAATTACACTTTAGTCCGGGAGCC
AAAGGTTGTGAAGAAGACAAAAATTTGCCATCTGGCTATGGATATAGACCAGCTTCCAGAGAGAATGAAGGCAGGAGACCTTTTAAAATT
GATAATGATGATGAACCACATACTTCTAAAAGAGATGAAGTTGATCGAGCTGTGATATTGTTTAAACCAATGGTATCAGAGCCAATTCAT
ATACACAGGAAGTCTCCACTTCCAAGATCTAGGAAGACGGCTACAAATGATGAAGAGAGCCCCCTGAGTGTGTCTAGCCCAGAGGGTACT
GGTACCTGGCTGCATTATACCAGTGGTGTGGGTACTGGGCGTCGAAGACGCAGATCAGGGGAACAAATCACTTCTTCCCCTGTCTCCCCC
AAATCATTGGCTTTCACATCCAGTATTTTTGGCTCATGGCAACAGGTTGTATCTGAAAATGCTAATTACCTGAGAACACCAAGAACTCTT
GTGGAACAGAAGCAGAATCCTACTGTAGGGTCTCACTGTGCGGGCCTGTTTAGCACCTCGGTGCTCGGGGGTTCTTCAAGCGCACCTAAC
CTACAGGATTATGCTCGTACTCATCGTAAAAAGCTGACCTCTTCTGGCTGCATAGATGGCTTTGAATTGTATTCCATGGTGCCATCTATT
TGTCCTCTAGAAACTCTTCATAATGCCCTATCTTTAAAGCAAGTGGATGAATTTCTTGCTTCCATTGCTTCTCCATCATCTGACGTTCCA
CGGAAGACCGCTGAAATTTCCTCTACAGCTTTACGTTCCAGTCCAATAATGAGAAAAAAAGTATCTTTAAATACGTATACACCTGCAAAG
ATCCTCCCAACACCACCAGCTACCTTAAAGAGCACTAAAGCAAGCAGCAAACCAGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAAT
ACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGA
AGCTGGAACTTTTTATACTTATAAAAATAGTATGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTA
AGGTTTTCTTTGTTTATGTTCAGGTAAGGAACTGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAA
AACTTATAGTGATAAAAATCGATTGTTGTTAATATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTC
GTACCAAAGTCACAGCAGTAATGCTATGTACTGCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTA
GCTGTTAAAACTTCTAGATTGAAATTTGACAGCCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGT
TTAGATTAGAATATCTTTCCCAATTGTTACAGTGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTC
AATCTGTGTTTTGAATTTTTTTATTGTGTGTTATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATA
TATTAATTTGTAGAAAATATTTTCTTTATATATTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGAC
AAGAAAGGCACCTTCAGAGTTTCTTTTTAAGTATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAG
AAGTCAGTTCAAAAATGGAAATCAACAATGTTAGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAAC
CATTTCCATTCTTATCCCTAGTGTATCAGTTGATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGAT
TAGATTTTTGAAGGGATATTGAAATCATTGCGCTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCC
ACCAATGCACAAATAATTGTGAACAGCTTGAAATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGT
TAAATAACTTAAATTGCTAAAGCTTTAGCTTGAAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATT
CTTCAAATGAGACTCTTCTCACCTTAAATAGTCATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGT
ACCAGATGTAAGAGTCATAAATATATGCAATTAAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTA
AACAGTTGAATGTATGTAAGTTTTCTGTTTGTGAAAATGTAGTTAATGTACTCACTGTGGAGGTCATAAGGAAGCTACTTTTTTTTTAAA
GTGGAACCTAATTAAAATATTTCCAGAATCAAAGAGACTTAAATGGTAAATTTTTAAAATTTTCTTATCTCTTACTTTTTAGTTTTCAAA
GTAGAAAAAATCAGGAATTTTTTTATTAACTAGTACTTACATATTAAATAAAATTTATTATTGGCTATATACATAGCAATATATTACTTT
CCAAACTAGAAAGTACAGTACAACTAACTTTTTCCATTGTTATGCAAGAACTATTACTTTCCTGTAGTCACCAAACTCAGTAGTATTGCT
CTGTAGACTAGACACTCTATTTGTAAAAATCTTAGAATCACTTTCCAAAACAAATAAAAAGTCTACTGTATCAGAGCAAAATGTTATAGT
TATCACTGTTTAGTGGCAGTTTGACTGAAGCATCTGTTTCTCACTTGATTCTGTCCTGAGAAGATGTGGGATTTTTTGGTTTTAAATACT
AGAAGATATTTCTTCTTAGAGCCCAGTCCTCCATCCCAAAGAGGTGAACTAGCCCAGCATGAAGAATTGTCTAGTCACCCTGAGATATTA
ATCTTCATAATGTATTATTCAGTTCCTTCACCCTTAAAAGCCATATAATAGGCTCAGACCTAACTTAGCCCTTGAAGTCTAGTGCTGGCA
GATTCTGCTGCCCTGGTTTAAATGAGTTACGTAGTCCATTCTCAAATACTAGCAAATTTGGGGGGCGTGGTACAGCAATTTTGGGTGAAG
AAAAGTGTGCTGAACACCTTATGTCAGTGATAGACAAGATATAGAGGCTGAAGGGAATACAGTAAAGTAACAAAAACATGTGGCAGTGTG
CTTAGCATAAACATAGAGCACAAAGGCAATAGATGGAAATTATGAGAGAAAAGTTAAAGTTCTTCAAGAAATATCCAATTAAAACTCACT
AGCCAAGGAAAAAGTTTCTGTTTTCACCCGGATTTCTTTTTGGGTTGACTCTGTCTGACCTAAATGTCCACTGTTAACTAGTGCCATGCC
AGTTTGAACCAAGATTTCACATTTTTGTTTTGTATTCATACTTTGGTAGAAATTTCTCAGTCTTTGTGTATTTATAAGAATTTGCTTTAC
ACATAGTGTACAGTGTTTATTAACTTTACATCATTTTATCCTTGCCTTACTATCTGGACAGTGTAGACTGCCTATATTCTTAGTTGGGGT
TGGGATCTCTTCTCTTAGAGTGGCCCAGCAGTTTTAGCCCCTCTCTAATTCTCTTTTCCTGTGTTGGGAGATATCAAAACAACAGAATTC
TTGCCAGTGGGAACATTTTTCTTTTTTAGACAAGGTCTCATTCTGTCACCCCAGCTGGAGTGCAGTGGCACAGTCTTAATTCACTACAGC
CTTGAACTCCTGGGCTCAAGAAATCTTTCTGCTTCAGCCTCCTAAATAGCTGGTACTATAGGTGCGTGCCACCACACCCAGCTCATGGGA
ATAATTTTTACACTCCTTCAGAAGGAGTCATTTGTGATTGGAGTCCACATAGAAACAGGTTTCCCTCTGTACATAATCGTAGGTACCAAA
ATATTACTGTGTAAAGTGTTGTTTATATAGGTCAATTTTTGTGGAAGATCTAATTTCTATTTTCAGAGAACAGAGCACATTAAAAAATCT
ATTTAGTATTGTGTACTATATAATCTATGTGAATTATAGCTCCTTAACTAAATATATTACTGAGTTTTTTTTTTAATACTGTAAGTTCTA
GGGTACATGTGCACAATGTGCAGGTTTGTTACATAGGTATACATGTGCCATGTTGGTTTGCTGCACCCATGAACTCATCATTTACATTAG
GTATTTCTCCTAATGCTATCCCTCCCCCAGCCCCCCACCCACTGACAGGCCCAGTGTGTGATGTTCCCCGCCCTGTGTCCAAGTACTGTT
CTCATTGTTCAGTTCCCTCTTATGAGTGAGAACATGCGGTGTTTGGTTTTCTGTCCTTGTGATAGTTTGCTGAGAATGATGGTTTCCAGC
TTCATCCATGTCCTTGTCATCCTTTTTTTTGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCTATCATTGA
TGGACATCTGGGTTGGTCCCAAGTCTTTGCTATTGTGAATAGTGCCACAATAAACATACGTGTGCATGTGTCTTTATAGTGGCATGATTT
ATAATCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATGGTATTTCTAGTTCTAGATCCTTGAGGAATCGCCACACTGTCTT
CCACAATGGTTGAACTAATTTACACTCCCACCAAGTGTTCCTATTTCTCCACATCCTCTCCAGCATCTGTTGTTTCCTGACTTTTCAATG
ATCGCCATTCTAACTGGCGTGAGATGGTATCTCATTTGTAAGATGATATCTCATTGAGATTTTTATAAACTGCTTTTCTTTTGGTTCATG
TGCTTTGTCATGGATTGTGAGAAAAACATCTTTTCGCTTAGGGATCACTGTCAATTTCTCCTTTTATTATCAATGGTTTTTACTTTACTT
TTTATATAGTATGTGGGTATGTTTTCTGGTGCATATAAATTCATGAATGCTAGATTTTCATTATAGGTTTTACCTTATCATTATTAAAAT
GTCCTTTTTGTCCATTGGATACTTTTTGTTCTATAAATTGTCAGATATTAAGATTATGACCTATGCTTTATTTTGGCTTGCATTTGCCTG
ATATTCATCTTTTTACTTTTTGGTATTTGTGTCACTTTGTTTTAGGTTATTTAATATAGTATATATTGGGTTTTGCTTTGTGATTCAATT
TTAAGATCCCTTTTACTTAATAGATTAGTGTAGTCTGTTTTATGTAATGTATCTTTGCTTTTAGATTGTGCTTGCTTTTTTTATTGCTTT
AAAATTCTTTTGTCTTTCTGTAACAATACTTTCCACTGCAAGTAGGAAAATTCCAATTGAAACTGGTTTAAATCATCAGAAAATGTATTA
TTACACATTTCTGAAGGTCCAAAGGTGGGGTTGGCTTCAGCCACAGTTGCATTAGCCATATTGTCATCAAAAGCCCAAGTGACCTCCCTT
GTCACCTCTGGCATAGTATAAACTTTATCCCAAAGTTGTTTTCTCTCGTGTTAACAATAATTGCTGTCGGTTTCAGTGAGGACTACATAT
TTTTTTTGTTCATGTCCAACACAATAAAAATTGAGGGAAGTTCTGTCCCAATCCTGGAATATTAATATTAAGCCATCTACTTCAGTGTGA
TTGAGCCAACTTCTTTGATCATCTACTCACCCCTAGATAAATAGAATACTCCAGGAGATTCCCATGACCTTACTGACCCTAGAGCAGATG
ATGGAGTCAGTTTTTCCGAAAAGCCTCAGCACTGTTGACATTTTGGACCATAAAATTCTACATCATAGGAAGCTGTTCCATGCATAGCAG
CATGTCTAGTAGGATCTCTGTACCTAGCTGTGAAGTGTTGAGAGTCAGTTAAGGTAAGTAGCTGAAATGAAAATAACAATCACATCTTTA
TTCACTTACTATGATAAAATTATAAGCAAGAGACCAAAAAGGAAAGTAGGGCCAGCTCCTTGTTGTTCCATTTTTCCCCTACCATGGACT
AGCACTGGACATGCGTCAATCAGACGACATGCAGTCCAGGCAGAGGAAATTGTTTCACTGCTAAGGAGCAATGAACAAAAGGTTCCTGCC
ATCTTATGGACCTCAAGGACTGCGGACAGGGAGCAGGGAAGGGTTAGAAGTAGAAAACAACTGAGTCAGAGTGGAGATGAGTGTCTCAGT
CAAGGCCCACCAATAGCGAGGTCTCTGTGGAGGCACCTGAAAAGTGTCTCAACCAAGGCCCCCTGATAAGGAAGACTCAGCATGGAGGTA
CCTGGTCTAGGAATGCAGCTAGGTTTATAGACATGGCCAGCCCAGGGGGTCCTGAGCACCAGATACAACTCCCTCCAGAGACTGGCTGTG
TTTAAATCTCATGTGGGAAGGGCACCTTTCCCCTACAAAGCCTGTCAGGCAAAGCCTTTGTAATTGCTTATGGTCAGGCCTGAAAGATCA
CACATCAGACTTTGGCCTGGAACATATCTCCTCACCCTAAATGCCAGCAGCATCGCCTCCAAACTGTGGCAGTCAAAAATGTCTCCAGAC
ATTAGTAAATGTCTTTTGTGAGGGAAGAATTGACCCTAGTTAAGAACCACTGCCCTAAAGCACATGATTCTGTGGAAAAGAAGGATATAT
GACCAAAATCATCATTTTGGATAGTGAGGGCATGGATAATGGATACATAATCAGCAATGTATGCTGTATACTACACTTGCATTATGTTAT
TCACATTTGCTATAGTTCACTTGTTGTGCTAATGGTTTTTTCCTTCACTATGATTTTGAATTATATTTAATTTTAAAGTCTATATATATA
TATATATAGATCCTATCTGTTGACTCCTTGCTGTGAACAATATCCAATTAGTGTATTTTTTCCTCTACTGCACAGTTTTGGTTGATTATT
TTTTCCTTTTCATTTCTTTTCTGAACTTTGTTAGCTTATGTTGCATTTCCTTTGGTTGTTTTGCTATGGTGTTTCTGATCAACTACATTT
CTTTATGAACTCTATTTCCTTAAGTTCTTTGAGTTATGACAGTATATTTGGTCACATTTTTCATGTGCTCAGCTGATTCATTCTTTCCTG
TTGAGTGGTTTTTATCTGCTAATTGTTTCTGCTTGTTCCATTTCTCCTTTTCTTGAAGTGTTTGTGCATGAACACTGTGCAGGTTTATTT
TCAAGTATTACTTACCTTTATATGAGATAAATTTCTTTCTGGCTCATCTATTTGATACAATTTCTTTTTTGTTTGTTTTTGTTTTGTTTT
TGTTGTTTTTTAAAATGCAATTTCATATGTTAGGTAGGTTGGCTTTTCTTTTTCTTTTTCTTTTTTTTTTTGAGATGGAGTTTTACTCTT
GTTGCCTAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCCACCTTCCAGTTTCAAATGATTCTCCTCCCTCAGCCTCCAG
AGTAGCTGGGATTACAGGCGCCCGCCACCACGCCTGGCTAATTTTTGCATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAGGCTGG
TCTCGAACTCCTGACCTCATGATCTTCCTGCCTCAGCCTCCCAAAATGCTGGAATTACAGGCATGAGCCATCATGCCCGGCCGTAGGTTG
GCATTTTAAGCTCACACAATCCTACCAAGGTGACAGTGAATCTCCTTATGACAGGATTGTGGGTCTGAGAGAGCTGTTGTAGCCTTTTAC
TCTCTCCAGTCAACAAAGATTGGCAACTACAGGGTTACCACCTTTGGAGTCTCTTTCCTCCTGTCTGCCACGTCTACAGACTACTGCTTG
TCAATGTGATATGCATGTATTTTCTTCTTCAGCTTTGCCCCTCCTGCCACTGTACCAGACAATATCCAGGAAATCCCCTACTACTGACAC
TCATCCCATTTCCATTGTTTTAGAGAAGGAACTAGTTGTTGTTGTTTTTTTTTCCCTGTCTCAGATTATGTCATCTATTTTGGAGTATTT
TGGTCTAATGACTTTGGCTGCGATATGGAGCTATCTGACCTTTACTGCACCTGGCAGCTCTATCTCCTATTTTGGGGTTGAGGTTAAAGT
GTCTTCTAGTTTTGTTGAAGATAGTTTATGTTTCTCTTCATATTTGATGATAATTTTTTAAATTAAGACCTAATTTCTCCTTCATTTTCA
AACTGGATATCATTTCTTTTGTGGTTAATATTCTTTGACAAGAAGGAAGAGGAGGAGGAAGAAGAACAAAAGAAGCCTGCCTCTCTTTAG
ACTGCCCATCTCAATTATATTTTAAAAATGAAGTTAATATCTGTCCTGCTAACAGTAGTGTTGTCAGAATCAAATGAAATAATATTTGGT
AAACTATAAAGTGAAGACCAAATTTGAAGGACTATTTGTTTTTGTTGTAATAGAGTTGTATATAGTCCAGATGTCAACCAGGCCTCTTCA
GCATTTTTATAGTCAAAGATGTACAAGATAGCTCCTAATGCTCTTTTATGGCTGCTCCTGTTGCCAGGGCAACAGCCTGCCTAGTAACAA
TCTAACAGACACCCCCCAAAAACCAAAAAATAAAGGTTATTCTAGCATCTTCTCCTTTTAAAAATCTTTAAAATAAGAGAATTCAGTTCT
TCCCAAAGCAGTGTTTAAAAAAAAAAAGTATTTAAATAAAATCAAGGATACCATCCCACCCACCTATCTTACATTTTGTGTGGTATGAGT
GGCACCATTGTGTGACCCAGGTAGGATAGTGGATGTACAGTTTAGATACCCATTTTAAAGCAGTTAGAAAGATGTAACTTGACAAGGAAA
GCAGTCTCTTTTGTCATTCTACATTTAGTGCTTCAGGAGTACTTGATATATGGAAGGATTTTTTTAAAAAAAAGGAAAAATGAATATGCC
TTCAGAAAGTTTTTTGCTGCTTTTAAAAGCCATAGATTTGTCTTAAGTTAGTCAATGCTGAATAGAAAGCTTGATGATAAAGGTGGGTGG
GTGGATGGATGGATGGATGAATGAAGGAAAAATTAGGAGAAAAGAGAAAGCAGAGGAGGGGTGAGACAGAGAACAAAAGAACACAGGCTC
TACTGTTAACAAAAAGCAGCATCGCTGATGTGTGGGGAATAAATTGGAAGTCATATCATTACGACTTTTTTTTCATGCCACATAGATATG
CTGATTTGTCCAACAATGCCTGTACTCAAAAGTCATGACAATAAAATGAGACCTGGGAGTCCCAAATGTTATTAACTACCACAATTTTAT
ATAACTGATTCTTCACTGGTCATCCAGAAGCCTTTTTGAAAGTCCCACTGCCATACCTGCCTCCTCGGTGAAATAGATGTAAAAGCCACA
AAGAGAGAATCAATGAGCCACACTCATATTGGAAGCGAATGGAGTTGACTTCACCAGTGGGAAAAGCAATTACTTTTCAAAGTGAAAACT
GATCAATTCACAACTCAAGGAAAGCATGGAGTAATTTCAGAACTCCAGTAAGAAGTGATAAATGTCTAGTTTGGAATCATGTGGCTGAAA
ATCTTACCATATGCTTTCCACAGGCTGAGCAAGAGGATAGATCATTGAATAGATGCTTTAATTCCATTTTTGACAATGAACCTTGTGCTT
CTGAAAATATTTATATTTAACCATGAGGTTATGATGATTTTTTCTCTACACTTTTTGAGAAGCCTCTTCAGAAAAGAGCAAAGTTGTCTG
CTCTAATGGATAGAATAAGGAGCTGGGAGAAAGGAGACCTGGGTATTAATCTCAGCTCTACCACTACATGGTAGAGCTATGTAGTGGTAG
ACTATCTGGGAGACTCTAGAATCTTTACCATTCCCTCTACTATTCCTAGCTCCCTTTTCTTTCATAGTCAACAAGTGCTTTTTGAACAAT
TATTGAGGTAAATAACATACCCTAAAAGTTAGTACTGATTCCCATTATCATGCTCTGTTGTTCCCTGGATGCTCTTTTGAGGAATTTACT
TGGTTAATACAGTTAATAGTATAATACTTATAATAACAATTTTGAGAATTATCAGCATGAGACAATTTATTTGCATAATAGCTTTTTGTT
ATTATCCAGAATACATTTAGTTCTGGATTTTGTTTGATATTGTGAATGCAAACTATTTTTTTGTGTTAGCCTAAATAAAATGAAATACAG
TTATGGAAATATTTCTGCTGCAAGAAAAGAATTACATACAACTAGTATACATATTTAGAGGTGCTGTAGTCTTCTAGACTGTAAAGGCAG
ATGGCCGTGAGTGGAAATCTGAGTGTATAGGATGTGTTTCGTGTTCCCACTGCATATGCATTATTACCCTTGTCTGAGTGGTTGTTTAAA
CTGACATCTGTAAAACTAATCTGTAAAGTGAGATCTGGGTTCTGACCTATCTCTTACAGTCCATAATGTTGTGATTCTAAGAATATTTCA
TTCCTTACTGCTTTCTGCCCTCCATTCTGACCAATGCTGCAACCACAAATAAAAACATTACTTACCCTATGAGAAAGACTAGACCTTATA
CTCATTTTATCTTAACAGTTTATTATAACTCATTTTGACCACTCCTCCCTCAAAAAAAATTGTCCCTAGAAAACTAGAGTGATCATAGGG
ATCAGATGACATGTTACTGGGTGAAGCCAGGAAGCTACCATATACATAGAAAAGTTAGTTGCCAAATATGGTGTGGGAATTTGGGAGGAA
TTTATCTGCTCAAAAACTCTCACCTACTTACTAGATATAGTGTTTGTAATGTTAGCCTTGGAGATTCTACCTTAAAAATATCATTGAGAA
AGCTCAGAGAACTCCCAGGTAAACACACAGGTAGCCCCTTCTAAAATGCAAATGCCCTTTGAAGGCCAGCTTTATTAATCTTGCCATTAA
CCCCATAGTTAATCATATGCATTTCTCACAGTGACCTGAAAACAGGCATTCCTTCTCTAAATGTGTGCTGAATGCTGGTTATAAACCAGT
TACTACACTAAGCCCTGATGATACAAATATGAAAAGTCCTGTTTCCAGGGAATTTACTTTCTAATGAGGAACCAAGTGCTCAAAAGCAGT
CATAAAGTTCATGGCAAAATAACCCACATAATTAACTGCTTTGTTACAAAAACTTGGAAATATAGATAAAATATTTATTTTGGAAATATA
TGTTACAGGTGAAAAGCAAGAATTAAAACTAGTTATCTGAATGTAAAAGGAATCAACGGCTAAATCAAGCTTAAAGTCTTCCTGTCCAAG
GGATATGAAAGGTACCTCAACCTTTGGTTTTGGTTTTGGTTTTGGTTTTGTTTTTTTGGTCAACATGAATTATAGCTAGGGGAAGAGATA
AACAGGGGGTTAGGTTGTAGATTATATGCATGACAGATTGCTGGAATTGGGCTCCATTCACAAAGGAGGGAGCAGGAAAGGGTTTCTCTT
GACTGGACCACAAATATAAAATCTCATGCCCTCTCATTATCTTGATAAGCCCTATAGGTCCATAAAAGAAATAAAATGCCAAAACATACC
ATGAGGACACTTTCACAATCCAGGGCACACACATGACTCCCGCAATAGGAAACCACACTGAAGACATTCTCACAATTTAAAACAAGTTGT
AAACTACAGGAAACAGTTGGCATCCCAGGAGAGTTGTTGCCTGAGGAACTAGATGGTGGTATGTTATTCTGGCATATAGGGAACAGAATA
AGACATGAGGGTAGGAAGAGGTTTTTAAAAGCAAAGTTAGGCATTCAATGATGACTTCATAAATGTGCCTGGGCTGGCCTTTAATGGAAG
GCTTTAATTTAGGGAACTTAAAGAATTTCATAATATTGGAGTATAAACTGCTGGAAATAAGGATGCTATTTAATAGACTCTCTTAGATTT
TTCATAAAATGCTAATAGAATCCCAAAGGAAGTGTGTATTCTAAAATGTTATTGTGTATGTTATAAAAGCTTTGTAAAATAAAGTGATGT

>22366_22366_1_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000444300_PPIP5K2_chr5_102490373_ENST00000321521_length(amino acids)=1315AA_BP=497
MVGQILKRDVIMDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQ
TSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPP
FFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRF
CYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSE
DVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTE
AVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQN
NDSEIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGG
QGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEIL
QKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKTKNGR
YDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYS
RGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGA
KGCEEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKTATNDEESPLSVSSPEGT
GTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSSSAPN
LQDYARTHRKKLTSSGCIDGFELYSMVPSICPLETLHNALSLKQVDEFLASIASPSSDVPRKTAEISSTALRSSPIMRKKVSLNTYTPAK

--------------------------------------------------------------
>22366_22366_2_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000444300_PPIP5K2_chr5_102490373_ENST00000358359_length(transcript)=5583nt_BP=1496nt
ATGGTGGGACAGATACTAAAAAGAGATGTGATAATGGATCATCATGTTTCTACCATCAAGCCTCGAAGAATCCAAAACCAAAATGTCATT
CACCGCTTGGAACGCCGGCGGATCAGTTCAGGCAAGGCAGGTACCCACTGGCACCAAGTCCGAGTGTTCCATCAGAATGTCTTCCCCAAC
TTCACAGTTGTCAACGTTGAAAAGCCTCCTTGTTTCTTGCGTAAATTCTCACCTGATGGACGCTACTTTATTGCTTTTTCTTCAGACCAG
ACATCTCTTGAAATCTATGAGTACCAGGGCTGCCAGGCAGCAGAGGACCTACTGCAGGGATACGAAGGAGAAATCCTGTCCAATGGCAAT
GACCAGCGGTCAGTGAATATCCGGGGCCGGCTCTTTGAACGCTTTTTTGTCCTGCTGCACATTACCAATGTTGCGGCCAATGGTGAGCAC
CTGAACCGGGAGTGTAGTCTCTTCACTGATGACTGCCGCTGTGTCATCGTGGGCTCAGCTGCCTACCTCCCAGATGAGCCTCACCCTCCA
TTTTTTGAGGTATATCGGAACAGTGAATCAGTGACCCCCAACCCACGGTCCCCTCTAGAAGACTATTCCCTCCATATCATTGACCTTCAC
ACCGGCCGCTTATGTGATACACGCACGTTCAAGTGTGACAAGGTGGTCTTGTCACACAACCAAGGGCTGTACTTGTACAAAAACATCCTG
GCCATCTTGTCTGTGCAACAACAGACCATCCATGTCTTCCAGGTGACTCCTGAAGGCACTTTCATTGATGTGCGGACCATTGGCCGCTTT
TGCTATGAGGATGACCTGCTCACTGTGTCAGCTGTTTTCCCTGAGGTACAGCGGGACAGTCAGACAGGCATGGCCAATCCCTTTAGGGAT
CCTTTCATCAATTCCCTCAAACACCGGTTGCTGGTATATTTGTGGCGCCGGGCAGAACAGGATGGTAGTGCAATGGCCAAGAGGCGCTTC
TTCCAGTATTTTGACCAACTGCGGCAGCTGCGAATGTGGAAAATGCAGCTTCTGGATGAAAACCACCTGTTTATCAAGTACACTAGTGAG
GATGTAGTAACACTGCGAGTCACAGATCCATCACAGGCATCTTTCTTTGTGGTGTACAATATGGTGACGACAGAGGTGATTGCTGTGTTT
GAGAATACATCAGATGAGCTTTTGGAGCTCTTTGAGAACTTCTGTGACCTTTTTCGTAATGCTACCCTGCACAGTGAAGTTCAGTTTCCC
TGCTCAGCTTCTAGCAACAATTTTGCAAGGCAGATCCAGCGCCGGTTCAAAGACACTATTATAAATGCCAAGTATGGAGGGCACACAGAG
GCAGTACGCCGGCTGCTGGGTCAGCTCCCCATCAGTGCTCAGTCTTACAGCGGTAGCCCCTATCTGGATTTGTCTCTCTTCAGTTATGAT
GACAAGTGGGTATCTGTCATGGAGCGGCCCAAGACTTGTGGAGATCACCCAATCAGATTTTTTGATCTTTTTGAAAAGTGTGATGGATAT
AAATCAGGGAAATTAAAACTCAAAAAACCAAAACAGTTACAGGAAGTGCTAGATATTGCACGACAGCTTCTTATGGAGCTAGGGCAAAAT
AATGATTCTGAAATTGAAGAAAACAAGCCAAAACTTGAACAACTTAAGACTGTATTAGAGATGTATGGTCATTTTTCTGGAATAAATCGT
AAGGTTCAGTTGACCTATCTCCCTCATGGTTGTCCTAAAACATCTAGTGAAGAGGAGGACAGCCGAAGAGAAGAACCATCTTTACTTTTG
GTTCTAAAATGGGGAGGTGAATTAACTCCTGCAGGCAGGGTCCAGGCTGAAGAACTTGGAAGAGCCTTCAGGTGTATGTATCCTGGAGGT
CAAGGAGATTATGCAGGATTTCCTGGTTGTGGTTTACTTAGATTACATAGCACCTACAGACATGACCTCAAAATATATGCCTCTGATGAA
GGACGAGTCCAGATGACTGCAGCTGCTTTTGCAAAGGGGCTTTTAGCTTTGGAAGGAGAGCTTACACCCATTCTTGTTCAAATGGTGAAA
AGTGCAAATATGAACGGTCTTTTGGATAGTGATAGTGACTCTCTGAGCAGTTGTCAGCAACGTGTGAAGGCAAGGCTTCATGAAATACTT
CAGAAAGACAGAGATTTTACTGCTGAAGATTATGAAAAGCTTACTCCATCTGGAAGCATTTCTCTTATCAAATCAATGCATTTAATTAAA
AACCCTGTGAAGACCTGTGATAAAGTTTATTCCTTAATTCAGAGTTTGACTTCTCAAATCAGACATCGAATGGAAGATCCTAAATCATCA
GATATTCAGCTTTACCATAGTGAAACATTGGAGCTTATGCTACGTAGATGGTCCAAGTTAGAGAAAGACTTTAAAACAAAGAATGGAAGA
TATGATATTAGTAAAATCCCTGACATATATGACTGTATAAAATATGATGTCCAGCATAATGGTTCCTTGAAATTAGAAAACACAATGGAA
TTATATAGGCTTTCGAAGGCATTAGCAGATATTGTTATCCCTCAGGAATATGGTATAACTAAAGCTGAAAAACTGGAGATTGCCAAAGGC
TACTGTACTCCTCTGGTTAGAAAAATTCGCTCAGACCTTCAGAGGACACAAGATGATGACACTGTAAATAAACTTCATCCTGTGTATTCT
AGAGGTGTTCTGTCTCCTGAACGTCATGTTCGTACTAGATTATATTTTACCAGTGAAAGTCATGTACATTCTTTGCTGTCTATTCTTCGC
TATGGTGCCTTATGCAATGAATCAAAGGATGAACAGTGGAAACGAGCTATGGATTATTTAAACGTTGTCAATGAGCTCAACTACATGACT
CAGATTGTTATCATGCTTTATGAGGATCCTAATAAGGATCTTTCCTCAGAAGAACGCTTTCATGTTGAATTACACTTTAGTCCGGGAGCC
AAAGGTTGTGAAGAAGACAAAAATTTGCCATCTGGCTATGGATATAGACCAGCTTCCAGAGAGAATGAAGGCAGGAGACCTTTTAAAATT
GATAATGATGATGAACCACATACTTCTAAAAGAGATGAAGTTGATCGAGCTGTGATATTGTTTAAACCAATGGTATCAGAGCCAATTCAT
ATACACAGGAAGTCTCCACTTCCAAGATCTAGGAAGACGGCTACAAATGATGAAGAGAGCCCCCTGAGTGTGTCTAGCCCAGAGGGTACT
GGTACCTGGCTGCATTATACCAGTGGTGTGGGTACTGGGCGTCGAAGACGCAGATCAGGGGAACAAATCACTTCTTCCCCTGTCTCCCCC
AAATCATTGGCTTTCACATCCAGTATTTTTGGCTCATGGCAACAGGTTGTATCTGAAAATGCTAATTACCTGAGAACACCAAGAACTCTT
GTGGAACAGAAGCAGAATCCTACTGTAGGGTCTCACTGTGCGGGCCTGTTTAGCACCTCGGTGCTCGGGGGTTCTTCAAGCGCACCTAAC
CTACAGGATTATGCTCGTACTCATCGTAAAAAGCTGACCTCTTCTGGCTGCATAGATGACGCCACACGCGGTTCTGCTGTTAAAAGGTTT
TCTATCTCATTTGCTCGACACCCAACCAATGGCTTTGAATTGTATTCCATGGTGCCATCTATTTGTCCTCTAGAAACTCTTCATAATGCC
CTATCTTTAAAGCAAGTGGATGAATTTCTTGCTTCCATTGCTTCTCCATCATCTGACGTTCCACGGAAGACCGCTGAAATTTCCTCTACA
GCTTTACGTTCCAGTCCAATAATGAGAAAAAAAGTATCTTTAAATACGTATACACCTGCAAAGATCCTCCCAACACCACCAGCTACCTTA
AAGAGCACTAAAGCAAGCAGCAAACCAGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACT
AGCAAAACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAA
TAGTATGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAA
GGAACTGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTT
GTTAATATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTAT
GTACTGCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTT
GACAGCCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGT
TACAGTGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGT
GTGTTATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTT
ATATATTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTT
TAAGTATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACA
ATGTTAGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATC
AGTTGATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCA
TTGCGCTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGC
TTGAAATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTA
GCTTGAAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAA
ATAGTCATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATG
CAATTAAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTG
TTTGTGAAAATGTAGTTAATGTACTCACTGTGGAGGTCATAAGGAAGCTACTTTTTTTTTAAAGTGGAACCTAATTAAAATATTTCCAGA

>22366_22366_2_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000444300_PPIP5K2_chr5_102490373_ENST00000358359_length(amino acids)=1336AA_BP=497
MVGQILKRDVIMDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQ
TSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPP
FFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRF
CYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSE
DVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTE
AVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQN
NDSEIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGG
QGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEIL
QKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKTKNGR
YDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYS
RGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGA
KGCEEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKTATNDEESPLSVSSPEGT
GTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSSSAPN
LQDYARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALSLKQVDEFLASIASPSSDVPRKTAEISST

--------------------------------------------------------------
>22366_22366_3_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000564406_PPIP5K2_chr5_102490373_ENST00000321521_length(transcript)=15274nt_BP=1657nt
GTGCAGCCGCGGGTGCAGGAGTCCTGGGGCATGGCGGGGGCGGGGCAGGGGGAGGCGCGCACAGAACAGGCTGGGGCATCCCTCGCCCTG
GCTCTTTGAGCCCGGACCAGACAGGTGCTGGGAATACAGCAAGGAATTAGACCAGTTCCCTGCTCTCTGGTATGGTGGGACAGATACTAA
AAAGAGATGTGATAATGGATCATCATGTTTCTACCATCAAGCCTCGAAGAATCCAAAACCAAAATGTCATTCACCGCTTGGAACGCCGGC
GGATCAGTTCAGGCAAGGCAGGTACCCACTGGCACCAAGTCCGAGTGTTCCATCAGAATGTCTTCCCCAACTTCACAGTTGTCAACGTTG
AAAAGCCTCCTTGTTTCTTGCGTAAATTCTCACCTGATGGACGCTACTTTATTGCTTTTTCTTCAGACCAGACATCTCTTGAAATCTATG
AGTACCAGGGCTGCCAGGCAGCAGAGGACCTACTGCAGGGATACGAAGGAGAAATCCTGTCCAATGGCAATGACCAGCGGTCAGTGAATA
TCCGGGGCCGGCTCTTTGAACGCTTTTTTGTCCTGCTGCACATTACCAATGTTGCGGCCAATGGTGAGCACCTGAACCGGGAGTGTAGTC
TCTTCACTGATGACTGCCGCTGTGTCATCGTGGGCTCAGCTGCCTACCTCCCAGATGAGCCTCACCCTCCATTTTTTGAGGTATATCGGA
ACAGTGAATCAGTGACCCCCAACCCACGGTCCCCTCTAGAAGACTATTCCCTCCATATCATTGACCTTCACACCGGCCGCTTATGTGATA
CACGCACGTTCAAGTGTGACAAGGTGGTCTTGTCACACAACCAAGGGCTGTACTTGTACAAAAACATCCTGGCCATCTTGTCTGTGCAAC
AACAGACCATCCATGTCTTCCAGGTGACTCCTGAAGGCACTTTCATTGATGTGCGGACCATTGGCCGCTTTTGCTATGAGGATGACCTGC
TCACTGTGTCAGCTGTTTTCCCTGAGGTACAGCGGGACAGTCAGACAGGCATGGCCAATCCCTTTAGGGATCCTTTCATCAATTCCCTCA
AACACCGGTTGCTGGTATATTTGTGGCGCCGGGCAGAACAGGATGGTAGTGCAATGGCCAAGAGGCGCTTCTTCCAGTATTTTGACCAAC
TGCGGCAGCTGCGAATGTGGAAAATGCAGCTTCTGGATGAAAACCACCTGTTTATCAAGTACACTAGTGAGGATGTAGTAACACTGCGAG
TCACAGATCCATCACAGGCATCTTTCTTTGTGGTGTACAATATGGTGACGACAGAGGTGATTGCTGTGTTTGAGAATACATCAGATGAGC
TTTTGGAGCTCTTTGAGAACTTCTGTGACCTTTTTCGTAATGCTACCCTGCACAGTGAAGTTCAGTTTCCCTGCTCAGCTTCTAGCAACA
ATTTTGCAAGGCAGATCCAGCGCCGGTTCAAAGACACTATTATAAATGCCAAGTATGGAGGGCACACAGAGGCAGTACGCCGGCTGCTGG
GTCAGCTCCCCATCAGTGCTCAGTCTTACAGCGGTAGCCCCTATCTGGATTTGTCTCTCTTCAGTTATGATGACAAGTGGGTATCTGTCA
TGGAGCGGCCCAAGACTTGTGGAGATCACCCAATCAGATTTTTTGATCTTTTTGAAAAGTGTGATGGATATAAATCAGGGAAATTAAAAC
TCAAAAAACCAAAACAGTTACAGGAAGTGCTAGATATTGCACGACAGCTTCTTATGGAGCTAGGGCAAAATAATGATTCTGAAATTGAAG
AAAACAAGCCAAAACTTGAACAACTTAAGACTGTATTAGAGATGTATGGTCATTTTTCTGGAATAAATCGTAAGGTTCAGTTGACCTATC
TCCCTCATGGTTGTCCTAAAACATCTAGTGAAGAGGAGGACAGCCGAAGAGAAGAACCATCTTTACTTTTGGTTCTAAAATGGGGAGGTG
AATTAACTCCTGCAGGCAGGGTCCAGGCTGAAGAACTTGGAAGAGCCTTCAGGTGTATGTATCCTGGAGGTCAAGGAGATTATGCAGGAT
TTCCTGGTTGTGGTTTACTTAGATTACATAGCACCTACAGACATGACCTCAAAATATATGCCTCTGATGAAGGACGAGTCCAGATGACTG
CAGCTGCTTTTGCAAAGGGGCTTTTAGCTTTGGAAGGAGAGCTTACACCCATTCTTGTTCAAATGGTGAAAAGTGCAAATATGAACGGTC
TTTTGGATAGTGATAGTGACTCTCTGAGCAGTTGTCAGCAACGTGTGAAGGCAAGGCTTCATGAAATACTTCAGAAAGACAGAGATTTTA
CTGCTGAAGATTATGAAAAGCTTACTCCATCTGGAAGCATTTCTCTTATCAAATCAATGCATTTAATTAAAAACCCTGTGAAGACCTGTG
ATAAAGTTTATTCCTTAATTCAGAGTTTGACTTCTCAAATCAGACATCGAATGGAAGATCCTAAATCATCAGATATTCAGCTTTACCATA
GTGAAACATTGGAGCTTATGCTACGTAGATGGTCCAAGTTAGAGAAAGACTTTAAAACAAAGAATGGAAGATATGATATTAGTAAAATCC
CTGACATATATGACTGTATAAAATATGATGTCCAGCATAATGGTTCCTTGAAATTAGAAAACACAATGGAATTATATAGGCTTTCGAAGG
CATTAGCAGATATTGTTATCCCTCAGGAATATGGTATAACTAAAGCTGAAAAACTGGAGATTGCCAAAGGCTACTGTACTCCTCTGGTTA
GAAAAATTCGCTCAGACCTTCAGAGGACACAAGATGATGACACTGTAAATAAACTTCATCCTGTGTATTCTAGAGGTGTTCTGTCTCCTG
AACGTCATGTTCGTACTAGATTATATTTTACCAGTGAAAGTCATGTACATTCTTTGCTGTCTATTCTTCGCTATGGTGCCTTATGCAATG
AATCAAAGGATGAACAGTGGAAACGAGCTATGGATTATTTAAACGTTGTCAATGAGCTCAACTACATGACTCAGATTGTTATCATGCTTT
ATGAGGATCCTAATAAGGATCTTTCCTCAGAAGAACGCTTTCATGTTGAATTACACTTTAGTCCGGGAGCCAAAGGTTGTGAAGAAGACA
AAAATTTGCCATCTGGCTATGGATATAGACCAGCTTCCAGAGAGAATGAAGGCAGGAGACCTTTTAAAATTGATAATGATGATGAACCAC
ATACTTCTAAAAGAGATGAAGTTGATCGAGCTGTGATATTGTTTAAACCAATGGTATCAGAGCCAATTCATATACACAGGAAGTCTCCAC
TTCCAAGATCTAGGAAGACGGCTACAAATGATGAAGAGAGCCCCCTGAGTGTGTCTAGCCCAGAGGGTACTGGTACCTGGCTGCATTATA
CCAGTGGTGTGGGTACTGGGCGTCGAAGACGCAGATCAGGGGAACAAATCACTTCTTCCCCTGTCTCCCCCAAATCATTGGCTTTCACAT
CCAGTATTTTTGGCTCATGGCAACAGGTTGTATCTGAAAATGCTAATTACCTGAGAACACCAAGAACTCTTGTGGAACAGAAGCAGAATC
CTACTGTAGGGTCTCACTGTGCGGGCCTGTTTAGCACCTCGGTGCTCGGGGGTTCTTCAAGCGCACCTAACCTACAGGATTATGCTCGTA
CTCATCGTAAAAAGCTGACCTCTTCTGGCTGCATAGATGGCTTTGAATTGTATTCCATGGTGCCATCTATTTGTCCTCTAGAAACTCTTC
ATAATGCCCTATCTTTAAAGCAAGTGGATGAATTTCTTGCTTCCATTGCTTCTCCATCATCTGACGTTCCACGGAAGACCGCTGAAATTT
CCTCTACAGCTTTACGTTCCAGTCCAATAATGAGAAAAAAAGTATCTTTAAATACGTATACACCTGCAAAGATCCTCCCAACACCACCAG
CTACCTTAAAGAGCACTAAAGCAAGCAGCAAACCAGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGA
ATATAACTAGCAAAACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACT
TATAAAAATAGTATGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGT
TCAGGTAAGGAACTGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAAT
CGATTGTTGTTAATATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGT
AATGCTATGTACTGCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGAT
TGAAATTTGACAGCCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTC
CCAATTGTTACAGTGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTT
TTTATTGTGTGTTATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATA
TTTTCTTTATATATTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAG
TTTCTTTTTAAGTATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGA
AATCAACAATGTTAGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCT
AGTGTATCAGTTGATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATAT
TGAAATCATTGCGCTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTG
TGAACAGCTTGAAATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTA
AAGCTTTAGCTTGAAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCT
CACCTTAAATAGTCATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATA
AATATATGCAATTAAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAA
GTTTTCTGTTTGTGAAAATGTAGTTAATGTACTCACTGTGGAGGTCATAAGGAAGCTACTTTTTTTTTAAAGTGGAACCTAATTAAAATA
TTTCCAGAATCAAAGAGACTTAAATGGTAAATTTTTAAAATTTTCTTATCTCTTACTTTTTAGTTTTCAAAGTAGAAAAAATCAGGAATT
TTTTTATTAACTAGTACTTACATATTAAATAAAATTTATTATTGGCTATATACATAGCAATATATTACTTTCCAAACTAGAAAGTACAGT
ACAACTAACTTTTTCCATTGTTATGCAAGAACTATTACTTTCCTGTAGTCACCAAACTCAGTAGTATTGCTCTGTAGACTAGACACTCTA
TTTGTAAAAATCTTAGAATCACTTTCCAAAACAAATAAAAAGTCTACTGTATCAGAGCAAAATGTTATAGTTATCACTGTTTAGTGGCAG
TTTGACTGAAGCATCTGTTTCTCACTTGATTCTGTCCTGAGAAGATGTGGGATTTTTTGGTTTTAAATACTAGAAGATATTTCTTCTTAG
AGCCCAGTCCTCCATCCCAAAGAGGTGAACTAGCCCAGCATGAAGAATTGTCTAGTCACCCTGAGATATTAATCTTCATAATGTATTATT
CAGTTCCTTCACCCTTAAAAGCCATATAATAGGCTCAGACCTAACTTAGCCCTTGAAGTCTAGTGCTGGCAGATTCTGCTGCCCTGGTTT
AAATGAGTTACGTAGTCCATTCTCAAATACTAGCAAATTTGGGGGGCGTGGTACAGCAATTTTGGGTGAAGAAAAGTGTGCTGAACACCT
TATGTCAGTGATAGACAAGATATAGAGGCTGAAGGGAATACAGTAAAGTAACAAAAACATGTGGCAGTGTGCTTAGCATAAACATAGAGC
ACAAAGGCAATAGATGGAAATTATGAGAGAAAAGTTAAAGTTCTTCAAGAAATATCCAATTAAAACTCACTAGCCAAGGAAAAAGTTTCT
GTTTTCACCCGGATTTCTTTTTGGGTTGACTCTGTCTGACCTAAATGTCCACTGTTAACTAGTGCCATGCCAGTTTGAACCAAGATTTCA
CATTTTTGTTTTGTATTCATACTTTGGTAGAAATTTCTCAGTCTTTGTGTATTTATAAGAATTTGCTTTACACATAGTGTACAGTGTTTA
TTAACTTTACATCATTTTATCCTTGCCTTACTATCTGGACAGTGTAGACTGCCTATATTCTTAGTTGGGGTTGGGATCTCTTCTCTTAGA
GTGGCCCAGCAGTTTTAGCCCCTCTCTAATTCTCTTTTCCTGTGTTGGGAGATATCAAAACAACAGAATTCTTGCCAGTGGGAACATTTT
TCTTTTTTAGACAAGGTCTCATTCTGTCACCCCAGCTGGAGTGCAGTGGCACAGTCTTAATTCACTACAGCCTTGAACTCCTGGGCTCAA
GAAATCTTTCTGCTTCAGCCTCCTAAATAGCTGGTACTATAGGTGCGTGCCACCACACCCAGCTCATGGGAATAATTTTTACACTCCTTC
AGAAGGAGTCATTTGTGATTGGAGTCCACATAGAAACAGGTTTCCCTCTGTACATAATCGTAGGTACCAAAATATTACTGTGTAAAGTGT
TGTTTATATAGGTCAATTTTTGTGGAAGATCTAATTTCTATTTTCAGAGAACAGAGCACATTAAAAAATCTATTTAGTATTGTGTACTAT
ATAATCTATGTGAATTATAGCTCCTTAACTAAATATATTACTGAGTTTTTTTTTTAATACTGTAAGTTCTAGGGTACATGTGCACAATGT
GCAGGTTTGTTACATAGGTATACATGTGCCATGTTGGTTTGCTGCACCCATGAACTCATCATTTACATTAGGTATTTCTCCTAATGCTAT
CCCTCCCCCAGCCCCCCACCCACTGACAGGCCCAGTGTGTGATGTTCCCCGCCCTGTGTCCAAGTACTGTTCTCATTGTTCAGTTCCCTC
TTATGAGTGAGAACATGCGGTGTTTGGTTTTCTGTCCTTGTGATAGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCTTGTCA
TCCTTTTTTTTGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCTATCATTGATGGACATCTGGGTTGGTCC
CAAGTCTTTGCTATTGTGAATAGTGCCACAATAAACATACGTGTGCATGTGTCTTTATAGTGGCATGATTTATAATCCTTTGGGTATATA
CCCAGTAATGGGATGGCTGGGTCAAATGGTATTTCTAGTTCTAGATCCTTGAGGAATCGCCACACTGTCTTCCACAATGGTTGAACTAAT
TTACACTCCCACCAAGTGTTCCTATTTCTCCACATCCTCTCCAGCATCTGTTGTTTCCTGACTTTTCAATGATCGCCATTCTAACTGGCG
TGAGATGGTATCTCATTTGTAAGATGATATCTCATTGAGATTTTTATAAACTGCTTTTCTTTTGGTTCATGTGCTTTGTCATGGATTGTG
AGAAAAACATCTTTTCGCTTAGGGATCACTGTCAATTTCTCCTTTTATTATCAATGGTTTTTACTTTACTTTTTATATAGTATGTGGGTA
TGTTTTCTGGTGCATATAAATTCATGAATGCTAGATTTTCATTATAGGTTTTACCTTATCATTATTAAAATGTCCTTTTTGTCCATTGGA
TACTTTTTGTTCTATAAATTGTCAGATATTAAGATTATGACCTATGCTTTATTTTGGCTTGCATTTGCCTGATATTCATCTTTTTACTTT
TTGGTATTTGTGTCACTTTGTTTTAGGTTATTTAATATAGTATATATTGGGTTTTGCTTTGTGATTCAATTTTAAGATCCCTTTTACTTA
ATAGATTAGTGTAGTCTGTTTTATGTAATGTATCTTTGCTTTTAGATTGTGCTTGCTTTTTTTATTGCTTTAAAATTCTTTTGTCTTTCT
GTAACAATACTTTCCACTGCAAGTAGGAAAATTCCAATTGAAACTGGTTTAAATCATCAGAAAATGTATTATTACACATTTCTGAAGGTC
CAAAGGTGGGGTTGGCTTCAGCCACAGTTGCATTAGCCATATTGTCATCAAAAGCCCAAGTGACCTCCCTTGTCACCTCTGGCATAGTAT
AAACTTTATCCCAAAGTTGTTTTCTCTCGTGTTAACAATAATTGCTGTCGGTTTCAGTGAGGACTACATATTTTTTTTGTTCATGTCCAA
CACAATAAAAATTGAGGGAAGTTCTGTCCCAATCCTGGAATATTAATATTAAGCCATCTACTTCAGTGTGATTGAGCCAACTTCTTTGAT
CATCTACTCACCCCTAGATAAATAGAATACTCCAGGAGATTCCCATGACCTTACTGACCCTAGAGCAGATGATGGAGTCAGTTTTTCCGA
AAAGCCTCAGCACTGTTGACATTTTGGACCATAAAATTCTACATCATAGGAAGCTGTTCCATGCATAGCAGCATGTCTAGTAGGATCTCT
GTACCTAGCTGTGAAGTGTTGAGAGTCAGTTAAGGTAAGTAGCTGAAATGAAAATAACAATCACATCTTTATTCACTTACTATGATAAAA
TTATAAGCAAGAGACCAAAAAGGAAAGTAGGGCCAGCTCCTTGTTGTTCCATTTTTCCCCTACCATGGACTAGCACTGGACATGCGTCAA
TCAGACGACATGCAGTCCAGGCAGAGGAAATTGTTTCACTGCTAAGGAGCAATGAACAAAAGGTTCCTGCCATCTTATGGACCTCAAGGA
CTGCGGACAGGGAGCAGGGAAGGGTTAGAAGTAGAAAACAACTGAGTCAGAGTGGAGATGAGTGTCTCAGTCAAGGCCCACCAATAGCGA
GGTCTCTGTGGAGGCACCTGAAAAGTGTCTCAACCAAGGCCCCCTGATAAGGAAGACTCAGCATGGAGGTACCTGGTCTAGGAATGCAGC
TAGGTTTATAGACATGGCCAGCCCAGGGGGTCCTGAGCACCAGATACAACTCCCTCCAGAGACTGGCTGTGTTTAAATCTCATGTGGGAA
GGGCACCTTTCCCCTACAAAGCCTGTCAGGCAAAGCCTTTGTAATTGCTTATGGTCAGGCCTGAAAGATCACACATCAGACTTTGGCCTG
GAACATATCTCCTCACCCTAAATGCCAGCAGCATCGCCTCCAAACTGTGGCAGTCAAAAATGTCTCCAGACATTAGTAAATGTCTTTTGT
GAGGGAAGAATTGACCCTAGTTAAGAACCACTGCCCTAAAGCACATGATTCTGTGGAAAAGAAGGATATATGACCAAAATCATCATTTTG
GATAGTGAGGGCATGGATAATGGATACATAATCAGCAATGTATGCTGTATACTACACTTGCATTATGTTATTCACATTTGCTATAGTTCA
CTTGTTGTGCTAATGGTTTTTTCCTTCACTATGATTTTGAATTATATTTAATTTTAAAGTCTATATATATATATATATAGATCCTATCTG
TTGACTCCTTGCTGTGAACAATATCCAATTAGTGTATTTTTTCCTCTACTGCACAGTTTTGGTTGATTATTTTTTCCTTTTCATTTCTTT
TCTGAACTTTGTTAGCTTATGTTGCATTTCCTTTGGTTGTTTTGCTATGGTGTTTCTGATCAACTACATTTCTTTATGAACTCTATTTCC
TTAAGTTCTTTGAGTTATGACAGTATATTTGGTCACATTTTTCATGTGCTCAGCTGATTCATTCTTTCCTGTTGAGTGGTTTTTATCTGC
TAATTGTTTCTGCTTGTTCCATTTCTCCTTTTCTTGAAGTGTTTGTGCATGAACACTGTGCAGGTTTATTTTCAAGTATTACTTACCTTT
ATATGAGATAAATTTCTTTCTGGCTCATCTATTTGATACAATTTCTTTTTTGTTTGTTTTTGTTTTGTTTTTGTTGTTTTTTAAAATGCA
ATTTCATATGTTAGGTAGGTTGGCTTTTCTTTTTCTTTTTCTTTTTTTTTTTGAGATGGAGTTTTACTCTTGTTGCCTAGGCTGGAGTGC
AGTGGCATGATCTCAGCTCACTGCAACCTCCACCTTCCAGTTTCAAATGATTCTCCTCCCTCAGCCTCCAGAGTAGCTGGGATTACAGGC
GCCCGCCACCACGCCTGGCTAATTTTTGCATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCA
TGATCTTCCTGCCTCAGCCTCCCAAAATGCTGGAATTACAGGCATGAGCCATCATGCCCGGCCGTAGGTTGGCATTTTAAGCTCACACAA
TCCTACCAAGGTGACAGTGAATCTCCTTATGACAGGATTGTGGGTCTGAGAGAGCTGTTGTAGCCTTTTACTCTCTCCAGTCAACAAAGA
TTGGCAACTACAGGGTTACCACCTTTGGAGTCTCTTTCCTCCTGTCTGCCACGTCTACAGACTACTGCTTGTCAATGTGATATGCATGTA
TTTTCTTCTTCAGCTTTGCCCCTCCTGCCACTGTACCAGACAATATCCAGGAAATCCCCTACTACTGACACTCATCCCATTTCCATTGTT
TTAGAGAAGGAACTAGTTGTTGTTGTTTTTTTTTCCCTGTCTCAGATTATGTCATCTATTTTGGAGTATTTTGGTCTAATGACTTTGGCT
GCGATATGGAGCTATCTGACCTTTACTGCACCTGGCAGCTCTATCTCCTATTTTGGGGTTGAGGTTAAAGTGTCTTCTAGTTTTGTTGAA
GATAGTTTATGTTTCTCTTCATATTTGATGATAATTTTTTAAATTAAGACCTAATTTCTCCTTCATTTTCAAACTGGATATCATTTCTTT
TGTGGTTAATATTCTTTGACAAGAAGGAAGAGGAGGAGGAAGAAGAACAAAAGAAGCCTGCCTCTCTTTAGACTGCCCATCTCAATTATA
TTTTAAAAATGAAGTTAATATCTGTCCTGCTAACAGTAGTGTTGTCAGAATCAAATGAAATAATATTTGGTAAACTATAAAGTGAAGACC
AAATTTGAAGGACTATTTGTTTTTGTTGTAATAGAGTTGTATATAGTCCAGATGTCAACCAGGCCTCTTCAGCATTTTTATAGTCAAAGA
TGTACAAGATAGCTCCTAATGCTCTTTTATGGCTGCTCCTGTTGCCAGGGCAACAGCCTGCCTAGTAACAATCTAACAGACACCCCCCAA
AAACCAAAAAATAAAGGTTATTCTAGCATCTTCTCCTTTTAAAAATCTTTAAAATAAGAGAATTCAGTTCTTCCCAAAGCAGTGTTTAAA
AAAAAAAAGTATTTAAATAAAATCAAGGATACCATCCCACCCACCTATCTTACATTTTGTGTGGTATGAGTGGCACCATTGTGTGACCCA
GGTAGGATAGTGGATGTACAGTTTAGATACCCATTTTAAAGCAGTTAGAAAGATGTAACTTGACAAGGAAAGCAGTCTCTTTTGTCATTC
TACATTTAGTGCTTCAGGAGTACTTGATATATGGAAGGATTTTTTTAAAAAAAAGGAAAAATGAATATGCCTTCAGAAAGTTTTTTGCTG
CTTTTAAAAGCCATAGATTTGTCTTAAGTTAGTCAATGCTGAATAGAAAGCTTGATGATAAAGGTGGGTGGGTGGATGGATGGATGGATG
AATGAAGGAAAAATTAGGAGAAAAGAGAAAGCAGAGGAGGGGTGAGACAGAGAACAAAAGAACACAGGCTCTACTGTTAACAAAAAGCAG
CATCGCTGATGTGTGGGGAATAAATTGGAAGTCATATCATTACGACTTTTTTTTCATGCCACATAGATATGCTGATTTGTCCAACAATGC
CTGTACTCAAAAGTCATGACAATAAAATGAGACCTGGGAGTCCCAAATGTTATTAACTACCACAATTTTATATAACTGATTCTTCACTGG
TCATCCAGAAGCCTTTTTGAAAGTCCCACTGCCATACCTGCCTCCTCGGTGAAATAGATGTAAAAGCCACAAAGAGAGAATCAATGAGCC
ACACTCATATTGGAAGCGAATGGAGTTGACTTCACCAGTGGGAAAAGCAATTACTTTTCAAAGTGAAAACTGATCAATTCACAACTCAAG
GAAAGCATGGAGTAATTTCAGAACTCCAGTAAGAAGTGATAAATGTCTAGTTTGGAATCATGTGGCTGAAAATCTTACCATATGCTTTCC
ACAGGCTGAGCAAGAGGATAGATCATTGAATAGATGCTTTAATTCCATTTTTGACAATGAACCTTGTGCTTCTGAAAATATTTATATTTA
ACCATGAGGTTATGATGATTTTTTCTCTACACTTTTTGAGAAGCCTCTTCAGAAAAGAGCAAAGTTGTCTGCTCTAATGGATAGAATAAG
GAGCTGGGAGAAAGGAGACCTGGGTATTAATCTCAGCTCTACCACTACATGGTAGAGCTATGTAGTGGTAGACTATCTGGGAGACTCTAG
AATCTTTACCATTCCCTCTACTATTCCTAGCTCCCTTTTCTTTCATAGTCAACAAGTGCTTTTTGAACAATTATTGAGGTAAATAACATA
CCCTAAAAGTTAGTACTGATTCCCATTATCATGCTCTGTTGTTCCCTGGATGCTCTTTTGAGGAATTTACTTGGTTAATACAGTTAATAG
TATAATACTTATAATAACAATTTTGAGAATTATCAGCATGAGACAATTTATTTGCATAATAGCTTTTTGTTATTATCCAGAATACATTTA
GTTCTGGATTTTGTTTGATATTGTGAATGCAAACTATTTTTTTGTGTTAGCCTAAATAAAATGAAATACAGTTATGGAAATATTTCTGCT
GCAAGAAAAGAATTACATACAACTAGTATACATATTTAGAGGTGCTGTAGTCTTCTAGACTGTAAAGGCAGATGGCCGTGAGTGGAAATC
TGAGTGTATAGGATGTGTTTCGTGTTCCCACTGCATATGCATTATTACCCTTGTCTGAGTGGTTGTTTAAACTGACATCTGTAAAACTAA
TCTGTAAAGTGAGATCTGGGTTCTGACCTATCTCTTACAGTCCATAATGTTGTGATTCTAAGAATATTTCATTCCTTACTGCTTTCTGCC
CTCCATTCTGACCAATGCTGCAACCACAAATAAAAACATTACTTACCCTATGAGAAAGACTAGACCTTATACTCATTTTATCTTAACAGT
TTATTATAACTCATTTTGACCACTCCTCCCTCAAAAAAAATTGTCCCTAGAAAACTAGAGTGATCATAGGGATCAGATGACATGTTACTG
GGTGAAGCCAGGAAGCTACCATATACATAGAAAAGTTAGTTGCCAAATATGGTGTGGGAATTTGGGAGGAATTTATCTGCTCAAAAACTC
TCACCTACTTACTAGATATAGTGTTTGTAATGTTAGCCTTGGAGATTCTACCTTAAAAATATCATTGAGAAAGCTCAGAGAACTCCCAGG
TAAACACACAGGTAGCCCCTTCTAAAATGCAAATGCCCTTTGAAGGCCAGCTTTATTAATCTTGCCATTAACCCCATAGTTAATCATATG
CATTTCTCACAGTGACCTGAAAACAGGCATTCCTTCTCTAAATGTGTGCTGAATGCTGGTTATAAACCAGTTACTACACTAAGCCCTGAT
GATACAAATATGAAAAGTCCTGTTTCCAGGGAATTTACTTTCTAATGAGGAACCAAGTGCTCAAAAGCAGTCATAAAGTTCATGGCAAAA
TAACCCACATAATTAACTGCTTTGTTACAAAAACTTGGAAATATAGATAAAATATTTATTTTGGAAATATATGTTACAGGTGAAAAGCAA
GAATTAAAACTAGTTATCTGAATGTAAAAGGAATCAACGGCTAAATCAAGCTTAAAGTCTTCCTGTCCAAGGGATATGAAAGGTACCTCA
ACCTTTGGTTTTGGTTTTGGTTTTGGTTTTGTTTTTTTGGTCAACATGAATTATAGCTAGGGGAAGAGATAAACAGGGGGTTAGGTTGTA
GATTATATGCATGACAGATTGCTGGAATTGGGCTCCATTCACAAAGGAGGGAGCAGGAAAGGGTTTCTCTTGACTGGACCACAAATATAA
AATCTCATGCCCTCTCATTATCTTGATAAGCCCTATAGGTCCATAAAAGAAATAAAATGCCAAAACATACCATGAGGACACTTTCACAAT
CCAGGGCACACACATGACTCCCGCAATAGGAAACCACACTGAAGACATTCTCACAATTTAAAACAAGTTGTAAACTACAGGAAACAGTTG
GCATCCCAGGAGAGTTGTTGCCTGAGGAACTAGATGGTGGTATGTTATTCTGGCATATAGGGAACAGAATAAGACATGAGGGTAGGAAGA
GGTTTTTAAAAGCAAAGTTAGGCATTCAATGATGACTTCATAAATGTGCCTGGGCTGGCCTTTAATGGAAGGCTTTAATTTAGGGAACTT
AAAGAATTTCATAATATTGGAGTATAAACTGCTGGAAATAAGGATGCTATTTAATAGACTCTCTTAGATTTTTCATAAAATGCTAATAGA
ATCCCAAAGGAAGTGTGTATTCTAAAATGTTATTGTGTATGTTATAAAAGCTTTGTAAAATAAAGTGATGTTAAGCTACTATTGTAAAGT

>22366_22366_3_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000564406_PPIP5K2_chr5_102490373_ENST00000321521_length(amino acids)=1319AA_BP=501
MLSGMVGQILKRDVIMDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAF
SSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDE
PHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRT
IGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIK
YTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYG
GHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLME
LGQNNDSEIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCM
YPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARL
HEILQKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKT
KNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLH
PVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHF
SPGAKGCEEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKTATNDEESPLSVSS
PEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSS
SAPNLQDYARTHRKKLTSSGCIDGFELYSMVPSICPLETLHNALSLKQVDEFLASIASPSSDVPRKTAEISSTALRSSPIMRKKVSLNTY

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>22366_22366_4_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000564406_PPIP5K2_chr5_102490373_ENST00000358359_length(transcript)=5744nt_BP=1657nt
GTGCAGCCGCGGGTGCAGGAGTCCTGGGGCATGGCGGGGGCGGGGCAGGGGGAGGCGCGCACAGAACAGGCTGGGGCATCCCTCGCCCTG
GCTCTTTGAGCCCGGACCAGACAGGTGCTGGGAATACAGCAAGGAATTAGACCAGTTCCCTGCTCTCTGGTATGGTGGGACAGATACTAA
AAAGAGATGTGATAATGGATCATCATGTTTCTACCATCAAGCCTCGAAGAATCCAAAACCAAAATGTCATTCACCGCTTGGAACGCCGGC
GGATCAGTTCAGGCAAGGCAGGTACCCACTGGCACCAAGTCCGAGTGTTCCATCAGAATGTCTTCCCCAACTTCACAGTTGTCAACGTTG
AAAAGCCTCCTTGTTTCTTGCGTAAATTCTCACCTGATGGACGCTACTTTATTGCTTTTTCTTCAGACCAGACATCTCTTGAAATCTATG
AGTACCAGGGCTGCCAGGCAGCAGAGGACCTACTGCAGGGATACGAAGGAGAAATCCTGTCCAATGGCAATGACCAGCGGTCAGTGAATA
TCCGGGGCCGGCTCTTTGAACGCTTTTTTGTCCTGCTGCACATTACCAATGTTGCGGCCAATGGTGAGCACCTGAACCGGGAGTGTAGTC
TCTTCACTGATGACTGCCGCTGTGTCATCGTGGGCTCAGCTGCCTACCTCCCAGATGAGCCTCACCCTCCATTTTTTGAGGTATATCGGA
ACAGTGAATCAGTGACCCCCAACCCACGGTCCCCTCTAGAAGACTATTCCCTCCATATCATTGACCTTCACACCGGCCGCTTATGTGATA
CACGCACGTTCAAGTGTGACAAGGTGGTCTTGTCACACAACCAAGGGCTGTACTTGTACAAAAACATCCTGGCCATCTTGTCTGTGCAAC
AACAGACCATCCATGTCTTCCAGGTGACTCCTGAAGGCACTTTCATTGATGTGCGGACCATTGGCCGCTTTTGCTATGAGGATGACCTGC
TCACTGTGTCAGCTGTTTTCCCTGAGGTACAGCGGGACAGTCAGACAGGCATGGCCAATCCCTTTAGGGATCCTTTCATCAATTCCCTCA
AACACCGGTTGCTGGTATATTTGTGGCGCCGGGCAGAACAGGATGGTAGTGCAATGGCCAAGAGGCGCTTCTTCCAGTATTTTGACCAAC
TGCGGCAGCTGCGAATGTGGAAAATGCAGCTTCTGGATGAAAACCACCTGTTTATCAAGTACACTAGTGAGGATGTAGTAACACTGCGAG
TCACAGATCCATCACAGGCATCTTTCTTTGTGGTGTACAATATGGTGACGACAGAGGTGATTGCTGTGTTTGAGAATACATCAGATGAGC
TTTTGGAGCTCTTTGAGAACTTCTGTGACCTTTTTCGTAATGCTACCCTGCACAGTGAAGTTCAGTTTCCCTGCTCAGCTTCTAGCAACA
ATTTTGCAAGGCAGATCCAGCGCCGGTTCAAAGACACTATTATAAATGCCAAGTATGGAGGGCACACAGAGGCAGTACGCCGGCTGCTGG
GTCAGCTCCCCATCAGTGCTCAGTCTTACAGCGGTAGCCCCTATCTGGATTTGTCTCTCTTCAGTTATGATGACAAGTGGGTATCTGTCA
TGGAGCGGCCCAAGACTTGTGGAGATCACCCAATCAGATTTTTTGATCTTTTTGAAAAGTGTGATGGATATAAATCAGGGAAATTAAAAC
TCAAAAAACCAAAACAGTTACAGGAAGTGCTAGATATTGCACGACAGCTTCTTATGGAGCTAGGGCAAAATAATGATTCTGAAATTGAAG
AAAACAAGCCAAAACTTGAACAACTTAAGACTGTATTAGAGATGTATGGTCATTTTTCTGGAATAAATCGTAAGGTTCAGTTGACCTATC
TCCCTCATGGTTGTCCTAAAACATCTAGTGAAGAGGAGGACAGCCGAAGAGAAGAACCATCTTTACTTTTGGTTCTAAAATGGGGAGGTG
AATTAACTCCTGCAGGCAGGGTCCAGGCTGAAGAACTTGGAAGAGCCTTCAGGTGTATGTATCCTGGAGGTCAAGGAGATTATGCAGGAT
TTCCTGGTTGTGGTTTACTTAGATTACATAGCACCTACAGACATGACCTCAAAATATATGCCTCTGATGAAGGACGAGTCCAGATGACTG
CAGCTGCTTTTGCAAAGGGGCTTTTAGCTTTGGAAGGAGAGCTTACACCCATTCTTGTTCAAATGGTGAAAAGTGCAAATATGAACGGTC
TTTTGGATAGTGATAGTGACTCTCTGAGCAGTTGTCAGCAACGTGTGAAGGCAAGGCTTCATGAAATACTTCAGAAAGACAGAGATTTTA
CTGCTGAAGATTATGAAAAGCTTACTCCATCTGGAAGCATTTCTCTTATCAAATCAATGCATTTAATTAAAAACCCTGTGAAGACCTGTG
ATAAAGTTTATTCCTTAATTCAGAGTTTGACTTCTCAAATCAGACATCGAATGGAAGATCCTAAATCATCAGATATTCAGCTTTACCATA
GTGAAACATTGGAGCTTATGCTACGTAGATGGTCCAAGTTAGAGAAAGACTTTAAAACAAAGAATGGAAGATATGATATTAGTAAAATCC
CTGACATATATGACTGTATAAAATATGATGTCCAGCATAATGGTTCCTTGAAATTAGAAAACACAATGGAATTATATAGGCTTTCGAAGG
CATTAGCAGATATTGTTATCCCTCAGGAATATGGTATAACTAAAGCTGAAAAACTGGAGATTGCCAAAGGCTACTGTACTCCTCTGGTTA
GAAAAATTCGCTCAGACCTTCAGAGGACACAAGATGATGACACTGTAAATAAACTTCATCCTGTGTATTCTAGAGGTGTTCTGTCTCCTG
AACGTCATGTTCGTACTAGATTATATTTTACCAGTGAAAGTCATGTACATTCTTTGCTGTCTATTCTTCGCTATGGTGCCTTATGCAATG
AATCAAAGGATGAACAGTGGAAACGAGCTATGGATTATTTAAACGTTGTCAATGAGCTCAACTACATGACTCAGATTGTTATCATGCTTT
ATGAGGATCCTAATAAGGATCTTTCCTCAGAAGAACGCTTTCATGTTGAATTACACTTTAGTCCGGGAGCCAAAGGTTGTGAAGAAGACA
AAAATTTGCCATCTGGCTATGGATATAGACCAGCTTCCAGAGAGAATGAAGGCAGGAGACCTTTTAAAATTGATAATGATGATGAACCAC
ATACTTCTAAAAGAGATGAAGTTGATCGAGCTGTGATATTGTTTAAACCAATGGTATCAGAGCCAATTCATATACACAGGAAGTCTCCAC
TTCCAAGATCTAGGAAGACGGCTACAAATGATGAAGAGAGCCCCCTGAGTGTGTCTAGCCCAGAGGGTACTGGTACCTGGCTGCATTATA
CCAGTGGTGTGGGTACTGGGCGTCGAAGACGCAGATCAGGGGAACAAATCACTTCTTCCCCTGTCTCCCCCAAATCATTGGCTTTCACAT
CCAGTATTTTTGGCTCATGGCAACAGGTTGTATCTGAAAATGCTAATTACCTGAGAACACCAAGAACTCTTGTGGAACAGAAGCAGAATC
CTACTGTAGGGTCTCACTGTGCGGGCCTGTTTAGCACCTCGGTGCTCGGGGGTTCTTCAAGCGCACCTAACCTACAGGATTATGCTCGTA
CTCATCGTAAAAAGCTGACCTCTTCTGGCTGCATAGATGACGCCACACGCGGTTCTGCTGTTAAAAGGTTTTCTATCTCATTTGCTCGAC
ACCCAACCAATGGCTTTGAATTGTATTCCATGGTGCCATCTATTTGTCCTCTAGAAACTCTTCATAATGCCCTATCTTTAAAGCAAGTGG
ATGAATTTCTTGCTTCCATTGCTTCTCCATCATCTGACGTTCCACGGAAGACCGCTGAAATTTCCTCTACAGCTTTACGTTCCAGTCCAA
TAATGAGAAAAAAAGTATCTTTAAATACGTATACACCTGCAAAGATCCTCCCAACACCACCAGCTACCTTAAAGAGCACTAAAGCAAGCA
GCAAACCAGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATG
AACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTATGTTCTTATGTTTC
TCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAACTGTTGTCATGATCT
GGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAATATGATGTTTACCA
TGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACTGCAGAGTCTGATGA
GCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAGCCAGGGTTACATAT
TGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAGTGACATATATGCTG
CAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTTATTTAAAATATTAC
ATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATATTTCCTTACCATAC
AAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGTATAGTTGACAAGTG
TATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTTAGGAGAAATCTGAA
TTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTGATCACACTAAGAAA
GCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCGCTGTGATTTCATCT
GTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAAATGACTTAAACTGT
AATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTGAAATTTATGTTTAG
AAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGTCATATATTAATTAA
CTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATTAAAGAAGTTCATAG
ATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGTGAAAATGTAGTTAA

>22366_22366_4_DET1-PPIP5K2_DET1_chr15_89060012_ENST00000564406_PPIP5K2_chr5_102490373_ENST00000358359_length(amino acids)=1340AA_BP=501
MLSGMVGQILKRDVIMDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAF
SSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDE
PHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRT
IGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIK
YTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYG
GHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLME
LGQNNDSEIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCM
YPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARL
HEILQKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKT
KNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLH
PVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHF
SPGAKGCEEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKTATNDEESPLSVSS
PEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSS
SAPNLQDYARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALSLKQVDEFLASIASPSSDVPRKTAE

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Fusion Gene PPI Analysis for DET1-PPIP5K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DET1-PPIP5K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DET1-PPIP5K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource