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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DGCR2-ACOT7 (FusionGDB2 ID:22398)

Fusion Gene Summary for DGCR2-ACOT7

check button Fusion gene summary
Fusion gene informationFusion gene name: DGCR2-ACOT7
Fusion gene ID: 22398
HgeneTgene
Gene symbol

DGCR2

ACOT7

Gene ID

9993

11332

Gene nameDiGeorge syndrome critical region gene 2acyl-CoA thioesterase 7
SynonymsDGS-C|IDD|LAN|SEZ-12ACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACH
Cytomap

22q11.21

1p36.31

Type of geneprotein-codingprotein-coding
Descriptionintegral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndromecytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase
Modification date2020031320200313
UniProtAcc

P98153

O00154

Ensembl transtripts involved in fusion geneENST00000263196, ENST00000537045, 
ENST00000545799, ENST00000473832, 
ENST00000361521, ENST00000377842, 
ENST00000377845, ENST00000541130, 
ENST00000545482, ENST00000377855, 
ENST00000608083, 
Fusion gene scores* DoF score16 X 15 X 8=19209 X 8 X 7=504
# samples 2113
** MAII scorelog2(21/1920*10)=-3.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGCR2 [Title/Abstract] AND ACOT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGCR2(19052361)-ACOT7(6409926), # samples:1
Anticipated loss of major functional domain due to fusion event.DGCR2-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

TgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

TgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

TgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

TgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051


check buttonFusion gene breakpoints across DGCR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACOT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-ZM-AA0B-01ADGCR2chr22

19052361

-ACOT7chr1

6409926

-


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Fusion Gene ORF analysis for DGCR2-ACOT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263196ENST00000361521DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000263196ENST00000377842DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000263196ENST00000377845DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000263196ENST00000541130DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000263196ENST00000545482DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000537045ENST00000361521DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000537045ENST00000377842DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000537045ENST00000377845DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000537045ENST00000541130DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000537045ENST00000545482DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000545799ENST00000361521DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000545799ENST00000377842DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000545799ENST00000377845DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000545799ENST00000541130DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5CDS-intronENST00000545799ENST00000545482DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-3CDSENST00000473832ENST00000377855DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-3CDSENST00000473832ENST00000608083DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-intronENST00000473832ENST00000361521DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-intronENST00000473832ENST00000377842DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-intronENST00000473832ENST00000377845DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-intronENST00000473832ENST00000541130DGCR2chr22

19052361

-ACOT7chr1

6409926

-
5UTR-intronENST00000473832ENST00000545482DGCR2chr22

19052361

-ACOT7chr1

6409926

-
Frame-shiftENST00000545799ENST00000377855DGCR2chr22

19052361

-ACOT7chr1

6409926

-
Frame-shiftENST00000545799ENST00000608083DGCR2chr22

19052361

-ACOT7chr1

6409926

-
In-frameENST00000263196ENST00000377855DGCR2chr22

19052361

-ACOT7chr1

6409926

-
In-frameENST00000263196ENST00000608083DGCR2chr22

19052361

-ACOT7chr1

6409926

-
In-frameENST00000537045ENST00000377855DGCR2chr22

19052361

-ACOT7chr1

6409926

-
In-frameENST00000537045ENST00000608083DGCR2chr22

19052361

-ACOT7chr1

6409926

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537045DGCR2chr2219052361-ENST00000608083ACOT7chr16409926-19716732481642464
ENST00000537045DGCR2chr2219052361-ENST00000377855ACOT7chr16409926-19676732481642464
ENST00000263196DGCR2chr2219052361-ENST00000608083ACOT7chr16409926-20947962481765505
ENST00000263196DGCR2chr2219052361-ENST00000377855ACOT7chr16409926-20907962481765505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537045ENST00000608083DGCR2chr2219052361-ACOT7chr16409926-0.0038212880.99617875
ENST00000537045ENST00000377855DGCR2chr2219052361-ACOT7chr16409926-0.0037838610.9962161
ENST00000263196ENST00000608083DGCR2chr2219052361-ACOT7chr16409926-0.0045377440.99546224
ENST00000263196ENST00000377855DGCR2chr2219052361-ACOT7chr16409926-0.004496040.99550396

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Fusion Genomic Features for DGCR2-ACOT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGCR2-ACOT7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19052361/chr1:6409926)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGCR2

P98153

ACOT7

O00154

FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051). {ECO:0000269|PubMed:10578051, ECO:0000303|PubMed:10578051}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-41028_68182551.0DomainLDL-receptor class A
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-3928_68141510.0DomainLDL-receptor class A
TgeneACOT7chr22:19052361chr1:6409926ENST0000036152109224_33847371.0DomainHotDog ACOT-type 2
TgeneACOT7chr22:19052361chr1:6409926ENST000003615210950_16847371.0DomainHotDog ACOT-type 1
TgeneACOT7chr22:19052361chr1:6409926ENST0000037784209224_3386330.0DomainHotDog ACOT-type 2
TgeneACOT7chr22:19052361chr1:6409926ENST000003778420950_1686330.0DomainHotDog ACOT-type 1
TgeneACOT7chr22:19052361chr1:6409926ENST0000037784509224_33827351.0DomainHotDog ACOT-type 2
TgeneACOT7chr22:19052361chr1:6409926ENST000003778450950_16827351.0DomainHotDog ACOT-type 1
TgeneACOT7chr22:19052361chr1:6409926ENST0000037785509224_33857381.0DomainHotDog ACOT-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-410115_241182551.0DomainC-type lectin
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-410270_333182551.0DomainNote=VWFC
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-39115_241141510.0DomainC-type lectin
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-39270_333141510.0DomainNote=VWFC
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-41021_349182551.0Topological domainExtracellular
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-410369_550182551.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-3921_349141510.0Topological domainExtracellular
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-39369_550141510.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052361chr1:6409926ENST00000263196-410350_368182551.0TransmembraneHelical
HgeneDGCR2chr22:19052361chr1:6409926ENST00000537045-39350_368141510.0TransmembraneHelical
TgeneACOT7chr22:19052361chr1:6409926ENST000003778550950_16857381.0DomainHotDog ACOT-type 1


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Fusion Gene Sequence for DGCR2-ACOT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22398_22398_1_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000263196_ACOT7_chr1_6409926_ENST00000377855_length(transcript)=2090nt_BP=796nt
GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT
GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG
GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG
GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTC
GCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGCTGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAG
AAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCC
ACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCT
GCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTG
ACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGATCATGCGGCCAG
ATGATGCCAACGTGGCCGGCAATGTCCACGGGGGGACCATCCTGAAGATGATCGAGGAGGCAGGCGCCATCATCAGCACCCGGCATTGCA
ACAGCCAGAACGGGGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCATCGGTGAGGTGGCGC
ATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCTCACAGGTGCCAAAA
AGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCCTGTTGTGTATTCCC
GGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAACGGGGACATCGTCC
AGCCAGTCCTCAACCCAGAGCCGAACACTGTCAGCTACAGCCAGTCCAGCTTGATCCACCTGGTGGGGCCTTCAGACTGCACCCTGCACG
GCTTTGTGCACGGAGGTGTGACCATGAAGCTCATGGATGAGGTCGCCGGGATCGTGGCTGCACGCCACTGCAAGACCAACATCGTCACAG
CTTCCGTGGACGCCATTAATTTTCATGACAAGATCAGAAAAGGCTGCGTCATCACCATCTCGGGACGCATGACCTTCACGAGCAATAAGT
CCATGGAGATCGAGGTGTTGGTGGACGCCGACCCTGTTGTGGACAGCTCTCAGAAGCGCTACCGGGCCGCCAGTGCCTTCTTCACCTACG
TGTCGCTGAGCCAGGAAGGCAGGTCGCTGCCTGTGCCCCAGCTGGTGCCCGAGACCGAGGACGAGAAGAAGCGCTTTGAGGAAGGCAAAG
GGCGGTACCTGCAGATGAAGGCGAAGCGACAGGGCCACGCGGAGCCTCAGCCCTAGACTCCCTCCTCCTGCCACTGGTGCCTCGAGTAGC
CATGGCAACGGGCCCAGTGTCCAGTCACTTAGAAGTTCCCCCCTTGGCCAAAAACCCAATTCACATTGAGAGCTGGTGTTGTCTGAAGTT
TTCGTATCACAGTGTTAACCTGTACTCTCTCCTGCAAACCTACACACCAAAGCTTTATTTATATCATTCCAGTATCAATGCTACACAGTG
TTGTCCCGAGCGCCGGGAGGCGTTGGGCAGAAACCCTCGGGAATGCTTCCGAGCACGCTGTAGGGTATGGGAAGAACCCAGCACCACTAA

>22398_22398_1_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000263196_ACOT7_chr1_6409926_ENST00000377855_length(amino acids)=505AA_BP=183
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKD
QRKIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSE
NILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVG
PSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRA

--------------------------------------------------------------
>22398_22398_2_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000263196_ACOT7_chr1_6409926_ENST00000608083_length(transcript)=2094nt_BP=796nt
GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT
GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG
GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG
GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTC
GCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGCTGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAG
AAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCC
ACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCT
GCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTG
ACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGATCATGCGGCCAG
ATGATGCCAACGTGGCCGGCAATGTCCACGGGGGGACCATCCTGAAGATGATCGAGGAGGCAGGCGCCATCATCAGCACCCGGCATTGCA
ACAGCCAGAACGGGGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCATCGGTGAGGTGGCGC
ATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCTCACAGGTGCCAAAA
AGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCCTGTTGTGTATTCCC
GGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAACGGGGACATCGTCC
AGCCAGTCCTCAACCCAGAGCCGAACACTGTCAGCTACAGCCAGTCCAGCTTGATCCACCTGGTGGGGCCTTCAGACTGCACCCTGCACG
GCTTTGTGCACGGAGGTGTGACCATGAAGCTCATGGATGAGGTCGCCGGGATCGTGGCTGCACGCCACTGCAAGACCAACATCGTCACAG
CTTCCGTGGACGCCATTAATTTTCATGACAAGATCAGAAAAGGCTGCGTCATCACCATCTCGGGACGCATGACCTTCACGAGCAATAAGT
CCATGGAGATCGAGGTGTTGGTGGACGCCGACCCTGTTGTGGACAGCTCTCAGAAGCGCTACCGGGCCGCCAGTGCCTTCTTCACCTACG
TGTCGCTGAGCCAGGAAGGCAGGTCGCTGCCTGTGCCCCAGCTGGTGCCCGAGACCGAGGACGAGAAGAAGCGCTTTGAGGAAGGCAAAG
GGCGGTACCTGCAGATGAAGGCGAAGCGACAGGGCCACGCGGAGCCTCAGCCCTAGACTCCCTCCTCCTGCCACTGGTGCCTCGAGTAGC
CATGGCAACGGGCCCAGTGTCCAGTCACTTAGAAGTTCCCCCCTTGGCCAAAAACCCAATTCACATTGAGAGCTGGTGTTGTCTGAAGTT
TTCGTATCACAGTGTTAACCTGTACTCTCTCCTGCAAACCTACACACCAAAGCTTTATTTATATCATTCCAGTATCAATGCTACACAGTG
TTGTCCCGAGCGCCGGGAGGCGTTGGGCAGAAACCCTCGGGAATGCTTCCGAGCACGCTGTAGGGTATGGGAAGAACCCAGCACCACTAA

>22398_22398_2_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000263196_ACOT7_chr1_6409926_ENST00000608083_length(amino acids)=505AA_BP=183
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKD
QRKIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSE
NILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVG
PSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRA

--------------------------------------------------------------
>22398_22398_3_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000537045_ACOT7_chr1_6409926_ENST00000377855_length(transcript)=1967nt_BP=673nt
GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT
GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG
GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG
GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGA
AGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCA
GCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACT
GGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAAT
GGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGATCATGCGGCCAGATGATGCCAACGTGGCCGGCAATGTCCACGGGG
GGACCATCCTGAAGATGATCGAGGAGGCAGGCGCCATCATCAGCACCCGGCATTGCAACAGCCAGAACGGGGAGCGCTGTGTGGCCGCCC
TGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCATCGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGC
ACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCTCACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGC
CCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCCTGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGT
ATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAACGGGGACATCGTCCAGCCAGTCCTCAACCCAGAGCCGAACACTGTCA
GCTACAGCCAGTCCAGCTTGATCCACCTGGTGGGGCCTTCAGACTGCACCCTGCACGGCTTTGTGCACGGAGGTGTGACCATGAAGCTCA
TGGATGAGGTCGCCGGGATCGTGGCTGCACGCCACTGCAAGACCAACATCGTCACAGCTTCCGTGGACGCCATTAATTTTCATGACAAGA
TCAGAAAAGGCTGCGTCATCACCATCTCGGGACGCATGACCTTCACGAGCAATAAGTCCATGGAGATCGAGGTGTTGGTGGACGCCGACC
CTGTTGTGGACAGCTCTCAGAAGCGCTACCGGGCCGCCAGTGCCTTCTTCACCTACGTGTCGCTGAGCCAGGAAGGCAGGTCGCTGCCTG
TGCCCCAGCTGGTGCCCGAGACCGAGGACGAGAAGAAGCGCTTTGAGGAAGGCAAAGGGCGGTACCTGCAGATGAAGGCGAAGCGACAGG
GCCACGCGGAGCCTCAGCCCTAGACTCCCTCCTCCTGCCACTGGTGCCTCGAGTAGCCATGGCAACGGGCCCAGTGTCCAGTCACTTAGA
AGTTCCCCCCTTGGCCAAAAACCCAATTCACATTGAGAGCTGGTGTTGTCTGAAGTTTTCGTATCACAGTGTTAACCTGTACTCTCTCCT
GCAAACCTACACACCAAAGCTTTATTTATATCATTCCAGTATCAATGCTACACAGTGTTGTCCCGAGCGCCGGGAGGCGTTGGGCAGAAA

>22398_22398_3_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000537045_ACOT7_chr1_6409926_ENST00000377855_length(amino acids)=464AA_BP=142
MVPKADSGAFLLLFLLVLTVTEPLRPEVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRV
YLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQN
GERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQ
EEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVD
AINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYL

--------------------------------------------------------------
>22398_22398_4_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000537045_ACOT7_chr1_6409926_ENST00000608083_length(transcript)=1971nt_BP=673nt
GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT
GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG
GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG
GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGA
AGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCA
GCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACT
GGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAAT
GGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGATCATGCGGCCAGATGATGCCAACGTGGCCGGCAATGTCCACGGGG
GGACCATCCTGAAGATGATCGAGGAGGCAGGCGCCATCATCAGCACCCGGCATTGCAACAGCCAGAACGGGGAGCGCTGTGTGGCCGCCC
TGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCATCGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGC
ACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCTCACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGC
CCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCCTGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGT
ATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAACGGGGACATCGTCCAGCCAGTCCTCAACCCAGAGCCGAACACTGTCA
GCTACAGCCAGTCCAGCTTGATCCACCTGGTGGGGCCTTCAGACTGCACCCTGCACGGCTTTGTGCACGGAGGTGTGACCATGAAGCTCA
TGGATGAGGTCGCCGGGATCGTGGCTGCACGCCACTGCAAGACCAACATCGTCACAGCTTCCGTGGACGCCATTAATTTTCATGACAAGA
TCAGAAAAGGCTGCGTCATCACCATCTCGGGACGCATGACCTTCACGAGCAATAAGTCCATGGAGATCGAGGTGTTGGTGGACGCCGACC
CTGTTGTGGACAGCTCTCAGAAGCGCTACCGGGCCGCCAGTGCCTTCTTCACCTACGTGTCGCTGAGCCAGGAAGGCAGGTCGCTGCCTG
TGCCCCAGCTGGTGCCCGAGACCGAGGACGAGAAGAAGCGCTTTGAGGAAGGCAAAGGGCGGTACCTGCAGATGAAGGCGAAGCGACAGG
GCCACGCGGAGCCTCAGCCCTAGACTCCCTCCTCCTGCCACTGGTGCCTCGAGTAGCCATGGCAACGGGCCCAGTGTCCAGTCACTTAGA
AGTTCCCCCCTTGGCCAAAAACCCAATTCACATTGAGAGCTGGTGTTGTCTGAAGTTTTCGTATCACAGTGTTAACCTGTACTCTCTCCT
GCAAACCTACACACCAAAGCTTTATTTATATCATTCCAGTATCAATGCTACACAGTGTTGTCCCGAGCGCCGGGAGGCGTTGGGCAGAAA

>22398_22398_4_DGCR2-ACOT7_DGCR2_chr22_19052361_ENST00000537045_ACOT7_chr1_6409926_ENST00000608083_length(amino acids)=464AA_BP=142
MVPKADSGAFLLLFLLVLTVTEPLRPEVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRV
YLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQN
GERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQ
EEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVD
AINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DGCR2-ACOT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGCR2-ACOT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGCR2-ACOT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource