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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DGKZ-GYG1 (FusionGDB2 ID:22489)

Fusion Gene Summary for DGKZ-GYG1

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKZ-GYG1
Fusion gene ID: 22489
HgeneTgene
Gene symbol

DGKZ

GYG1

Gene ID

8525

2992

Gene namediacylglycerol kinase zetaglycogenin 1
SynonymsDAGK5|DAGK6|DGK-ZETA|hDGKzetaGSD15|GYG
Cytomap

11p11.2

3q24

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase zetaDAG kinase zetadiacylglycerol kinase, zeta 104kDadiglyceride kinase zetaglycogenin-1GN-1glycogenin glucosyltransferase
Modification date2020032020200313
UniProtAcc

Q13574

P46976

Ensembl transtripts involved in fusion geneENST00000318201, ENST00000343674, 
ENST00000395574, ENST00000421244, 
ENST00000454345, ENST00000456247, 
ENST00000525434, ENST00000527911, 
ENST00000528615, ENST00000532868, 
ENST00000543978, 		ENST00000296048, 
ENST00000345003, ENST00000483267, 
ENST00000479119, ENST00000484197, 
Fusion gene scores* DoF score6 X 6 X 2=729 X 7 X 3=189
# samples 611
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/189*10)=-0.780882710696413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGKZ [Title/Abstract] AND GYG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGKZ(46366147)-GYG1(148741837), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKZ

GO:0046339

diacylglycerol metabolic process

22627129

HgeneDGKZ

GO:0046486

glycerolipid metabolic process

22627129

HgeneDGKZ

GO:0046834

lipid phosphorylation

18004883|22627129


check buttonFusion gene breakpoints across DGKZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GYG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV698475DGKZchr11

46366147

+GYG1chr3

148741837

+


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Fusion Gene ORF analysis for DGKZ-GYG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000318201ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000318201ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000318201ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000343674ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000343674ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000343674ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000395574ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000395574ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000395574ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000421244ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000421244ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000421244ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000454345ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000454345ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000454345ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000456247ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000456247ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000456247ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000525434ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000525434ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000525434ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000527911ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000527911ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000527911ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000528615ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000528615ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000528615ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000532868ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000532868ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000532868ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000543978ENST00000296048DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000543978ENST00000345003DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-3CDSENST00000543978ENST00000483267DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000318201ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000318201ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000343674ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000343674ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000395574ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000395574ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000421244ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000421244ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000454345ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000454345ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000456247ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000456247ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000525434ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000525434ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000527911ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000527911ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000528615ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000528615ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000532868ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000532868ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000543978ENST00000479119DGKZchr11

46366147

+GYG1chr3

148741837

+
intron-intronENST00000543978ENST00000484197DGKZchr11

46366147

+GYG1chr3

148741837

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DGKZ-GYG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGKZ-GYG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46366147/:148741837)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKZ

Q13574

GYG1

P46976

FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q80UP3, ECO:0000269|PubMed:15157668, ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:9159104, ECO:0000305|PubMed:8626588}.; FUNCTION: [Isoform 1]: Regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.; FUNCTION: [Isoform 2]: Does not regulate RASGRP1 activity. {ECO:0000269|PubMed:11257115}.FUNCTION: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. {ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DGKZ-GYG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DGKZ-GYG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGKZ-GYG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGKZ-GYG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource