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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DGKD-INPP5D (FusionGDB2 ID:22447)

Fusion Gene Summary for DGKD-INPP5D

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKD-INPP5D
Fusion gene ID: 22447
HgeneTgene
Gene symbol

DGKD

INPP5D

Gene ID

8527

3635

Gene namediacylglycerol kinase deltainositol polyphosphate-5-phosphatase D
SynonymsDGK-delta|DGKdelta|dgkd-2SHIP|SHIP-1|SHIP1|SIP-145|hp51CN|p150Ship
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase deltaphosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1SH2 domain-containing inositol 5'-phosphatase 1inositol polyphosphate-5-phosphatase, 145kDinositol polyphosphate-5-phosphatase, 145kDaphosphatidylinositol 4,5-bisphosphate 5-phosphatasesignaling
Modification date2020031320200313
UniProtAcc

Q16760

Q92835

Ensembl transtripts involved in fusion geneENST00000264057, ENST00000409813, 
ENST00000489613, 		ENST00000359570, 
ENST00000450745, ENST00000455936, 
ENST00000474278, ENST00000538935, 
Fusion gene scores* DoF score21 X 6 X 10=12608 X 10 X 5=400
# samples 2310
** MAII scorelog2(23/1260*10)=-2.4537179674429
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGKD [Title/Abstract] AND INPP5D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGKD(234372929)-INPP5D(234098496), # samples:2
Anticipated loss of major functional domain due to fusion event.DGKD-INPP5D seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DGKD-INPP5D seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DGKD-INPP5D seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKD

GO:0010033

response to organic substance

12200442


check buttonFusion gene breakpoints across DGKD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INPP5D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-MX-A663DGKDchr2

234263320

+INPP5Dchr2

234066958

+
ChimerDB4STADTCGA-VQ-A8E0-01ADGKDchr2

234372929

-INPP5Dchr2

234098496

+
ChimerDB4STADTCGA-VQ-A8E0-01ADGKDchr2

234372929

+INPP5Dchr2

234098496

+
ChimerDB4STADTCGA-VQ-A8E0DGKDchr2

234372929

+INPP5Dchr2

234098495

+


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Fusion Gene ORF analysis for DGKD-INPP5D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264057ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000264057ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000264057ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000264057ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000264057ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000264057ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000264057ENST00000474278DGKDchr2

234263320

+INPP5Dchr2

234066958

+
5CDS-intronENST00000264057ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000264057ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000264057ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000264057ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000409813ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000409813ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000409813ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000409813ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000409813ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000409813ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000409813ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000409813ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098495

+
5CDS-intronENST00000409813ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098496

+
5CDS-intronENST00000409813ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098495

+
Frame-shiftENST00000264057ENST00000359570DGKDchr2

234263320

+INPP5Dchr2

234066958

+
Frame-shiftENST00000264057ENST00000450745DGKDchr2

234263320

+INPP5Dchr2

234066958

+
Frame-shiftENST00000264057ENST00000455936DGKDchr2

234263320

+INPP5Dchr2

234066958

+
Frame-shiftENST00000264057ENST00000538935DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000409813ENST00000359570DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000409813ENST00000450745DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000409813ENST00000455936DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000409813ENST00000538935DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000489613ENST00000359570DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000489613ENST00000450745DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000489613ENST00000455936DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-3CDSENST00000489613ENST00000538935DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-intronENST00000409813ENST00000474278DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-intronENST00000489613ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098496

+
intron-intronENST00000489613ENST00000359570DGKDchr2

234372929

+INPP5Dchr2

234098495

+
intron-intronENST00000489613ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098496

+
intron-intronENST00000489613ENST00000450745DGKDchr2

234372929

+INPP5Dchr2

234098495

+
intron-intronENST00000489613ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098496

+
intron-intronENST00000489613ENST00000455936DGKDchr2

234372929

+INPP5Dchr2

234098495

+
intron-intronENST00000489613ENST00000474278DGKDchr2

234263320

+INPP5Dchr2

234066958

+
intron-intronENST00000489613ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098496

+
intron-intronENST00000489613ENST00000474278DGKDchr2

234372929

+INPP5Dchr2

234098495

+
intron-intronENST00000489613ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098496

+
intron-intronENST00000489613ENST00000538935DGKDchr2

234372929

+INPP5Dchr2

234098495

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DGKD-INPP5D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DGKDchr2234372929+INPP5Dchr2234098495+3.00E-101
DGKDchr2234263320+INPP5Dchr2234066958+1.17E-101
DGKDchr2234372929+INPP5Dchr2234098495+3.00E-101
DGKDchr2234372929+INPP5Dchr2234098495+3.00E-101
DGKDchr2234263320+INPP5Dchr2234066958+1.17E-101
DGKDchr2234372929+INPP5Dchr2234098495+3.00E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DGKD-INPP5D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:234372929/:234098496)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKD

Q16760

INPP5D

Q92835

FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}.FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DGKD-INPP5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DGKD-INPP5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGKD-INPP5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGKD-INPP5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource