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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DGKB-NAGA (FusionGDB2 ID:22442)

Fusion Gene Summary for DGKB-NAGA

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKB-NAGA
Fusion gene ID: 22442
HgeneTgene
Gene symbol

DGKB

NAGA

Gene ID

1607

4668

Gene namediacylglycerol kinase betaalpha-N-acetylgalactosaminidase
SynonymsDAGK2|DGK|DGK-BETAD22S674|GALB
Cytomap

7p21.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase beta90 kDa diacylglycerol kinaseDAG kinase betadiacylglycerol kinase, beta 90kDadiglyceride kinase betaalpha-N-acetylgalactosaminidaseAcetylgalactosaminidase, alpha-N- (alpha-galactosidase B)N-acetylgalactosaminidase, alpha-alpha-galactosidase B
Modification date2020031320200313
UniProtAcc

Q9Y6T7

P17050

Ensembl transtripts involved in fusion geneENST00000258767, ENST00000399322, 
ENST00000402815, ENST00000403951, 
ENST00000403963, ENST00000406247, 
ENST00000407950, ENST00000444700, 
ENST00000396398, ENST00000402937, 
ENST00000403363, 
Fusion gene scores* DoF score8 X 8 X 1=642 X 2 X 1=4
# samples 82
** MAII scorelog2(8/64*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: DGKB [Title/Abstract] AND NAGA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGKB(14579012)-NAGA(42455380), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKB

GO:0046486

glycerolipid metabolic process

22627129

HgeneDGKB

GO:0046834

lipid phosphorylation

22627129

TgeneNAGA

GO:0016052

carbohydrate catabolic process

19683538


check buttonFusion gene breakpoints across DGKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NAGA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC580396DGKBchr7

14579012

+NAGAchr22

42455380

+


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Fusion Gene ORF analysis for DGKB-NAGA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000258767ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000399322ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000402815ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000403951ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000403963ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000406247ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000407950ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-3UTRENST00000444700ENST00000396398DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000258767ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000258767ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000399322ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000399322ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000402815ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000402815ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000403951ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000403951ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000403963ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000403963ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000406247ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000406247ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000407950ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000407950ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000444700ENST00000402937DGKBchr7

14579012

+NAGAchr22

42455380

+
intron-intronENST00000444700ENST00000403363DGKBchr7

14579012

+NAGAchr22

42455380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DGKB-NAGA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGKB-NAGA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:14579012/:42455380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKB

Q9Y6T7

NAGA

P17050

FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}.FUNCTION: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. {ECO:0000269|PubMed:9741689}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DGKB-NAGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DGKB-NAGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGKB-NAGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGKB-NAGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource