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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DGKD-NDUFA10 (FusionGDB2 ID:22450)

Fusion Gene Summary for DGKD-NDUFA10

Fusion gene summary

Fusion gene information	Fusion gene name: DGKD-NDUFA10
	Fusion gene ID: 22450
		Hgene	Tgene
	Gene symbol	DGKD	NDUFA10
	Gene ID	8527	4705
	Gene name	diacylglycerol kinase delta	NADH:ubiquinone oxidoreductase subunit A10
	Synonyms	DGK-delta\|DGKdelta\|dgkd-2	CI-42KD\|CI-42k\|MC1DN22
	Cytomap	2q37.1	2q37.3
	Type of gene	protein-coding	protein-coding
	Description	diacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNADH-ubiquinone oxidoreductase 42 kDa subunitcomplex I 42kDa subunit
	Modification date	20200313	20200313
	UniProtAcc	Q16760	O95299
	Ensembl transtripts involved in fusion gene	ENST00000264057, ENST00000409813, ENST00000489613,	ENST00000307300, ENST00000404554, ENST00000407129, ENST00000471378, ENST00000252711,
Fusion gene scores	* DoF score	21 X 6 X 10=1260	9 X 7 X 4=252
	# samples	23	9
	** MAII score	log2(23/1260*10)=-2.4537179674429 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DGKD [Title/Abstract] AND NDUFA10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DGKD(234299129)-NDUFA10(240961757), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DGKD	GO:0010033	response to organic substance	12200442

Fusion gene breakpoints across DGKD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFA10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A3LY-01B	DGKD	chr2	234299129	-	NDUFA10	chr2	240961757	-
ChimerDB4	SARC	TCGA-DX-A3LY-01B	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-

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Fusion Gene ORF analysis for DGKD-NDUFA10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000264057	ENST00000307300	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000264057	ENST00000404554	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000264057	ENST00000407129	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000264057	ENST00000471378	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000409813	ENST00000307300	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000409813	ENST00000404554	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000409813	ENST00000407129	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
5CDS-intron	ENST00000409813	ENST00000471378	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
In-frame	ENST00000264057	ENST00000252711	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
In-frame	ENST00000409813	ENST00000252711	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
intron-3CDS	ENST00000489613	ENST00000252711	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
intron-intron	ENST00000489613	ENST00000307300	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
intron-intron	ENST00000489613	ENST00000404554	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
intron-intron	ENST00000489613	ENST00000407129	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-
intron-intron	ENST00000489613	ENST00000471378	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000264057

DGKD

chr2

234299129

ENST00000252711

NDUFA10

chr2

240961757

5099

360

1352

446

ENST00000409813

DGKD

chr2

234299129

ENST00000252711

NDUFA10

chr2

240961757

5034

295

1287

402

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264057	ENST00000252711	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-	0.000290365	0.99970967
ENST00000409813	ENST00000252711	DGKD	chr2	234299129	+	NDUFA10	chr2	240961757	-	0.000139563	0.9998604

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Fusion Genomic Features for DGKD-NDUFA10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGKD-NDUFA10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:234299129/chr2:240961757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DGKD Q16760	NDUFA10 O95299
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250\|UniProtKB:E9PUQ8, ECO:0000269\|PubMed:12200442, ECO:0000269\|PubMed:17880279, ECO:0000269\|PubMed:23949095, ECO:0000305}.	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269\|PubMed:27626371}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

8_36

116

1215.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

8_36

1171.0

Compositional bias

Note=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

1145_1208

116

1215.0

Domain

SAM

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

317_451

116

1215.0

Domain

DAGKc

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

53_146

116

1215.0

Domain

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

1145_1208

1171.0

Domain

SAM

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

317_451

1171.0

Domain

DAGKc

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

53_146

1171.0

Domain

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

163_213

116

1215.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000264057

235_286

116

1215.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

163_213

1171.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234299129

chr2:240961757

ENST00000409813

235_286

1171.0

Zinc finger

Phorbol-ester/DAG-type 2

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Fusion Gene Sequence for DGKD-NDUFA10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22450_22450_1_DGKD-NDUFA10_DGKD_chr2_234299129_ENST00000264057_NDUFA10_chr2_240961757_ENST00000252711_length(transcript)=5099nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
AGAGGAATTCATAGCAGTGTGCAGTGCAAACTGCGCTATGGAATGTGGCATTTCCTACTTGGGGATAAAGCAAGCAAAAGACTGACAGAA
CGCAGCAGAGTGATAACTGTAGATGGCAATATATGTACTGGAAAAGGCAAACTTGCAAAAGAAATAGCAGAGAAACTAGGCTTCAAGCAC
TTTCCTGAAGCGGGGATTCATTATCCAGACAGTACCACAGGAGATGGGAAGCCCCTCGCCACCGACTATAATGGCAACTGTAGTTTGGAG
AAATTTTACGATGATCCGAGAAGCAATGATGGCAACAGTTACCGCCTGCAGTCCTGGTTGTACAGCAGTCGCCTGCTGCAGTACTCAGAT
GCCTTGGAGCACTTGCTGACCACAGGACAAGGTGTTGTGTTGGAGCGCTCCATCTTCAGTGACTTTGTGTTCCTGGAGGCGATGTACAAC
CAGGGATTCATCCGAAAGCAGTGTGTGGACCACTACAACGAGGTGAAGAGCGTCACCATCTGCGATTACCTGCCCCCCCACCTGGTGATT
TACATCGATGTGCCCGTTCCAGAGGTCCAGAGGCGGATTCAGAAGAAAGGAGATCCACATGAAATGAAGATCACCTCTGCCTATCTACAG
GACATTGAGAATGCCTATAAGAAAACCTTTCTCCCTGAGATGAGTGAAAAATGTGAGGTTTTACAATATTCTGCAAGGGAAGCTCAAGAT
TCAAAAAAGGTGGTAGAGGACATTGAATACCTGAAGTTCGATAAAGGGCCGTGGCTCAAGCAGGACAATCGCACTTTATACCACCTGCGA
TTACTGGTTCAGGATAAGTTTGAGGTGCTGAATTACACAAGCATTCCTATCTTTCTCCCGGAAGTCACCATTGGAGCTCATCAGACTGAC
CGTGTCTTACATCAGTTCAGAGAGCTGCCGGGCCGCAAGTACAGCCCTGGGTACAACACCGAGGTGGGAGACAAGTGGATCTGGCTGAAG
TGAACGGGCCGCCTTCTGCTCCAGCTGCATCACAGTGATGGCCAAGCTGCATCAGCCGCACTCTCCTGGACGCCATATAGCTTTAAGATC
GGGGGAGGGTAAATAATGCAAAAATTGCACAGTGGAAGAAGGGGTCTCACAAAAAGCAATCCATCCTGTAGTATAGGTAATGGAGTTGGG
GGAAGCAGCTTCCATTCTGGATGTTTGGAACCCTTTAGCTTTGTTTTGGAATGGCCCACCATTCTCACTGGAAAACAGTGGTCTGCTGTG
AAAGGCCAGCTCTCGGCAGCCCCTGTGGTTTCAGCGCTGCCGCTCTGTGTCATTCAGGTTGTGCACATTGTTTTTCTTCTGACTTCCAGA
AATAAAAGTGTTTCCATGGGAATTTCCCCATCGTACGTCTATGTGCGTGCGGGCACGTCGAAACTGCACACGTGCACACACGCTGCTCTG
GGCCCTGTTTGGTGTGGTGTGGTTTAATTGAGGCTTACATTATGCTGAAGAGTTTTTCTAAAGGCCTACTGTATTTATTTTAGTAATGTG
CTACATTAGAGTAGAAAAAATAAGAACGTGAAGAAGAAATAGCAAAAGGAGAAAATTACCACAGATTTACAGAACAATATGTTTTAAGAG
AGACGTTGAGAAAGATTCACGTGGCCGTCCTCAGCGTCTCAAACTCCTTTGAAGGGAGATTTGAGCTTAGGCTGTTGATGACATAAGATG
CAAAAGCAAAATAATATACTCTCTTTATTACCCAGAAAATCAAGTTGCCAGTCAAAACTGAGAAATGAGAAAGAAAATCAGATTTCTTTA
TTCATCTCTGTTGAAGCCTAGAAAACCAAAACAAGCTGGTTGTGGTTCAGCATCATGGTTTAGGAATCAAGCTGTCAGTTGTGAGTCCTA
CTGAACTGTGGGTTTTCCACTGTAAAGCTCCACTGTGTCCATTAGGAATCAGGCTGCCAGTTGTGAGTCCTACTGAACTGTGGGTTTTCC
ACTGTAAAGCTCCACTGTGTCCAATATGGTAGCTCCTAGCCACATGTGGGTATTGAAATTTAAATGAGCTAAAATGTAATAGAGTTTAAA
ATTGGGTTCCTTGGTTGCACTGGCCATAGTTCAGGCACTCCACAGCCGCCTGTGGGCAGTAGTTCCAGTGCTGGTGCAGAGGACGATGCT
CTGCTCCCCGCGGAAGCTCTACCAGGCCTCGCTGCTGCGGAGCATGCGAAGAAGATGCACACTCCTTCCCTCCTTGCGTCCGCCTGCCTT
TTTCCCTCTCCCCTTCCTTCCCTCCTTCTTTCCTCCTCCTTCCCTCCCTTCCTTTCTTCCTTCCATCTGTCCTTGTTTTCCTCCCTTCCC
TTCCTCCCTGCCTCTTTCCTTCCCTCCTTCTCTTCCTTCCTTCCGTCTGTCCTTGTTTTCCTCCCTGCCTCTTTCCTTCCCTCCTTCTCT
TCCTTCCTTCCTTCCGTCTGTCCTTGTTTTCCTCCCTTCCCTTCCTCCCTGCCTCCTTCCTTGTTTTAAGAATTTGAAAATAAAGTTTCC
CAGGAGTTTTGAATTGGAGTCGAGATTTAAGTGGCTGAAGTTTTGCATTTCACTAGGAAACCAACAGCTTTAATCATGAAATGAAAGCAC
AGCTGGGCATTGGGCCAGTCACAGAGTGTCTTTTGCTCTGAGCACTTCACAAACCCATTGTGGAGGGGAGGAAAGAAAAAGAAAGCCATC
TTTAATTATCTTAGCTGTTCCTAATGTCTTTGGCTGCAAAGAGCTAGCTGTTTCCTTCAACCTTGGTGGTTGCACGGGTAGTGTCCTCAG
CAGTGAGAGGGCAGGTCTGCCCTGTGGTCAGGATTGCCCTTGTGAGGGGCAGAGCTCTCCAACCATGCAGGGCTCCGTGTCGGCATGGTG
TGGACTCGGGTGCTCTGATCATCCCCTGTGTTTGCGTCTGACCCTGTGTGGTTGCATTCCCTTGATGGAGTGGGAAGTATGTAATTTGTA
GTGCTGAGGACATTCGTCTGTTTGATTTTCTGGTGTTTTCAATGACATGCATGTTCAGCAGAGAAAGATGAATAAACACTGTCCAATTCT
TCTCTCCACATAGAAGCCTCAAGAAGAGGTGAGGAGATGCCCCGATTTCCTTATTTCAGAGCAGTACATGCGTTCGTCTCACGAAAGCTC
TTACAACTAAAACAACAGCACCAACAAACCAGGATCAAAATAATCGTGCATTTTCCAGGATTCCATGTTGGACTTCTCAGTGCTTTGGAG
ATCAGGAAATAATCATGCTGTTGCAGCAGTATGGTTTTGTGTCTGGATTTTATTCATACAGGCATGTGTTTACAGGCATGAGAATTCTGT
ATTGAAAAGAAAGTCCTTGTTTTTTTCTAACGTATCTTTCTGTTCCATCAACTGTTAAAACCAAATTGTTAAGAACATTGAGCTTCTTAG
GAGAGATTACATGCAGCTACTTAGGACCACCTCAGCAAAATGGAGTTGCCTGGGTAGATAGCAGCAGCAGCTCACCAGCCCCACGCTGCC
AGGCTGCTGGCTGCTGTCCACCAGGCAGCTGTGGAACCTCCATGTTCTGCCTAGGTGTTGTGGCAAGAACAGCAGGGAAACAGGCGGCCG
CCTCCAGGCCACAGGTGGACCCAGGGACCTTCAGTTACGCCGCTTCAATTGAATTCGTGGTGGTTTCTCTGCTACAGCAGAAGTGGAAGA
AGCTCTTGTCTTGTTTGGCATTTGTCCCATTTTTTGGCTAATAATTGGCTTTGAATTTCTCTGTGCCCTGCTTACCAATTATAGCTTTCT
GGATTGGCTGTTCTTAGCAGTGCAAATGTCAATGCAAAGAAGCAAGCAGGCGGCTACTTTCTGGGAAGAAGCATAGTCCGTGCTCACACT
GGATATAAATCTGCAAGATTTGGGGGTTTGGCAAAATAGGGGTGGAGGGAAAGCTGCCATGGCTGTCAGAAATTGGGGCTTTTTGAAGAA
AAGCTTGTGTAGGCATCAGCCACTGGCTGGCCAGAATTCCATGAATGGAAGCAGGTGCCCGAGTGATCTGGGGCTTTACATGTGGATATA
AATAGAAGCCGGGAGCCTGAGGCTTTGCTTTAGGAAAATCATGAGCCAGAAAACAGAGGAGGTGATTGTCAGTAGTCACCTCACGCCGCT
AGTGTTTTCTAATACTCTCTCGAATTGTCAAAGCAAAGGACCTTATAACAGCAACACGTGTGTGACTCGAAGCAGCGAGCTTCCCTTGGG
AAAAGGAGCCTCTTCTCAGCAGAGGGTCCCAGCCTTTCTGTCCTTCCCCATCGGAATGCCAGGCTCTGTGAGTTTGGATGTTGGACATTG
CCACCTGAATTCCAGGAGGCCGGGGAGCTCCAGTGATGGACTTGTCCCCAAAAGAGTGGTGCTGTTCTCAGAGCCATAAATGTTCCACTG
AAAGTGTCTGTCCCCTGGCTCACGCTGGCTGCGCTTGCTTGAAGGAGGCTGATTTAAGGGTTCTAATAGGAAGACAAATGAAACTGTCAA
ATTTTATCTTTAAGCATGTGAGTAAGTTTGCTCATTCGCTTTTACTATTGATGTATAGTTTTAAAATTCTTAATTTAAAAATTATTTTAA
TAGTAAATTTTTCACAAGTGAACACTTTTTATCTTTAAATTAAAATTCTGAAGCTCCCTAGTTAGTTAGATCCAATTGCTGGTTACATTT

>22450_22450_1_DGKD-NDUFA10_DGKD_chr2_234299129_ENST00000264057_NDUFA10_chr2_240961757_ENST00000252711_length(amino acids)=446AA_BP=114
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEA
GIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFI
RKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKV

--------------------------------------------------------------
>22450_22450_2_DGKD-NDUFA10_DGKD_chr2_234299129_ENST00000409813_NDUFA10_chr2_240961757_ENST00000252711_length(transcript)=5034nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGAGAGGAATTCATAGCAGTGTGCAGTGCAAACTGCGCTATGGAATGTGGCATTTCCTACTTGGGGA
TAAAGCAAGCAAAAGACTGACAGAACGCAGCAGAGTGATAACTGTAGATGGCAATATATGTACTGGAAAAGGCAAACTTGCAAAAGAAAT
AGCAGAGAAACTAGGCTTCAAGCACTTTCCTGAAGCGGGGATTCATTATCCAGACAGTACCACAGGAGATGGGAAGCCCCTCGCCACCGA
CTATAATGGCAACTGTAGTTTGGAGAAATTTTACGATGATCCGAGAAGCAATGATGGCAACAGTTACCGCCTGCAGTCCTGGTTGTACAG
CAGTCGCCTGCTGCAGTACTCAGATGCCTTGGAGCACTTGCTGACCACAGGACAAGGTGTTGTGTTGGAGCGCTCCATCTTCAGTGACTT
TGTGTTCCTGGAGGCGATGTACAACCAGGGATTCATCCGAAAGCAGTGTGTGGACCACTACAACGAGGTGAAGAGCGTCACCATCTGCGA
TTACCTGCCCCCCCACCTGGTGATTTACATCGATGTGCCCGTTCCAGAGGTCCAGAGGCGGATTCAGAAGAAAGGAGATCCACATGAAAT
GAAGATCACCTCTGCCTATCTACAGGACATTGAGAATGCCTATAAGAAAACCTTTCTCCCTGAGATGAGTGAAAAATGTGAGGTTTTACA
ATATTCTGCAAGGGAAGCTCAAGATTCAAAAAAGGTGGTAGAGGACATTGAATACCTGAAGTTCGATAAAGGGCCGTGGCTCAAGCAGGA
CAATCGCACTTTATACCACCTGCGATTACTGGTTCAGGATAAGTTTGAGGTGCTGAATTACACAAGCATTCCTATCTTTCTCCCGGAAGT
CACCATTGGAGCTCATCAGACTGACCGTGTCTTACATCAGTTCAGAGAGCTGCCGGGCCGCAAGTACAGCCCTGGGTACAACACCGAGGT
GGGAGACAAGTGGATCTGGCTGAAGTGAACGGGCCGCCTTCTGCTCCAGCTGCATCACAGTGATGGCCAAGCTGCATCAGCCGCACTCTC
CTGGACGCCATATAGCTTTAAGATCGGGGGAGGGTAAATAATGCAAAAATTGCACAGTGGAAGAAGGGGTCTCACAAAAAGCAATCCATC
CTGTAGTATAGGTAATGGAGTTGGGGGAAGCAGCTTCCATTCTGGATGTTTGGAACCCTTTAGCTTTGTTTTGGAATGGCCCACCATTCT
CACTGGAAAACAGTGGTCTGCTGTGAAAGGCCAGCTCTCGGCAGCCCCTGTGGTTTCAGCGCTGCCGCTCTGTGTCATTCAGGTTGTGCA
CATTGTTTTTCTTCTGACTTCCAGAAATAAAAGTGTTTCCATGGGAATTTCCCCATCGTACGTCTATGTGCGTGCGGGCACGTCGAAACT
GCACACGTGCACACACGCTGCTCTGGGCCCTGTTTGGTGTGGTGTGGTTTAATTGAGGCTTACATTATGCTGAAGAGTTTTTCTAAAGGC
CTACTGTATTTATTTTAGTAATGTGCTACATTAGAGTAGAAAAAATAAGAACGTGAAGAAGAAATAGCAAAAGGAGAAAATTACCACAGA
TTTACAGAACAATATGTTTTAAGAGAGACGTTGAGAAAGATTCACGTGGCCGTCCTCAGCGTCTCAAACTCCTTTGAAGGGAGATTTGAG
CTTAGGCTGTTGATGACATAAGATGCAAAAGCAAAATAATATACTCTCTTTATTACCCAGAAAATCAAGTTGCCAGTCAAAACTGAGAAA
TGAGAAAGAAAATCAGATTTCTTTATTCATCTCTGTTGAAGCCTAGAAAACCAAAACAAGCTGGTTGTGGTTCAGCATCATGGTTTAGGA
ATCAAGCTGTCAGTTGTGAGTCCTACTGAACTGTGGGTTTTCCACTGTAAAGCTCCACTGTGTCCATTAGGAATCAGGCTGCCAGTTGTG
AGTCCTACTGAACTGTGGGTTTTCCACTGTAAAGCTCCACTGTGTCCAATATGGTAGCTCCTAGCCACATGTGGGTATTGAAATTTAAAT
GAGCTAAAATGTAATAGAGTTTAAAATTGGGTTCCTTGGTTGCACTGGCCATAGTTCAGGCACTCCACAGCCGCCTGTGGGCAGTAGTTC
CAGTGCTGGTGCAGAGGACGATGCTCTGCTCCCCGCGGAAGCTCTACCAGGCCTCGCTGCTGCGGAGCATGCGAAGAAGATGCACACTCC
TTCCCTCCTTGCGTCCGCCTGCCTTTTTCCCTCTCCCCTTCCTTCCCTCCTTCTTTCCTCCTCCTTCCCTCCCTTCCTTTCTTCCTTCCA
TCTGTCCTTGTTTTCCTCCCTTCCCTTCCTCCCTGCCTCTTTCCTTCCCTCCTTCTCTTCCTTCCTTCCGTCTGTCCTTGTTTTCCTCCC
TGCCTCTTTCCTTCCCTCCTTCTCTTCCTTCCTTCCTTCCGTCTGTCCTTGTTTTCCTCCCTTCCCTTCCTCCCTGCCTCCTTCCTTGTT
TTAAGAATTTGAAAATAAAGTTTCCCAGGAGTTTTGAATTGGAGTCGAGATTTAAGTGGCTGAAGTTTTGCATTTCACTAGGAAACCAAC
AGCTTTAATCATGAAATGAAAGCACAGCTGGGCATTGGGCCAGTCACAGAGTGTCTTTTGCTCTGAGCACTTCACAAACCCATTGTGGAG
GGGAGGAAAGAAAAAGAAAGCCATCTTTAATTATCTTAGCTGTTCCTAATGTCTTTGGCTGCAAAGAGCTAGCTGTTTCCTTCAACCTTG
GTGGTTGCACGGGTAGTGTCCTCAGCAGTGAGAGGGCAGGTCTGCCCTGTGGTCAGGATTGCCCTTGTGAGGGGCAGAGCTCTCCAACCA
TGCAGGGCTCCGTGTCGGCATGGTGTGGACTCGGGTGCTCTGATCATCCCCTGTGTTTGCGTCTGACCCTGTGTGGTTGCATTCCCTTGA
TGGAGTGGGAAGTATGTAATTTGTAGTGCTGAGGACATTCGTCTGTTTGATTTTCTGGTGTTTTCAATGACATGCATGTTCAGCAGAGAA
AGATGAATAAACACTGTCCAATTCTTCTCTCCACATAGAAGCCTCAAGAAGAGGTGAGGAGATGCCCCGATTTCCTTATTTCAGAGCAGT
ACATGCGTTCGTCTCACGAAAGCTCTTACAACTAAAACAACAGCACCAACAAACCAGGATCAAAATAATCGTGCATTTTCCAGGATTCCA
TGTTGGACTTCTCAGTGCTTTGGAGATCAGGAAATAATCATGCTGTTGCAGCAGTATGGTTTTGTGTCTGGATTTTATTCATACAGGCAT
GTGTTTACAGGCATGAGAATTCTGTATTGAAAAGAAAGTCCTTGTTTTTTTCTAACGTATCTTTCTGTTCCATCAACTGTTAAAACCAAA
TTGTTAAGAACATTGAGCTTCTTAGGAGAGATTACATGCAGCTACTTAGGACCACCTCAGCAAAATGGAGTTGCCTGGGTAGATAGCAGC
AGCAGCTCACCAGCCCCACGCTGCCAGGCTGCTGGCTGCTGTCCACCAGGCAGCTGTGGAACCTCCATGTTCTGCCTAGGTGTTGTGGCA
AGAACAGCAGGGAAACAGGCGGCCGCCTCCAGGCCACAGGTGGACCCAGGGACCTTCAGTTACGCCGCTTCAATTGAATTCGTGGTGGTT
TCTCTGCTACAGCAGAAGTGGAAGAAGCTCTTGTCTTGTTTGGCATTTGTCCCATTTTTTGGCTAATAATTGGCTTTGAATTTCTCTGTG
CCCTGCTTACCAATTATAGCTTTCTGGATTGGCTGTTCTTAGCAGTGCAAATGTCAATGCAAAGAAGCAAGCAGGCGGCTACTTTCTGGG
AAGAAGCATAGTCCGTGCTCACACTGGATATAAATCTGCAAGATTTGGGGGTTTGGCAAAATAGGGGTGGAGGGAAAGCTGCCATGGCTG
TCAGAAATTGGGGCTTTTTGAAGAAAAGCTTGTGTAGGCATCAGCCACTGGCTGGCCAGAATTCCATGAATGGAAGCAGGTGCCCGAGTG
ATCTGGGGCTTTACATGTGGATATAAATAGAAGCCGGGAGCCTGAGGCTTTGCTTTAGGAAAATCATGAGCCAGAAAACAGAGGAGGTGA
TTGTCAGTAGTCACCTCACGCCGCTAGTGTTTTCTAATACTCTCTCGAATTGTCAAAGCAAAGGACCTTATAACAGCAACACGTGTGTGA
CTCGAAGCAGCGAGCTTCCCTTGGGAAAAGGAGCCTCTTCTCAGCAGAGGGTCCCAGCCTTTCTGTCCTTCCCCATCGGAATGCCAGGCT
CTGTGAGTTTGGATGTTGGACATTGCCACCTGAATTCCAGGAGGCCGGGGAGCTCCAGTGATGGACTTGTCCCCAAAAGAGTGGTGCTGT
TCTCAGAGCCATAAATGTTCCACTGAAAGTGTCTGTCCCCTGGCTCACGCTGGCTGCGCTTGCTTGAAGGAGGCTGATTTAAGGGTTCTA
ATAGGAAGACAAATGAAACTGTCAAATTTTATCTTTAAGCATGTGAGTAAGTTTGCTCATTCGCTTTTACTATTGATGTATAGTTTTAAA
ATTCTTAATTTAAAAATTATTTTAATAGTAAATTTTTCACAAGTGAACACTTTTTATCTTTAAATTAAAATTCTGAAGCTCCCTAGTTAG

>22450_22450_2_DGKD-NDUFA10_DGKD_chr2_234299129_ENST00000409813_NDUFA10_chr2_240961757_ENST00000252711_length(amino acids)=402AA_BP=70
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTRGIHSSVQCKLRYGMWHF
LLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQS
WLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGD
PHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIF

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Fusion Gene PPI Analysis for DGKD-NDUFA10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DGKD-NDUFA10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DGKD-NDUFA10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source