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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DGCR8-DGCR14 (FusionGDB2 ID:22423) |
Fusion Gene Summary for DGCR8-DGCR14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DGCR8-DGCR14 | Fusion gene ID: 22423 | Hgene | Tgene | Gene symbol | DGCR8 | DGCR14 | Gene ID | 54487 | 8220 |
| Gene name | DGCR8 microprocessor complex subunit | ess-2 splicing factor homolog | |
| Synonyms | C22orf12|DGCRK6|Gy1|pasha | DGCR13|DGCR14|DGS-H|DGS-I|DGSH|DGSI|ES2|ESS-2|Es2el|bis1 | |
| Cytomap | 22q11.21 | 22q11.21|22q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microprocessor complex subunit DGCR8DiGeorge syndrome critical region 8DiGeorge syndrome critical region gene 8 | splicing factor ESS-2 homologDiGeorge syndrome critical region gene 13DiGeorge syndrome critical region gene 14DiGeorge syndrome critical region gene DGSIDiGeorge syndrome gene HDiGeorge syndrome gene IProtein DGCR13diGeorge syndrome protein Hprot | |
| Modification date | 20200320 | 20200320 | |
| UniProtAcc | Q8WYQ5 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000351989, ENST00000383024, ENST00000407755, | ENST00000252137, | |
| Fusion gene scores | * DoF score | 8 X 5 X 8=320 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DGCR8 [Title/Abstract] AND DGCR14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DGCR8(20082318)-DGCR14(19127242), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DGCR8 | GO:0031053 | primary miRNA processing | 15531877|15574589|24449907|24910438 |
| Fusion gene breakpoints across DGCR8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DGCR14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-A6-5657-01A | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - |
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Fusion Gene ORF analysis for DGCR8-DGCR14 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000351989 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - |
| In-frame | ENST00000383024 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - |
| In-frame | ENST00000407755 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000351989 | DGCR8 | chr22 | 20082318 | - | ENST00000252137 | DGCR14 | chr22 | 19127242 | - | 6995 | 2217 | 429 | 3077 | 882 |
| ENST00000383024 | DGCR8 | chr22 | 20082318 | - | ENST00000252137 | DGCR14 | chr22 | 19127242 | - | 6896 | 2118 | 429 | 2978 | 849 |
| ENST00000407755 | DGCR8 | chr22 | 20082318 | - | ENST00000252137 | DGCR14 | chr22 | 19127242 | - | 6609 | 1831 | 142 | 2691 | 849 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000351989 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - | 0.001855022 | 0.998145 |
| ENST00000383024 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - | 0.002152121 | 0.9978479 |
| ENST00000407755 | ENST00000252137 | DGCR8 | chr22 | 20082318 | - | DGCR14 | chr22 | 19127242 | - | 0.002289099 | 0.99771094 |
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Fusion Genomic Features for DGCR8-DGCR14 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DGCR8-DGCR14 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:20082318/chr22:19127242) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DGCR8 | . |
| FUNCTION: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 301_334 | 596 | 774.0 | Domain | WW |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 511_578 | 596 | 774.0 | Domain | DRBM 1 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 301_334 | 563 | 741.0 | Domain | WW |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 301_334 | 563 | 741.0 | Domain | WW |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 1_275 | 596 | 774.0 | Region | Note=Necessary for nuclear localization and retention |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 1_275 | 563 | 741.0 | Region | Note=Necessary for nuclear localization and retention |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 1_275 | 563 | 741.0 | Region | Note=Necessary for nuclear localization and retention |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 620_685 | 596 | 774.0 | Domain | DRBM 2 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 511_578 | 563 | 741.0 | Domain | DRBM 1 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 620_685 | 563 | 741.0 | Domain | DRBM 2 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 511_578 | 563 | 741.0 | Domain | DRBM 1 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 620_685 | 563 | 741.0 | Domain | DRBM 2 |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 276_751 | 596 | 774.0 | Region | Note=Necessary for heme-binding and pri-miRNA processing |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 276_751 | 563 | 741.0 | Region | Note=Necessary for heme-binding and pri-miRNA processing |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 276_751 | 563 | 741.0 | Region | Note=Necessary for heme-binding and pri-miRNA processing |
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Fusion Gene Sequence for DGCR8-DGCR14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22423_22423_1_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000351989_DGCR14_chr22_19127242_ENST00000252137_length(transcript)=6995nt_BP=2217nt AGGCCCGCCCTCCGCTCGCCCGGCGCGGCAGGCGGGTGCCGGCGACCGGAGAGCCTGGACAGGCTTTCCAGATGGCTGCGGCGGTCGGTC GGTGAGGCTTTCCCGGCTGTGGTTTGGCTGCGGGCGGCTTGGGCAGCCCGCGGGCGCCTCAGGTAGAAGAAGAAAGGTGCCACTCCGGCA TGAAGACAGACTCGCTTAGTCGCCAGTCACTTAAGCTGAGTGCATTGTGATTTCCAATAATTGAGGCAGTGGTTCTAAAAGCTGTCTACA TTAATGAAAAGAGCAATGTGGCCAGCTTGACTAAGCCGCCAGCGCACAGCGCGGCAGGACGCGCCCGGGTCTCAGCGGACTTGTGCATGT TAGCTGTGTAGATTTATGTGAGGGCTTGTAAAACTCTGGTCTTGTAAACTAGTCTTAAGCGCTTTTAATATGGAGACAGATGAGAGCCCC TCTCCGCTCCCGTGTGGGCCCGCAGGAGAAGCGGTGATGGAGAGCCGAGCTCGCCCCTTCCAAGCGCTGCCCCGTGAGCAGTCTCCACCA CCTCCCCTGCAAACGTCCAGTGGTGCAGAGGTAATGGACGTTGGCTCTGGTGGTGATGGACAGTCCGAACTCCCTGCTGAGGACCCCTTC AACTTCTACGGAGCTTCTCTTCTCTCCAAAGGATCCTTCTCTAAGGGCCGCCTCCTCATAGACCCGAACTGTAGTGGCCACAGCCCGCGC ACCGCCCGGCACGCACCTGCGGTCCGGAAGTTCTCCCCTGACCTTAAGTTGCTTAAGGATGTAAAGATTAGCGTGAGCTTTACCGAGAGC TGCAGGAGTAAGGACAGGAAGGTGCTGTACACAGGAGCAGAGCGCGACGTGCGGGCGGAGTGCGGTCTGCTCCTTAGCCCTGTCAGTGGG GACGTGCATGCTTGTCCCTTTGGCGGGAGTGTTGGTGACGGGGTAGGCATAGGGGGTGAGAGTGCTGATAAGAAGGATGAGGAGAATGAG CTGGATCAGGAAAAGAGAGTGGAGTATGCAGTGCTCGATGAGTTAGAAGATTTTACTGACAATTTGGAGCTAGATGAAGAAGGAGCAGGC GGGTTCACGGCTAAAGCAATCGTTCAGAGAGACAGAGTGGATGAAGAGGCCTTGAATTTCCCCTACGAGGATGACTTTGACAACGATGTG GATGCTCTGCTGGAAGAAGGCCTTTGTGCCCCCAAAAAGAGGCGAACAGAGGAAAAATATGGCGGAGACAGCGACCATCCGTCCGATGGA GAGACAAGTGTGCAGCCGATGATGACCAAGATTAAAACAGTGCTCAAAAGTCGTGGCCGCCCACCTACAGAGCCGCTGCCCGACGGGTGG ATCATGACATTCCATAACTCTGGAGTCCCGGTGTACCTACACAGAGAGTCTCGGGTGGTCACCTGGTCCAGGCCATACTTCTTGGGAACG GGAAGCATACGGAAACACGACCCTCCTCTGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGC AGTGACCTCACCCCTAGTGGGGATGTGTCCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCT ATGGGTGCTGACCCGGGGCCCCCGGACGAGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTC GAGGTGTGCAAAGATGAATCCGTTGATCTCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAA TTCAGGACTTGGGCTGAGCGGCGGCAATTCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAG AAGCTCATTACTTTATCAGTGCAAGATGCACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCAC GAGTACATGCAGCGTGTCCTCAAGGTCCGCCCTGTCTATAATTTCTTTGAATGTGAGAACCCAAGTGAGCCTTTTGGTGCCTCGGTGACC ATTGATGGTGTGACTTACGGATCTGGAACTGCAAGCAGCAAAAAACTTGCGAAGAATAAAGCTGCCCGAGCTACACTGGAAATCCTCATC CCTGACTTTGTTAAACAGACCTCTGAAGAGAAGCCCAAAGACAGTGAAGAACTCGAGAGGCAGAAAGATAATCTCGAACTCCCGTCAGCA GAGCACCAGGCCATCGAGAGCAGCCAGGCCAGTGTGGAGACCTGGAAGTACAAGGCCAAGAATTCCCTCATGTACTATCCAGAGGGTGTC CCTGACGAGGAGCAGCTGTTTAAGAAGCCCCGGCAGGTGGTACATAAGAACACGCGCTTCCTTAGGGACCCCTTCAGCCAAGCCCTGAGC AGGTGCCAGCTCCAGCAGGCAGCCGCCCTCAATGCCCAGCACAAACAGGGCAAGGTGGGCCCCGATGGCAAGGAGCTGATCCCCCAGGAG TCCCCTCGAGTGGGTGGATTTGGATTTGTTGCCACTCCTTCCCCTGCCCCTGGTGTGAACGAGTCCCCGATGATGACCTGGGGGGAGGTT GAGAACACACCCTTGAGAGTTGAAGGGTCGGAAACGCCCTACGTGGACAGGACACCCGGCCCAGCTTTTAAGATCCTGGAGCCAGGCCGC AGGGAGCGGCTGGGTCTGAAGATGGCCAACGAGGCCGCTGCCAAGAACCGGGCCAAGAAGCAGGAAGCCTTGCGGAGAGTGACGGAGAAT CTGGCCAGCCTCACCCCCAAAGGCCTGAGCCCAGCCATGTCGCCAGCCCTACAGCGCCTTGTGAGCAGGACGGCCAGCAAGTACACAGAC CGGGCCCTGCGGGCCAGCTACACACCATCCCCAGCACGCTCCACCCACCTCAAGACCCCGGCCAGTGGGCTGCAGACCCCCACAAGCACA CCGGCGCCTGGCTCTGCCACACGCACCCCTCTCACACAGGACCCGGCCTCCATCACGGACAACCTGCTGCAGCTCCCTGCCCGGCGCAAA GCTTCGGACTTCTTTTAGAGCCAGGCCTGGGCTGGGCTCATAGACGCTTCACAGAGCCTGCAGGGCAGCTGTACACCCAGCAGAGGACTC CAGCCTTCTCGGGGCCCAGGCCTGGGCCAGAAGCTGTTGACCATACCAGGAGTCACTGGAGAAAGGGGCTGTGCTGGGGCCAGACTGGCA CAAGGCACTCGTGCCCACACCACACCCCAGGGCCTTGCCAAGCTGTTTGCTGTTTAATTGGCCCCTTGAACTGTCATTAAAGAACACCTA GGTACAGTCTGGGGGGTTGCCTCTCCATCTTGCTCCCCACACGAGCCCTAGCCTTGCCCTGGGGCCTGCATCACGTCTCAGGACTGCGGG GCTTGAAGCGAGGGGCCCCCCAGGTGAGGAAGCTGCAGGTGGGGCGGCTGTGGGAGCACCGGGTGACTGGCGTTGCTTTCTGCGGCACTC GGAACCTGTGTTCTGAGTTGAGCTCACATCCTGCAGTGCTTTCTGCTTCTCTGGGGGGATATGAAGGAGAAACGGAGCCCTTGGAAGTTG TACCCTTAGGTTCCCCTGCGGTTCTGGGCCCAGGTCTGCAGCCTCCACTCTGGGCTTGCCGGCTGTGAGGTGCGCTGGTTATAGGACTGT GTGGGGGCTGCATATCAGGTGATCTCAGCTATCACCTTCTCCCAGCACCTGGCTTCCAGCTCATGGGGTGGGACTATCCCACTCACCCCT CTGCTATAGGCACTGCCCATCTTATGCTGCTGGCCCTGGCCTCACCTGGTCACTTCCACCAACAGGAGCTCCCAGATAACAGTGGGTTGC TGGACAGATCAGGCTGGGACTCTTAAGGGGTGGGGGACGTGGGGCCTTCAGTGCTTTATCCCCTAGGAAAGGGTGCACGTTATCCCAAGG GAGCCCCCAGGAAGTGGGGAGGGAGGGGGGAGGAGCATGTCTAGGTGCTGACCACCTGGAGCACTTGGCCAGCAAGTGGGCCGCATGCTT TGGGAGCAATGGGTGACCCAGCAGGAAGCACAAAAGACCGGCCAGTGTGCCATCATCAAGGGCTGCTGAGCAGCTTGAAGAGCCACTGGG TGGGGAGGGCACACGGGGAGGTCTCAGCTGGGGCTGCCCCTGGAGGACAGGGCAGGGAACTTGAGGGCTGAGGACAGAAATCTCACATGA CTCCAGGAAATAGAGGAAGAGGAGGATGCTGAGCGAGGGATTGTGAGGGAGTGGGGGTAGGTCAGAGGGGGCTGAACTGCAGGAAGCCAG GGGGAGTCGTGGACCACTGGAGCTGGCCAGCCCCAGGGCATTGGGGACAAGGCCAGGTCAGAGGGAGACAGTGTGGGCCTGGTGGGTGGA CCCTGGCAGAGGCCCTCTTGTCCCCCACAAGGCCAGGCCACACTGTGATTCTGCCTGTACCTGAGCATCTGTCCTGTGCTCCTAGGCCGG AGACCACTGTGTGTCAGGTGGGGCGGTTGGCTGAGTCCCAGAGAAAAACACTCCTCACTGGGCACTCTTGATGCTTGCACACACCCTGTG GTTTATTTGGTGGTCAGTAAGGAACGTCTTTGCTGCTAAGTGGAAGAAAGCTAATGGAACGTAATCAAAATAGTGGTTTAATTGACGAAT TTTACTTGCACCTGTGCCTTCTTCAGATCCTACCTGCCTACTTAGTTTACGTGAAGGCCGACTGCACCATGCCCCCCAACCCCGACCCCC ACCACACACAACGGGGCCATTGTCATGCTAGGTGCTTGCTTTCCCCACCTCAGCTCCGGAGATGTGATGGTCTTTGGCCCTGGAGGTCTC GGCCAGCCTGTCCTCCATCCTGTTCTCGTTCTCGGGCACCACCAGCAGCCGGTGCTGGGTTTTGGCTCCAAGCTTGTGGTCGGGCCGGTG GTCGGGCCTCAAGCCTGTCTTGGTGTCCAGTTTGCACTCAGCGCGGTACTTGCCCTCCCCCTCCCTCTTGAAGGAGGCAGAAGACGTGGC TTTGGGCTTGGGGGGCTGCAGCCACGAGTGGCTGAGGATCTCATCGATGTGGAGCCGCTGGCTGACGTCGGGCTGCAGCATGCGGTAGAT GAGGTCCTTGCACTCGCAGGTCAGGTTCTTGGAGCGCGGGAAGTCCACACGGTGCTCCTTCTGGATACGCAGCATCTTCCTGATGTCGGA GTCGTCATAGGGCATGGAGCCGCAGACCATGATGTACAGGATCACGCCCAGGCTCCAGATGTCATACACCTTGGGCTGGTAGGGGATGCT CTGCAGCACCTCGGGGGCTGCATATGCTGCCGACCCGCAGAAGGTCTTGCTGAGGATGATGCGCCCATTGCTGTCCCGCAGGCAGCGCTT GGAGAAGCCAAAGTCAGACAGCTTGATGTTGAAGTCCTTGTCGAGGAGAAGGTTCTCGCACTTGAGGTCCCGGTGGACGATGTCCAGGTC GTGGCAGTACTTGACGGCGGAGGAGAGCTGTCGGAACATCTTGCGTGCCACGTCCTCATGCAGGGCTCCCTGGCACTTGATGAACTCGAG GAGGTCGCCCTGGACGCCAAGCTCCATGATGATGTAGATCCGTCCGTCAGAGGTCTCAAAGATCTCGTAAGTCTTGATGATGGAGCCGTG GTTGACAGTTGCCAGGATGTCCATCTCCCGAGGAAGGAATCTCTCCACAAAGTCAGTAGGTGTTTTCTTGCGGTCGATGATCTTGACAGC CACATTGAACTTGAGGCGCTCAGAGTAGGCAGATTTGACTTTTGCGTAGGAACCCTTGCCAAGATTGATGCCTACGATGTAACCCTTCTT CCTTAGGACTGTGGCATCGTCCATGGTGCCAGGAGCGACTGGCGCCGCTGCCGTCTACATCCCCCCGTCATGTGGGCCAGCAGGCATTGT CCTCATTTACACTACCGGAGGCGTCTGGCTGGGCTGCCCTGGGCTGGGCTTCGACTCAGGGGTGGAACACTCAGCATTGTCTCCGGGTGA CTTCAGCCAATGAACTCATAAAGCCAAGGAGTGGGGGCGGGGACTGGGCTGAGGGAGAACAGGGTCTCTGGAACCGTGGAAGCCAGGCTG GTCTGGCAGGAGCACCCACTCCCCGCCCGCTGGAAGGAAGCCTGTCCCCAGGACAGGACTCTGGTGGCCCTGCTGCTGCTGCATTGGTTT CCCTGTCACAAGTCAAGCTGGAGGGGAGGCGGCCCACGTCCAGCCTGTTTGCATCACCTGGCTGTGGGGACTGACCCTGCATTGGTCTTT GTCCCACTAGGGTGGGTTTCCTGCAGCTTCTTTGGCTATGAAGAAAAGCACCCCCAGGGCTGTGTCCTTGGTGTGGTAGGACAGTTGTCC CTGACAGTCACCCAGACAGGCCTGCATAGCACCCCAGTTACACAGACAGATTTCCACAGCACTGCCTTACCATTGAGCACATAGTTAAAT CTAGGGAAATCAGTGCCCAGACATCAAAGCTAGAAATGAAACATGGTCAGCAGGAGCCTTGCATGGGCTTCTCTTTTGCTGGAGCAAGCC AAAATAATAGGAACGGTTTTACATTCCTAGTGCCAGGACCCATCTCGGGTCGACAAAATCTGAAGACAAGTTAAGGGAACAGGCAGCTGT TTGAATAGATCAATTGGATAGTCTAAGGCAGCTCTCTGGACCAAGCTGTAAAGGAGATACAATCGAAATAATCACTCCGGTACCACAGTA GACAGGCCTTGAAGGCACTGGGCCCCTTTTAATCGGACTTAGCAAGCATTTTTTTTGCCTCTGACCTTCTCCTTGGAACAAAATTAGTTA CCAGTAGACTTAGGTGATTGCTGTACTGCATGTAGGCACATAACCCCAACCTATATAAACAGTAAGAAAATTGTAGCACTTTGAGTTGGT >22423_22423_1_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000351989_DGCR14_chr22_19127242_ENST00000252137_length(amino acids)=882AA_BP=594 METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSELPAEDPFNFYGASLLSKGSFSKGRLLIDPN CSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD KKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYEDDFDNDVDALLEEGLCAPKKRRTEEKYGGD SDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKD NEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDF EQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSE PFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELERQKDNLELPSAEHQAIESSQASVETWKYKAKNSL MYYPEGVPDEEQLFKKPRQVVHKNTRFLRDPFSQALSRCQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESP MMTWGEVENTPLRVEGSETPYVDRTPGPAFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPKGLSPAMSPALQRLVSR -------------------------------------------------------------- >22423_22423_2_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000383024_DGCR14_chr22_19127242_ENST00000252137_length(transcript)=6896nt_BP=2118nt AGGCCCGCCCTCCGCTCGCCCGGCGCGGCAGGCGGGTGCCGGCGACCGGAGAGCCTGGACAGGCTTTCCAGATGGCTGCGGCGGTCGGTC GGTGAGGCTTTCCCGGCTGTGGTTTGGCTGCGGGCGGCTTGGGCAGCCCGCGGGCGCCTCAGGTAGAAGAAGAAAGGTGCCACTCCGGCA TGAAGACAGACTCGCTTAGTCGCCAGTCACTTAAGCTGAGTGCATTGTGATTTCCAATAATTGAGGCAGTGGTTCTAAAAGCTGTCTACA TTAATGAAAAGAGCAATGTGGCCAGCTTGACTAAGCCGCCAGCGCACAGCGCGGCAGGACGCGCCCGGGTCTCAGCGGACTTGTGCATGT TAGCTGTGTAGATTTATGTGAGGGCTTGTAAAACTCTGGTCTTGTAAACTAGTCTTAAGCGCTTTTAATATGGAGACAGATGAGAGCCCC TCTCCGCTCCCGTGTGGGCCCGCAGGAGAAGCGGTGATGGAGAGCCGAGCTCGCCCCTTCCAAGCGCTGCCCCGTGAGCAGTCTCCACCA CCTCCCCTGCAAACGTCCAGTGGTGCAGAGGTAATGGACGTTGGCTCTGGTGGTGATGGACAGTCCGAACTCCCTGCTGAGGACCCCTTC AACTTCTACGGAGCTTCTCTTCTCTCCAAAGGATCCTTCTCTAAGGGCCGCCTCCTCATAGACCCGAACTGTAGTGGCCACAGCCCGCGC ACCGCCCGGCACGCACCTGCGGTCCGGAAGTTCTCCCCTGACCTTAAGTTGCTTAAGGATGTAAAGATTAGCGTGAGCTTTACCGAGAGC TGCAGGAGTAAGGACAGGAAGGTGCTGTACACAGGAGCAGAGCGCGACGTGCGGGCGGAGTGCGGTCTGCTCCTTAGCCCTGTCAGTGGG GACGTGCATGCTTGTCCCTTTGGCGGGAGTGTTGGTGACGGGGTAGGCATAGGGGGTGAGAGTGCTGATAAGAAGGATGAGGAGAATGAG CTGGATCAGGAAAAGAGAGTGGAGTATGCAGTGCTCGATGAGTTAGAAGATTTTACTGACAATTTGGAGCTAGATGAAGAAGGAGCAGGC GGGTTCACGGCTAAAGCAATCGTTCAGAGAGACAGAGTGGATGAAGAGGCCTTGAATTTCCCCTACGAGGATGACTTTGACAACGATGTG GATGCTCTGCTGGAAGAAGGCCTTTGTGCCCCCAAAAAGAGGCGAACAGAGGAAAAATATGGCGGAGACAGCGACCATCCGTCCGATGGA GAGACAAGTGTGCAGCCGATGATGACCAAGATTAAAACAGTGCTCAAAAGTCGTGGCCGCCCACCTACAGAGCCGCTGCCCGACGGGTGG ATCATGACATTCCATAACTCTGGAGTCCCGGTGTACCTACACAGAGAGTCTCGGGTGGTCACCTGGTCCAGGCCATACTTCTTGGGAACG GGAAGCATACGGAAACACGACCCTCCTCTGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGC AGTGACCTCACCCCTAGTGGGGATGTGTCCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCT ATGGGTGCTGACCCGGGGCCCCCGGACGAGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTC GAGGTGTGCAAAGATGAATCCGTTGATCTCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAA TTCAGGACTTGGGCTGAGCGGCGGCAATTCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAG AAGCTCATTACTTTATCAGTGCAAGATGCACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCAC GAGTACATGCAGCGTGTCCTCAAGGTCCGCCCTGTCTATAATTTCTTTGAATGTGCCCGAGCTACACTGGAAATCCTCATCCCTGACTTT GTTAAACAGACCTCTGAAGAGAAGCCCAAAGACAGTGAAGAACTCGAGAGGCAGAAAGATAATCTCGAACTCCCGTCAGCAGAGCACCAG GCCATCGAGAGCAGCCAGGCCAGTGTGGAGACCTGGAAGTACAAGGCCAAGAATTCCCTCATGTACTATCCAGAGGGTGTCCCTGACGAG GAGCAGCTGTTTAAGAAGCCCCGGCAGGTGGTACATAAGAACACGCGCTTCCTTAGGGACCCCTTCAGCCAAGCCCTGAGCAGGTGCCAG CTCCAGCAGGCAGCCGCCCTCAATGCCCAGCACAAACAGGGCAAGGTGGGCCCCGATGGCAAGGAGCTGATCCCCCAGGAGTCCCCTCGA GTGGGTGGATTTGGATTTGTTGCCACTCCTTCCCCTGCCCCTGGTGTGAACGAGTCCCCGATGATGACCTGGGGGGAGGTTGAGAACACA CCCTTGAGAGTTGAAGGGTCGGAAACGCCCTACGTGGACAGGACACCCGGCCCAGCTTTTAAGATCCTGGAGCCAGGCCGCAGGGAGCGG CTGGGTCTGAAGATGGCCAACGAGGCCGCTGCCAAGAACCGGGCCAAGAAGCAGGAAGCCTTGCGGAGAGTGACGGAGAATCTGGCCAGC CTCACCCCCAAAGGCCTGAGCCCAGCCATGTCGCCAGCCCTACAGCGCCTTGTGAGCAGGACGGCCAGCAAGTACACAGACCGGGCCCTG CGGGCCAGCTACACACCATCCCCAGCACGCTCCACCCACCTCAAGACCCCGGCCAGTGGGCTGCAGACCCCCACAAGCACACCGGCGCCT GGCTCTGCCACACGCACCCCTCTCACACAGGACCCGGCCTCCATCACGGACAACCTGCTGCAGCTCCCTGCCCGGCGCAAAGCTTCGGAC TTCTTTTAGAGCCAGGCCTGGGCTGGGCTCATAGACGCTTCACAGAGCCTGCAGGGCAGCTGTACACCCAGCAGAGGACTCCAGCCTTCT CGGGGCCCAGGCCTGGGCCAGAAGCTGTTGACCATACCAGGAGTCACTGGAGAAAGGGGCTGTGCTGGGGCCAGACTGGCACAAGGCACT CGTGCCCACACCACACCCCAGGGCCTTGCCAAGCTGTTTGCTGTTTAATTGGCCCCTTGAACTGTCATTAAAGAACACCTAGGTACAGTC TGGGGGGTTGCCTCTCCATCTTGCTCCCCACACGAGCCCTAGCCTTGCCCTGGGGCCTGCATCACGTCTCAGGACTGCGGGGCTTGAAGC GAGGGGCCCCCCAGGTGAGGAAGCTGCAGGTGGGGCGGCTGTGGGAGCACCGGGTGACTGGCGTTGCTTTCTGCGGCACTCGGAACCTGT GTTCTGAGTTGAGCTCACATCCTGCAGTGCTTTCTGCTTCTCTGGGGGGATATGAAGGAGAAACGGAGCCCTTGGAAGTTGTACCCTTAG GTTCCCCTGCGGTTCTGGGCCCAGGTCTGCAGCCTCCACTCTGGGCTTGCCGGCTGTGAGGTGCGCTGGTTATAGGACTGTGTGGGGGCT GCATATCAGGTGATCTCAGCTATCACCTTCTCCCAGCACCTGGCTTCCAGCTCATGGGGTGGGACTATCCCACTCACCCCTCTGCTATAG GCACTGCCCATCTTATGCTGCTGGCCCTGGCCTCACCTGGTCACTTCCACCAACAGGAGCTCCCAGATAACAGTGGGTTGCTGGACAGAT CAGGCTGGGACTCTTAAGGGGTGGGGGACGTGGGGCCTTCAGTGCTTTATCCCCTAGGAAAGGGTGCACGTTATCCCAAGGGAGCCCCCA GGAAGTGGGGAGGGAGGGGGGAGGAGCATGTCTAGGTGCTGACCACCTGGAGCACTTGGCCAGCAAGTGGGCCGCATGCTTTGGGAGCAA TGGGTGACCCAGCAGGAAGCACAAAAGACCGGCCAGTGTGCCATCATCAAGGGCTGCTGAGCAGCTTGAAGAGCCACTGGGTGGGGAGGG CACACGGGGAGGTCTCAGCTGGGGCTGCCCCTGGAGGACAGGGCAGGGAACTTGAGGGCTGAGGACAGAAATCTCACATGACTCCAGGAA ATAGAGGAAGAGGAGGATGCTGAGCGAGGGATTGTGAGGGAGTGGGGGTAGGTCAGAGGGGGCTGAACTGCAGGAAGCCAGGGGGAGTCG TGGACCACTGGAGCTGGCCAGCCCCAGGGCATTGGGGACAAGGCCAGGTCAGAGGGAGACAGTGTGGGCCTGGTGGGTGGACCCTGGCAG AGGCCCTCTTGTCCCCCACAAGGCCAGGCCACACTGTGATTCTGCCTGTACCTGAGCATCTGTCCTGTGCTCCTAGGCCGGAGACCACTG TGTGTCAGGTGGGGCGGTTGGCTGAGTCCCAGAGAAAAACACTCCTCACTGGGCACTCTTGATGCTTGCACACACCCTGTGGTTTATTTG GTGGTCAGTAAGGAACGTCTTTGCTGCTAAGTGGAAGAAAGCTAATGGAACGTAATCAAAATAGTGGTTTAATTGACGAATTTTACTTGC ACCTGTGCCTTCTTCAGATCCTACCTGCCTACTTAGTTTACGTGAAGGCCGACTGCACCATGCCCCCCAACCCCGACCCCCACCACACAC AACGGGGCCATTGTCATGCTAGGTGCTTGCTTTCCCCACCTCAGCTCCGGAGATGTGATGGTCTTTGGCCCTGGAGGTCTCGGCCAGCCT GTCCTCCATCCTGTTCTCGTTCTCGGGCACCACCAGCAGCCGGTGCTGGGTTTTGGCTCCAAGCTTGTGGTCGGGCCGGTGGTCGGGCCT CAAGCCTGTCTTGGTGTCCAGTTTGCACTCAGCGCGGTACTTGCCCTCCCCCTCCCTCTTGAAGGAGGCAGAAGACGTGGCTTTGGGCTT GGGGGGCTGCAGCCACGAGTGGCTGAGGATCTCATCGATGTGGAGCCGCTGGCTGACGTCGGGCTGCAGCATGCGGTAGATGAGGTCCTT GCACTCGCAGGTCAGGTTCTTGGAGCGCGGGAAGTCCACACGGTGCTCCTTCTGGATACGCAGCATCTTCCTGATGTCGGAGTCGTCATA GGGCATGGAGCCGCAGACCATGATGTACAGGATCACGCCCAGGCTCCAGATGTCATACACCTTGGGCTGGTAGGGGATGCTCTGCAGCAC CTCGGGGGCTGCATATGCTGCCGACCCGCAGAAGGTCTTGCTGAGGATGATGCGCCCATTGCTGTCCCGCAGGCAGCGCTTGGAGAAGCC AAAGTCAGACAGCTTGATGTTGAAGTCCTTGTCGAGGAGAAGGTTCTCGCACTTGAGGTCCCGGTGGACGATGTCCAGGTCGTGGCAGTA CTTGACGGCGGAGGAGAGCTGTCGGAACATCTTGCGTGCCACGTCCTCATGCAGGGCTCCCTGGCACTTGATGAACTCGAGGAGGTCGCC CTGGACGCCAAGCTCCATGATGATGTAGATCCGTCCGTCAGAGGTCTCAAAGATCTCGTAAGTCTTGATGATGGAGCCGTGGTTGACAGT TGCCAGGATGTCCATCTCCCGAGGAAGGAATCTCTCCACAAAGTCAGTAGGTGTTTTCTTGCGGTCGATGATCTTGACAGCCACATTGAA CTTGAGGCGCTCAGAGTAGGCAGATTTGACTTTTGCGTAGGAACCCTTGCCAAGATTGATGCCTACGATGTAACCCTTCTTCCTTAGGAC TGTGGCATCGTCCATGGTGCCAGGAGCGACTGGCGCCGCTGCCGTCTACATCCCCCCGTCATGTGGGCCAGCAGGCATTGTCCTCATTTA CACTACCGGAGGCGTCTGGCTGGGCTGCCCTGGGCTGGGCTTCGACTCAGGGGTGGAACACTCAGCATTGTCTCCGGGTGACTTCAGCCA ATGAACTCATAAAGCCAAGGAGTGGGGGCGGGGACTGGGCTGAGGGAGAACAGGGTCTCTGGAACCGTGGAAGCCAGGCTGGTCTGGCAG GAGCACCCACTCCCCGCCCGCTGGAAGGAAGCCTGTCCCCAGGACAGGACTCTGGTGGCCCTGCTGCTGCTGCATTGGTTTCCCTGTCAC AAGTCAAGCTGGAGGGGAGGCGGCCCACGTCCAGCCTGTTTGCATCACCTGGCTGTGGGGACTGACCCTGCATTGGTCTTTGTCCCACTA GGGTGGGTTTCCTGCAGCTTCTTTGGCTATGAAGAAAAGCACCCCCAGGGCTGTGTCCTTGGTGTGGTAGGACAGTTGTCCCTGACAGTC ACCCAGACAGGCCTGCATAGCACCCCAGTTACACAGACAGATTTCCACAGCACTGCCTTACCATTGAGCACATAGTTAAATCTAGGGAAA TCAGTGCCCAGACATCAAAGCTAGAAATGAAACATGGTCAGCAGGAGCCTTGCATGGGCTTCTCTTTTGCTGGAGCAAGCCAAAATAATA GGAACGGTTTTACATTCCTAGTGCCAGGACCCATCTCGGGTCGACAAAATCTGAAGACAAGTTAAGGGAACAGGCAGCTGTTTGAATAGA TCAATTGGATAGTCTAAGGCAGCTCTCTGGACCAAGCTGTAAAGGAGATACAATCGAAATAATCACTCCGGTACCACAGTAGACAGGCCT TGAAGGCACTGGGCCCCTTTTAATCGGACTTAGCAAGCATTTTTTTTGCCTCTGACCTTCTCCTTGGAACAAAATTAGTTACCAGTAGAC TTAGGTGATTGCTGTACTGCATGTAGGCACATAACCCCAACCTATATAAACAGTAAGAAAATTGTAGCACTTTGAGTTGGTCTGCTGGAA >22423_22423_2_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000383024_DGCR14_chr22_19127242_ENST00000252137_length(amino acids)=849AA_BP=561 METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSELPAEDPFNFYGASLLSKGSFSKGRLLIDPN CSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD KKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYEDDFDNDVDALLEEGLCAPKKRRTEEKYGGD SDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKD NEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDF EQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECARATL EILIPDFVKQTSEEKPKDSEELERQKDNLELPSAEHQAIESSQASVETWKYKAKNSLMYYPEGVPDEEQLFKKPRQVVHKNTRFLRDPFS QALSRCQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPMMTWGEVENTPLRVEGSETPYVDRTPGPAFKIL EPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPKGLSPAMSPALQRLVSRTASKYTDRALRASYTPSPARSTHLKTPASGLQT -------------------------------------------------------------- >22423_22423_3_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000407755_DGCR14_chr22_19127242_ENST00000252137_length(transcript)=6609nt_BP=1831nt GTGGCCAGCTTGACTAAGCCGCCAGCGCACAGCGCGGCAGGACGCGCCCGGGTCTCAGCGGACTTGTGCATGTTAGCTGTGTAGATTTAT GTGAGGGCTTGTAAAACTCTGGTCTTGTAAACTAGTCTTAAGCGCTTTTAATATGGAGACAGATGAGAGCCCCTCTCCGCTCCCGTGTGG GCCCGCAGGAGAAGCGGTGATGGAGAGCCGAGCTCGCCCCTTCCAAGCGCTGCCCCGTGAGCAGTCTCCACCACCTCCCCTGCAAACGTC CAGTGGTGCAGAGGTAATGGACGTTGGCTCTGGTGGTGATGGACAGTCCGAACTCCCTGCTGAGGACCCCTTCAACTTCTACGGAGCTTC TCTTCTCTCCAAAGGATCCTTCTCTAAGGGCCGCCTCCTCATAGACCCGAACTGTAGTGGCCACAGCCCGCGCACCGCCCGGCACGCACC TGCGGTCCGGAAGTTCTCCCCTGACCTTAAGTTGCTTAAGGATGTAAAGATTAGCGTGAGCTTTACCGAGAGCTGCAGGAGTAAGGACAG GAAGGTGCTGTACACAGGAGCAGAGCGCGACGTGCGGGCGGAGTGCGGTCTGCTCCTTAGCCCTGTCAGTGGGGACGTGCATGCTTGTCC CTTTGGCGGGAGTGTTGGTGACGGGGTAGGCATAGGGGGTGAGAGTGCTGATAAGAAGGATGAGGAGAATGAGCTGGATCAGGAAAAGAG AGTGGAGTATGCAGTGCTCGATGAGTTAGAAGATTTTACTGACAATTTGGAGCTAGATGAAGAAGGAGCAGGCGGGTTCACGGCTAAAGC AATCGTTCAGAGAGACAGAGTGGATGAAGAGGCCTTGAATTTCCCCTACGAGGATGACTTTGACAACGATGTGGATGCTCTGCTGGAAGA AGGCCTTTGTGCCCCCAAAAAGAGGCGAACAGAGGAAAAATATGGCGGAGACAGCGACCATCCGTCCGATGGAGAGACAAGTGTGCAGCC GATGATGACCAAGATTAAAACAGTGCTCAAAAGTCGTGGCCGCCCACCTACAGAGCCGCTGCCCGACGGGTGGATCATGACATTCCATAA CTCTGGAGTCCCGGTGTACCTACACAGAGAGTCTCGGGTGGTCACCTGGTCCAGGCCATACTTCTTGGGAACGGGAAGCATACGGAAACA CGACCCTCCTCTGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGCAGTGACCTCACCCCTAG TGGGGATGTGTCCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCTATGGGTGCTGACCCGGG GCCCCCGGACGAGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTCGAGGTGTGCAAAGATGA ATCCGTTGATCTCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAATTCAGGACTTGGGCTGA GCGGCGGCAATTCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAGAAGCTCATTACTTTATC AGTGCAAGATGCACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCACGAGTACATGCAGCGTGT CCTCAAGGTCCGCCCTGTCTATAATTTCTTTGAATGTGCCCGAGCTACACTGGAAATCCTCATCCCTGACTTTGTTAAACAGACCTCTGA AGAGAAGCCCAAAGACAGTGAAGAACTCGAGAGGCAGAAAGATAATCTCGAACTCCCGTCAGCAGAGCACCAGGCCATCGAGAGCAGCCA GGCCAGTGTGGAGACCTGGAAGTACAAGGCCAAGAATTCCCTCATGTACTATCCAGAGGGTGTCCCTGACGAGGAGCAGCTGTTTAAGAA GCCCCGGCAGGTGGTACATAAGAACACGCGCTTCCTTAGGGACCCCTTCAGCCAAGCCCTGAGCAGGTGCCAGCTCCAGCAGGCAGCCGC CCTCAATGCCCAGCACAAACAGGGCAAGGTGGGCCCCGATGGCAAGGAGCTGATCCCCCAGGAGTCCCCTCGAGTGGGTGGATTTGGATT TGTTGCCACTCCTTCCCCTGCCCCTGGTGTGAACGAGTCCCCGATGATGACCTGGGGGGAGGTTGAGAACACACCCTTGAGAGTTGAAGG GTCGGAAACGCCCTACGTGGACAGGACACCCGGCCCAGCTTTTAAGATCCTGGAGCCAGGCCGCAGGGAGCGGCTGGGTCTGAAGATGGC CAACGAGGCCGCTGCCAAGAACCGGGCCAAGAAGCAGGAAGCCTTGCGGAGAGTGACGGAGAATCTGGCCAGCCTCACCCCCAAAGGCCT GAGCCCAGCCATGTCGCCAGCCCTACAGCGCCTTGTGAGCAGGACGGCCAGCAAGTACACAGACCGGGCCCTGCGGGCCAGCTACACACC ATCCCCAGCACGCTCCACCCACCTCAAGACCCCGGCCAGTGGGCTGCAGACCCCCACAAGCACACCGGCGCCTGGCTCTGCCACACGCAC CCCTCTCACACAGGACCCGGCCTCCATCACGGACAACCTGCTGCAGCTCCCTGCCCGGCGCAAAGCTTCGGACTTCTTTTAGAGCCAGGC CTGGGCTGGGCTCATAGACGCTTCACAGAGCCTGCAGGGCAGCTGTACACCCAGCAGAGGACTCCAGCCTTCTCGGGGCCCAGGCCTGGG CCAGAAGCTGTTGACCATACCAGGAGTCACTGGAGAAAGGGGCTGTGCTGGGGCCAGACTGGCACAAGGCACTCGTGCCCACACCACACC CCAGGGCCTTGCCAAGCTGTTTGCTGTTTAATTGGCCCCTTGAACTGTCATTAAAGAACACCTAGGTACAGTCTGGGGGGTTGCCTCTCC ATCTTGCTCCCCACACGAGCCCTAGCCTTGCCCTGGGGCCTGCATCACGTCTCAGGACTGCGGGGCTTGAAGCGAGGGGCCCCCCAGGTG AGGAAGCTGCAGGTGGGGCGGCTGTGGGAGCACCGGGTGACTGGCGTTGCTTTCTGCGGCACTCGGAACCTGTGTTCTGAGTTGAGCTCA CATCCTGCAGTGCTTTCTGCTTCTCTGGGGGGATATGAAGGAGAAACGGAGCCCTTGGAAGTTGTACCCTTAGGTTCCCCTGCGGTTCTG GGCCCAGGTCTGCAGCCTCCACTCTGGGCTTGCCGGCTGTGAGGTGCGCTGGTTATAGGACTGTGTGGGGGCTGCATATCAGGTGATCTC AGCTATCACCTTCTCCCAGCACCTGGCTTCCAGCTCATGGGGTGGGACTATCCCACTCACCCCTCTGCTATAGGCACTGCCCATCTTATG CTGCTGGCCCTGGCCTCACCTGGTCACTTCCACCAACAGGAGCTCCCAGATAACAGTGGGTTGCTGGACAGATCAGGCTGGGACTCTTAA GGGGTGGGGGACGTGGGGCCTTCAGTGCTTTATCCCCTAGGAAAGGGTGCACGTTATCCCAAGGGAGCCCCCAGGAAGTGGGGAGGGAGG GGGGAGGAGCATGTCTAGGTGCTGACCACCTGGAGCACTTGGCCAGCAAGTGGGCCGCATGCTTTGGGAGCAATGGGTGACCCAGCAGGA AGCACAAAAGACCGGCCAGTGTGCCATCATCAAGGGCTGCTGAGCAGCTTGAAGAGCCACTGGGTGGGGAGGGCACACGGGGAGGTCTCA GCTGGGGCTGCCCCTGGAGGACAGGGCAGGGAACTTGAGGGCTGAGGACAGAAATCTCACATGACTCCAGGAAATAGAGGAAGAGGAGGA TGCTGAGCGAGGGATTGTGAGGGAGTGGGGGTAGGTCAGAGGGGGCTGAACTGCAGGAAGCCAGGGGGAGTCGTGGACCACTGGAGCTGG CCAGCCCCAGGGCATTGGGGACAAGGCCAGGTCAGAGGGAGACAGTGTGGGCCTGGTGGGTGGACCCTGGCAGAGGCCCTCTTGTCCCCC ACAAGGCCAGGCCACACTGTGATTCTGCCTGTACCTGAGCATCTGTCCTGTGCTCCTAGGCCGGAGACCACTGTGTGTCAGGTGGGGCGG TTGGCTGAGTCCCAGAGAAAAACACTCCTCACTGGGCACTCTTGATGCTTGCACACACCCTGTGGTTTATTTGGTGGTCAGTAAGGAACG TCTTTGCTGCTAAGTGGAAGAAAGCTAATGGAACGTAATCAAAATAGTGGTTTAATTGACGAATTTTACTTGCACCTGTGCCTTCTTCAG ATCCTACCTGCCTACTTAGTTTACGTGAAGGCCGACTGCACCATGCCCCCCAACCCCGACCCCCACCACACACAACGGGGCCATTGTCAT GCTAGGTGCTTGCTTTCCCCACCTCAGCTCCGGAGATGTGATGGTCTTTGGCCCTGGAGGTCTCGGCCAGCCTGTCCTCCATCCTGTTCT CGTTCTCGGGCACCACCAGCAGCCGGTGCTGGGTTTTGGCTCCAAGCTTGTGGTCGGGCCGGTGGTCGGGCCTCAAGCCTGTCTTGGTGT CCAGTTTGCACTCAGCGCGGTACTTGCCCTCCCCCTCCCTCTTGAAGGAGGCAGAAGACGTGGCTTTGGGCTTGGGGGGCTGCAGCCACG AGTGGCTGAGGATCTCATCGATGTGGAGCCGCTGGCTGACGTCGGGCTGCAGCATGCGGTAGATGAGGTCCTTGCACTCGCAGGTCAGGT TCTTGGAGCGCGGGAAGTCCACACGGTGCTCCTTCTGGATACGCAGCATCTTCCTGATGTCGGAGTCGTCATAGGGCATGGAGCCGCAGA CCATGATGTACAGGATCACGCCCAGGCTCCAGATGTCATACACCTTGGGCTGGTAGGGGATGCTCTGCAGCACCTCGGGGGCTGCATATG CTGCCGACCCGCAGAAGGTCTTGCTGAGGATGATGCGCCCATTGCTGTCCCGCAGGCAGCGCTTGGAGAAGCCAAAGTCAGACAGCTTGA TGTTGAAGTCCTTGTCGAGGAGAAGGTTCTCGCACTTGAGGTCCCGGTGGACGATGTCCAGGTCGTGGCAGTACTTGACGGCGGAGGAGA GCTGTCGGAACATCTTGCGTGCCACGTCCTCATGCAGGGCTCCCTGGCACTTGATGAACTCGAGGAGGTCGCCCTGGACGCCAAGCTCCA TGATGATGTAGATCCGTCCGTCAGAGGTCTCAAAGATCTCGTAAGTCTTGATGATGGAGCCGTGGTTGACAGTTGCCAGGATGTCCATCT CCCGAGGAAGGAATCTCTCCACAAAGTCAGTAGGTGTTTTCTTGCGGTCGATGATCTTGACAGCCACATTGAACTTGAGGCGCTCAGAGT AGGCAGATTTGACTTTTGCGTAGGAACCCTTGCCAAGATTGATGCCTACGATGTAACCCTTCTTCCTTAGGACTGTGGCATCGTCCATGG TGCCAGGAGCGACTGGCGCCGCTGCCGTCTACATCCCCCCGTCATGTGGGCCAGCAGGCATTGTCCTCATTTACACTACCGGAGGCGTCT GGCTGGGCTGCCCTGGGCTGGGCTTCGACTCAGGGGTGGAACACTCAGCATTGTCTCCGGGTGACTTCAGCCAATGAACTCATAAAGCCA AGGAGTGGGGGCGGGGACTGGGCTGAGGGAGAACAGGGTCTCTGGAACCGTGGAAGCCAGGCTGGTCTGGCAGGAGCACCCACTCCCCGC CCGCTGGAAGGAAGCCTGTCCCCAGGACAGGACTCTGGTGGCCCTGCTGCTGCTGCATTGGTTTCCCTGTCACAAGTCAAGCTGGAGGGG AGGCGGCCCACGTCCAGCCTGTTTGCATCACCTGGCTGTGGGGACTGACCCTGCATTGGTCTTTGTCCCACTAGGGTGGGTTTCCTGCAG CTTCTTTGGCTATGAAGAAAAGCACCCCCAGGGCTGTGTCCTTGGTGTGGTAGGACAGTTGTCCCTGACAGTCACCCAGACAGGCCTGCA TAGCACCCCAGTTACACAGACAGATTTCCACAGCACTGCCTTACCATTGAGCACATAGTTAAATCTAGGGAAATCAGTGCCCAGACATCA AAGCTAGAAATGAAACATGGTCAGCAGGAGCCTTGCATGGGCTTCTCTTTTGCTGGAGCAAGCCAAAATAATAGGAACGGTTTTACATTC CTAGTGCCAGGACCCATCTCGGGTCGACAAAATCTGAAGACAAGTTAAGGGAACAGGCAGCTGTTTGAATAGATCAATTGGATAGTCTAA GGCAGCTCTCTGGACCAAGCTGTAAAGGAGATACAATCGAAATAATCACTCCGGTACCACAGTAGACAGGCCTTGAAGGCACTGGGCCCC TTTTAATCGGACTTAGCAAGCATTTTTTTTGCCTCTGACCTTCTCCTTGGAACAAAATTAGTTACCAGTAGACTTAGGTGATTGCTGTAC TGCATGTAGGCACATAACCCCAACCTATATAAACAGTAAGAAAATTGTAGCACTTTGAGTTGGTCTGCTGGAATTATCTCCAGCCTTCTC >22423_22423_3_DGCR8-DGCR14_DGCR8_chr22_20082318_ENST00000407755_DGCR14_chr22_19127242_ENST00000252137_length(amino acids)=849AA_BP=561 METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSELPAEDPFNFYGASLLSKGSFSKGRLLIDPN CSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD KKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYEDDFDNDVDALLEEGLCAPKKRRTEEKYGGD SDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKD NEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDF EQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECARATL EILIPDFVKQTSEEKPKDSEELERQKDNLELPSAEHQAIESSQASVETWKYKAKNSLMYYPEGVPDEEQLFKKPRQVVHKNTRFLRDPFS QALSRCQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPMMTWGEVENTPLRVEGSETPYVDRTPGPAFKIL EPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPKGLSPAMSPALQRLVSRTASKYTDRALRASYTPSPARSTHLKTPASGLQT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DGCR8-DGCR14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000351989 | - | 9 | 14 | 701_773 | 596.0 | 774.0 | DROSHA |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000383024 | - | 8 | 13 | 701_773 | 563.0 | 741.0 | DROSHA |
| Hgene | DGCR8 | chr22:20082318 | chr22:19127242 | ENST00000407755 | - | 7 | 12 | 701_773 | 563.0 | 741.0 | DROSHA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DGCR8-DGCR14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DGCR8-DGCR14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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