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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DGKD-UGT1A4 (FusionGDB2 ID:22459)

Fusion Gene Summary for DGKD-UGT1A4

Fusion gene summary

Fusion gene information	Fusion gene name: DGKD-UGT1A4
	Fusion gene ID: 22459
		Hgene	Tgene
	Gene symbol	DGKD	UGT1A4
	Gene ID	8527	54657
	Gene name	diacylglycerol kinase delta	UDP glucuronosyltransferase family 1 member A4
	Synonyms	DGK-delta\|DGKdelta\|dgkd-2	GNT1\|HUG-BR2\|UDPGT\|UDPGT 1-4\|UGT-1A\|UGT-1D\|UGT1\|UGT1-01\|UGT1-04\|UGT1.1\|UGT1.4\|UGT1A\|UGT1A1\|UGT1A4S\|UGT1D\|hUG-BR1
	Cytomap	2q37.1	2q37.1
	Type of gene	protein-coding	protein-coding
	Description	diacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta	UDP-glucuronosyltransferase 1-4Bilirubin-specific UDPGT isozyme 1UDP glucuronosyltransferase 1 family, polypeptide A4UDP glycosyltransferase 1 family, polypeptide A4UDP-glucuronosyltransferase 1 family polypeptide A4sUDP-glucuronosyltransferase 1-1U
	Modification date	20200313	20200313
	UniProtAcc	Q16760	.
	Ensembl transtripts involved in fusion gene	ENST00000264057, ENST00000409813, ENST00000489613,	ENST00000373409,
Fusion gene scores	* DoF score	21 X 6 X 10=1260	5 X 2 X 6=60
	# samples	23	8
	** MAII score	log2(23/1260*10)=-2.4537179674429 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/60*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DGKD [Title/Abstract] AND UGT1A4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DGKD(234263320)-UGT1A4(234675679), # samples:1 DGKD(234263320)-UGT1A4(234675680), # samples:1 DGKD(234299129)-UGT1A4(234675680), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DGKD	GO:0010033	response to organic substance	12200442
Tgene	UGT1A4	GO:0052695	cellular glucuronidation	22579593

Fusion gene breakpoints across DGKD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UGT1A4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-91-6836-01A	DGKD	chr2	234263320	+	UGT1A4	chr2	234675680	+
ChimerDB4	LUAD	TCGA-91-6836	DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+
ChimerDB4	STAD	TCGA-BR-8284-01A	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+

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Fusion Gene ORF analysis for DGKD-UGT1A4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000264057	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675680	+
In-frame	ENST00000264057	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+
In-frame	ENST00000264057	ENST00000373409	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+
In-frame	ENST00000409813	ENST00000373409	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+
intron-3CDS	ENST00000409813	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675680	+
intron-3CDS	ENST00000409813	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+
intron-3CDS	ENST00000489613	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675680	+
intron-3CDS	ENST00000489613	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+
intron-3CDS	ENST00000489613	ENST00000373409	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000264057

DGKD

chr2

234263320

ENST00000373409

UGT1A4

chr2

234675679

1646

168

905

297

ENST00000264057

DGKD

chr2

234263320

ENST00000373409

UGT1A4

chr2

234675680

1646

168

905

297

ENST00000264057

DGKD

chr2

234299129

ENST00000373409

UGT1A4

chr2

234675680

1838

360

1097

361

ENST00000409813

DGKD

chr2

234299129

ENST00000373409

UGT1A4

chr2

234675680

1773

295

1032

317

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264057	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+	0.001209681	0.9987903
ENST00000264057	ENST00000373409	DGKD	chr2	234263320	+	UGT1A4	chr2	234675680	+	0.001209681	0.9987903
ENST00000264057	ENST00000373409	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+	0.000337005	0.999663
ENST00000409813	ENST00000373409	DGKD	chr2	234299129	+	UGT1A4	chr2	234675680	+	0.000530974	0.999469

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Fusion Genomic Features for DGKD-UGT1A4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+	6.18E-06	0.9999938
DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+	6.18E-06	0.9999938
DGKD	chr2	234299129	+	UGT1A4	chr2	234675679	+	2.24E-09	1
DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+	6.18E-06	0.9999938
DGKD	chr2	234263320	+	UGT1A4	chr2	234675679	+	6.18E-06	0.9999938
DGKD	chr2	234299129	+	UGT1A4	chr2	234675679	+	2.24E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGKD-UGT1A4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:234263320/chr2:234675679)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DGKD Q16760	.
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250\|UniProtKB:E9PUQ8, ECO:0000269\|PubMed:12200442, ECO:0000269\|PubMed:17880279, ECO:0000269\|PubMed:23949095, ECO:0000305}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

8_36

1215.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

8_36

1215.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

8_36

116

1215.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

8_36

1171.0

Compositional bias

Note=Pro-rich

Tgene

UGT1A4

chr2:234263320

chr2:234675679

ENST00000373409

492_508

289

535.0

Transmembrane

Helical

Tgene

UGT1A4

chr2:234263320

chr2:234675680

ENST00000373409

492_508

289

535.0

Transmembrane

Helical

Tgene

UGT1A4

chr2:234299129

chr2:234675680

ENST00000373409

492_508

289

535.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

8_36

1171.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

8_36

1171.0

Compositional bias

Note=Pro-rich

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

1145_1208

1215.0

Domain

SAM

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

317_451

1215.0

Domain

DAGKc

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

53_146

1215.0

Domain

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

1145_1208

1171.0

Domain

SAM

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

317_451

1171.0

Domain

DAGKc

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

53_146

1171.0

Domain

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

1145_1208

1215.0

Domain

SAM

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

317_451

1215.0

Domain

DAGKc

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

53_146

1215.0

Domain

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

1145_1208

1171.0

Domain

SAM

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

317_451

1171.0

Domain

DAGKc

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

53_146

1171.0

Domain

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

1145_1208

116

1215.0

Domain

SAM

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

317_451

116

1215.0

Domain

DAGKc

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

53_146

116

1215.0

Domain

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

1145_1208

1171.0

Domain

SAM

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

317_451

1171.0

Domain

DAGKc

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

53_146

1171.0

Domain

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

163_213

1215.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000264057

235_286

1215.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

163_213

1171.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234263320

chr2:234675679

ENST00000409813

235_286

1171.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

163_213

1215.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000264057

235_286

1215.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

163_213

1171.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234263320

chr2:234675680

ENST00000409813

235_286

1171.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

163_213

116

1215.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000264057

235_286

116

1215.0

Zinc finger

Phorbol-ester/DAG-type 2

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

163_213

1171.0

Zinc finger

Phorbol-ester/DAG-type 1

Hgene

DGKD

chr2:234299129

chr2:234675680

ENST00000409813

235_286

1171.0

Zinc finger

Phorbol-ester/DAG-type 2

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Fusion Gene Sequence for DGKD-UGT1A4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22459_22459_1_DGKD-UGT1A4_DGKD_chr2_234263320_ENST00000264057_UGT1A4_chr2_234675679_ENST00000373409_length(transcript)=1646nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>22459_22459_1_DGKD-UGT1A4_DGKD_chr2_234263320_ENST00000264057_UGT1A4_chr2_234675679_ENST00000373409_length(amino acids)=297AA_BP=0
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>22459_22459_2_DGKD-UGT1A4_DGKD_chr2_234263320_ENST00000264057_UGT1A4_chr2_234675680_ENST00000373409_length(transcript)=1646nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>22459_22459_2_DGKD-UGT1A4_DGKD_chr2_234263320_ENST00000264057_UGT1A4_chr2_234675680_ENST00000373409_length(amino acids)=297AA_BP=0
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>22459_22459_3_DGKD-UGT1A4_DGKD_chr2_234299129_ENST00000264057_UGT1A4_chr2_234675680_ENST00000373409_length(transcript)=1838nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC
AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT
GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA
TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA
CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT
GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT
CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG
GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC
ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC

>22459_22459_3_DGKD-UGT1A4_DGKD_chr2_234299129_ENST00000264057_UGT1A4_chr2_234675680_ENST00000373409_length(amino acids)=361AA_BP=0
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>22459_22459_4_DGKD-UGT1A4_DGKD_chr2_234299129_ENST00000409813_UGT1A4_chr2_234675680_ENST00000373409_length(transcript)=1773nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA
AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT
TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT
AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG
ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC
GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC
TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT
GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT
GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA

>22459_22459_4_DGKD-UGT1A4_DGKD_chr2_234299129_ENST00000409813_UGT1A4_chr2_234675680_ENST00000373409_length(amino acids)=317AA_BP=0
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DGKD-UGT1A4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DGKD-UGT1A4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DGKD-UGT1A4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source